Christoph Hoeschen
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View article: Low-Dose radiation risk in medicine: a look at risk models, challenges, and future prospects
Low-Dose radiation risk in medicine: a look at risk models, challenges, and future prospects Open
The application of ionizing radiation in medical diagnostics and treatments has been transformative in advancing healthcare for the benefit of patients. However, with these advancements comes the need to understand and mitigate the risks o…
View article: Image Fusion of High-Resolution DynaCT and T2-Weighted MRI for Image-Guided Programming of dDBS
Image Fusion of High-Resolution DynaCT and T2-Weighted MRI for Image-Guided Programming of dDBS Open
Objectives: This study aimed to develop a semi-automated registration method for aligning preoperative non-contrast T2-weighted MRI with postoperative high-resolution cone-beam CT (DynaCT) in patients undergoing directional deep brain stim…
View article: The vital role of radiation protection research in Europe’s future: a PIANOFORTE white paper
The vital role of radiation protection research in Europe’s future: a PIANOFORTE white paper Open
Radiation protection is a cornerstone of public health, occupational safety, patient welfare, and environmental stewardship. A strong emphasis on radiation protection is necessary to contribute to the well-being of citizens, to innovation …
View article: Comparing the Achievable Sensitivity Limits of Synchrotron-based X-ray Fluorescence Imaging versus conventional X-ray absorption imaging and comparing absorbed dose levels including PET/SPECT
Comparing the Achievable Sensitivity Limits of Synchrotron-based X-ray Fluorescence Imaging versus conventional X-ray absorption imaging and comparing absorbed dose levels including PET/SPECT Open
The field of X-ray Fluorescence Imaging (XFI) is relatively new, with recent breakthroughs in preclinical applications using synchrotron radiation, whereas X-ray tube-based absorption imaging, such as CT, is a very well-known and widely us…
View article: The PIANOFORTE partnership: Elevating European research for enhanced radiation protection
The PIANOFORTE partnership: Elevating European research for enhanced radiation protection Open
The PIANOFORTE partnership (2022–2029) aims to enhance radiation protection for the public, patients, workers, and the environment across various exposure scenarios. This European initiative addresses key barriers in health and environment…
View article: Implementing verifiable oncological imaging by quality assurance and optimization (i‑Violin)
Implementing verifiable oncological imaging by quality assurance and optimization (i‑Violin) Open
View article: The use of Dose Management Systems in Europe: Results of an ESR EuroSafe Imaging Questionnaire
The use of Dose Management Systems in Europe: Results of an ESR EuroSafe Imaging Questionnaire Open
Dose management systems (DMS) are an essential tool for quality assurance and optimising patient radiation exposure. For radiologists and medical physicists, they are important for managing many radiation protection tasks. In addition, the…
View article: 3D-visualization of segmented contacts of directional deep brain stimulation electrodes via registration and fusion of CT and FDCT
3D-visualization of segmented contacts of directional deep brain stimulation electrodes via registration and fusion of CT and FDCT Open
Objectives 3D-visualization of the segmented contacts of directional deep brain stimulation (DBS) electrodes is desirable since knowledge about the position of every segmented contact could shorten the timespan for electrode programming. C…
View article: Enabling Low-Dose In Vivo Benchtop X-ray Fluorescence Computed Tomography through Deep-Learning-Based Denoising
Enabling Low-Dose In Vivo Benchtop X-ray Fluorescence Computed Tomography through Deep-Learning-Based Denoising Open
X-ray Fluorescence Computed Tomography (XFCT) is an emerging non-invasive imaging technique providing high-resolution molecular-level data. However, increased sensitivity with current benchtop X-ray sources comes at the cost of high radiat…
View article: High-Spatial-Resolution Benchtop X-ray Fluorescence Imaging through Bragg-Diffraction-Based Focusing with Bent Mosaic Graphite Crystals: A Simulation Study
High-Spatial-Resolution Benchtop X-ray Fluorescence Imaging through Bragg-Diffraction-Based Focusing with Bent Mosaic Graphite Crystals: A Simulation Study Open
X-ray fluorescence imaging (XFI) can localize diagnostic or theranostic entities utilizing nanoparticle (NP)-based probes at high resolution in vivo, in vitro, and ex vivo. However, small-animal benchtop XFI systems demonstrating high spat…
View article: Enabling Low-Dose In Vivo Benchtop X-ray Fluorescence Computed Tomography through Deep Learning-Based Denoising
Enabling Low-Dose In Vivo Benchtop X-ray Fluorescence Computed Tomography through Deep Learning-Based Denoising Open
X-ray Fluorescence Computed Tomography (XFCT) is an emerging non-invasive imaging technique providing molecular-level data, gaining attention for high-resolution imaging. However, increased sensitivity with benchtop X-ray sources raises ra…
View article: Utilizing predictive machine-learning modelling unveils feature-based risk assessment system for hyperinflammatory patterns and infectious outcomes in polytrauma
Utilizing predictive machine-learning modelling unveils feature-based risk assessment system for hyperinflammatory patterns and infectious outcomes in polytrauma Open
Purpose Earlier research has identified several potentially predictive features including biomarkers associated with trauma, which can be used to assess the risk for harmful outcomes of polytraumatized patients. These features encompass va…
View article: Estimation of central blood pressure waveform from femoral blood pressure waveform by blind sources separation
Estimation of central blood pressure waveform from femoral blood pressure waveform by blind sources separation Open
Background Central blood pressure ( cBP ) is a better indicator of cardiovascular morbidity and mortality than peripheral BP ( pBP ). However, direct cBP measurement requires invasive techniques and indirect cBP measurement is based on rig…
View article: Modelling DTPA therapy following Am contamination in rats
Modelling DTPA therapy following Am contamination in rats Open
A major challenge in modelling the decorporation of actinides (An), such as americium (Am), with DTPA (diethylenetriaminepentaacetic acid) is the fact that standard biokinetic models become inadequate for assessing radionuclide intake and …
View article: The potential role of 3D-printed phantoms in quality control of artificial intelligence-based algorithms in medical imaging
The potential role of 3D-printed phantoms in quality control of artificial intelligence-based algorithms in medical imaging Open
To ensure accurate and consistent imaging of patients, medical imaging systems are controlled and tested using phantoms. Despite the availability of commercial standard phantoms for decades, 3D printing technology has gained special attent…
View article: Optimization Techniques for Semi-Automated 3D Rigid Registration in Multimodal Image-Guided Deep Brain Stimulation
Optimization Techniques for Semi-Automated 3D Rigid Registration in Multimodal Image-Guided Deep Brain Stimulation Open
Multimodal image registration is vital in Deep Brain Stimulation (DBS) surgery. DBS treats movement disorders by implanting a neurostimulator device in the brain to deliver electrical impulses. Image registration between computed tomograph…
View article: U-Net-based SUV calculation in FDG-PET imaging of mice brain for enhanced analysis
U-Net-based SUV calculation in FDG-PET imaging of mice brain for enhanced analysis Open
Positron emission tomography (PET) is a widely used imaging modality in nuclear medicine for a variety of applications. Amongst the methods used for the quantifying and interpretation of PET images, the standardized uptake value (SUV) is a…
View article: Simulation study of the effect of the geometrical parameters on the performance of a beta probe
Simulation study of the effect of the geometrical parameters on the performance of a beta probe Open
An intraoperative probe is a small tool used to identify, locate, and dissect pathological lesions during surgery and confirm their removal. The most common type of probe is the gamma probe, which detects gamma-emitting sources. Despite th…
View article: Calculation of standardized uptake values (SUVs) and time activity curves (TACs) of mice in FDG-PET
Calculation of standardized uptake values (SUVs) and time activity curves (TACs) of mice in FDG-PET Open
Positron Emission Tomography (PET) with 18Ffluorodeoxyglucose (FDG) is an important imaging practice in cancer diagnosis, staging, treatment planning, and response assessment. Accurate interpretation of PET results requires an understandin…
View article: Möglichkeiten der künstlichen Intelligenz im Strahlenschutz
Möglichkeiten der künstlichen Intelligenz im Strahlenschutz Open
Zusammenfassung Klinisch-methodisches Problem Die Bildgebung von Strukturen im Körperinneren erfordert oft den Einsatz ionisierender Strahlung, die grundsätzlich ein Gesundheitsrisiko darstellt. Eine Reduktion der Strahlendosis kann zu ver…
View article: Dynamic Stability of Volatile Organic Compounds in Respiratory Air in Schizophrenic Patients and Its Potential Predicting Efficacy of TAAR Agonists
Dynamic Stability of Volatile Organic Compounds in Respiratory Air in Schizophrenic Patients and Its Potential Predicting Efficacy of TAAR Agonists Open
Objectives: Volatile organic compounds (VOCs) in the breathing air were found to be altered in schizophrenia patients compared to healthy participants. The aim of this study was to confirm these findings and to examine for the first time w…
View article: Characterization of a polychromatic microfocus X-ray fluorescence imaging setup with metallic contrast agents in a microphysiological tumor model
Characterization of a polychromatic microfocus X-ray fluorescence imaging setup with metallic contrast agents in a microphysiological tumor model Open
Introduction: Accurate diagnosis and personalized treatments involving site-targeted cancer localization, drug delivery, therapeutic strategy, and disease pathways identification, rely on a precise understanding of biomarker kinetics, drug…
View article: Gut–brain axis volatile organic compounds derived from breath distinguish between schizophrenia and major depressive disorder
Gut–brain axis volatile organic compounds derived from breath distinguish between schizophrenia and major depressive disorder Open
Background: Signatures from the metabolome and microbiome have already been introduced as candidates for diagnostic and treatment support. The aim of this study was to investigate the utility of volatile organic compounds (VOCs) from the b…
View article: Education and training in radiation protection in Europe: results from the EURAMED Rocc-n-Roll project survey
Education and training in radiation protection in Europe: results from the EURAMED Rocc-n-Roll project survey Open
Purpose To analyse the existing radiation protection (RP) education and training (E&T) capabilities in the European Union and identify associated needs, problems and challenges. Method An online survey was disseminated via the EURAMED Rocc…
View article: Artifacts’ Detection for MRI Non-Metallic Needles: Comparative Analysis for Artifact Evaluation Using K-Means and Manual Quantification
Artifacts’ Detection for MRI Non-Metallic Needles: Comparative Analysis for Artifact Evaluation Using K-Means and Manual Quantification Open
Interventional biopsy needles need to be accurately localized to the target tissue during magnetic resonance imaging (MRI) interventions. In this context, severe susceptibility artifacts affect the visibility of structures in the MR images…
View article: Lung and Lung Tumor Segmentation of CT Images During MWA Therapy Using AI Algorithm
Lung and Lung Tumor Segmentation of CT Images During MWA Therapy Using AI Algorithm Open
Microwave ablation (MWA) therapy as a thermal ablation procedure is an excellent alternative to open surgery for tumor treatment. The technique is considered advantageous for patients who are not candidates for open surgery due to factors …
View article: Tomographic imaging using poissonian detector data
Tomographic imaging using poissonian detector data Open
An image reconstruction method for reconstructing a tomographic image (f.sub.j) of a region of investigation within an object (1), comprises the steps of providing detector data (y.sub.i) comprising Poisson random values measured at an i-t…
View article: Breathomics profiling of metabolic pathways affected by major depression: Possibilities and limitations
Breathomics profiling of metabolic pathways affected by major depression: Possibilities and limitations Open
Background Major depressive disorder (MDD) is one of the most common psychiatric disorders with multifactorial etiologies. Metabolomics has recently emerged as a particularly potential quantitative tool that provides a multi-parametric sig…
View article: Detruncation of clinical CT scans using a discrete algebraic reconstruction technique prior
Detruncation of clinical CT scans using a discrete algebraic reconstruction technique prior Open
Successful image reconstruction in computed tomography (CT) relies on the completeness of the projections. If the patient does not fit in the field of measurement, the projections are truncated causing cupping artifacts in the image and a …
View article: Education and training in radiation protection in Europe: an analysis from the EURAMED rocc-n-roll project
Education and training in radiation protection in Europe: an analysis from the EURAMED rocc-n-roll project Open
Background A Strengths, weaknesses, opportunities and threats analysis was performed to understand the status quo of education and training in radiation protection (RP) and to develop a coordinated European approach to RP training needs ba…