Christine Sütterlin
YOU?
Author Swipe
View article: Statistical analysis supports the size control mechanism of Chlamydia development
Statistical analysis supports the size control mechanism of Chlamydia development Open
Chlamydia is an intracellular bacterium that reproduces via an unusual developmental cycle that only occurs within a eukaryotic host cell. A replicating form of the bacterium (RB) repeatedly divides to produce about a thousand progeny, whi…
View article: Development of an sRNA-mediated conditional knockdown system for <i>Chlamydia trachomatis</i>
Development of an sRNA-mediated conditional knockdown system for <i>Chlamydia trachomatis</i> Open
We describe a new Chlamydia trachomatis protein depletion method that uses an engineered small RNA (sRNA) to inhibit translation of a target gene. In proof-of-principle experiments, we induced functional knockdown of IncA, a fusion-mediati…
View article: Chlamydia trachomatis induces disassembly of the primary cilium to promote the intracellular infection
Chlamydia trachomatis induces disassembly of the primary cilium to promote the intracellular infection Open
Chlamydia trachomatis is a clinically important bacterium that infects epithelial cells of the genitourinary and respiratory tracts and the eye. These differentiated cells are in a quiescent growth state and have a surface organelle called…
View article: A Reverse Genetic Approach for Studying sRNAs in Chlamydia trachomatis
A Reverse Genetic Approach for Studying sRNAs in Chlamydia trachomatis Open
Small RNAs (sRNAs) are a class of regulatory RNAs that play important roles in bacterial physiology and pathogenesis. In the intracellular bacterium Chlamydia , however, sRNAs are poorly understood, and functional studies have been limited…
View article: Differential Effects of Small Molecule Inhibitors on the Intracellular Chlamydia Infection
Differential Effects of Small Molecule Inhibitors on the Intracellular Chlamydia Infection Open
Chlamydia is the most reported cause of bacterial, sexually transmitted infection in the United States. This bacterium infects human cells and reproduces within a cytoplasmic inclusion via an unusual developmental cycle involving two speci…
View article: <i>Chlamydia</i> and HPV induce centrosome amplification in the host cell through additive mechanisms
<i>Chlamydia</i> and HPV induce centrosome amplification in the host cell through additive mechanisms Open
Based on epidemiology studies, Chlamydia trachomatis has been proposed as a co-factor for human papillomavirus (HPV) in the development of cervical cancer. These two intracellular pathogens have been independently reported to induce the pr…
View article: The Small Molecule H89 Inhibits <i>Chlamydia</i> Inclusion Growth and Production of Infectious Progeny
The Small Molecule H89 Inhibits <i>Chlamydia</i> Inclusion Growth and Production of Infectious Progeny Open
Chlamydia is an obligate intracellular bacterium and the most common reportable cause of human infection in the United States. This pathogen proliferates inside a eukaryotic host cell, where it resides within a membrane-bound compartment c…
View article: Stochastic Chlamydia Dynamics and Optimal Spread
Stochastic Chlamydia Dynamics and Optimal Spread Open
View article: Function of Golgi-centrosome proximity in RPE-1 cells
Function of Golgi-centrosome proximity in RPE-1 cells Open
The close physical proximity between the Golgi and the centrosome is a unique feature of mammalian cells that has baffled scientists for years. Several knockdown and overexpression studies have linked the spatial relationship between these…
View article: Replication-dependent size reduction precedes differentiation in Chlamydia trachomatis
Replication-dependent size reduction precedes differentiation in Chlamydia trachomatis Open
Chlamydia trachomatis is the most common cause of bacterial sexually transmitted infection. It produces an unusual intracellular infection in which a vegetative form, called the reticulate body (RB), replicates and then converts into an el…
View article: Spatial analysis of Cdc42 activity reveals a role for plasma membrane–associated Cdc42 in centrosome regulation
Spatial analysis of Cdc42 activity reveals a role for plasma membrane–associated Cdc42 in centrosome regulation Open
The ability of the small GTPase Cdc42 to regulate diverse cellular processes depends on tight spatial control of its activity. Cdc42 function is best understood at the plasma membrane (PM), where it regulates cytoskeletal organization and …
View article: The daughter centriole controls ciliogenesis by regulating Neurl-4 localization at the centrosome
The daughter centriole controls ciliogenesis by regulating Neurl-4 localization at the centrosome Open
The two centrioles of the centrosome differ in age and function. Although the mother centriole mediates most centrosome-dependent processes, the role of the daughter remains poorly understood. A recent study has implicated the daughter cen…
View article: CCDC 762683: Experimental Crystal Structure Determination
CCDC 762683: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Spatial analysis of Cdc42 activity reveals a role for plasma membrane–associated Cdc42 in centrosome regulation
Spatial analysis of Cdc42 activity reveals a role for plasma membrane–associated Cdc42 in centrosome regulation Open
The ability of the small GTPase Cdc42 to regulate diverse cellular processes depends on tight spatial control of its activity. Cdc42 function is best understood at the plasma membrane (PM), where it regulates cytoskeletal organization and …
View article: CCDC 762682: Experimental Crystal Structure Determination
CCDC 762682: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Induction and inhibition of CPAF activity during analysis of Chlamydia-infected cells
Induction and inhibition of CPAF activity during analysis of Chlamydia-infected cells Open
Studies of the chlamydial protease CPAF have been complicated by difficulties in distinguishing bona fide intracellular proteolysis from in vitro proteolysis. This confounding issue has been attributed to CPAF activity in lysates from Chla…