Christoph Högenauer
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View article: The Fecal Microbiome of IBD Patients Is Less Divertible by Bowel Preparation Compared to Healthy Controls: Results From a Prospective Study
The Fecal Microbiome of IBD Patients Is Less Divertible by Bowel Preparation Compared to Healthy Controls: Results From a Prospective Study Open
Background The fecal microbiome of patients with inflammatory bowel diseases (IBD) is characterized by longitudinal variability. It remains unknown if this is caused by decreased resilience of the microbiome to external factors. We investi…
View article: Enrichment of human IgA-coated bacterial vesicles in ulcerative colitis as a driver of inflammation
Enrichment of human IgA-coated bacterial vesicles in ulcerative colitis as a driver of inflammation Open
The gut microbiome contributes to chronic inflammatory responses in ulcerative colitis (UC), but molecular mechanisms and disease-relevant effectors remain unclear. Here we analyze the pro-inflammatory properties of colonic fluid obtained …
View article: Acquired Low Factor XIII Activity Is Associated with an Increased Need for Blood Transfusions in Patients with Gastrointestinal Bleedings
Acquired Low Factor XIII Activity Is Associated with an Increased Need for Blood Transfusions in Patients with Gastrointestinal Bleedings Open
View article: Targeted isolation of Methanobrevibacter strains from fecal samples expands the cultivated human archaeome
Targeted isolation of Methanobrevibacter strains from fecal samples expands the cultivated human archaeome Open
View article: Filgotinib bei Colitis ulcerosa: ein Review
Filgotinib bei Colitis ulcerosa: ein Review Open
Zusammenfassung Colitis ulcerosa ist eine chronisch entzündliche Darmerkrankung mit Befall des Kolons. Die häufigsten Symptome sind blutige und schleimige Durchfälle, Stuhldrang sowie abdominelle Schmerzen. Diese Symptome stellen für die B…
View article: Rapid biotransformation of STW 5 constituents by human gut microbiome from IBS- and non-IBS donors
Rapid biotransformation of STW 5 constituents by human gut microbiome from IBS- and non-IBS donors Open
STW 5, a blend of nine medicinal plant extracts, exhibits promising efficacy in treating functional gastrointestinal disorders, notably irritable bowel syndrome (IBS). Nonetheless, its effects on the gastrointestinal microbiome and the rol…
View article: Expanding the cultivated human archaeome by targeted isolation of novel Methanobrevibacter strains from fecal samples
Expanding the cultivated human archaeome by targeted isolation of novel Methanobrevibacter strains from fecal samples Open
Archaea are vital components of the human microbiome, yet their study within the gastrointestinal tract (GIT) is limited by the scarcity of cultured representatives. Our study presents a targeted cultivation method enriching methanogenic a…
View article: Expanding the cultivated human archaeome by targeted isolation of novel<i>Methanobrevibacter</i>strains from fecal samples
Expanding the cultivated human archaeome by targeted isolation of novel<i>Methanobrevibacter</i>strains from fecal samples Open
Archaea are integral components of the human microbiome but persist as understudied entities within the gastrointestinal tract (GIT), primarily due to the lack of cultured representatives for comprehensive mechanistic investigations. With …
View article: P809 VARIETY BEACH: Real-world treatment patterns for vedolizumab intravenous and subcutaneous maintenance dosing observed over 1 year in studies from Belgium, Austria and Switzerland
P809 VARIETY BEACH: Real-world treatment patterns for vedolizumab intravenous and subcutaneous maintenance dosing observed over 1 year in studies from Belgium, Austria and Switzerland Open
Background Vedolizumab (VDZ) is approved for moderate to severe ulcerative colitis (UC) and Crohn’s disease (CD) as intravenous (IV) or subcutaneous (SC) formulations. Real-world data on VDZ treatment patterns in patients (pts) with inflam…
View article: Fecal microbiota transplantation from individual with bipolar disorder and healthy control elicits distinct behaviors and metabolite profiles in mice
Fecal microbiota transplantation from individual with bipolar disorder and healthy control elicits distinct behaviors and metabolite profiles in mice Open
Bipolar disorder (BD) is a chronic mood disorder characterized by recurrent episodes of depression and (hypo-) mania. The gut microbiome is a potential avenue through which metabolic signaling, inflammatory pathways, environmental factors,…
View article: Factors Associated with Response to Systemic Corticosteroids in Active Ulcerative Colitis: Results from a Prospective, Multicenter Trial
Factors Associated with Response to Systemic Corticosteroids in Active Ulcerative Colitis: Results from a Prospective, Multicenter Trial Open
Background: Among patients with ulcerative colitis, 30–50% receive corticosteroids within the first five years after diagnosis. We aimed to reconsider their effectiveness in the context of the biologic era. Methods: In this prospective, mu…
View article: Prediction of Response to Systemic Corticosteroids in Active UC by Microbial Composition—A Prospective Multicenter Study
Prediction of Response to Systemic Corticosteroids in Active UC by Microbial Composition—A Prospective Multicenter Study Open
Background Corticosteroids are used for induction of remission in patients with moderately to severely active ulcerative colitis. However, up to one-third of patients fail to this therapy. We investigated if fecal microbial composition or …
View article: Complete Genome Sequence of Klebsiella oxytoca Strain AHC-6, Isolated from a Patient during Acute Antibiotic-Associated Hemorrhagic Colitis
Complete Genome Sequence of Klebsiella oxytoca Strain AHC-6, Isolated from a Patient during Acute Antibiotic-Associated Hemorrhagic Colitis Open
Klebsiella oxytoca is a ubiquitous bacterium that is increasingly associated with inflammatory diseases. Here, we report the hybrid assembled genome for cytotoxic K. oxytoca strain AHC-6. The genome comprises a total of 5.7 Mbp, with a GC …
View article: Corrigendum: Variation in accessory genes within the Klebsiella oxytoca species complex delineates monophyletic members and simplifies coherent genotyping
Corrigendum: Variation in accessory genes within the Klebsiella oxytoca species complex delineates monophyletic members and simplifies coherent genotyping Open
[This corrects the article DOI: 10.3389/fmicb.2021.692453.].
View article: Tofacitinib in the treatment of ulcerative colitis
Tofacitinib in the treatment of ulcerative colitis Open
Summary Ulcerative colitis (UC) is one of the main forms of inflammatory bowel disease (IBD). Despite the widening range of drug treatment options, primary nonresponse, secondary loss of response as well as adverse events call for addition…
View article: Cardiogenic shock due to yew poisoning rescued by VA-ECMO: case report and literature review
Cardiogenic shock due to yew poisoning rescued by VA-ECMO: case report and literature review Open
Ingestion of leaves of the European yew tree (Taxus baccata) can result in fatal cardiac arrhythmias and acute cardiogenic shock. This cardiotoxicity derives from taxine alkaloids that block cardiac voltage-gated sodium and calcium …
View article: Identification of clinical and ecological determinants of strain engraftment after fecal microbiota transplantation using metagenomics
Identification of clinical and ecological determinants of strain engraftment after fecal microbiota transplantation using metagenomics Open
Fecal microbiota transplantation (FMT) is a promising therapeutic approach for microbiota-associated pathologies, but our understanding of the post-FMT microbiome assembly process and its ecological and clinical determinants is incomplete.…
View article: P181 IBD patients with early clinical and sonographic improvements achieve better long-term outcomes than patients with clinical improvements alone – one-year interim results of the TRUST BEYOND study
P181 IBD patients with early clinical and sonographic improvements achieve better long-term outcomes than patients with clinical improvements alone – one-year interim results of the TRUST BEYOND study Open
Background In the treat-to-target era, frequent and objective monitoring of disease activity in IBD patients is emphasized [1]. Over the past years, intestinal ultrasound (IUS) has become a useful modality to monitor and assess disease act…
View article: Improved diagnosis of antibiotic-associated haemorrhagic colitis (AAHC) in faecal specimens by a new qualitative real-time PCR assay detecting relevant toxin genes of Klebsiella oxytoca sensu lato
Improved diagnosis of antibiotic-associated haemorrhagic colitis (AAHC) in faecal specimens by a new qualitative real-time PCR assay detecting relevant toxin genes of Klebsiella oxytoca sensu lato Open
Compared with culture, additional clinical specimens positive for K. oxytoca s.l. were detected with real-time PCR. The specificity of the toxin targets appears moderate due to the inferior sensitivity of the culture-based reference method…
View article: Reduced B12 uptake and increased gastrointestinal formate are associated with archaeome-mediated breath methane emission in humans
Reduced B12 uptake and increased gastrointestinal formate are associated with archaeome-mediated breath methane emission in humans Open
Background Methane is an end product of microbial fermentation in the human gastrointestinal tract. This gas is solely produced by an archaeal subpopulation of the human microbiome. Increased methane production has been associated with abd…
View article: Intraspecies strain exclusion, antibiotic pretreatment, and donor selection control microbiota engraftment after fecal transplantation
Intraspecies strain exclusion, antibiotic pretreatment, and donor selection control microbiota engraftment after fecal transplantation Open
Fecal microbiota transplantation (FMT) is both a promising therapeutic approach to treat microbiota-associated pathologies and an experimental tool to establish a causal role of microbiome dysbiosis in human pathologies. Although clearly e…
View article: Variation in Accessory Genes Within the Klebsiella oxytoca Species Complex Delineates Monophyletic Members and Simplifies Coherent Genotyping
Variation in Accessory Genes Within the Klebsiella oxytoca Species Complex Delineates Monophyletic Members and Simplifies Coherent Genotyping Open
Members of the Klebsiella oxytoca species complex (KoSC) are emerging human pathogens causing infections of increasing significance especially in healthcare settings. KoSC strains are affiliated with distinct phylogroups based on genetic v…
View article: Limited long‐term treatment persistence of first anti‐TNF therapy in 538 patients with inflammatory bowel diseases: a 20‐year real‐world study
Limited long‐term treatment persistence of first anti‐TNF therapy in 538 patients with inflammatory bowel diseases: a 20‐year real‐world study Open
Summary Background Anti‐TNF antibodies were the first biologic treatment option for patients with inflammatory bowel diseases. Aims To assess length of treatment persistence of first anti‐TNF therapy and influencing factors used in the sta…
View article: EndoBarrier™ Implantation Rapidly Improves Insulin Sensitivity in Obese Individuals with Type 2 Diabetes Mellitus
EndoBarrier™ Implantation Rapidly Improves Insulin Sensitivity in Obese Individuals with Type 2 Diabetes Mellitus Open
The EndoBarrier™ medical device is a duodenal-jejunal bypass liner designed to mimic the effects of gastric bypass surgery to induce weight loss and glycaemic improvement. In this study, 10 participants with type 2 diabetes mellitus (T2DM)…
View article: High Prevalence of Ultrasound Verified Enthesitis in Patients With Inflammatory Bowel Disease With or Without Spondylarthritis
High Prevalence of Ultrasound Verified Enthesitis in Patients With Inflammatory Bowel Disease With or Without Spondylarthritis Open
Background: Inflammatory bowel disease (IBD) is closely associated with spondylarthritis (SpA) and enthesitis, as an important feature of SpA, is a common extraintestinal manifestation of IBD. Enthesitis may be clinically silent in a high …
View article: Additional file 8 of Reduced B12 uptake and increased gastrointestinal formate are associated with archaeome-mediated breath methane emission in humans
Additional file 8 of Reduced B12 uptake and increased gastrointestinal formate are associated with archaeome-mediated breath methane emission in humans Open
Additional file 7: Supplementary Item 3. Krona chart based on metagenomic data (SEED, n=30).
View article: Additional file 6 of Reduced B12 uptake and increased gastrointestinal formate are associated with archaeome-mediated breath methane emission in humans
Additional file 6 of Reduced B12 uptake and increased gastrointestinal formate are associated with archaeome-mediated breath methane emission in humans Open
Additional file 5: Supplementary Item 1. Krona chart based on amplicon data (universal, n=100).
View article: Additional file 7 of Reduced B12 uptake and increased gastrointestinal formate are associated with archaeome-mediated breath methane emission in humans
Additional file 7 of Reduced B12 uptake and increased gastrointestinal formate are associated with archaeome-mediated breath methane emission in humans Open
Additional file 6: Supplementary Item 2. Krona chart based on amplicon data (archaea, n=100).
View article: Additional file 9 of Reduced B12 uptake and increased gastrointestinal formate are associated with archaeome-mediated breath methane emission in humans
Additional file 9 of Reduced B12 uptake and increased gastrointestinal formate are associated with archaeome-mediated breath methane emission in humans Open
Additional file 8: Supplementary Item 4. Krona chart based on metagenomic data (RefSeq, archaea and bacteria only, n=30).
View article: Additional file 3 of Reduced B12 uptake and increased gastrointestinal formate are associated with archaeome-mediated breath methane emission in humans
Additional file 3 of Reduced B12 uptake and increased gastrointestinal formate are associated with archaeome-mediated breath methane emission in humans Open
Additional file 2: Supplementary Tables. Supplementary Table 1. Characteristics of all participants (n=100). Supplementary Table 2. Characteristics of the matched subset (n=30). Supplementary Table 3. Key stone taxa of high and low methane…