Christoph Kellendonk
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View article: Altered striatal dopamine regulation in <i>ADGRL3</i> knockout mice
Altered striatal dopamine regulation in <i>ADGRL3</i> knockout mice Open
Dopaminergic signaling is essential for regulating movement, learning, and reward. Disruptions in this system are linked to neuropsychiatric disorders such as ADHD. ADGRL3, an adhesion G protein-coupled receptor highly expressed in the bra…
View article: Translational Evidence for Dopaminergic Rewiring of the Basal Ganglia in Persons with Schizophrenia
Translational Evidence for Dopaminergic Rewiring of the Basal Ganglia in Persons with Schizophrenia Open
Background In prior work, a transgenic mouse model of striatal dopamine dysfunction observed in persons with schizophrenia (PSZ) exhibited dopamine-related neuroplasticity in the basal ganglia, a phenotype that has never been demonstrated …
View article: A corticostriatal learning mechanism linking excess striatal dopamine and auditory hallucinations
A corticostriatal learning mechanism linking excess striatal dopamine and auditory hallucinations Open
1 Abstract Auditory hallucinations are linked to elevated striatal dopamine, but their underlying computational mechanisms have been obscured by regional heterogeneity in striatal dopamine signaling. To address this, we developed a normati…
View article: Prefrontal representations of retrospective spatial working memory in a rodent radial maze task
Prefrontal representations of retrospective spatial working memory in a rodent radial maze task Open
Working memory is the cognitive capacity for temporarily holding information in mind for processing or use. It has been theorized to depend upon executive and mnemonic subcomponents, although the contextual mapping of these subcomponents i…
View article: Adolescent Thalamoprefrontal Inhibition Leads to Changes in Intrinsic Prefrontal Network Connectivity
Adolescent Thalamoprefrontal Inhibition Leads to Changes in Intrinsic Prefrontal Network Connectivity Open
Adolescent inhibition of thalamocortical projections from postnatal days P20 to 50 leads to long-lasting deficits in prefrontal cortex function and cognition in the adult mouse. While this suggests a role of thalamic activity in prefrontal…
View article: Inhibition of striatal indirect pathway during second postnatal week leads to long lasting deficits in motivated behavior
Inhibition of striatal indirect pathway during second postnatal week leads to long lasting deficits in motivated behavior Open
Schizophrenia is a neuropsychiatric disorder with postulated neurodevelopmental etiology. Genetic and imaging studies have shown enhanced dopamine and D2 receptor occupancy in the striatum of patients with schizophrenia. However, whether a…
View article: mPFC spike data Bolkan et al. 2027 Nat Neuro
mPFC spike data Bolkan et al. 2027 Nat Neuro Open
mPFC single unit data fro Bolkan et al. 2017 Nature Neuroscience. Explanation document to follow.
View article: Adolescent Thalamocortical Inhibition Alters Prefrontal Excitation-Inhibition Balance
Adolescent Thalamocortical Inhibition Alters Prefrontal Excitation-Inhibition Balance Open
Adolescent inhibition of thalamo-cortical projections from postnatal day P20-50 leads to long lasting deficits in prefrontal cortex function and cognition in the adult mouse. While this suggests a role of thalamic activity in prefrontal co…
View article: Dopaminergic D2 receptor modulation of striatal cholinergic interneurons contributes to sequence learning
Dopaminergic D2 receptor modulation of striatal cholinergic interneurons contributes to sequence learning Open
Learning action sequences is necessary for normal daily activities. Medium spiny neurons (MSNs) in the dorsal striatum (dStr) encode action sequences through changes in firing at the start and/or stop of action sequences or sustained chang…
View article: Data for paper Labouesse et al., 2023 (Bridging collaterals)
Data for paper Labouesse et al., 2023 (Bridging collaterals) Open
raw data for Labouesse et al Bridging collaterals paper
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View article: Mature parvalbumin interneuron function in prefrontal cortex requires activity during a postnatal sensitive period
Mature parvalbumin interneuron function in prefrontal cortex requires activity during a postnatal sensitive period Open
In their seminal findings, Hubel and Wiesel identified sensitive periods in which experience can exert lasting effects on adult visual cortical functioning and behavior via transient changes in neuronal activity during development. Whether…
View article: Dopamine D2 receptors bidirectionally regulate striatal enkephalin expression: Implications for cocaine reward
Dopamine D2 receptors bidirectionally regulate striatal enkephalin expression: Implications for cocaine reward Open
Low dopamine D2 receptor (D2R) availability in the striatum can predispose for cocaine abuse; though how low striatal D2Rs facilitate cocaine reward is unclear. Overexpression of D2Rs in striatal neurons or activation of D2Rs by acute coca…
View article: Dopamine D2Rs coordinate cue-evoked changes in striatal acetylcholine levels
Dopamine D2Rs coordinate cue-evoked changes in striatal acetylcholine levels Open
In the striatum, acetylcholine (ACh) neuron activity is modulated co-incident with dopamine (DA) release in response to unpredicted rewards and reward-predicting cues and both neuromodulators are thought to regulate each other. While this …
View article: Author response: Dopamine D2Rs coordinate cue-evoked changes in striatal acetylcholine levels
Author response: Dopamine D2Rs coordinate cue-evoked changes in striatal acetylcholine levels Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract In the striatum, acety…
View article: DeepLabCut network trained to track mouse 'back' body parts during rotarod running (back-view)
DeepLabCut network trained to track mouse 'back' body parts during rotarod running (back-view) Open
DeepLabCut (https://github.com/DeepLabCut/) (Mathis et al., 2018; Nath et al., 2019) was used for tracking body parts of mice in an open field arena or in the rotarod. DeepLabCut 2.1.8.2 (local version on Windows with CPU, using the GUI) a…
View article: DeepLabCut network trained to track mouse body parts during open field locomotion (top-down view)
DeepLabCut network trained to track mouse body parts during open field locomotion (top-down view) Open
DeepLabCut (https://github.com/DeepLabCut/) (Mathis et al., 2018; Nath et al., 2019) was used for tracking body parts of mice in an open field arena or in the rotarod. DeepLabCut 2.1.8.2 (local version on Windows with CPU, using the GUI) a…
View article: DeepLabCut network trained to track mouse 'front' body parts during rotarod running (front-view)
DeepLabCut network trained to track mouse 'front' body parts during rotarod running (front-view) Open
DeepLabCut (https://github.com/DeepLabCut/) (Mathis et al., 2018; Nath et al., 2019) was used for tracking body parts of mice in an open field arena or in the rotarod. DeepLabCut 2.1.8.2 (local version on Windows with CPU, using the GUI) a…
View article: DeepLabCut network trained to track mouse body parts during open field locomotion (top-down view)
DeepLabCut network trained to track mouse body parts during open field locomotion (top-down view) Open
DeepLabCut (https://github.com/DeepLabCut/) (Mathis et al., 2018; Nath et al., 2019) was used for tracking body parts of mice in an open field arena or in the rotarod. DeepLabCut 2.1.8.2 (local version on Windows with CPU, using the GUI) a…
View article: DeepLabCut network trained to track mouse 'back' body parts during rotarod running (back-view)
DeepLabCut network trained to track mouse 'back' body parts during rotarod running (back-view) Open
DeepLabCut (https://github.com/DeepLabCut/) (Mathis et al., 2018; Nath et al., 2019) was used for tracking body parts of mice in an open field arena or in the rotarod. DeepLabCut 2.1.8.2 (local version on Windows with CPU, using the GUI) a…
View article: DeepLabCut network trained to track mouse 'front' body parts during rotarod running (front-view)
DeepLabCut network trained to track mouse 'front' body parts during rotarod running (front-view) Open
DeepLabCut (https://github.com/DeepLabCut/) (Mathis et al., 2018; Nath et al., 2019) was used for tracking body parts of mice in an open field arena or in the rotarod. DeepLabCut 2.1.8.2 (local version on Windows with CPU, using the GUI) a…
View article: rawFR_prism.mat
rawFR_prism.mat Open
In vivo physiology raw firing rates for all cells for all groups in the ASST task of Benoit et al. "Adolescent thalamic inhibition leads to long-lasting impairments in prefrontal cortex function" (NN-A76458A).
View article: hM4D Light OFF
hM4D Light OFF Open
In vivo physiological source data from hM4D Light OFF group for Benoit et al. "Adolescent thalamic inhibition leads to long-lasting impairments in prefrontal cortex function" (NN-A76458A).
View article: Behavioral data
Behavioral data Open
Behavioral data for Benoit et al. "Adolescent thalamic inhibition leads to long-lasting impairments in prefrontal cortex function" (NN-A76458A).Rescue behavior shows ASST data with and without adolescent thalamic inhibition, and with and w…