Explanipedia

Comparative Evaluation of Contrast-enhanced Ultrasound and Indocyanine Green Lymphography for Lymphatic Mapping: A Retrospective Study Open

Samyd S. Bustos, María Rios, Samuel Jang, Gina K. Hesley, Christine U. Lee , et al. · 2025

Background: Lymphaticovenous anastomosis (LVA) is an effective surgical treatment for extremity lymphedema. Indocyanine green (ICG) fluorescent lymphography, the traditional standard for imaging lymphatic vessels, has limitations, includin…

El legado irónico de un obispo del Opus Dei. Sacerdotes nativos y catolicismo andino en la diócesis de Abancay después del conflicto Open

Christine U. Lee · 2025

Sobre el clero nativo de la diócesis de Abancay durante el episcopado de Mons. Enrique Pèlach y Feliu.

Contrast-enhanced ultrasound for lymphatic mapping: a comprehensive review Open

Maria V. Rios‐Sanchez, Samyd S. Bustos, Elizabeth Bárcena Barreto, Gina K. Hesley, Christine U. Lee , et al. · 2025

Contrast-enhanced ultrasound (CEUS) offers vascular-based real-time visualization of anatomy and pathology while maintaining the advantages of ultrasound: no radiation exposure and cost-effectiveness. This review provides an overview of th…

Safety and immunogenicity of an adjuvanted chikungunya virus virus-like particle (CHIKV VLP) vaccine in previous recipients of other alphavirus vaccines versus alphavirus vaccine-naive controls: an open-label, parallel-group, age-matched, sex-matched, phase 2 randomised controlled study Open

Melinda Hamer, James McCarty, Benjamin C. Pierson, Jason A. Regules, Jason Mendy , et al. · 2025

Defense Health Program, Emergent Travel Health, and Bavarian Nordic A/S.

Beyond the ink: Marking the skin with henna through ultrasound gel Open

Samuel Jang, Brooke E. Willborg, Gina K. Hesley, Nathan Brinkman, Nho V. Tran , et al. · 2025

Henna is an effective skin marker that can be applied through US gel where short staining wait-times result in markings lasting several days. To achieve the same durability, staining wait-times are about double for high-melanin skin tones …

Underlying factors that affect ultrasound conspicuity of breast biopsy markers: an exploratory study Open

Jenna Cario, Christine U. Lee, Michael L. Oelze · 2025

Viewing angle is not affected by any other settings on an ultrasound system besides probe position, suggesting that conspicuity may not be recoverable if repositioning cannot clarify clip location. Even when viewing angle is not a concern …

Breast ultrasound knobology and the knobology of twinkling for marker detection Open

Christine U. Lee, Gina K. Hesley, Taylor A. Pierson, Rosemary O. Higgins, Matthew W. Urban · 2024

Breast ultrasound utilizes various scanning techniques to acquire optimal images for diagnostic evaluation. During interventional procedures, such as ultrasound-guided biopsies or preoperative localizations, knowledgeable and purposeful sc…

Randomized Feasibility Study Evaluating Multiple FDA-approved Microbubbles for CEUS Lymphography Open

Samuel Jang, Jess D. Rames, Gina K. Hesley, Nathan Brinkman, Nho V. Tran , et al. · 2024

Summary: Prior studies on contrast-enhanced ultrasound (CEUS) lymphography for preoperative mapping before lymphaticovenous anastomosis surgery in patients with extremity lymphedema have been limited to using only Lumason and Sonazoid as m…

3D‐Printed Hollow Microneedles Array with Luer Lock Connection for Facile and Painless Intradermal Injection: A Proof of Concept Open

Amirreza Ghaznavi, Jie Xu, Christine U. Lee, Seth A. Hara · 2024

A 3D‐printed array of hollow microneedles (HMNs) is designed and fabricated using a high‐resolution stereolithography 3D printer and assembled with a 3D‐printed reservoir that incorporates a Luer lock mechanism, ensuring standard and secur…

An Allergic Reaction in Contrast-enhanced Ultrasound Lymphography for Lymphovenous Bypass Surgery Open

Jess D. Rames, Nho V. Tran, Gina K. Hesley, Vahe Fahradyan, Christine U. Lee · 2024

Summary: Lymphedema following oncologic intervention can cause significant lifelong morbidity for patients in whom conservative management fails. The associated swelling, discomfort, pain, and recurrent cellulitis greatly diminish quality …

Contents Open

Daisuke Miura, Hiromi Suenaga, Kiyoshi Ichihara, Alexander D Gleed, Divyanshu Mishra , et al. · 2024

SARS-CoV-2 recombinant spike ferritin nanoparticle vaccine adjuvanted with Army Liposome Formulation containing monophosphoryl lipid A and QS-21: a phase 1, randomised, double-blind, placebo-controlled, first-in-human clinical trial Open

Brittany L Ober Shepherd, Paul T Scott, Jack N Hutter, Christine U. Lee, Melanie McCauley , et al. · 2024

US Department of Defense, Defense Health Agency.

A Radiological Clip Design Using Ultrasound Identification to Improve Localization Open

Jenna Cario, Zhengchang Kou, Rita J. Miller, April Dickenson, Christine U. Lee , et al. · 2024

Radiological clips are used to mark breast cancer being treated by neoadjuvant chemotherapy (NAC) via implant in or near treated lesions. As NAC progresses, available marking clips can lose visibility in ultrasound, the imaging modality of…

Proposing a framework to quantify the potential impact of pharmacokinetic drug–drug interactions caused by a new drug candidate by using real world data about the target patient population Open

Simon Dagenais, Christine U. Lee, Carol Cronenberger, Ellen Wang, Vaishali Sahasrabudhe · 2024

Drug development teams must evaluate the risk/benefit profile of new drug candidates that perpetrate drug–drug interactions (DDIs). Real‐world data (RWD) can inform this decision. The purpose of this study was to develop a predicted impact…

Using 3-D-Printed Structures to Evaluate the Potential Causes of the Color Doppler Twinkling Signature Open

Benjamin Wood, Renc Saracaydin, Seth A. Hara, Christine U. Lee, Matthew W. Urban · 2024

Idiopathic Granulomatous Mastitis Open

Christina A. Dilaveri, Amy C. Degnim, Christine U. Lee, Daniel C. DeSimone, Dan Moldoveanu , et al. · 2024

Idiopathic granulomatous mastitis (IGM) is a rare, benign inflammatory disorder of the breast that is often underrecognized. The exact etiology and pathophysiology are unknown, but milk stasis is felt to play a role. Classically, this cond…

Lymphatic Mapping with Contrast-enhanced Ultrasound for Lymphaticovenous Anastomosis Surgery: How We Do It Open

Samuel Jang, Samyd S. Bustos, Austin D. Chen, Eugene E. Zheng, Gina K. Hesley , et al. · 2023

Summary: Lymphaticovenous anastomosis (LVA) surgery is an effective surgery for the treatment of lymphedema in the extremities. Indocyanine green lymphography is the reference standard for visualizing lymphatics for LVA surgery, but it has…

Safety and efficacy of delaying lung transplant surgery to a morning start Open

Samuel T. Kim, Yu Xia, Peter Cho, Jonathan K. Ho, Swati Patel , et al. · 2023

Joint localization and classification of breast masses on ultrasound images using an auxiliary attention-based framework Open

Zong Fan, Ping Gong, Shanshan Tang, Christine U. Lee, Xiaohui Zhang , et al. · 2023

A Radiological Clip Design Using Ultrasound Identification to Improve Localization Open

Jenna Cario, Zhengchang Kou, April Dickenson, Christine U. Lee, Michael L. Oelze · 2023

Objective: We demonstrate the use of ultrasound to receive an acoustic signal transmitted from a radiological clip designed from a custom circuit. This signal encodes an identification number and is localized and identified wirelessly by t…

Using US Twinkling Artifact to Identify Breast Biopsy Markers: Brief Report Open

Christine U. Lee, Mara A. Piltin, Dan Moldoveanu, Matthew W. Urban, Gina K. Hesley · 2023

Breast biopsy markers play an essential role in the surgical management of patients with clinically node-positive breast cancer. Marking a pathology-proven lymph node ensures accurate imaging assessment of response to neoadjuvant systemic …

Cerebral venous sinus thrombosis and skull base osteomyelitis as manifestations of cat‐scratch disease in a pediatric patient: A case report and literature review Open

Ayodeji Otufowora, Christine U. Lee, Aneeb Mohideen, Grace DeSena, Charlene Pringle , et al. · 2023

Key Clinical Message Cat‐scratch disease (CSD) is caused by Bartonella henselae and usually presents with regional lymphadenopathy. Skull base osteomyelitis and cerebral venous sinus thrombosis are rarely reported, particularly in immunoco…

Supplementary Figures and Tables from <i>SDHD</i> Promoter Mutations Ablate GABP Transcription Factor Binding in Melanoma Open

Tongwu Zhang, Mai Xu, Matthew Makowski, Christine U. Lee, Michael J. Kovacs , et al. · 2023

Supplementary Figure 1. Confirmation of the recurrent C524, C541 and C544 SDHD promoter mutations in melanoma cell lines via Sanger sequencing. Supplementary Figure 2. Expression of SDHD in melanomas harboring promoter mutati…

Supplementary Figures and Tables from <i>SDHD</i> Promoter Mutations Ablate GABP Transcription Factor Binding in Melanoma Open

Tongwu Zhang, Mai Xu, Matthew Makowski, Christine U. Lee, Michael J. Kovacs , et al. · 2023

Supplementary Figure 1. Confirmation of the recurrent C524, C541 and C544 SDHD promoter mutations in melanoma cell lines via Sanger sequencing. Supplementary Figure 2. Expression of SDHD in melanomas harboring promoter mutati…

Semi‐automated total body photography can identify subtle melanomas but false‐negatives on automated comparison highlight the need for manual side‐by‐side image comparison Open

Mohsen Hassani, Christine U. Lee, Aksana Marozava, Nikita Rosendahl, Blake O’Brien , et al. · 2023

It is known that dermatoscopy improves diagnostic accuracy for skin lesions whether pigmented or not,1, 2 but it is also known that approximately 10% of melanomas are featureless, lacking diagnostic dermatoscopic criteria.3(page 620) Of re…

Assessment of Quality of Life Among Patients With Recurrent Clostridioides difficile Infection Treated with Investigational Oral Microbiome Therapeutic SER-109 Open

Kevin W. Garey, Jinhee Jo, Anne J Gonzales-Luna, Brittany Lapin, Abhishek Deshpande , et al. · 2023

Importance Recurrent Clostridioides difficile infection (CDI) is a debilitating disease leading to poor health-related quality of life (HRQOL), loss of productivity, anxiety, and depression. The potential association of treatment with HRQO…

Outcomes of shared institutional review board compared with multiple individual site institutional review board models in a multisite clinical trial Open

Samantha Martin, Phillip Allman, Lorraine Dugoff, Baha M. Sibai, Stephanie Lynch , et al. · 2023

Anatomy Versus Physiology: Is Breast Lymphatic Drainage to the Internal Thoracic (Internal Mammary) Lymphatic System Clinically Relevant? Open

Priscilla Machado, Ji‐Bin Liu, Laurence Needleman, Christine U. Lee, Flemming Forsberg · 2023

Approximately 15%-25% of breast lymphatic drainage passes through the internal thoracic (internal mammary) lymphatic system, draining the inner quadrants of the breast. This study aimed to use lymphosonography to identify sentinel lymph no…

Ultrasonographic Detection and Surgical Retrieval of a Nonmetallic Twinkle Marker in Breast Cancer: Pilot Study Open

James W. Jakub, Gina K. Hesley, Nicholas B. Larson, Michael J. Yaszemski, A. Lee Miller , et al. · 2022

Purpose To evaluate the short-term safety of a nonmetallic twinkle marker and compare its conspicuity at color Doppler US with that of standard breast biopsy clips and radioactive seeds by using B-mode US in axillary lymph nodes. Materials…

Joint localization and classification of breast tumors on ultrasound images using a novel auxiliary attention-based framework Open

Zong Min Fan, Ping Gong, Shanshan Tang, Christine U. Lee, Xiaohui Zhang , et al. · 2022

Automatic breast lesion detection and classification is an important task in computer-aided diagnosis, in which breast ultrasound (BUS) imaging is a common and frequently used screening tool. Recently, a number of deep learning-based metho…

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