Christoph H. Tripp
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View article: Multi-Epitope DC Vaccines with Melanoma Antigens for Immunotherapy of Melanoma
Multi-Epitope DC Vaccines with Melanoma Antigens for Immunotherapy of Melanoma Open
Background/Objectives: The revolution for the treatment of melanoma came with the approval of checkpoint blockade antibodies. However, a substantial proportion of patients show primary or secondary resistance to this type of immunotherapy,…
View article: Guidelines for preparation and flow cytometry analysis of human nonlymphoid tissue DC
Guidelines for preparation and flow cytometry analysis of human nonlymphoid tissue DC Open
This article is part of the Dendritic Cell Guidelines article series, which provides a collection of state‐of‐the‐art protocols for the preparation, phenotype analysis by flow cytometry, generation, fluorescence microscopy, and functional …
View article: Langerhans cells orchestrate apoptosis of DNA‐damaged keratinocytes upon high‐dose UVB skin exposure
Langerhans cells orchestrate apoptosis of DNA‐damaged keratinocytes upon high‐dose UVB skin exposure Open
Ultraviolet (UV) irradiation of the skin causes mutations that can promote the development of melanoma and nonmelanoma skin cancer. High‐dose UVB exposure triggers a vigorous skin reaction characterized by inflammation resulting in acute s…
View article: Tumor-targeted therapy with BRAF-inhibitor recruits activated dendritic cells to promote tumor immunity in melanoma
Tumor-targeted therapy with BRAF-inhibitor recruits activated dendritic cells to promote tumor immunity in melanoma Open
Background Tumor-targeted therapy causes impressive tumor regression, but the emergence of resistance limits long-term survival benefits in patients. Little information is available on the role of the myeloid cell network, especially dendr…
View article: Silicone implant surface microtopography modulates inflammation and tissue repair in capsular fibrosis
Silicone implant surface microtopography modulates inflammation and tissue repair in capsular fibrosis Open
Excessive fibrous capsule formation around silicone mammary implants (SMI) involves immune reactions to silicone. Capsular fibrosis, a common SMI complication linked to host responses, worsens with specific implant topographies. Our study …
View article: Preadipocytes in human granulation tissue: role in wound healing and response to macrophage polarization
Preadipocytes in human granulation tissue: role in wound healing and response to macrophage polarization Open
View article: Guidelines for DC preparation and flow cytometry analysis of mouse nonlymphoid tissues
Guidelines for DC preparation and flow cytometry analysis of mouse nonlymphoid tissues Open
This article is part of the Dendritic Cell Guidelines article series, which provides a collection of state‐of‐the‐art protocols for the preparation, phenotype analysis by flow cytometry, generation, fluorescence microscopy and functional c…
View article: Contents: Eur. J. Immunol. 12'22
Contents: Eur. J. Immunol. 12'22 Open
View article: Mouse dendritic cells and other myeloid subtypes in healthy lymph nodes and skin: 26‐Color flow cytometry panel for immune phenotyping
Mouse dendritic cells and other myeloid subtypes in healthy lymph nodes and skin: 26‐Color flow cytometry panel for immune phenotyping Open
This novel 26-color flow cytometry panel allows the detailed immune phenotyping of the complex network of myeloid cells in murine lymph nodes and skin. With the optimized panel the different murine DC-subsets and other myeloid cell types c…
View article: Targeted delivery of a vaccine protein to Langerhans cells in the human skin via the C‐type lectin receptor Langerin
Targeted delivery of a vaccine protein to Langerhans cells in the human skin via the C‐type lectin receptor Langerin Open
Human skin is a preferred vaccination site as it harbors multiple dendritic cell (DC) subsets, which display distinct C‐type lectin receptors (CLR) that recognize pathogens. Antigens can be delivered to CLR by antibodies or ligands to boos…
View article: Author response for "Targeted delivery of a vaccine protein to Langerhans cells in the human skin via the C‐type lectin receptor Langerin"
Author response for "Targeted delivery of a vaccine protein to Langerhans cells in the human skin via the C‐type lectin receptor Langerin" Open
View article: Laser‐assisted epicutaneous immunization to target human skin dendritic cells
Laser‐assisted epicutaneous immunization to target human skin dendritic cells Open
Dendritic cells (DC) are promising targets for immunotherapy of cancer. Clinically, immunization against cancer antigens by means of the most potent antigen‐presenting cells, that is DC, remains an important treatment option in combination…
View article: Skin dendritic cells in melanoma are key for successful checkpoint blockade therapy
Skin dendritic cells in melanoma are key for successful checkpoint blockade therapy Open
Background Immunotherapy with checkpoint inhibitors has shown impressive results in patients with melanoma, but still many do not benefit from this line of treatment. A lack of tumor-infiltrating T cells is a common reason for therapy fail…
View article: Combining chemotherapy and autologous peptide‐pulsed dendritic cells provides survival benefit in stage IV melanoma patients
Combining chemotherapy and autologous peptide‐pulsed dendritic cells provides survival benefit in stage IV melanoma patients Open
Summary Background and Objectives We examined retrospectively whether the combination of standard dacarbazine (DTIC) and/or fotemustine chemotherapy and autologous peptide‐loaded dendritic cell (DC) vaccination may improve survival of stag…
View article: Kombination von Chemotherapie und autologen, Peptid‐beladenen dendritischen Zellen bringt Überlebensvorteil bei Melanompatienten im Stadium IV
Kombination von Chemotherapie und autologen, Peptid‐beladenen dendritischen Zellen bringt Überlebensvorteil bei Melanompatienten im Stadium IV Open
Zusammenfassung Hintergrund und Studienziele Wir untersuchten retrospektiv, ob die Kombination der Standardchemotherapie (Dacarbazin [DTIC] und/oder Fotemustin) und Vakzination mit autologen, Tumorpeptid‐beladenen dendritischen Zellen (DZ)…
View article: Notch-Mediated Generation of Monocyte-Derived Langerhans Cells: Phenotype and Function
Notch-Mediated Generation of Monocyte-Derived Langerhans Cells: Phenotype and Function Open
View article: A TLR7 agonist strengthens T and NK cell function during BRAF‐targeted therapy in a preclinical melanoma model
A TLR7 agonist strengthens T and NK cell function during BRAF‐targeted therapy in a preclinical melanoma model Open
Therapeutic success of targeted therapy with BRAF inhibitors (BRAFi) for melanoma is limited by resistance development. Observations from preclinical mouse models and recent insights into the immunological effects caused by BRAFi give prom…
View article: E-Cadherin is Dispensable to Maintain Langerhans Cells in the Epidermis
E-Cadherin is Dispensable to Maintain Langerhans Cells in the Epidermis Open
View article: Oncolytic virotherapy enhances the efficacy of a cancer vaccine by modulating the tumor microenvironment
Oncolytic virotherapy enhances the efficacy of a cancer vaccine by modulating the tumor microenvironment Open
The efficacy of cancer vaccines has been limited by the immunosuppressive tumor microenvironment, which can be alleviated by immune checkpoint inhibitor (ICI) therapy. Here, we tested if oncolytic viruses (OVs), similar to ICI, can also sy…
View article: Langerhans cells and NK cells cooperate in the inhibition of chemical skin carcinogenesis
Langerhans cells and NK cells cooperate in the inhibition of chemical skin carcinogenesis Open
Tissue immunosurveillance is an important mechanism to prevent cancer. Skin treatment with the carcinogen 7,12-dimethylbenz(a)anthracene (DMBA), followed by the tumor promoter 12-O-tetra-decanoyl-phorbol-13-acetate (TPA), is an established…
View article: Atopic dermatitis induces the expansion of thymus‐derived regulatory T cells exhibiting a Th2‐like phenotype in mice
Atopic dermatitis induces the expansion of thymus‐derived regulatory T cells exhibiting a Th2‐like phenotype in mice Open
Atopic dermatitis ( AD ) is a widespread inflammatory skin disease with an early onset, characterized by pruritus, eczematous lesions and skin dryness. This chronic relapsing disease is believed to be primarily a result of a defective epid…
View article: Langerhans cells in the sebaceous gland of the murine skin
Langerhans cells in the sebaceous gland of the murine skin Open
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View article: Impaired gp100-Specific CD8+ T-Cell Responses in the Presence of Myeloid-Derived Suppressor Cells in a Spontaneous Mouse Melanoma Model
Impaired gp100-Specific CD8+ T-Cell Responses in the Presence of Myeloid-Derived Suppressor Cells in a Spontaneous Mouse Melanoma Model Open