Explanipedia

Quantitative evaluation of 123I-MIBG imaging in patients with myocarditis: impairment of cardiac neuronal function revisited Open

Lukas Kessler, Stephan Settelmeier, Kim M. Pabst, Tuğçe Telli, Zohreh Varasteh , et al. · 2025

Background 123 I-MIBG has been shown to visualize impaired cardiac neuronal function, but data of this imaging modality in patients with acute myocarditis are scarce. Nonetheless, an association with reduced cardiac function has been obser…

New Promising Targets for Imaging in Cardiovascular Diseases Open

Mia Ståhle, Cristina Popescu, Christoph Rischpler, Han Zhang, Samia Massalha , et al. · 2025

Medicine

Cardiovascular diseases (CVDs) remain the leading cause of morbidity and mortality worldwide, driven by complex and dynamic molecular processes such as inflammation, fibrosis, metabolic dysregulation, thrombosis, and vascular remodeling. W…

Staging of prostate Cancer with ultra-fast PSMA-PET scans enhanced by AI Open

David Kersting, Katarzyna Borys, Alina Küper, Moon Kim, Johannes Haubold , et al. · 2025

Medicine Computer science

Purpose PSMA-PET is a reference standard examination for patients with prostate cancer, but even using recently introduced digital PET detectors image acquisition with standard field-of-view scanners is still in the range of 20 min. This m…

Screening for Occult Transthyretin Amyloidosis in Patients with Severe Aortic Stenosis and Amyloid Red Flags Open

Aistė Monika Jakštaitė, Julia Vogel, Peter Luedike, Rolf Alexander Jánosi, Alexander Carpinteiro , et al. · 2024

Medicine

Aims: The optimal strategy to identify transthyretin-type cardiac amyloidosis (ATTR-CA) in patients with aortic stenosis (AS) is still unclear. This study aimed to investigate if targeted screening for ATTR-CA in patients with severe AS an…

Delayed 68Ga-FAPI-46 PET/MR imaging confirms ongoing fibroblast activation in patients after acute myocardial infarction Open

Jana Kupusović, Lukas Kessler, Sandra Kazek, Michal Chodyla, Lale Umutlu , et al. · 2024

Medicine Chemistry

68Ga-FAPI-46 PET/MRI offers molecular and morphological imaging of affected myocardium after AMI. This study demonstrates ongoing fibroblast activation in a delayed phase after AMI and generates hypotheses for future studies while aiming f…

Reply: Recent Evidence on Cardiac99mTc-DPD Uptake After Therapy with Tafamidis May Reveal the Road to an Ultra-Early Diagnosis in Patients with ATTR Amyloidosis Open

Christoph Rischpler, David Kersting, Lukas Kessler, Zohreh Varasteh, Peter Luedike , et al. · 2024

Medicine

REPLY: We read with great interest the letter from Dr. Caobelli, which referred to our recent article in The Journal of Nuclear Medicine on using bone scintigraphy to monitor patients with amyloid transthyretin–related (ATTR) cardiac amylo…

Molecular Imaging Biomarkers in Cardiooncology: A View on Established Technologies and Future Perspectives Open

David Kersting, Ilektra-Antonia Mavroeidi, Stephan Settelmeier, Robert Seifert, Martin Schüler , et al. · 2023

Medicine Biology

Novel therapeutic options have significantly improved survival and long-term outcomes in many cancer entities. Unfortunately, this improvement in outcome is often accompanied by new and increasingly relevant therapy-related cardiovascular …

Regression of Myocardial99mTc-DPD Uptake After Tafamidis Treatment of Cardiac Transthyretin Amyloidosis Open

Μαρία Παπαθανασίου, Lukas Kessler, Frank M. Bengel, Aiste‐Monika Jakstaite, David Kersting , et al. · 2023

Medicine

Cardiac transthyretin amyloidosis is an infiltrative cardiomyopathy with high mortality. To date, there are no specific biomarkers to directly assess disease activity and response to specific treatments. Our aim was to evaluate scintigraph…

Myocardial Perfusion SPECT and ATTR imaging 2021 in Germany: Results of the 9th Survey Open

Oliver Lindner, Wolfgang M. Schaefer, Sigmund Silber, Christoph Rischpler, Wolfgang Burchert · 2023

Medicine

Aim This paper presents the results of the 9th survey of myocardial perfusion SPECT (MPS) from the reporting year 2021. Methods 218 questionnaires (131 practices (PR), 58 hospitals (HO), 29 university hospitals (UH)) were evaluated. Result…

Demonstration of the Early Cardiac Bioavailability of a Non-Specific Cell-Targeted Peptide Using Radionuclide-Based Imaging In Vivo Open

Stephan Settelmeier, Zohreh Varasteh, Magdalena Staniszewska, Anna-Lena Beerlage, Fadi Zarrad , et al. · 2023

Chemistry Medicine Biology

The cardiac bioavailability of peptide drugs that inhibit harmful intracellular protein–protein interactions in cardiovascular diseases remains a challenging task in drug development. This study investigates whether a non-specific cell-tar…

68Ga-FAPI PET/CT Interobserver Agreement on Tumor Assessment: An International Multicenter Prospective Study Open

Riccardo Mei, Lukas Kessler, Kim M. Pabst, Manuel Weber, Christian Schmidkonz , et al. · 2023

Medicine

68Ga-fibroblast activation protein inhibitors (FAPIs) are promising radiotracers for cancer imaging, with emerging data in the recent years. Nonetheless, the interobserver agreement on 68Ga-FAPI PET/CT study interpretations in cancer patie…

Diagnostic significance of MRI versus CT using identical PET data in patients with recurrent differentiated thyroid cancer: A PET/MRI study Open

Korbinian Westphal, Matthias Eiber, Martin Henninger, Klemens Scheidhauer, Ambros J. Beer , et al. · 2023

Medicine

In this retrospective study we compared magnet resonance imaging (MRI) and computed tomography (CT) each combined with identical 2-deoxy-2-[18F] fluoro-D-glucose or 2-[18F] F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) d…

Supplementary Data from Enhancing Radioiodine Incorporation into Radioiodine-Refractory Thyroid Cancer with MAPK Inhibition (ERRITI): A Single-Center Prospective Two-Arm Study Open