Christine Payré
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View article: Anti Phospholipase A2 Receptor 1 Antibodies and Membranous Nephropathy Recurrence After Kidney Transplantation
Anti Phospholipase A2 Receptor 1 Antibodies and Membranous Nephropathy Recurrence After Kidney Transplantation Open
View article: Ectodomain shedding of PLA2R1 is mediated by the metalloproteases ADAM10 and ADAM17
Ectodomain shedding of PLA2R1 is mediated by the metalloproteases ADAM10 and ADAM17 Open
Phospholipase A2 receptor 1 (PLA2R1) is a 180-kDa transmembrane protein that plays a role in inflammation and cancer and is the major autoantigen in membranous nephropathy, a rare but severe autoimmune kidney disease. A soluble form of PLA…
View article: Interference with Lipoprotein Maturation Sensitizes Methicillin-Resistant <b><i>Staphylococcus aureus</i></b> to Human Group IIA-Secreted Phospholipase A<sub>2</sub> and Daptomycin
Interference with Lipoprotein Maturation Sensitizes Methicillin-Resistant <b><i>Staphylococcus aureus</i></b> to Human Group IIA-Secreted Phospholipase A<sub>2</sub> and Daptomycin Open
Methicillin-resistant Staphylococcus aureus (MRSA) has been classified as a high priority pathogen by the World Health Organization underlining the high demand for new therapeutics to treat infections. Human group IIA-secreted phosp…
View article: The free fatty acid–binding pocket is a conserved hallmark in pathogenic β-coronavirus spike proteins from SARS-CoV to Omicron
The free fatty acid–binding pocket is a conserved hallmark in pathogenic β-coronavirus spike proteins from SARS-CoV to Omicron Open
As coronavirus disease 2019 (COVID-19) persists, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) emerge, accumulating spike (S) glycoprotein mutations. S receptor binding domain (RBD) comprises a fre…
View article: Interplay between C1-inhibitor and group IIA secreted phospholipase A2 impairs their respective function
Interplay between C1-inhibitor and group IIA secreted phospholipase A2 impairs their respective function Open
View article: Multimodal regulation of the osteoclastogenesis process by secreted group IIA phospholipase A2
Multimodal regulation of the osteoclastogenesis process by secreted group IIA phospholipase A2 Open
Increasing evidence points to the involvement of group IIA secreted phospholipase A 2 (sPLA 2 -IIA) in pathologies characterized by abnormal osteoclast bone-resorption activity. Here, the role of this moonlighting protein has been deepened…
View article: Treatment of Mouse Sperm with a Non-Catalytic Mutant of PLA2G10 Reveals That PLA2G10 Improves In Vitro Fertilization through Both Its Enzymatic Activity and as Ligand of PLA2R1
Treatment of Mouse Sperm with a Non-Catalytic Mutant of PLA2G10 Reveals That PLA2G10 Improves In Vitro Fertilization through Both Its Enzymatic Activity and as Ligand of PLA2R1 Open
The group X secreted phospholipase A2 (PLA2G10) is present at high levels in mouse sperm acrosome. The enzyme is secreted during capacitation and amplifies the acrosome reaction and its own secretion via an autocrine loop. PLA2G10 also imp…
View article: The Free Fatty Acid-Binding Pocket is a Conserved Hallmark in Pathogenic β-Coronavirus Spike Proteins from SARS-CoV to Omicron
The Free Fatty Acid-Binding Pocket is a Conserved Hallmark in Pathogenic β-Coronavirus Spike Proteins from SARS-CoV to Omicron Open
As COVID-19 persists, severe acquired respiratory syndrome coronavirus-2 (SARS-CoV-2) Variants of Concern (VOCs) emerge, accumulating spike (S) glycoprotein mutations. S receptor-binding domain (RBD) comprises a free fatty acid (FFA)-bindi…
View article: Interference with lipoprotein maturation sensitizes methicillin-resistant<i>Staphylococcus aureus</i>to human group IIA secreted phospholipase A<sub>2</sub>and daptomycin
Interference with lipoprotein maturation sensitizes methicillin-resistant<i>Staphylococcus aureus</i>to human group IIA secreted phospholipase A<sub>2</sub>and daptomycin Open
Methicillin-resistant Staphylococcus aureus (MRSA) has been classified as a high priority pathogen by the World Health Organization underlining the high demand for new therapeutics to treat infections. Human group IIA secreted phospholipas…
View article: The interaction of secreted phospholipase A2-IIA with the microbiota alters its lipidome and promotes inflammation
The interaction of secreted phospholipase A2-IIA with the microbiota alters its lipidome and promotes inflammation Open
Secreted phospholipase A2-IIA (sPLA2-IIA) hydrolyzes phospholipids to liberate lysophospholipids and fatty acids. Given its poor activity toward eukaryotic cell membranes, its role in the generation of proinflammatory lipid mediators is un…
View article: Supplementary Material for: Interference with Lipoprotein Maturation Sensitizes Methicillin-Resistant <b><i>Staphylococcus aureus</i></b> to Human Group IIA-Secreted Phospholipase A<sub>2</sub> and Daptomycin
Supplementary Material for: Interference with Lipoprotein Maturation Sensitizes Methicillin-Resistant <b><i>Staphylococcus aureus</i></b> to Human Group IIA-Secreted Phospholipase A<sub>2</sub> and Daptomycin Open
Methicillin-resistant Staphylococcus aureus (MRSA) has been classified as a high priority pathogen by the World Health Organization underlining the high demand for new therapeutics to treat infections. Human group IIA-secreted phosp…
View article: Group IIA secreted phospholipase A2 (PLA2G2A) augments adipose tissue thermogenesis
Group IIA secreted phospholipase A2 (PLA2G2A) augments adipose tissue thermogenesis Open
Group IIA secreted phospholipase A2 (PLA2G2A) hydrolyzes glycerophospholipids at the sn‐2 position resulting in the release of fatty acids and lysophospholipids. C57BL/6 mice do not express Pla2g2a due to a frameshift mutation (wild‐type […
View article: Role of human group IIA secreted phospholipase A2 in malaria pathophysiology: Insights from a transgenic mouse model
Role of human group IIA secreted phospholipase A2 in malaria pathophysiology: Insights from a transgenic mouse model Open
View article: Multi-Autoantibody Signature and Clinical Outcome in Membranous Nephropathy
Multi-Autoantibody Signature and Clinical Outcome in Membranous Nephropathy Open
Background and objectives Patients with membranous nephropathy can have circulating autoantibodies against membrane-bound (phospholipase A2 receptor 1 [PLA2R1] and thrombospondin type-1 domain containing 7A [THSD7A]) and intracellular (ald…
View article: Surfactant-secreted phospholipase A<sub>2</sub>interplay and respiratory outcome in preterm neonates
Surfactant-secreted phospholipase A<sub>2</sub>interplay and respiratory outcome in preterm neonates Open
Secreted phospholipase A 2 hydrolyzes surfactant phospholipids and is crucial for the inflammatory cascade; preterm neonates are treated with exogenous surfactant, but the interaction between surfactant and phospholipase is unknown. We hyp…
View article: Anti-PLA2R1 Antibodies Containing Sera Induce In Vitro Cytotoxicity Mediated by Complement Activation
Anti-PLA2R1 Antibodies Containing Sera Induce In Vitro Cytotoxicity Mediated by Complement Activation Open
The phospholipase A2 receptor (PLA2R1) is the major autoantigen in idiopathic membranous nephropathy (MN). However, the pathogenic role of anti-PLA2R1 autoantibodies is unclear. Our aim was to evaluate the in vitro cytotoxicity of anti-PLA…
View article: Antimalarial activity of human group IIA secreted phospholipase A2 in relation with enzymatic hydrolysis of oxidized lipoproteins
Antimalarial activity of human group IIA secreted phospholipase A2 in relation with enzymatic hydrolysis of oxidized lipoproteins Open
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View article: Antimalarial Activity of Human Group IIA Secreted Phospholipase A<sub>2</sub>in Relation to Enzymatic Hydrolysis of Oxidized Lipoproteins
Antimalarial Activity of Human Group IIA Secreted Phospholipase A<sub>2</sub>in Relation to Enzymatic Hydrolysis of Oxidized Lipoproteins Open
The level of human group IIA secreted phospholipase A 2 (hGIIA sPLA 2 ) is increased in the plasma of malaria patients, but its role is unknown. In parasite culture with normal plasma, hGIIA is inactive against Plasmodium falciparum , cont…
View article: SaO023Anti-PLA2R1 antibodies induce in vitro cytotoxicity mediated by complement activation
SaO023Anti-PLA2R1 antibodies induce in vitro cytotoxicity mediated by complement activation Open
INTRODUCTION: Phospholipase A2 receptor (PLA2R1) is a major autoantigen in idiopathic membranous nephropathy (MN).Anti-PLA2R1 antibody titers rise during clinical activity and decrease before remission.However, the pathogenic role of anti-…
View article: FP196NOVEL ELISA FOR THSD7A AUTOANTIBODIES IN MEMBRANOUS NEPHROPATHY
FP196NOVEL ELISA FOR THSD7A AUTOANTIBODIES IN MEMBRANOUS NEPHROPATHY Open
View article: Novel ELISA for thrombospondin type 1 domain-containing 7A autoantibodies in membranous nephropathy
Novel ELISA for thrombospondin type 1 domain-containing 7A autoantibodies in membranous nephropathy Open
View article: Streptococcal Lancefield polysaccharides are critical cell wall determinants for human Group IIA secreted phospholipase A2 to exert its bactericidal effects
Streptococcal Lancefield polysaccharides are critical cell wall determinants for human Group IIA secreted phospholipase A2 to exert its bactericidal effects Open
Human Group IIA secreted phospholipase A2 (hGIIA) is an acute phase protein with bactericidal activity against Gram-positive bacteria. Infection models in hGIIA transgenic mice have suggested the importance of hGIIA as an innate defense me…
View article: Group IIA-Secreted Phospholipase A <sub>2</sub> in Human Serum Kills Commensal but Not Clinical Enterococcus faecium Isolates
Group IIA-Secreted Phospholipase A <sub>2</sub> in Human Serum Kills Commensal but Not Clinical Enterococcus faecium Isolates Open
Human innate immunity employs cellular and humoral mechanisms to facilitate rapid killing of invading bacteria. The direct killing of bacteria by human serum is attributed mainly to the activity of the complement system, which forms pores …
View article: Streptococcal Lancefield polysaccharides are critical cell wall determinants for human group IIA secreted phospholipase A2 to exert its bactericidal effects
Streptococcal Lancefield polysaccharides are critical cell wall determinants for human group IIA secreted phospholipase A2 to exert its bactericidal effects Open
Human Group IIA secreted phospholipase A 2 (hGIIA) is an acute phase protein with bactericidal activity against Gram-positive bacteria. Infection models in hGIIA transgenic mice have suggested the importance of hGIIA as an innate defense m…
View article: Phospholipase A2 Receptor 1 Epitope Spreading at Baseline Predicts Reduced Likelihood of Remission of Membranous Nephropathy
Phospholipase A2 Receptor 1 Epitope Spreading at Baseline Predicts Reduced Likelihood of Remission of Membranous Nephropathy Open
The phospholipase A2 receptor (PLA2R1) is the major autoantigen in primary membranous nephropathy. Several PLA2R1 epitopes have been characterized, and a retrospective study identified PLA2R1 epitope spreading as a potential indicator of p…
View article: Preparation of the Full Set of Recombinant Mouse and Human Secreted Phospholipases A2
Preparation of the Full Set of Recombinant Mouse and Human Secreted Phospholipases A2 Open
View article: Secreted Phospholipases A2 Are Intestinal Stem Cell Niche Factors with Distinct Roles in Homeostasis, Inflammation, and Cancer
Secreted Phospholipases A2 Are Intestinal Stem Cell Niche Factors with Distinct Roles in Homeostasis, Inflammation, and Cancer Open
View article: Epitope Spreading of Autoantibody Response to PLA2R Associates with Poor Prognosis in Membranous Nephropathy
Epitope Spreading of Autoantibody Response to PLA2R Associates with Poor Prognosis in Membranous Nephropathy Open
The phospholipase A2 receptor (PLA2R1) is the major autoantigen in idiopathic membranous nephropathy. However, the value of anti-PLA2R1 antibody titers in predicting patient outcomes is unknown. Here, we screened serum samples from 50 pati…
View article: <i>In Vitro</i> Anti-Plasmodium falciparum Properties of the Full Set of Human Secreted Phospholipases A <sub>2</sub>
<i>In Vitro</i> Anti-Plasmodium falciparum Properties of the Full Set of Human Secreted Phospholipases A <sub>2</sub> Open
We have previously shown that secreted phospholipases A 2 (sPLA 2 s) from animal venoms inhibit the in vitro development of Plasmodium falciparum , the agent of malaria. In addition, the inflammatory-type human group IIA (hGIIA) sPLA 2 cir…