Christoph Arolt
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View article: Deciphering the cellular tumor microenvironment landscape in salivary gland carcinomas using multiplexed imaging mass cytometry
Deciphering the cellular tumor microenvironment landscape in salivary gland carcinomas using multiplexed imaging mass cytometry Open
View article: Tissue factor expression in salivary gland carcinoma: a potential novel therapeutic target for advanced disease
Tissue factor expression in salivary gland carcinoma: a potential novel therapeutic target for advanced disease Open
Background: Salivary gland carcinomas (SGC) are rare head and neck malignancies with diverse molecular profiles and treatment challenges. Tissue factor (TF), a transmembrane glycoprotein involved in cancer pathophysiology, has emerged as a…
View article: Deciphering the cellular tumor microenvironment landscape in salivary gland carcinomas using multiplexed imaging mass cytometry
Deciphering the cellular tumor microenvironment landscape in salivary gland carcinomas using multiplexed imaging mass cytometry Open
Purpose To spatially characterize the single-cell tumor microenvironment (TME) of salivary gland carcinomas (SGC) and identify prognostic biomarkers. Experimental Design SGC, including salivary duct carcinomas (SDC), acinic cell, mucoepide…
View article: Histological and genetic criteria define a clinically relevant subgroup of HPV-positive oropharyngeal carcinoma
Histological and genetic criteria define a clinically relevant subgroup of HPV-positive oropharyngeal carcinoma Open
HPV PC distinguished two histomorphological subgroups within HPV-positive OPSCCs: cHPV with excellent prognosis and non-cHPV with poorer overall survival. Non-cHPV tumors also exhibited higher overall mutation rates, notably LOF-TP53 and P…
View article: The Impact of Lesion-Specific and Sampling-Related Factors on Success of Salivary Gland Fine-Needle Aspiration Cytology
The Impact of Lesion-Specific and Sampling-Related Factors on Success of Salivary Gland Fine-Needle Aspiration Cytology Open
Purpose Ultrasound-guided fine-needle aspiration cytology (FNAC) is a widely used diagnostic procedure which facilitates the differentiation of salivary gland lesions. Although the performance of salivary gland FNAC (SG-FNAC) has improved …
View article: Success of salivary gland fine-needle aspiration cytology is depending on various lesion- and sampling-related factors
Success of salivary gland fine-needle aspiration cytology is depending on various lesion- and sampling-related factors Open
Purpose. Ultrasound-guided fine-needle aspiration cytology (FNAC) is a widely used diagnostic procedure which facilitates the differentiation of salivary gland lesions. Although the performance of salivary gland FNAC (SG-FNAC) has improved…
View article: Benchmark of screening markers for KEAP1/NFE2L2 mutations and joint analysis with the K1N2-score
Benchmark of screening markers for KEAP1/NFE2L2 mutations and joint analysis with the K1N2-score Open
View article: Klinische und molekulare Epidemiologie maligner Speicheldrüsentumore
Klinische und molekulare Epidemiologie maligner Speicheldrüsentumore Open
Zusammenfassung Speicheldrüsenkarzinome sind eine seltene und heterogene Gruppe von bösartigen Tumoren, die 3–6% aller bösartigen Tumoren im Kopf-Hals-Bereich ausmachen. Die 1-, 3- und 5-Jahres-Überlebensraten liegen bei 83%, 69% bzw. 63%.…
View article: Recurrence after primary salivary gland carcinoma: Frequency, survival, and risk factors
Recurrence after primary salivary gland carcinoma: Frequency, survival, and risk factors Open
Background Primary salivary gland carcinomas (SGC) are rare neoplasms that present therapeutic challenges especially in recurrent tumors. The aim of this study was to investigate the incidence and distribution of tumor recurrence, associat…
View article: The extent of androgen receptor and HER2 expression allows for targeted therapy in most cases of salivary duct carcinoma: analysis of clinical and histopathological data in a tertiary care center
The extent of androgen receptor and HER2 expression allows for targeted therapy in most cases of salivary duct carcinoma: analysis of clinical and histopathological data in a tertiary care center Open
Purpose The incidence of salivary duct carcinoma (SDC) seems to be underestimated due to inaccurate classification. Further, the frequency of SDC patients with targeted therapy options according to current guidelines is unclear. Therefore,…
View article: Nectin-4 is frequently expressed in primary salivary gland cancer and corresponding lymph node metastases and represents an important treatment-related biomarker
Nectin-4 is frequently expressed in primary salivary gland cancer and corresponding lymph node metastases and represents an important treatment-related biomarker Open
Many locally advanced and metastatic salivary gland carcinomas (SGC) lack therapeutic targets. Enfortumab vedotin , an antibody–drug conjugate binding to Nectin-4, recently gained FDA approval for third-line urothelial carcinoma. Therefore…
View article: KEAP1/NFE2L2 Pathway Signature Outperforms KEAP1/NFE2L2 Mutation Status and Reveals Alternative Pathway-Activating Mutations in NSCLC
KEAP1/NFE2L2 Pathway Signature Outperforms KEAP1/NFE2L2 Mutation Status and Reveals Alternative Pathway-Activating Mutations in NSCLC Open
The K1N2-score identified KEAP1/NFE2L2-activated NSCLC by robustly detecting KEAP1/NFE2L2mut cases and discovering alternative genomic activators. It is a potential means for selecting patients with a constitutively active KEAP1/NFE2L2 pat…
View article: Intratumoral Abundance of M2-Macrophages is Associated With Unfavorable Prognosis and Markers of T-Cell Exhaustion in Small Cell Lung Cancer Patients
Intratumoral Abundance of M2-Macrophages is Associated With Unfavorable Prognosis and Markers of T-Cell Exhaustion in Small Cell Lung Cancer Patients Open
Small cell lung cancer (SCLC) accounts for about 10% to 15% of lung cancer cases. Unlike non-SCLC, therapy options for SCLC are limited, reflected by a 5-year survival rate of about 7%. At the same time, the rise of immunotherapeutic appro…
View article: Correlation of morphologic and molecular criteria – Identifcation of a subtype in HPV-positive oropharyngeal carcinoma
Correlation of morphologic and molecular criteria – Identifcation of a subtype in HPV-positive oropharyngeal carcinoma Open
Introduction Subgroups with a reduced prognosis exist patients with HPV-positive oropharyngeal squamous cell carcinoma (HPV+ OPSCC). The aim of this study is to identify morphological and genetic differences within HPV+ OPSCC. These will s…
View article: Multi-Class Cancer Subtyping in Salivary Gland Carcinomas with MALDI Imaging and Deep Learning
Multi-Class Cancer Subtyping in Salivary Gland Carcinomas with MALDI Imaging and Deep Learning Open
Salivary gland carcinomas (SGC) are a heterogeneous group of tumors. The prognosis varies strongly according to its type, and even the distinction between benign and malign tumor is challenging. Adenoid cystic carcinoma (AdCy) is one subgr…
View article: Incidence and clinical outcome of primary carcinomas of the major salivary glands: 10-year data from a population-based state cancer registry in Germany
Incidence and clinical outcome of primary carcinomas of the major salivary glands: 10-year data from a population-based state cancer registry in Germany Open
View article: CD138 Is Expressed in Different Entities of Salivary Gland Cancer and Their Lymph Node Metastases and Therefore Represents a Potential Therapeutic Target
CD138 Is Expressed in Different Entities of Salivary Gland Cancer and Their Lymph Node Metastases and Therefore Represents a Potential Therapeutic Target Open
Advanced salivary gland carcinomas (SGC) often lack therapeutic options. Agents targeting CD138 have recently shown promising results in clinical trials for multiple myeloma and a preclinical trial for triple-negative breast cancer. Immuno…
View article: Incidence and clinical outcome of primary carcinomas of the major salivary glands: 10-year data from a population-based state cancer registry in Germany
Incidence and clinical outcome of primary carcinomas of the major salivary glands: 10-year data from a population-based state cancer registry in Germany Open
Purpose: The aim of this project was to provide an overview of the epidemiology of primary salivary gland carcinomas (SGC) in terms of incidence, distribution of clinicopathological features and survival in one of the largest cancer regist…
View article: Mutually Exclusive Expression of COL11A1 by Cancer Associated Fibroblasts and Tumour Cells in a Salivary Gland Carcinoma Cohort
Mutually Exclusive Expression of COL11A1 by Cancer Associated Fibroblasts and Tumour Cells in a Salivary Gland Carcinoma Cohort Open
Procollagen 11A1 (COL11A1) is a central component of the extracellular matrix in many carcinomas, which is considered to be mainly produced by cancer associated fibroblasts (CAFs). As COL11A1 expression correlates with adverse prognosis an…
View article: The configuration of the extracellular matrix divides salivary gland carcinomas into two subclasses and offers potential therapeutic targets
The configuration of the extracellular matrix divides salivary gland carcinomas into two subclasses and offers potential therapeutic targets Open
The extracellular matrix (ECM) is an important component of salivary gland carcinoma (SGC) tumor biology. We generated the hypothesis that the composition of the ECM depends on the cell-of-origin of the tumors and consists of 2 subgroups: …
View article: Charakteristische Expression von COL11A1 durch tumorassoziierte Fibroblasten und Tumorzellen in einer Speicheldrüsenkarzinom-Kohorte
Charakteristische Expression von COL11A1 durch tumorassoziierte Fibroblasten und Tumorzellen in einer Speicheldrüsenkarzinom-Kohorte Open
Prokollagen 11A1 (COL11A1) ist ein zentraler Bestandteil der extrazellulären Matrix in Karzinomen, der hauptsächlich von tumorassoziierten Fibroblasten (CAFs) produziert wird. Da die COL11A1-Expression mit einer ungünstigen Prognose korrel…
View article: Die Zusammensetzung der extrazellulären Matrix unterteilt Speicheldrüsenkarzinome in zwei Subklassen und bietet potenzielle therapeutische Ansatzpunkte
Die Zusammensetzung der extrazellulären Matrix unterteilt Speicheldrüsenkarzinome in zwei Subklassen und bietet potenzielle therapeutische Ansatzpunkte Open
Einleitung Die extrazelluläre Matrix (ECM) ist ein wichtiger Bestandteil der Tumorbiologie von Speicheldrüsenkarzinomen (SGC). Wir stellten die Hypothese auf, dass die Zusammensetzung der ECM von der cell-of-origin der Tumoren abhängt und …
View article: Expression of Mucins in Different Entities of Salivary Gland Cancer: Highest Expression of Mucin-1 in Salivary Duct Carcinoma
Expression of Mucins in Different Entities of Salivary Gland Cancer: Highest Expression of Mucin-1 in Salivary Duct Carcinoma Open
Therapeutic options for advanced salivary gland cancer (SGC) are rare. Therefore, it was the aim of this study to investigate the extent and intensity of Mucin-1 (MUC1), Mucin-16 (MUC16), and Mucin-5AC (MUC5AC) as potential molecular targe…
View article: Patterns of Tumor Infiltrating Lymphocytes in Adenoid Cystic Carcinoma of the Head and Neck
Patterns of Tumor Infiltrating Lymphocytes in Adenoid Cystic Carcinoma of the Head and Neck Open
Adenoid cystic carcinoma (ACC) is a rare malignancy in the head and neck. The prognosis remains poor and late recurrences often occur after 5 years and later. To date, there are no reliable prognostic markers for ACC. In several solid tumo…
View article: Comprehensive Analysis of VEGFR2 Expression in HPV-Positive and -Negative OPSCC Reveals Differing VEGFR2 Expression Patterns
Comprehensive Analysis of VEGFR2 Expression in HPV-Positive and -Negative OPSCC Reveals Differing VEGFR2 Expression Patterns Open
VEGF signaling regulated by the vascular endothelial growth factor receptor 2 (VEGFR2) plays a decisive role in tumor angiogenesis, initiation and progression in several tumors including HNSCC. However, the impact of HPV-status on the expr…
View article: Correction to: Mutually Exclusive Expression of COL11A1 by CAFs and Tumour Cells in a Large panCancer and a Salivary Gland Carcinoma Cohort
Correction to: Mutually Exclusive Expression of COL11A1 by CAFs and Tumour Cells in a Large panCancer and a Salivary Gland Carcinoma Cohort Open
View article: Genomic and Transcriptomic Characteristics of Esophageal Adenocarcinoma
Genomic and Transcriptomic Characteristics of Esophageal Adenocarcinoma Open
Esophageal adenocarcinoma (EAC) is a deadly disease with limited options for targeted therapy. With the help of next-generation sequencing studies over the last decade, we gained an understanding of the genomic architecture of EAC. The tum…
View article: Mutually Exclusive Expression of COL11A1 by CAFs and Tumour Cells in a Large panCancer and a Salivary Gland Carcinoma Cohort
Mutually Exclusive Expression of COL11A1 by CAFs and Tumour Cells in a Large panCancer and a Salivary Gland Carcinoma Cohort Open
View article: Expressionsanalyse von mRNAs extrazellulärer Matrixkomponente in aggressiven Entitäten der Speicheldrüsenkarzinome
Expressionsanalyse von mRNAs extrazellulärer Matrixkomponente in aggressiven Entitäten der Speicheldrüsenkarzinome Open
Einführung Die Zusammensetzung der extrazellulären Matrix (ECM) spielt eine entscheidende Rolle bei der Tumorinitiierung, Metastasierung und Therapieresistenz. Bei Speicheldrüsenkarzinomen (SGC) ist die Komposition des ECM bisher weitgehen…
View article: Trop-2 Protein wird bei Speicheldrüsenmalignomen stark exprimiert und stellt ein therapeutisches target dar
Trop-2 Protein wird bei Speicheldrüsenmalignomen stark exprimiert und stellt ein therapeutisches target dar Open
Zielsetzungen Die Behandlungsmöglichkeiten für inoperable, rezidivierende oder metastasierende Speicheldrüsenkarzinome sind begrenzt. Trophoblast cell surface antigen 2 (Trop-2) spielt eine Rolle bei der Karzinogenese und dient als target …