Christoph Wirblich
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View article: Rabies virus-vectored Lyme disease vaccine provides long-term protection against tick-transmitted Borrelia burgdorferi
Rabies virus-vectored Lyme disease vaccine provides long-term protection against tick-transmitted Borrelia burgdorferi Open
Lyme disease (LD) cases have doubled globally. LD is a tick-borne illness caused by the Borrelia burgdorferi sensu lato (Bb). If untreated, Bb can disseminate to distal organs, causing carditis, arthritis, and meningitis. Currently, no FDA…
View article: Immunogenicity of an adjuvanted, combination inactivated rabies-vectored, Lassa fever vaccine in healthy adults: interim results of a first-in-human Phase 1 trial
Immunogenicity of an adjuvanted, combination inactivated rabies-vectored, Lassa fever vaccine in healthy adults: interim results of a first-in-human Phase 1 trial Open
We conducted a randomized, controlled Phase 1 trial of an inactivated rabies virus-vectored Lassa virus glycoprotein complex (GPC) vaccine (LASSARAB) formulated with a synthetic oil-in-water TLR-4 agonist adjuvant (3D-6acyl PHAD-SE). In do…
View article: Immunogenicity and safety of a rabies-based highly pathogenic influenza A virus H5 vaccine in cattle
Immunogenicity and safety of a rabies-based highly pathogenic influenza A virus H5 vaccine in cattle Open
View article: A Vulnerable Subtype of Dopaminergic Neurons Drives Early Motor Deficits in Parkinson’s Disease
A Vulnerable Subtype of Dopaminergic Neurons Drives Early Motor Deficits in Parkinson’s Disease Open
In Parkinson’s disease, dopaminergic neurons (DANs) in the midbrain gradually degenerate, with ventral substantia nigra pars compacta (SNc) DANs exhibiting greater vulnerability. However, it remains unclear whether specific molecular subty…
View article: Toward the Development of a Pan-Lyssavirus Vaccine
Toward the Development of a Pan-Lyssavirus Vaccine Open
In addition to the rabies virus (RABV), 16 more lyssavirus species have been identified worldwide, causing a disease similar to RABV. Non-rabies-related human deaths have been described, but the number of cases is unknown, and the potentia…
View article: Effects of adjuvants in a rabies-vectored Ebola virus vaccine on protection from surrogate challenge
Effects of adjuvants in a rabies-vectored Ebola virus vaccine on protection from surrogate challenge Open
Ebola virus is the primary contributor to the global threat of filovirus severe hemorrhagic fever, and Ebola virus disease has a case fatality rate of 50–90%. An inactivated, bivalent filovirus/rabies virus vaccine, FILORAB1, consists of r…
View article: Inactivated rabies-vectored SARS-CoV-2 vaccine provides long-term immune response unaffected by vector immunity
Inactivated rabies-vectored SARS-CoV-2 vaccine provides long-term immune response unaffected by vector immunity Open
View article: Effects of adjuvants on protection in a rabies-vectored Ebola virus vaccine
Effects of adjuvants on protection in a rabies-vectored Ebola virus vaccine Open
Ebola virus is the primary contributor to the global threat of filovirus severe hemorrhagic fever, and Ebola virus disease has a case fatality rate of 50-90%. An inactivated, bivalent filovirus/Rabies virus vaccine, FILORAB1, consists of r…
View article: Preclinical mouse studies of vector immunity and long-term responses to CORAVAX, a Rabies virus-vectored COVID-19 vaccine
Preclinical mouse studies of vector immunity and long-term responses to CORAVAX, a Rabies virus-vectored COVID-19 vaccine Open
The objective of this study is to further analyze the recombinant Rabies virus-vectored SARS-CoV-2 vaccine, CORAVAX, as an effective COVID-19 vaccine strategy. CORAVAX has proven immunogenic and protective against SARS-CoV-2 in animal mode…
View article: A Single Dose of the Deactivated Rabies-Virus Vectored COVID-19 Vaccine, CORAVAX, Is Highly Efficacious and Alleviates Lung Inflammation in the Hamster Model
A Single Dose of the Deactivated Rabies-Virus Vectored COVID-19 Vaccine, CORAVAX, Is Highly Efficacious and Alleviates Lung Inflammation in the Hamster Model Open
Without sufficient herd immunity through either vaccination or natural infection, the coronavirus disease 2019 pandemic is unlikely to be controlled. Waning immunity with the currently approved vaccines suggests the need to evaluate vaccin…
View article: Measles-based Zika vaccine induces long-term immunity and requires NS1 antibodies to protect the female reproductive tract
Measles-based Zika vaccine induces long-term immunity and requires NS1 antibodies to protect the female reproductive tract Open
View article: A single-dose of the deactivated rabies virus vectored COVID-19 vaccine, CORAVAX, is highly efficacious and alleviates lung inflammation in the hamster model
A single-dose of the deactivated rabies virus vectored COVID-19 vaccine, CORAVAX, is highly efficacious and alleviates lung inflammation in the hamster model Open
Without sufficient herd immunity through either vaccination or natural infection, the Coronavirus Disease 2019 pandemic is unlikely to be controlled. Waning immunity with the currently approved vaccines suggests the need to evaluate vaccin…
View article: A single dose of replication-competent VSV-vectored vaccine expressing SARS-CoV-2 S1 protects against virus replication in a hamster model of severe COVID-19
A single dose of replication-competent VSV-vectored vaccine expressing SARS-CoV-2 S1 protects against virus replication in a hamster model of severe COVID-19 Open
View article: Inactivated rabies virus vectored SARS-CoV-2 vaccine prevents disease in a Syrian hamster model
Inactivated rabies virus vectored SARS-CoV-2 vaccine prevents disease in a Syrian hamster model Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emergent coronavirus that has caused a worldwide pandemic. Although human disease is often asymptomatic, some develop severe illnesses such as pneumonia, respiratory failur…
View article: A single dose of replication-competent VSV-vectored vaccine expressing SARS-CoV-2 S1 protects against virus replication in a hamster model of severe COVID-19
A single dose of replication-competent VSV-vectored vaccine expressing SARS-CoV-2 S1 protects against virus replication in a hamster model of severe COVID-19 Open
SUMMARY The development of effective countermeasures against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the agent responsible for the COVID-19 pandemic, is a priority. We designed and produced ConVac, a replication-compe…
View article: Inactivated rabies virus vectored SARS-CoV-2 vaccine prevents disease in a Syrian hamster model
Inactivated rabies virus vectored SARS-CoV-2 vaccine prevents disease in a Syrian hamster model Open
Summary Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emergent coronavirus that has caused a worldwide pandemic. Although human disease is often asymptomatic, some develop severe illnesses such as pneumonia, respirator…
View article: Tetravalent Rabies-Vectored Filovirus and Lassa Fever Vaccine Induces Long-term Immunity in Nonhuman Primates
Tetravalent Rabies-Vectored Filovirus and Lassa Fever Vaccine Induces Long-term Immunity in Nonhuman Primates Open
Background The objective of this study is to evaluate the immunogenicity of adjuvanted monovalent rabies virus (RABV)–based vaccine candidates against Ebola virus (FILORAB1), Sudan virus (FILORAB2), Marburg virus (FILORAB3), Lassa virus (L…
View article: Rabies virus-based COVID-19 vaccine CORAVAX™ induces high levels of neutralizing antibodies against SARS-CoV-2
Rabies virus-based COVID-19 vaccine CORAVAX™ induces high levels of neutralizing antibodies against SARS-CoV-2 Open
View article: Measles-based Zika vaccine induces long-term immunity and requires NS1 antibodies to protect the female reproductive tract.
Measles-based Zika vaccine induces long-term immunity and requires NS1 antibodies to protect the female reproductive tract. Open
Zika virus (ZIKV) can cause devastating effects in the unborn fetus of pregnant women. To develop a candidate vaccine that can protect human fetuses, we generated a panel of live measles vaccine (MV) vectors expressing ZIKV-E and -NS1. Our…
View article: Lyssavirus Vaccine with a Chimeric Glycoprotein Protects across Phylogroups
Lyssavirus Vaccine with a Chimeric Glycoprotein Protects across Phylogroups Open
Rabies is nearly 100% lethal in the absence of treatment, killing an estimated 59,000 people annually. Vaccines and biologics are highly efficacious when administered properly. Sixteen rabies-related viruses (lyssaviruses) are similarly le…
View article: Identification and Characterization of a Small-Molecule Rabies Virus Entry Inhibitor
Identification and Characterization of a Small-Molecule Rabies Virus Entry Inhibitor Open
Rabies PEP depends on anti-RABV IgG, which is expensive and in limited supply in geographical areas with the highest disease burden. Replacing the IgG component with a cost-effective and shelf-stable small-molecule antiviral could address …
View article: Publisher Correction: Rabies-based vaccine induces potent immune responses against Nipah virus
Publisher Correction: Rabies-based vaccine induces potent immune responses against Nipah virus Open
View article: Rabies-based vaccine induces potent immune responses against Nipah virus
Rabies-based vaccine induces potent immune responses against Nipah virus Open
View article: A Recombinant Rabies Virus Expressing the Marburg Virus Glycoprotein Is Dependent upon Antibody-Mediated Cellular Cytotoxicity for Protection against Marburg Virus Disease in a Murine Model
A Recombinant Rabies Virus Expressing the Marburg Virus Glycoprotein Is Dependent upon Antibody-Mediated Cellular Cytotoxicity for Protection against Marburg Virus Disease in a Murine Model Open
Marburg virus (MARV) is a virus similar to Ebola virus and also causes a hemorrhagic disease which is highly lethal. In contrast to EBOV, only a few vaccines have been developed against MARV, and researchers do not understand what kind of …
View article: Non-neutralizing antibodies elicited by recombinant Lassa–Rabies vaccine are critical for protection against Lassa fever
Non-neutralizing antibodies elicited by recombinant Lassa–Rabies vaccine are critical for protection against Lassa fever Open
View article: Retrograde axonal transport of rabies virus is unaffected by interferon treatment but blocked by emetine locally in axons
Retrograde axonal transport of rabies virus is unaffected by interferon treatment but blocked by emetine locally in axons Open
Neuroinvasive viruses, such as alpha herpesviruses (αHV) and rabies virus (RABV), initially infect peripheral tissues, followed by invasion of the innervating axon termini. Virus particles must undergo long distance retrograde axonal trans…
View article: The Final (Oral Ebola) Vaccine Trial on Captive Chimpanzees?
The Final (Oral Ebola) Vaccine Trial on Captive Chimpanzees? Open
View article: One-Health: a Safe, Efficient, Dual-Use Vaccine for Humans and Animals against Middle East Respiratory Syndrome Coronavirus and Rabies Virus
One-Health: a Safe, Efficient, Dual-Use Vaccine for Humans and Animals against Middle East Respiratory Syndrome Coronavirus and Rabies Virus Open
Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012 and is a highly pathogenic respiratory virus. There are no treatment options against MERS-CoV for humans or animals, and there are no large-scale clinical trials for t…
View article: An Inactivated Rabies Virus–Based Ebola Vaccine, FILORAB1, Adjuvanted With Glucopyranosyl Lipid A in Stable Emulsion Confers Complete Protection in Nonhuman Primate Challenge Models
An Inactivated Rabies Virus–Based Ebola Vaccine, FILORAB1, Adjuvanted With Glucopyranosyl Lipid A in Stable Emulsion Confers Complete Protection in Nonhuman Primate Challenge Models Open
The 2013-2016 West African Ebola virus (EBOV) disease outbreak was the largest filovirus outbreak to date. Over 28 000 suspected, probable, or confirmed cases have been reported, with a 53% case-fatality rate. The magnitude and internation…
View article: Rabies Virus CVS-N2c ΔG Strain Enhances Retrograde Synaptic Transfer and Neuronal Viability
Rabies Virus CVS-N2c ΔG Strain Enhances Retrograde Synaptic Transfer and Neuronal Viability Open