Christoph Baldow
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View article: Modelling of immune response in chronic myeloid leukemia patients suggests potential for treatment reduction prior to cessation
Modelling of immune response in chronic myeloid leukemia patients suggests potential for treatment reduction prior to cessation Open
Introduction Discontinuation of tyrosine kinase inhibitor (TKI) treatment is emerging as the main therapy goal for Chronic Myeloid Leukemia (CML) patients. The DESTINY trial showed that TKI dose reduction prior to cessation can lead to an …
View article: Modelling of immune response in chronic myeloid leukemia patients suggests potential for treatment reduction prior to cessation
Modelling of immune response in chronic myeloid leukemia patients suggests potential for treatment reduction prior to cessation Open
Discontinuation of tyrosine kinase inhibitor (TKI) treatment is emerging as the main therapy goal for Chronic Myeloid Leukemia (CML) patients. The DESTINY trial showed that TKI dose reduction prior to cessation can lead to an increased num…
View article: Modelling of immune response in chronic myeloid leukemia patients suggests potential for treatment reduction prior to cessation
Modelling of immune response in chronic myeloid leukemia patients suggests potential for treatment reduction prior to cessation Open
Tyrosine kinase inhibitors (TKI) are highly efficient drugs to combat Chronic Myeloid Leukemia (CML). While long-term drug administration is associated with side effects and high economic costs, current efforts focus on the discontinuation…
View article: Clonal reconstruction from co-occurrence of vector integration sites accurately quantifies expanding clones in vivo
Clonal reconstruction from co-occurrence of vector integration sites accurately quantifies expanding clones in vivo Open
High transduction rates of viral vectors in gene therapies (GT) and experimental hematopoiesis ensure a high frequency of gene delivery, although multiple integration events can occur in the same cell. Therefore, tracing of integration sit…
View article: P691: MODELLING OF IMMUNE RESPONSE IN CHRONIC MYELOID LEUKEMIA PATIENTS SUGGESTS POTENTIAL FOR TREATMENT REDUCTION PRIOR TO CESSATION
P691: MODELLING OF IMMUNE RESPONSE IN CHRONIC MYELOID LEUKEMIA PATIENTS SUGGESTS POTENTIAL FOR TREATMENT REDUCTION PRIOR TO CESSATION Open
Background: Chronic myeloid leukemia (CML) is a malignancy driven by the characteristic BCR-ABL1-fusion oncogene, while the BCR-ABL1 transcript is used as a marker for diagnosis and monitoring. The introduction of tyrosine kinase inhibitor…
View article: How to predict relapse in leukemia using time series data: A comparative in silico study
How to predict relapse in leukemia using time series data: A comparative in silico study Open
Risk stratification and treatment decisions for leukemia patients are regularly based on clinical markers determined at diagnosis, while measurements on system dynamics are often neglected. However, there is increasing evidence that linkin…
View article: Clonal reconstruction from co-occurrence of vector integration sites allows accurate quantification of expanding clones in vivo
Clonal reconstruction from co-occurrence of vector integration sites allows accurate quantification of expanding clones in vivo Open
High transduction rates of viral vectors in gene therapies (GT) and experimental hematopoiesis ensure a high frequency of gene delivery, although multiple integration events can occur in the same cell. Therefore, tracing of integration sit…
View article: How to predict relapse in leukemia using time series data: A comparative in silico study
How to predict relapse in leukemia using time series data: A comparative in silico study Open
Risk stratification and treatment decisions for leukemia patients are regularly based on clinical markers determined at diagnosis, while measurements on system dynamics are often neglected. However, there is increasing evidence that linkin…
View article: How to predict relapse in leukemia using time series data: A comparative in silico study
How to predict relapse in leukemia using time series data: A comparative in silico study Open
Risk stratification and treatment decisions for leukemia patients are regularly based on clinical markers determined at diagnosis, while measurements on system dynamics are often neglected. However, there is increasing evidence that linkin…
View article: Mathematical modelling of megakaryopoiesis in Mpl-deficient and continuously thrombopoietin-stimulated mice points to an unknown control mechanism
Mathematical modelling of megakaryopoiesis in Mpl-deficient and continuously thrombopoietin-stimulated mice points to an unknown control mechanism Open
Thrombopoietin (TPO) is the ligand of the Mpl receptor and the key regulator of megakaryopoiesis and platelet production. A loss or gain of the TPO-receptor function affects haematopoiesis and results in severe diseases in humans. Appropri…
View article: Model-Based Inference and Classification of Immunologic Control Mechanisms from TKI Cessation and Dose Reduction in Patients with CML
Model-Based Inference and Classification of Immunologic Control Mechanisms from TKI Cessation and Dose Reduction in Patients with CML Open
Recent clinical findings in patients with chronic myeloid leukemia (CML) suggest that the risk of molecular recurrence after stopping tyrosine kinase inhibitor (TKI) treatment substantially depends on an individual's leukemia-specific immu…
View article: Integration of mathematical model predictions into routine workflows to support clinical decision making in haematology
Integration of mathematical model predictions into routine workflows to support clinical decision making in haematology Open
Background Individualization and patient-specific optimization of treatment is a major goal of modern health care. One way to achieve this goal is the application of high-resolution diagnostics together with the application of targeted the…
View article: How to Predict Relapse in Leukaemia Using Time Series Data: A Comparative <i>in silico</i> Study
How to Predict Relapse in Leukaemia Using Time Series Data: A Comparative <i>in silico</i> Study Open
View article: Inferring immunological control mechanisms from TKI dose alterations in CML patients
Inferring immunological control mechanisms from TKI dose alterations in CML patients Open
Recent clinical findings in chronic myeloid leukemia (CML) patients suggest that the risk of molecular recurrence after stopping tyrosine kinase inhibitors (TKI) treatment substantially depend on an individual, leukemia-specific immune res…
View article: Quantitative prediction of long-term molecular response in TKI-treated CML – Lessons from an imatinib versus dasatinib comparison
Quantitative prediction of long-term molecular response in TKI-treated CML – Lessons from an imatinib versus dasatinib comparison Open
Longitudinal monitoring of BCR-ABL transcript levels in peripheral blood of CML patients treated with tyrosine kinase inhibitors (TKI) revealed a typical biphasic response. Although second generation TKIs like dasatinib proved more efficie…
View article: Reduced tyrosine kinase inhibitor dose is predicted to be as effective as standard dose in chronic myeloid leukemia: a simulation study based on phase III trial data
Reduced tyrosine kinase inhibitor dose is predicted to be as effective as standard dose in chronic myeloid leukemia: a simulation study based on phase III trial data Open
Continuing tyrosine kinase inhibitor (TKI)-mediated targeting of the BCR-ABL1 oncoprotein is the standard therapy for chronic myeloid leukemia (CML) and allows for a sustained disease control in the majority of patients. While therapy cess…
View article: MAGPIE: Simplifying access and execution of computational models in the life sciences
MAGPIE: Simplifying access and execution of computational models in the life sciences Open
Over the past decades, quantitative methods linking theory and observation became increasingly important in many areas of life science. Subsequently, a large number of mathematical and computational models has been developed. The BioModels…
View article: Reconstruction of hierarchical differentiation processes based on the temporal clonal readout in distinct hematopoietic lineages
Reconstruction of hierarchical differentiation processes based on the temporal clonal readout in distinct hematopoietic lineages Open
View article: Response dynamics of pediatric patients with chronic myeloid leukemia on imatinib therapy
Response dynamics of pediatric patients with chronic myeloid leukemia on imatinib therapy Open
View article: Model Based Analysis of Clonal Developments Allows for Early Detection of Monoclonal Conversion and Leukemia
Model Based Analysis of Clonal Developments Allows for Early Detection of Monoclonal Conversion and Leukemia Open
The availability of several methods to unambiguously mark individual cells has strongly fostered the understanding of clonal developments in hematopoiesis and other stem cell driven regenerative tissues. While cellular barcoding is the met…
View article: Drug target prioritization by perturbed gene expression and network information
Drug target prioritization by perturbed gene expression and network information Open