Explanipedia

Cell-autonomous complement C3 activity in prostate epithelial cells suppresses malignant transformation through tonic restrain of the MYC-tumorigenesis program 3135 Open

Jack Bibby, Selda Pelin Kartal, Hidekazu Yamamoto, Jianping Ma, Martin Kolev , et al. · 2025

Description Prostate cancer (PC) remains among the leading causes of cancer-related deaths with a better understanding of the mechanisms underlying its pathogenesis urgently needed. The synthesis of complement component C3 by tumor-infiltr…

Invasive Candida infections in solid organ transplant recipients between 2008 and 2020 Open

Lilly Meyer, Jaromil Frossard, Peter W. Schreiber, Oriol Manuel, Frédéric Lamoth , et al. · 2025

Contemporary data on the epidemiology and outcomes of invasive candidiasis (IC) in solid organ transplant recipients (SOTr) are limited. This retrospective multicenter cohort study, nested within the Swiss Transplant Cohort Study, describe…

A ‘sweet spot’ for complement receptor CD46 activity: CYT-1 regulates glycolytic and moonlighting functions of glycolytic enzymes during human CD4+ T cell activation Open

Natalia Kunz, Gaëlle Le Friec, Jack Bibby, Erin E. West, Ayden Case , et al. · 2025

Cell-autonomous complement C3 activity in prostate epithelial cells suppresses malignant transformation through tonic restrain of the MYC-tumorigenesis program Open

Natalia Kunz, Selda Pelin Kartal, Jack Bibby, Nicolas S. Merle, Hidekazu Yamamoto , et al. · 2025

Surgical Site Infections, Risk Factors, and Outcomes After Liver Transplant Open

Peter W. Schreiber, Linard Hoessly, Katia Boggian, Dionysios Neofytos, Christian van Delden , et al. · 2025

Importance Surgical site infections (SSIs) are one of the most common health care–associated infections. Surgical site infections can have harmful effects in liver transplant (LT) recipients. Objective To assess the incidence of SSI after …

IL-7 promotes integrated glucose and amino acid sensing during homeostatic CD4+ T cell proliferation Open

Seema Bachoo, Nancy Gudgeon, Rebecca Mann, Victoria Stavrou, Emma L. Bishop , et al. · 2025

Interleukin (IL)-7 promotes T cell expansion during lymphopenia. We studied the metabolic basis in CD4⁺ T cells, observing increased glucose usage for nucleotide synthesis and oxidation in the tricarboxylic acid (TCA) cycle. Unl…

Epstein–Barr virus hijacks B cell metabolism to establish persistent infection and drive pathogenesis Open

Bojana Müller-Durovic, J. Jäger, Glenn R. Bantug, Christoph Hess · 2024

When B cells engage in an immune response, metabolic reprogramming is key to meeting cellular energetic and biosynthetic demands. Epstein-Barr virus (EBV) is a highly prevalent gamma-herpesvirus, latently infecting B cells for the human ho…

Reintegration Into the Workforce After Kidney Transplantation Based on Urbanization Status in Switzerland Open

Federica Bocchi, Selina Müller, Isabelle Binet, Déla Golshayan, Fadi Haidar , et al. · 2024

Patient and graft outcomes were favorable, with improved work reintegration observed at the 1-year mark post-KT for recipients from rural backgrounds compared to those from suburban and urban areas.

Nuclear and cytosolic fractions of SOX2 synergize as transcriptional and translational co-regulators of cell fate Open

Thorsten Schaefer, Nitish Mittal, Hui Wang, Meriç Ataman, Silvia Candido , et al. · 2024

Stemness and pluripotency are mediated by transcriptional master regulators that promote self-renewal and repress cell differentiation, among which is the high-mobility group (HMG) box transcription factor SOX2. Dysregulated SOX2 expressio…

Aerobic glycolysis but not GLS1-dependent glutamine metabolism is critical for anti-tumor immunity and response to checkpoint inhibition Open

Patrick M. Gubser, Sharanya K M Wijesinghe, Leonie Heyden, Sarah S. Gabriel, David P. De Souza , et al. · 2024

Tumor cells undergo uncontrolled proliferation driven by enhanced anabolic metabolism including glycolysis and glutaminolysis. Targeting these pathways to inhibit cancer growth is a strategy for cancer treatment. Critically, however, tumor…

Iron dysregulation and inflammatory stress erythropoiesis associates with long-term outcome of COVID-19 Open

Aimee Hanson, Matthew P. Mulè, Hélène Ruffieux, Federica Mescia, Laura Bergamaschi , et al. · 2024

Post-transplant Inflammatory Bowel Disease Associated with Donor-Derived TIM-3 Deficiency Open

Adrian Baldrich, Dominic Althaus, Thomas Menter, Julia R. Hirsiger, Julius Köppen , et al. · 2024

Do Infectious Diseases After Kidney Retransplantation Differ From Those After First Kidney Transplantation? Open

Katharina Kusejko, Dionysios Neofytos, Christian van Delden, Hans H. Hirsch, Pascal Meylan , et al. · 2024

Background Infectious diseases (IDs) are highly relevant after solid organ transplantation in terms of morbidity and mortality, being among the most common causes of death. Patients undergoing kidney retransplantation (re-K-Tx) have been a…

An evolutionary-conserved VPS34-PIKfyve-TRPML1-Myosin II axis regulates the speed of amoeboid cell migration Open

Philippe Dehio, Céline Michard, Juan Carlos Yam‐Puc, Adrià-Arnau Martí i Líndez, Lucien Fabre , et al. · 2024

Amoeboid cell migration is key to efficient T cell immunity. Spatial polarization of organelles within cells, including endo-lysosomes, is a prerequisite of migration. However, how ultrastructural polarization is linked to the signaling re…

Arachidonic acid inhibition of the NLRP3 inflammasome is a mechanism to explain the anti-inflammatory effects of fasting Open

Milton Pereira, J. Liang, Joy Edwards-Hicks, Allison M. Meadows, Christine Hinz , et al. · 2024

IL-7 Promotes Integrated Glucose and Amino Acid Sensing During Homeostatic CD4+ T Cell Proliferation Open

Seema Bachoo, Nancy Gudgeon, Emma L. Bishop, Audrey Kelly, Alejandro Huerta Uribe , et al. · 2024

B-251 Nmr Lipoproteins Help to Reveal Subphenotypes of Phenoreversion from sars-cov-2 Infection Open

Julien Wist, Samantha Lodge, Reika Masuda, Philipp Nitschke, Catherine Cannet , et al. · 2023

Background It is estimated that 10% of patients that suffered from severe acute SARS-CoV-2 infection experience symptoms beyond 3 months post-disease onset. Long COVID is a multisystemic condition that comprises more than 200 symptoms. Com…

Immune Monitoring-Guided Versus Fixed Duration of Antiviral Prophylaxis Against Cytomegalovirus in Solid-Organ Transplant Recipients: A Multicenter, Randomized Clinical Trial Open

Oriol Manuel, Mirjam Laager, Cédric Hirzel, Dionysios Neofytos, Laura N. Walti , et al. · 2023

Background The use of assays detecting cytomegalovirus (CMV)–specific T cell–mediated immunity may individualize the duration of antiviral prophylaxis after transplantation. Methods In this randomized trial, kidney and liver transplant rec…

Post-transplant inflammatory bowel disease associated with donor-derived TIM-3 deficiency Open

Adrian Baldrich, Dominic Althaus, Thomas Menter, Julia R. Hirsiger, Julius Köppen , et al. · 2023

Purpose Inflammatory bowel disease (IBD) occurring following allogenic stem cell transplantation (aSCT) is a very rare condition. The underlying pathogenesis is poorly defined. There is currently no systematic effort to exclude loss- or ga…

Correction to: Immunologic and Genetic Contributors to CD46‑Dependent Immune Dysregulation Open

B. Meyer, Natalia Kunz, Sayuri Seki, Rebecca Higgins, Adhideb Ghosh , et al. · 2023

Immunologic and Genetic Contributors to CD46-Dependent Immune Dysregulation Open

B. Meyer, Natalia Kunz, Sayuri Seki, Rebecca Higgins, Adhideb Ghosh , et al. · 2023

Mutations in CD46 predispose to atypical hemolytic uremic syndrome (aHUS) with low penetrance. Factors driving immune-dysregulatory disease in individual mutation carriers have remained ill-understood. In addition to its role as a negative…

Real-Time Volatile Metabolomics Analysis of Dendritic Cells Open

Kim Arnold, Philippe Dehio, Jonas Lötscher, Kapil Dev Singh, Diego García‐Gómez , et al. · 2023

Dendritic cells (DCs) actively sample and present antigen to cells of the adaptive immune system and are thus vital for successful immune control and memory formation. Immune cell metabolism and function are tightly interlinked, and a bett…

POS0243 KYNURENINE METABOLITES LIMIT INFLAMMATION THROUGH TRICARBOXYLIC ACID CYCLE (TCA) REMODELING Open

J. Jäger, C. Makowiec, Ming Yang, S. J. Camerin, Urs Duthaler , et al. · 2023

A compact gas attenuator for the SwissFEL ATHOS beamline realized using additive manufacturing Open

Claude Pradervand, Colette Rosenberg, Hans-Jörg Eckerlin, Kirsten Schnorr, André Al Haddad , et al. · 2023

Gas attenuators are important devices providing accurate variation of photon intensity for soft X-ray beamlines. In the SwissFEL ATHOS beamline front-end the space is very limited and an innovative approach has been taken to provide attenu…

Bacteremia During the First Year After Solid Organ Transplantation: An Epidemiological Update Open

Dionysios Neofytos, Susanne Stampf, Linard Hoessly, Matilde D’Asaro, Gael Nguyen Tang , et al. · 2023

Background There are limited contemporary data on the epidemiology and outcomes of bacteremia in solid organ transplant recipients (SOTr). Methods Using the Swiss Transplant Cohort Study registry from 2008 to 2019, we performed a retrospec…

Cell-autonomous complement C3 maintains prostate epithelial cell homeostasis and prevents malignant transformation Open

Natalia Kunz, Erin E. West, Hidekazu Yamamoto, Md Tajmul, Jonas Loetscher , et al. · 2023

Intracellularly active complement C3 and C3a emerged as central regulators of normal immune cell function and proliferation via control of mTOR and glycolysis. Because increased glycolysis is a hallmark of many cancer cells, we hypothesize…

Vaccine-Preventable Infections Among Solid Organ Transplant Recipients in Switzerland Open

Laura N. Walti, Catrina Mugglin, Matteo Mombelli, Oriol Manuel, Hans H. Hirsch , et al. · 2023

Importance Vaccine responses are decreased in solid organ transplant (SOT) recipients, and given the complexity of implementation, vaccination programs may be suboptimal. The actual burden of vaccine-preventable infections (VPIs) among SOT…

Autoimmunity and immunodeficiency associated with monoallelic LIG4 mutations via haploinsufficiency Open

Annaïse Jauch, Olivier Bignucolo, Sayuri Seki, Marie Ghraichy, Ottavia M. Delmonte , et al. · 2023

Clinical prediction model for prognosis in kidney transplant recipients (KIDMO): study protocol Open

Simon Schwab, Daniel Sidler, Fadi Haidar, Christian Kuhn, Stefan Schaub , et al. · 2023

Deletion of SNX9 alleviates CD8 T cell exhaustion for effective cellular cancer immunotherapy Open

Marcel P. Trefny, Nicole Kirchhammer, Priska Auf der Maur, Marina Natoli, Dominic Schmid , et al. · 2023

Tumor-specific T cells are frequently exhausted by chronic antigenic stimulation. We here report on a human antigen-specific ex vivo model to explore new therapeutic options for T cell immunotherapies. T cells generated with this model res…

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