Christoph Selg
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View article: Radioiodinated Carborane-based Indomethacin-Derivatives as Cyclooxygenase-2 Radiotracers
Radioiodinated Carborane-based Indomethacin-Derivatives as Cyclooxygenase-2 Radiotracers Open
View article: Cover Feature: Advances in Diclofenac Derivatives: Exploring Carborane‐Substituted <i>N</i>‐Methyl and Nitrile Analogs for Anticancer Therapy (ChemMedChem 11/2025)
Cover Feature: Advances in Diclofenac Derivatives: Exploring Carborane‐Substituted <i>N</i>‐Methyl and Nitrile Analogs for Anticancer Therapy (ChemMedChem 11/2025) Open
View article: Front Cover: Carborane‐Based Analogs of Celecoxib and Flurbiprofen, their COX Inhibition Potential, and COX Selectivity Index (ChemMedChem 11/2025)
Front Cover: Carborane‐Based Analogs of Celecoxib and Flurbiprofen, their COX Inhibition Potential, and COX Selectivity Index (ChemMedChem 11/2025) Open
View article: Carborane‐Based Analogs of Celecoxib and Flurbiprofen, their COX Inhibition Potential, and COX Selectivity Index
Carborane‐Based Analogs of Celecoxib and Flurbiprofen, their COX Inhibition Potential, and COX Selectivity Index Open
The cylcooxygenase isoforms COX‐1 and COX‐2 are involved in the production of prostaglandins in physiological and pathological processes. The overexpression of COX‐2 under inflammatory conditions, its role in cancer and neurodegenerative d…
View article: Advances in Diclofenac Derivatives: Exploring Carborane‐Substituted <i>N</i>‐Methyl and Nitrile Analogs for Anticancer Therapy
Advances in Diclofenac Derivatives: Exploring Carborane‐Substituted <i>N</i>‐Methyl and Nitrile Analogs for Anticancer Therapy Open
This study explores the anticancer potential of N ‐methylated open‐ring derivatives of carborane‐substituted diclofenac analogs. By N ‐methylation, the open‐chain form could be trapped and cyclization back to lactam or amidine derivatives …
View article: Re-design and evaluation of diclofenac-based carborane-substituted prodrugs and their anti-cancer potential
Re-design and evaluation of diclofenac-based carborane-substituted prodrugs and their anti-cancer potential Open
In this study, we investigated a novel anti-cancer drug design approach by revisiting diclofenac-based carborane-substituted prodrugs. The redesigned compounds combine the robust carborane scaffold with the oxindole framework, resulting in…
View article: Fusing Bismuth and Mercaptocarboranes: Design and Biological Evaluation of Low‐Toxicity Antimicrobial Thiolato Complexes
Fusing Bismuth and Mercaptocarboranes: Design and Biological Evaluation of Low‐Toxicity Antimicrobial Thiolato Complexes Open
This study proposes an innovative strategy to enhance the pharmacophore model of antimicrobial bismuth thiolato complex drugs by substituting hydrocarbon ligand structures with boron clusters, particularly icosahedral closo ‐dicarbadodecab…
View article: Borinostats: solid-phase synthesis of carborane-capped histone deacetylase inhibitors with a tailor-made selectivity profile
Borinostats: solid-phase synthesis of carborane-capped histone deacetylase inhibitors with a tailor-made selectivity profile Open
This work describes a versatile solid phase synthesis of carborane-capped histone deacetylase inhibitors with a tunable selectivity profile and synergistic anticancer activity with bortezomib.
View article: CCDC 919395: Experimental Crystal Structure Determination
CCDC 919395: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 919396: Experimental Crystal Structure Determination
CCDC 919396: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 919433: Experimental Crystal Structure Determination
CCDC 919433: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 919397: Experimental Crystal Structure Determination
CCDC 919397: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Carboranes as Aryl Mimetics in Catalysis: A Highly Active Zwitterionic NHC‐Precatalyst
Carboranes as Aryl Mimetics in Catalysis: A Highly Active Zwitterionic NHC‐Precatalyst Open
Invited for the cover of this issue are the groups of Kirsten Zeitler and Evamarie Hey‐Hawkins at the University of Leipzig. The image depicts the carborane catalyst being a result of a long hatching process that eventually provides the st…
View article: Carboranes as Aryl Mimetics in Catalysis: A Highly Active Zwitterionic NHC‐Precatalyst
Carboranes as Aryl Mimetics in Catalysis: A Highly Active Zwitterionic NHC‐Precatalyst Open
Modern catalysis takes advantage of aryl‐based interactions to tune and control reactions. In the design of N ‐heterocyclic‐carbene catalysts, both the electronic and steric nature of the nitrogen substituents play a crucial role. Although…
View article: CCDC 1477643: Experimental Crystal Structure Determination
CCDC 1477643: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …