Christoph Hartlmüller
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View article: Structural and DNA-binding properties of the cytoplasmic domain of Vibrio cholerae transcription factor ToxR
Structural and DNA-binding properties of the cytoplasmic domain of Vibrio cholerae transcription factor ToxR Open
View article: Cysteine oxidation triggers amyloid fibril formation of the tumor suppressor p16INK4A
Cysteine oxidation triggers amyloid fibril formation of the tumor suppressor p16INK4A Open
View article: NMR characterization of solvent accessibility and transient structure in intrinsically disordered proteins
NMR characterization of solvent accessibility and transient structure in intrinsically disordered proteins Open
View article: Cysteine oxidation triggers amyloid fibril formation of the tumor suppressor p16<sup>INK4A</sup>
Cysteine oxidation triggers amyloid fibril formation of the tumor suppressor p16<sup>INK4A</sup> Open
Accumulation of the CDK4/6 inhibitor p16 INK4A in response to oncogenic transformation leads to cell cycle arrest and senescence and is therefore frequently lost in cancer. p16 INK4A is also known to accumulate under conditions of oxidativ…
View article: Molecular basis for asymmetry sensing of siRNAs by the Drosophila Loqs-PD/Dcr-2 complex in RNA interference
Molecular basis for asymmetry sensing of siRNAs by the Drosophila Loqs-PD/Dcr-2 complex in RNA interference Open
RNA interference defends against RNA viruses and retro-elements within an organism's genome. It is triggered by duplex siRNAs, of which one strand is selected to confer sequence-specificity to the RNA induced silencing complex (RISC). In D…
View article: Characterization of Protein–Protein Interfaces in Large Complexes by Solid-State NMR Solvent Paramagnetic Relaxation Enhancements
Characterization of Protein–Protein Interfaces in Large Complexes by Solid-State NMR Solvent Paramagnetic Relaxation Enhancements Open
Solid-state NMR is becoming a viable alternative for obtaining information about structures and dynamics of large biomolecular complexes, including ones that are not accessible to other high-resolution biophysical techniques. In this conte…
View article: RNA structure refinement using NMR solvent accessibility data
RNA structure refinement using NMR solvent accessibility data Open
View article: The redox environment triggers conformational changes and aggregation of hIAPP in Type II Diabetes
The redox environment triggers conformational changes and aggregation of hIAPP in Type II Diabetes Open
View article: Verbesserung der Dispersion der chemischen Verschiebungen von unstrukturierten Proteinen durch einen kovalent gebundenen Lanthanoidkomplex
Verbesserung der Dispersion der chemischen Verschiebungen von unstrukturierten Proteinen durch einen kovalent gebundenen Lanthanoidkomplex Open
Die Erforschung von intrinsisch unstrukturierten Proteinen (IDPs) mit NMR‐spektroskopischen Methoden wird oftmals durch starke Überlagerung der Proteinsignale erschwert. Dies führt zu uneindeutigen Zuordnungen dieser Signale und erschwert …
View article: Increasing the Chemical‐Shift Dispersion of Unstructured Proteins with a Covalent Lanthanide Shift Reagent
Increasing the Chemical‐Shift Dispersion of Unstructured Proteins with a Covalent Lanthanide Shift Reagent Open
The study of intrinsically disordered proteins (IDPs) by NMR often suffers from highly overlapped resonances that prevent unambiguous chemical‐shift assignments, and data analysis that relies on well‐separated resonances. We present a cova…
View article: Prediction of Protein Structure Using Surface Accessibility Data
Prediction of Protein Structure Using Surface Accessibility Data Open
An approach to the de novo structure prediction of proteins is described that relies on surface accessibility data from NMR paramagnetic relaxation enhancements by a soluble paramagnetic compound (sPRE). This method exploits the distance‐t…
View article: Prediction of Protein Structure Using Surface Accessibility Data
Prediction of Protein Structure Using Surface Accessibility Data Open
An approach to the de novo structure prediction of proteins is described that relies on surface accessibility data from NMR paramagnetic relaxation enhancements by a soluble paramagnetic compound (sPRE). This method exploits the distance‐t…
View article: Structural basis of nucleic-acid recognition and double-strand unwinding by the essential neuronal protein Pur-alpha
Structural basis of nucleic-acid recognition and double-strand unwinding by the essential neuronal protein Pur-alpha Open
The neuronal DNA-/RNA-binding protein Pur-alpha is a transcription regulator and core factor for mRNA localization. Pur-alpha-deficient mice die after birth with pleiotropic neuronal defects. Here, we report the crystal structure of the DN…
View article: Author response: Structural basis of nucleic-acid recognition and double-strand unwinding by the essential neuronal protein Pur-alpha
Author response: Structural basis of nucleic-acid recognition and double-strand unwinding by the essential neuronal protein Pur-alpha Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The neuronal DNA-/RNA-binding…