Christoph Steiger
YOU?
Author Swipe
View article: Toward understanding lipid reorganization in RNA lipid nanoparticles in acidic environments
Toward understanding lipid reorganization in RNA lipid nanoparticles in acidic environments Open
The use of lipid nanoparticles (LNPs) for therapeutic RNA delivery has gained significant interest, particularly highlighted by recent milestones such as the approval of Onpattro and two mRNA-based SARS-CoV-2 vaccines. However, despite sub…
View article: A machine learning liver-on-a-chip system for safer drug formulation
A machine learning liver-on-a-chip system for safer drug formulation Open
Drug metabolism leads to biotransformations of pharmaceutical substances that alter drug efficacy, toxicity, as well as drug interactions. Modeling these processes ex vivo stands to greatly accelerate our capacity to develop safe and effic…
View article: Delivery of therapeutic carbon monoxide by gas-entrapping materials
Delivery of therapeutic carbon monoxide by gas-entrapping materials Open
Carbon monoxide (CO) has long been considered a toxic gas but is now a recognized bioactive gasotransmitter with potent immunomodulatory effects. Although inhaled CO is currently under investigation for use in patients with lung disease, t…
View article: Ingestible capsule for detecting labile inflammatory biomarkers in situ
Ingestible capsule for detecting labile inflammatory biomarkers in situ Open
Transient molecules in the gastrointestinal (GI) tract, such as nitric oxide and hydrogen sulfide, are key signals and mediators of inflammatory bowel disease (IBD). Because these molecules are extremely short-lived in the body, they are d…
View article: Dynamic Monitoring of Systemic Biomarkers with Gastric Sensors
Dynamic Monitoring of Systemic Biomarkers with Gastric Sensors Open
Continuous monitoring in the intensive care setting has transformed the capacity to rapidly respond with interventions for patients in extremis. Noninvasive monitoring has generally been limited to transdermal or intravascular systems coup…
View article: Controlled Delivery of Bile Acids to the Colon
Controlled Delivery of Bile Acids to the Colon Open
INTRODUCTION: Bile acids, such as chenodeoxycholic acid, play an important role in digestion but are also involved in intestinal motility, fluid homeostasis, and humoral activity. Colonic delivery of sodium chenodeoxycholate (CDC) has demo…
View article: Development of a long-acting direct-acting antiviral system for hepatitis C virus treatment in swine
Development of a long-acting direct-acting antiviral system for hepatitis C virus treatment in swine Open
Significance Direct-acting antiviral (DAA) therapy is highly effective against hepatitis C virus (HCV). Despite this, the burden of chronic HCV remains high, particularly in populations for whom daily medications can be challenging. The ge…
View article: Wavelength‐Dependent Control of the CO Release Kinetics of Manganese(I) Tricarbonyl PhotoCORMs with Benzimidazole Coligands
Wavelength‐Dependent Control of the CO Release Kinetics of Manganese(I) Tricarbonyl PhotoCORMs with Benzimidazole Coligands Open
A series of photoactivatable CO‐releasing molecules (PhotoCORMs) was prepared from manganese pentacarbonyl bromide and 1 H ‐benzimidazol‐2‐ylmethyl‐( N ‐phenyl)amine ligands (L) bearing different electron‐donating and electron‐withdrawing …
View article: Extracorporeal resuscitation with carbon monoxide improves renal function by targeting inflammatory pathways in cardiac arrest in pigs
Extracorporeal resuscitation with carbon monoxide improves renal function by targeting inflammatory pathways in cardiac arrest in pigs Open
Deleterious consequences like acute kidney injury frequently occur upon successful resuscitation from cardiac arrest. Extracorporeal life support is increasingly used to overcome high cardiac arrest mortality. Carbon monoxide (CO) is an en…
View article: “Inactive” ingredients in oral medications
“Inactive” ingredients in oral medications Open
Inactive ingredients in oral medications are generally poorly appreciated, and many include materials associated with adverse reactions in patients.
View article: A gastric resident drug delivery system for prolonged gram-level dosing of tuberculosis treatment
A gastric resident drug delivery system for prolonged gram-level dosing of tuberculosis treatment Open
A retrievable device, compatible with nasogastric tube administration, releases grams of drug over weeks while residing in the stomach.
View article: Ingestible hydrogel device
Ingestible hydrogel device Open
Devices that interact with living organisms are typically made of metals, silicon, ceramics, and plastics. Implantation of such devices for long-term monitoring or treatment generally requires invasive procedures. Hydrogels offer new oppor…
View article: Phosphodiesterase-4 inhibition reduces ECLS-induced vascular permeability and improves microcirculation in a rodent model of extracorporeal resuscitation
Phosphodiesterase-4 inhibition reduces ECLS-induced vascular permeability and improves microcirculation in a rodent model of extracorporeal resuscitation Open
Extracorporeal circulation can be accompanied by increased vascular permeability leading to pathological fluid balance and organ dysfunction. The second messenger cAMP is involved in capillary permeability and maintains endothelial integri…
View article: AOCS operations preparation for the BepiColombo mission to mercury
AOCS operations preparation for the BepiColombo mission to mercury Open
The 2018 ESA/JAXA BepiColombo mission to Mercury features a complex modular design, with two scientific Mercury orbiters and a cruise module. The spacecraft (S/C) and mission design lead to a number of challenges for the attitude and orbit…
View article: Drug delivery of therapeutic gases – strategies for controlled and local delivery of carbon monoxide
Drug delivery of therapeutic gases – strategies for controlled and local delivery of carbon monoxide Open
The isoenzyme heme oxygenase 1 (HO-1) is a key element for maintaining cellular homeostasis. Upregulated in response to cellular stress, the HO-1 degrades heme into carbon monoxide (CO), biliverdin, and Fe2+. By means of a local cell-prote…
View article: Flight Operations Preparation for the BepiColombo Mission to Mercury: Concepts and Challenges
Flight Operations Preparation for the BepiColombo Mission to Mercury: Concepts and Challenges Open
The ESA/JAXA BepiColombo mission to Mercury features a complex modular design, with two scientific Mercury orbiters and a cruise module.The spacecraft and mission design lead to a number of challenges for flight operations, including elect…