Christine M. Freeman
YOU?
Author Swipe
View article: Associations of serum and bronchoalveolar immunoglobulins with lung microbiota diversity, B-cell memory phenotypes, and COPD morbidity and exacerbations
Associations of serum and bronchoalveolar immunoglobulins with lung microbiota diversity, B-cell memory phenotypes, and COPD morbidity and exacerbations Open
These results demonstrate an association of low serum IgG with reduced lung bacterial diversity, a feature of dysbiosis that may predispose to exacerbation. Defining the role of Ig in specific anatomic compartments is relevant to designing…
View article: Extracellular iron and the lung microbiome in smoking and COPD
Extracellular iron and the lung microbiome in smoking and COPD Open
Background Most microorganisms that make up the lung microbiome use several iron acquisition strategies for survival. Iron levels and iron-associated proteins are higher in the bronchoalveolar lavage fluid (BALF) of smokers with and smoker…
View article: A model of dysregulated crosstalk between dendritic, natural killer, and regulatory T cells in chronic obstructive pulmonary disease
A model of dysregulated crosstalk between dendritic, natural killer, and regulatory T cells in chronic obstructive pulmonary disease Open
View article: Vessel and Airway Characteristics in One-Year Computed Tomography–defined Rapid Emphysema Progression: SPIROMICS
Vessel and Airway Characteristics in One-Year Computed Tomography–defined Rapid Emphysema Progression: SPIROMICS Open
Rationale: Rates of emphysema progression vary in chronic obstructive pulmonary disease (COPD), and the relationships with vascular and airway pathophysiology remain unclear. Objectives: We sought to determine if indices of p…
View article: Batf3-dependent orchestration of the robust Th1 responses and fungal control during cryptococcal infection, the role of cDC1
Batf3-dependent orchestration of the robust Th1 responses and fungal control during cryptococcal infection, the role of cDC1 Open
While type I conventional dendritic cells (cDC1s) are vital for generating adaptive immunity against intracellular pathogens and tumors, their role in defense against fungal pathogen Cryptococcus neoformans remains unclear. We investigated…
View article: Design of the SPIROMICS Study of Early COPD Progression: SOURCE Study
Design of the SPIROMICS Study of Early COPD Progression: SOURCE Study Open
SOURCE should provide novel insights into the natural history of lung disease in younger individuals with a smoking history, and its biological basis.
View article: Repeatability of Pulmonary Quantitative Computed Tomography Measurements in Chronic Obstructive Pulmonary Disease
Repeatability of Pulmonary Quantitative Computed Tomography Measurements in Chronic Obstructive Pulmonary Disease Open
"Repeatability of Pulmonary Quantitative Computed Tomography Measurements in Chronic Obstructive Pulmonary Disease." American Journal of Respiratory and Critical Care Medicine, 208(6), pp. 657–665
View article: Finding the Right Biological: Eosinophil Subset Differences in Asthma and Chronic Obstructive Pulmonary Disease
Finding the Right Biological: Eosinophil Subset Differences in Asthma and Chronic Obstructive Pulmonary Disease Open
"Finding the Right Biological: Eosinophil Subset Differences in Asthma and COPD." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp.
View article: Blood Gene Expression and Immune Cell Subtypes Associated with Chronic Obstructive Pulmonary Disease Exacerbations
Blood Gene Expression and Immune Cell Subtypes Associated with Chronic Obstructive Pulmonary Disease Exacerbations Open
Rationale: Acute exacerbations of chronic obstructive pulmonary disease (AE-COPDs) are associated with a significant disease burden. Blood immune phenotyping may improve our understanding of a COPD endotype at increased risk of exac…
View article: A blood and bronchoalveolar lavage protein signature of rapid FEV1 decline in smoking-associated COPD
A blood and bronchoalveolar lavage protein signature of rapid FEV1 decline in smoking-associated COPD Open
Accelerated progression of chronic obstructive pulmonary disease (COPD) is associated with increased risks of hospitalization and death. Prognostic insights into mechanisms and markers of progression could facilitate development of disease…
View article: A blood and bronchoalveolar lavage protein signature of rapid FEV1 decline in smoking-associated COPD
A blood and bronchoalveolar lavage protein signature of rapid FEV1 decline in smoking-associated COPD Open
View article: Bronchodilator Responsiveness in Tobacco-Exposed People With or Without COPD
Bronchodilator Responsiveness in Tobacco-Exposed People With or Without COPD Open
View article: Black carbon content in airway macrophages is associated with increased severe exacerbations and worse COPD morbidity in SPIROMICS
Black carbon content in airway macrophages is associated with increased severe exacerbations and worse COPD morbidity in SPIROMICS Open
Background Airway macrophages (AM), crucial for the immune response in chronic obstructive pulmonary disease (COPD), are exposed to environmental particulate matter (PM), which they retain in their cytoplasm as black carbon (BC). However, …
View article: Welcome to the Neighborhood: Tissue-Resident Lung Natural Killer Cells in Chronic Obstructive Pulmonary Disease and Viral Infections
Welcome to the Neighborhood: Tissue-Resident Lung Natural Killer Cells in Chronic Obstructive Pulmonary Disease and Viral Infections Open
View article: Reversible Airflow Obstruction Predicts Future Chronic Obstructive Pulmonary Disease Development in the SPIROMICS Cohort: An Observational Cohort Study
Reversible Airflow Obstruction Predicts Future Chronic Obstructive Pulmonary Disease Development in the SPIROMICS Cohort: An Observational Cohort Study Open
Rationale: Chronic obstructive pulmonary disease (COPD) is defined by fixed spirometric ratio, FEV1/FVC < 0.70 after inhaled bronchodilators. However, the implications of variable obstruction (VO), in which the prebroncho…
View article: Lung Microbiota and Metabolites Collectively Associate with Clinical Outcomes in Milder Stage Chronic Obstructive Pulmonary Disease
Lung Microbiota and Metabolites Collectively Associate with Clinical Outcomes in Milder Stage Chronic Obstructive Pulmonary Disease Open
Rationale: Chronic obstructive pulmonary disease (COPD) is variable in its development. Lung microbiota and metabolites collectively may impact COPD pathophysiology, but relationships to clinical outcomes in milder disease are uncle…
View article: Diet-induced obesity in mice impairs host defense against <i>Klebsiella</i> pneumonia in vivo and glucose transport and bactericidal functions in neutrophils in vitro
Diet-induced obesity in mice impairs host defense against <i>Klebsiella</i> pneumonia in vivo and glucose transport and bactericidal functions in neutrophils in vitro Open
Obesity impairs host defense against Klebsiella pneumoniae, but responsible mechanisms are incompletely understood. To determine the impact of diet-induced obesity on pulmonary host defense against K. pneumoniae, we fed 6-wk-old male C57BL…
View article: Identification of Sputum Biomarkers Predictive of Pulmonary Exacerbations in COPD
Identification of Sputum Biomarkers Predictive of Pulmonary Exacerbations in COPD Open
View article: Human lung cDC1 drive increased perforin-mediated NK cytotoxicity in chronic obstructive pulmonary disease
Human lung cDC1 drive increased perforin-mediated NK cytotoxicity in chronic obstructive pulmonary disease Open
In chronic obstructive pulmonary disease (COPD), lung natural killer cells (NKs) lyse autologous lung epithelial cells in vitro, but underlying mechanisms and their relationship to epithelial cell apoptosis in vivo are undefined. Although …
View article: Murine Inducible Nitric Oxide Synthase Expression Is Essential for Antifungal Defenses in Kidneys during Disseminated <i>Cryptococcus deneoformans</i> Infection
Murine Inducible Nitric Oxide Synthase Expression Is Essential for Antifungal Defenses in Kidneys during Disseminated <i>Cryptococcus deneoformans</i> Infection Open
Disseminated cryptococcosis has a nearly 70% mortality, mostly attributed to CNS infection, with lesser-known effects on other organs. Immune protection against Cryptococcus relies on Th1 immunity with M1 polarization, rendering macrophage…
View article: Comparative Impact of Depressive Symptoms and FEV<sub>1</sub>% on Chronic Obstructive Pulmonary Disease
Comparative Impact of Depressive Symptoms and FEV<sub>1</sub>% on Chronic Obstructive Pulmonary Disease Open
Rationale: Individuals with chronic obstructive pulmonary disease (COPD) have a high prevalence of depression, which is associated with increased COPD hospitalizations and readmissions. Objectives: Examine the impact of depre…
View article: Black Carbon Content in Airway Macrophages Is Associated with Worse COPD Patient-Reported Outcomes, FEV1 Decline, 6-Minute Walk Distance and a Higher Likelihood of Chronic Bronchitis in Current and Former Smokers from the SPIROMICS Cohort
Black Carbon Content in Airway Macrophages Is Associated with Worse COPD Patient-Reported Outcomes, FEV1 Decline, 6-Minute Walk Distance and a Higher Likelihood of Chronic Bronchitis in Current and Former Smokers from the SPIROMICS Cohort Open
View article: Restoring Regulatory T Cells in COPD Could Dampen Natural Killer Cell Cytotoxicity
Restoring Regulatory T Cells in COPD Could Dampen Natural Killer Cell Cytotoxicity Open
View article: Lung microbiota associations with clinical features of COPD in the SPIROMICS cohort
Lung microbiota associations with clinical features of COPD in the SPIROMICS cohort Open
Chronic obstructive pulmonary disease (COPD) is heterogeneous in development, progression, and phenotypes. Little is known about the lung microbiome, sampled by bronchoscopy, in milder COPD and its relationships to clinical features that r…
View article: The Association of Aging Biomarkers, Interstitial Lung Abnormalities, and Mortality
The Association of Aging Biomarkers, Interstitial Lung Abnormalities, and Mortality Open
Rationale: The association between aging and idiopathic pulmonary fibrosis has been established. The associations between aging-related biomarkers and interstitial lung abnormalities (ILA) have not been comprehensively evaluated.…
View article: PGE<sub>2</sub>accounts for bidirectional changes in alveolar macrophage self-renewal with aging and smoking
PGE<sub>2</sub>accounts for bidirectional changes in alveolar macrophage self-renewal with aging and smoking Open
Alveolar macrophages (AMs) are resident immune cells of the lung that are critical for host defense. AMs are capable of proliferative renewal, yet their numbers are known to decrease with aging and increase with cigarette smoking. The mech…
View article: Increased airway iron parameters and risk for exacerbation in COPD: an analysis from SPIROMICS
Increased airway iron parameters and risk for exacerbation in COPD: an analysis from SPIROMICS Open
Levels of iron and iron-related proteins including ferritin are higher in the lung tissue and lavage fluid of individuals with chronic obstructive pulmonary disease (COPD), when compared to healthy controls. Whether more iron in the extrac…
View article: Critical Relevance of Stochastic Effects on Low-Bacterial-Biomass 16S rRNA Gene Analysis
Critical Relevance of Stochastic Effects on Low-Bacterial-Biomass 16S rRNA Gene Analysis Open
DNA contamination from external sources (reagents, environment, operator, etc.) has long been assumed to be the main cause of spurious signals that appear under low-bacterial-biomass conditions. Here, we demonstrate that contamination can …
View article: Comparison of Proteomic Assessment Methods in Multiple Cohort Studies
Comparison of Proteomic Assessment Methods in Multiple Cohort Studies Open
Novel proteomics platforms, such as the aptamer‐based SOMAscan platform, can quantify large numbers of proteins efficiently and cost‐effectively and are rapidly growing in popularity. However, comparisons to conventional immunoassays remai…
View article: Intermediate (CD14++ CD16+) Monocytes Correlate with Parametric Response Mapping of Functional Small Airways Disease: Spiromics Immunophenotyping Sub-Study
Intermediate (CD14++ CD16+) Monocytes Correlate with Parametric Response Mapping of Functional Small Airways Disease: Spiromics Immunophenotyping Sub-Study Open