Thomas C. Mettenleiter
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View article: Strict Biosecurity and Epidemiological Segmentation Enable Partial Culling During a Highly Pathogenic Avian Influenza Outbreak
Strict Biosecurity and Epidemiological Segmentation Enable Partial Culling During a Highly Pathogenic Avian Influenza Outbreak Open
This case demonstrates the effectiveness of proper management and high-level biosecurity to avoid excessive destruction of animals in case of an infectious disease outbreak. It might be suitable as a best-practice example in similar situat…
View article: Neurotropism of alphaherpesviruses is most prominent in the mesiotemporal, piriform and prefrontal cortices in mice
Neurotropism of alphaherpesviruses is most prominent in the mesiotemporal, piriform and prefrontal cortices in mice Open
Alphaherpesviruses, such as Herpes Simplex Virus 1 (HSV-1) and Pseudorabies Virus (PrV), exhibit pronounced neurotropism. HSV-1 can cause Herpes simplex encephalitis (HSE), primarily affecting the mesiotemporal lobe. CD1 mice inoculated wi…
View article: Mpox: A case study for a one health approach to infectious disease prevention
Mpox: A case study for a one health approach to infectious disease prevention Open
Mpox has been declared a global health emergency twice by the World Health Organization due to its impacts within and beyond Africa. Enzootic in Central and West African wildlife, mpox outbreaks have resulted from zoonotic spillover, with …
View article: Different genetic determinants for high virulence, transmission and replication of high pathogenicity H7N7 avian influenza virus in turkeys and chickens
Different genetic determinants for high virulence, transmission and replication of high pathogenicity H7N7 avian influenza virus in turkeys and chickens Open
High pathogenicity (HP) avian influenza viruses (AIV) generally evolve from low pathogenicity (LP) precursors after transmission from wild birds to chickens ( Gallus gallus domesticus ) and turkeys ( Meleagris gallopavo ), causing severe e…
View article: Pseudorabies virus infection triggers pUL46-mediated phosphorylation of connexin-43 and closure of gap junctions to promote intercellular virus spread
Pseudorabies virus infection triggers pUL46-mediated phosphorylation of connexin-43 and closure of gap junctions to promote intercellular virus spread Open
Gap junctions (GJs) play a pivotal role in intercellular communication between eukaryotic cells, including transfer of biomolecules that contribute to the innate and adaptive immune response. However, if, how and why viruses affect gap jun…
View article: An integrated inventory of One Health tools: Mapping and analysis of globally available tools to advance One Health
An integrated inventory of One Health tools: Mapping and analysis of globally available tools to advance One Health Open
The global demand from multi-sectoral partners for operational tools for One Health implementation and capacity building is increasing, yet a validated global inventory of One Health tools did not exist. Here, we map and analyze available …
View article: Immune response after oral immunization of goats and foxes with an NDV vectored rabies vaccine candidate
Immune response after oral immunization of goats and foxes with an NDV vectored rabies vaccine candidate Open
Vaccination of the reservoir species is a key component in the global fight against rabies. For wildlife reservoir species and hard to reach spillover species (e. g. ruminant farm animals), oral vaccination is the only solution. In search …
View article: A Single Amino Acid Substitution in the Transmembrane Domain of Glycoprotein H Functionally Compensates for the Absence of gL in Pseudorabies Virus
A Single Amino Acid Substitution in the Transmembrane Domain of Glycoprotein H Functionally Compensates for the Absence of gL in Pseudorabies Virus Open
Herpesvirus entry requires the coordinated action of at least four viral glycoproteins. Virus-specific binding to a cellular receptor triggers a membrane fusion cascade involving the conserved gH/gL complex and gB. Although gB is the genui…
View article: Spatiotemporal analysis of SARS-CoV-2 infection reveals an expansive wave of monocyte-derived macrophages associated with vascular damage and virus clearance in hamster lungs
Spatiotemporal analysis of SARS-CoV-2 infection reveals an expansive wave of monocyte-derived macrophages associated with vascular damage and virus clearance in hamster lungs Open
Lung immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical for the ability to deal with infection. Using light sheet fluorescence microscopy of hamster lung slices in combination with virological, immu…
View article: Prevention of zoonotic spillover: From relying on response to reducing the risk at source
Prevention of zoonotic spillover: From relying on response to reducing the risk at source Open
BACKGROUND AND CONTEXT : The devastating impact of Coronavirus Disease 2019 (COVID-19) on human health globally has prompted extensive discussions on how to better prepare for and safeguard against the next pandemic. Zoonotic spillover of …
View article: Animals Experimentally Infected with SARS-CoV-2 Generate Functional Autoantibodies against G-Protein-Coupled Receptors
Animals Experimentally Infected with SARS-CoV-2 Generate Functional Autoantibodies against G-Protein-Coupled Receptors Open
(1) Background: SARS-CoV-2 infection has been linked to diverse clinical manifestations in humans, including cardiovascular complications. Functional autoantibodies targeting G-protein-coupled receptors have emerged as potential contributo…
View article: Archaeome structure and function of the intestinal tract in healthy and H1N1 infected swine
Archaeome structure and function of the intestinal tract in healthy and H1N1 infected swine Open
Background Methanogenic archaea represent a less investigated and likely underestimated part of the intestinal tract microbiome in swine. Aims/Methods This study aims to elucidate the archaeome structure and function in the porcine intesti…
View article: Oral immunization of goats and foxes with a recombinant NDV vectored rabies vaccine
Oral immunization of goats and foxes with a recombinant NDV vectored rabies vaccine Open
Vaccination of the reservoir species is a key component in the global fight against rabies. For wildlife reservoir species and hard to reach spillover species (e. g. ruminant farm animals), oral vaccination is the only solution. In search …
View article: Developing One Health surveillance systems
Developing One Health surveillance systems Open
The health of humans, domestic and wild animals, plants, and the environment are inter-dependent. Global anthropogenic change is a key driver of disease emergence and spread and leads to biodiversity loss and ecosystem function degradation…
View article: NECing goes: flexibility of the herpesvirus nuclear egress complex
NECing goes: flexibility of the herpesvirus nuclear egress complex Open
The nuclear egress complex (NEC) allows herpesvirus capsids to escape from the nucleus without breaking the nuclear envelope barrier. It assembles into a lattice on the inner nuclear membrane enveloping newly assembled nucleocapsids, which…
View article: Mass-Spectrometric Evaluation of the African Swine Fever Virus-Induced Host Shutoff Using Dynamic Stable Isotope Labeling with Amino Acids in Cell Culture (SILAC)
Mass-Spectrometric Evaluation of the African Swine Fever Virus-Induced Host Shutoff Using Dynamic Stable Isotope Labeling with Amino Acids in Cell Culture (SILAC) Open
African swine fever is a viral disease of swine caused by the African swine fever virus (ASFV). Currently, ASFV is spreading over the Eurasian continent and threatening global pig husbandry. One viral strategy to undermine an efficient hos…
View article: Suid alphaherpesvirus 1 of wild boar origin as a recent source of Aujeszky’s disease in carnivores in Germany
Suid alphaherpesvirus 1 of wild boar origin as a recent source of Aujeszky’s disease in carnivores in Germany Open
Background The high susceptibility of carnivores to Suid Alphaherpesvirus 1 [SuAHV1, synonymous pseudorabies virus (PrV)], renders them inadvertent sentinels for the possible occurrence of Aujeszky’s disease (AD) in domestic and wild swine…
View article: Zoonotic Animal Influenza Virus and Potential Mixing Vessel Hosts
Zoonotic Animal Influenza Virus and Potential Mixing Vessel Hosts Open
Influenza viruses belong to the family Orthomyxoviridae with a negative-sense, single-stranded segmented RNA genome. They infect a wide range of animals, including humans. From 1918 to 2009, there were four influenza pandemics, which cause…