Christine Varon
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View article: Wild-type and mutated ß-catenin differently repress <i>RND3/RHOE</i> expression in hepatocellular carcinoma
Wild-type and mutated ß-catenin differently repress <i>RND3/RHOE</i> expression in hepatocellular carcinoma Open
Background & Aims Tumor development and progression are mainly driven by oncogenic mutations but are also regulated by physical factors, such as applied forces or microenvironment stiffness. Through its structural and transcriptional funct…
View article: Induced volatolomics to uncover new enzymatic hallmarks of precancerous lesions: a proof of concept on gastric preneoplasia in mice
Induced volatolomics to uncover new enzymatic hallmarks of precancerous lesions: a proof of concept on gastric preneoplasia in mice Open
View article: Biombalance™, an Oligomeric Procyanidins-Enriched Grape Seed Extract, Prevents Inflammation and Microbiota Dysbiosis in a Mice Colitis Model
Biombalance™, an Oligomeric Procyanidins-Enriched Grape Seed Extract, Prevents Inflammation and Microbiota Dysbiosis in a Mice Colitis Model Open
Inflammatory bowel disease (IBD) results from genetic factors, environmental factors, and intestinal microbiota interactions. This study investigated the effects of Biombalance™ (BB) in dextran sulphate sodium (DSS)-induced colitis in mice…
View article: Chronic Infection With Gastric <i>Helicobacters</i> Induces Hepatic Lesions in Mice
Chronic Infection With Gastric <i>Helicobacters</i> Induces Hepatic Lesions in Mice Open
Background Helicobacter pylori infection is one of the most prevalent chronic bacterial infections worldwide. This bacillus colonizes the human stomach lifelong, where it induces chronic gastritis, evolving in some cases to gastro‐duodenal…
View article: Immunosuppressive myeloid cells induce mesenchymal-like breast cancer stem cells by a mechanism involving membrane-bound TGF-β1
Immunosuppressive myeloid cells induce mesenchymal-like breast cancer stem cells by a mechanism involving membrane-bound TGF-β1 Open
Summary Suppressive myeloid cells play a central role in cancer escape from anti-tumor immunity. Beyond their immunosuppressive function, these cells are capable of exerting multiple other pro-tumoral activities, including the promotion of…
View article: Effect of <i>Lactobacillus gasseri</i><scp>BIO</scp>6369 and <i>Lacticaseibacillus rhamnosus</i><scp>BIO</scp>5326 on Gastric Carcinogenesis Induced by <i>Helicobacter pylori</i> Infection
Effect of <i>Lactobacillus gasseri</i><span>BIO</span>6369 and <i>Lacticaseibacillus rhamnosus</i><span>BIO</span>5326 on Gastric Carcinogenesis Induced by <i>Helicobacter pylori</i> Infection Open
Background Helicobacter pylori infection‐associated gastric adenocarcinoma is influenced by various factors, including the digestive microbiota. Lactic acid bacteria role in digestive carcinogenesis has been discussed, and some Lactobacill…
View article: Targeting metastasis-initiating cancer stem cells in gastric cancer with leukaemia inhibitory factor
Targeting metastasis-initiating cancer stem cells in gastric cancer with leukaemia inhibitory factor Open
View article: The “StemDif Sensor Test”: A Straightforward, Non-Invasive Assay to Characterize the Secreted Stemness and/or Differentiation Activities of Tumor-Derived Cancer Cell Lines
The “StemDif Sensor Test”: A Straightforward, Non-Invasive Assay to Characterize the Secreted Stemness and/or Differentiation Activities of Tumor-Derived Cancer Cell Lines Open
Cancer stem cells are a subpopulation of tumor cells characterized by their ability to self-renew, induce tumors upon engraftment in animals and exhibit strong resistance to chemotherapy and radiotherapy. These cells exhibit numerous chara…
View article: The Helicobacter pylori Genome Project: insights into H. pylori population structure from analysis of a worldwide collection of complete genomes
The Helicobacter pylori Genome Project: insights into H. pylori population structure from analysis of a worldwide collection of complete genomes Open
View article: Supplementary Figure 1 from Characterization of Biomarkers of Tumorigenic and Chemoresistant Cancer Stem Cells in Human Gastric Carcinoma
Supplementary Figure 1 from Characterization of Biomarkers of Tumorigenic and Chemoresistant Cancer Stem Cells in Human Gastric Carcinoma Open
Detection of cells expressing CD44 and ALDH activity in gastric tumorspheres in vitro.
View article: Supplementary Figure 4 from Characterization of Biomarkers of Tumorigenic and Chemoresistant Cancer Stem Cells in Human Gastric Carcinoma
Supplementary Figure 4 from Characterization of Biomarkers of Tumorigenic and Chemoresistant Cancer Stem Cells in Human Gastric Carcinoma Open
Effect of verapamil treatment in combination with chemotherapies on tumorsphere formation by GC10.
View article: Supplementary Figure 3 from Characterization of Biomarkers of Tumorigenic and Chemoresistant Cancer Stem Cells in Human Gastric Carcinoma
Supplementary Figure 3 from Characterization of Biomarkers of Tumorigenic and Chemoresistant Cancer Stem Cells in Human Gastric Carcinoma Open
Effect of verapamil treatment in combination with dose-dependent chemotherapies on gastric cancer cell lines viability.
View article: Data from Characterization of Biomarkers of Tumorigenic and Chemoresistant Cancer Stem Cells in Human Gastric Carcinoma
Data from Characterization of Biomarkers of Tumorigenic and Chemoresistant Cancer Stem Cells in Human Gastric Carcinoma Open
Purpose: Gastric carcinomas are heterogeneous, and the current therapy remains essentially based on surgery with conventional chemotherapy and radiotherapy. This study aimed to characterize biomarkers allowing the detection of cance…
View article: Supplementary materials from Characterization of Biomarkers of Tumorigenic and Chemoresistant Cancer Stem Cells in Human Gastric Carcinoma
Supplementary materials from Characterization of Biomarkers of Tumorigenic and Chemoresistant Cancer Stem Cells in Human Gastric Carcinoma Open
Supplementary experimental procedures,figure legends and references
View article: Data from Characterization of Biomarkers of Tumorigenic and Chemoresistant Cancer Stem Cells in Human Gastric Carcinoma
Data from Characterization of Biomarkers of Tumorigenic and Chemoresistant Cancer Stem Cells in Human Gastric Carcinoma Open
Purpose: Gastric carcinomas are heterogeneous, and the current therapy remains essentially based on surgery with conventional chemotherapy and radiotherapy. This study aimed to characterize biomarkers allowing the detection of cance…
View article: Supplementary Figure 2 from Characterization of Biomarkers of Tumorigenic and Chemoresistant Cancer Stem Cells in Human Gastric Carcinoma
Supplementary Figure 2 from Characterization of Biomarkers of Tumorigenic and Chemoresistant Cancer Stem Cells in Human Gastric Carcinoma Open
Detection of ALDH+ population with SP protocol and with ALDEFLUOR protocol.
View article: Supplementary materials from Characterization of Biomarkers of Tumorigenic and Chemoresistant Cancer Stem Cells in Human Gastric Carcinoma
Supplementary materials from Characterization of Biomarkers of Tumorigenic and Chemoresistant Cancer Stem Cells in Human Gastric Carcinoma Open
Supplementary experimental procedures,figure legends and references
View article: Supplementary Figure 3 from Characterization of Biomarkers of Tumorigenic and Chemoresistant Cancer Stem Cells in Human Gastric Carcinoma
Supplementary Figure 3 from Characterization of Biomarkers of Tumorigenic and Chemoresistant Cancer Stem Cells in Human Gastric Carcinoma Open
Effect of verapamil treatment in combination with dose-dependent chemotherapies on gastric cancer cell lines viability.
View article: Supplementary Figure 4 from Characterization of Biomarkers of Tumorigenic and Chemoresistant Cancer Stem Cells in Human Gastric Carcinoma
Supplementary Figure 4 from Characterization of Biomarkers of Tumorigenic and Chemoresistant Cancer Stem Cells in Human Gastric Carcinoma Open
Effect of verapamil treatment in combination with chemotherapies on tumorsphere formation by GC10.
View article: Supplementary Figure 1 from Characterization of Biomarkers of Tumorigenic and Chemoresistant Cancer Stem Cells in Human Gastric Carcinoma
Supplementary Figure 1 from Characterization of Biomarkers of Tumorigenic and Chemoresistant Cancer Stem Cells in Human Gastric Carcinoma Open
Detection of cells expressing CD44 and ALDH activity in gastric tumorspheres in vitro.
View article: Supplementary Figure 2 from Characterization of Biomarkers of Tumorigenic and Chemoresistant Cancer Stem Cells in Human Gastric Carcinoma
Supplementary Figure 2 from Characterization of Biomarkers of Tumorigenic and Chemoresistant Cancer Stem Cells in Human Gastric Carcinoma Open
Detection of ALDH+ population with SP protocol and with ALDEFLUOR protocol.
View article: CD44v3 is a marker of invasive cancer stem cells driving metastasis in gastric carcinoma
CD44v3 is a marker of invasive cancer stem cells driving metastasis in gastric carcinoma Open
View article: Nrf2 Downregulation Contributes to Epithelial-to-Mesenchymal Transition in Helicobacter pylori-Infected Cells
Nrf2 Downregulation Contributes to Epithelial-to-Mesenchymal Transition in Helicobacter pylori-Infected Cells Open
Background: Gastric cancer, the fifth most common cancer worldwide, is mainly linked to Helicobacter pylori infection. H. pylori induces chronic inflammation of the gastric mucosa associated with high oxidative stress. Our study aimed at a…
View article: Adhesion of Gastric Cancer Cells to the Enteric Nervous System: Comparison between the Intestinal Type and Diffuse Type of Gastric Cancer
Adhesion of Gastric Cancer Cells to the Enteric Nervous System: Comparison between the Intestinal Type and Diffuse Type of Gastric Cancer Open
Background: Gastric cancer (GC) is the third leading cause of cancer-related deaths worldwide. The enteric nervous system (ENS) has been suggested to be involved in cancer development and spread. Objective: To analyze the GC cell adhesion …
View article: Hippo in Gastric Cancer: From Signalling to Therapy
Hippo in Gastric Cancer: From Signalling to Therapy Open
The Hippo pathway is one of the most important ones in mammals. Its key functions in cell proliferation, tissue growth, repair, and homeostasis make it the most crucial one to be controlled. Many means have been deployed for its regulation…
View article: The cytolethal distending toxin modulates cell differentiation and elicits epithelial to mesenchymal transition
The cytolethal distending toxin modulates cell differentiation and elicits epithelial to mesenchymal transition Open
We are frequently exposed to bacterial genotoxins, such as cytolethal distending toxin (CDT), a prevalent heterotrimeric toxin whose active moiety is its CdtB subunit. CdtB triggers potent DNA damage, predisposing factors in the developmen…
View article: Leukaemia inhibitory factor in gastric cancer: friend or foe?
Leukaemia inhibitory factor in gastric cancer: friend or foe? Open
View article: Two parallel pathways connect glutamine metabolism and mTORC1 activity to regulate glutamoptosis
Two parallel pathways connect glutamine metabolism and mTORC1 activity to regulate glutamoptosis Open
View article: Gastric Cancer: Advances in Carcinogenesis Research and New Therapeutic Strategies
Gastric Cancer: Advances in Carcinogenesis Research and New Therapeutic Strategies Open
Gastric cancer’s bad incidence, prognosis, cellular and molecular heterogeneity amongst others make this disease a major health issue worldwide. Understanding this affliction is a priority for proper patients’ management and for the develo…
View article: Organotypic Modeling of the Tumor Landscape
Organotypic Modeling of the Tumor Landscape Open
Cancer is a complex disease and it is now clear that not only epithelial tumor cells play a role in carcinogenesis. The tumor microenvironment is composed of non-stromal cells, including endothelial cells, adipocytes, immune and nerve cell…