Christophe Beauloye
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View article: Placental Angiogenic Imbalance and Its Association With Adverse Outcomes in Congenital Heart Disease Pregnancies
Placental Angiogenic Imbalance and Its Association With Adverse Outcomes in Congenital Heart Disease Pregnancies Open
Pregnant women with CHD exhibited a placental angiogenic imbalance, with higher sFlt-1 and lower PlGF in late pregnancy than controls. This imbalance was associated with a higher risk of adverse pregnancy outcomes, particularly in women wi…
View article: Acute Pulmonary Embolism Treated by Surgery and Complicated With a Pulmonary Artery Pseudoaneurysm: A Case Report
Acute Pulmonary Embolism Treated by Surgery and Complicated With a Pulmonary Artery Pseudoaneurysm: A Case Report Open
Acute pulmonary embolism (PE) remains a relatively common pathology, with a high morbidity and mortality. Recommended treatment is based on anticoagulation, and thrombolysis is reserved for patients with hemodynamic instability. However, i…
View article: skNAC is a Key Driver of Cardiomyocyte Integrity Against Pathological Cardiac Hypertrophy and Heart Failure
skNAC is a Key Driver of Cardiomyocyte Integrity Against Pathological Cardiac Hypertrophy and Heart Failure Open
BACKGROUND Myocardial hypertrophy caused by chronic pressure overload eventually leads to heart failure. Increased protein synthesis and sarcomere reorganization are crucial elements of cardiac remodeling under such conditions. The muscle-…
View article: Surgical and transcatheter aortic valve replacement align survival with general population expectations: insights from standardized mortality ratios
Surgical and transcatheter aortic valve replacement align survival with general population expectations: insights from standardized mortality ratios Open
Background Comparative long-term survival outcomes between transcatheter (TAVR) and surgical (SAVR) aortic valve replacement remain debated. While randomized controlled trials support TAVR's non-inferiority, real-world data indicate the op…
View article: P2 purinergic receptors: a key but underexplored player in post-myocardial infarction healing
P2 purinergic receptors: a key but underexplored player in post-myocardial infarction healing Open
View article: Exploring the impact of metabolic comorbidities on epicardial adipose tissue in heart failure with preserved ejection fraction
Exploring the impact of metabolic comorbidities on epicardial adipose tissue in heart failure with preserved ejection fraction Open
ClinicalTrials.gov. Identifier: NCT03197350; NCT02599480.
View article: Placental Vascular Malperfusion in Pregnancies With Congenital Heart Disease
Placental Vascular Malperfusion in Pregnancies With Congenital Heart Disease Open
Women with CHD had a higher prevalence of MVM compared to controls, which was associated with adverse pregnancy outcomes. However, no clinical or paraclinical risk factors for MVM were identified.
View article: Coronary artery calcification severity in long term breast cancer survivors treated with isolated contemporary radiotherapy: Relation to dose and CV risk factors
Coronary artery calcification severity in long term breast cancer survivors treated with isolated contemporary radiotherapy: Relation to dose and CV risk factors Open
View article: Prueba de cabecera para la valoración de la troponina de alta sensibilidad. Experiencia en el laboratorio clínico de un hospital terciario
Prueba de cabecera para la valoración de la troponina de alta sensibilidad. Experiencia en el laboratorio clínico de un hospital terciario Open
View article: Point of care testing for high-sensitive troponin measurement: experience from a tertiary care hospital clinical laboratory
Point of care testing for high-sensitive troponin measurement: experience from a tertiary care hospital clinical laboratory Open
View article: When the liver is in poor condition, so is the heart – cardiac remodelling in MASH mouse models
When the liver is in poor condition, so is the heart – cardiac remodelling in MASH mouse models Open
Metabolic dysfunction-associated steatohepatitis (MASH) confers a risk for cardiovascular diseases in patients. Animal models may help exploring the mechanisms linking liver and heart diseases. Hence, we explored the cardiac phenotype in t…
View article: Plasma myo-inositol elevation in heart failure: clinical implications and prognostic significance. Results from the BElgian and CAnadian MEtabolomics in HFpEF (BECAME-HF) research project
Plasma myo-inositol elevation in heart failure: clinical implications and prognostic significance. Results from the BElgian and CAnadian MEtabolomics in HFpEF (BECAME-HF) research project Open
View article: Platelet lipidomics and de novo lipogenesis: impact on health and disease
Platelet lipidomics and de novo lipogenesis: impact on health and disease Open
Purpose of review Lipids play vital roles in platelet structure, signaling, and metabolism. In addition to capturing exogenous lipids, platelets possess the capacity for de novo lipogenesis, regulated by acetyl-coA carboxylase 1 (ACC1). Th…
View article: When the liver is in poor condition, so is the heart - cardiac remodelling in MASH mouse models
When the liver is in poor condition, so is the heart - cardiac remodelling in MASH mouse models Open
Metabolic dysfunction-associated steatohepatitis (MASH) confers a risk for cardiovascular diseases in patients. Animal models may help exploring the mechanisms linking liver and heart diseases. Hence, we explored the cardiac phenotype in M…
View article: Carbohydrate antigen 125: a useful marker of congestion, fibrosis, and prognosis in heart failure with preserved ejection fraction
Carbohydrate antigen 125: a useful marker of congestion, fibrosis, and prognosis in heart failure with preserved ejection fraction Open
Aims Heart failure (HF) with preserved ejection fraction (HFpEF) is a disease associated with high morbidity and mortality, for which it is difficult to identify patients with the poorest prognosis in routine clinical practice. Carbohydrat…
View article: Quantifying the Survival Loss Linked to Late Therapeutic Indication in High-Gradient Severe Aortic Stenosis
Quantifying the Survival Loss Linked to Late Therapeutic Indication in High-Gradient Severe Aortic Stenosis Open
View article: Fibroblasts and platelets: a face-to-face dialogue at the heart of cardiac fibrosis
Fibroblasts and platelets: a face-to-face dialogue at the heart of cardiac fibrosis Open
Myocardial fibrosis is a feature found in most cardiac diseases and a key element contributing to heart failure and its progression. It has therefore become a subject of particular interest in cardiac research. Mechanisms leading to pathol…
View article: Left Atrial Glucose Metabolism Evaluation by 18F-FDG-PET in Persistent Atrial Fibrillation and in Sinus Rhythm
Left Atrial Glucose Metabolism Evaluation by 18F-FDG-PET in Persistent Atrial Fibrillation and in Sinus Rhythm Open
The role of atrial metabolism alterations for initiation and atrial fibrillation (AF) persistence remains poorly understood. Therefore, we evaluated left atrial glucose metabolism by nicotinic acid derivative stimulated 18-fluorodeoxygluco…
View article: Potential for recovery after extremely prolonged VV-ECMO support in well-selected severe COVID-19 patients: a retrospective cohort study
Potential for recovery after extremely prolonged VV-ECMO support in well-selected severe COVID-19 patients: a retrospective cohort study Open
View article: Cardiac structure, function, and coronary anatomy 10 years after isolated contemporary adjuvant radiotherapy in breast cancer patients with low cardiovascular baseline risk
Cardiac structure, function, and coronary anatomy 10 years after isolated contemporary adjuvant radiotherapy in breast cancer patients with low cardiovascular baseline risk Open
Aims The effects of isolated contemporary low-dose breast cancer (BC) radiotherapy (RT) on the heart remain poorly understood. This study aims to assess the long-term impacts of BC-RT on cardiac structure and function. Methods and results …
View article: Left atrial glucose metabolism by 18F-FDG PET/CT in persistent atrial fibrillation and after return to sinus rhythm
Left atrial glucose metabolism by 18F-FDG PET/CT in persistent atrial fibrillation and after return to sinus rhythm Open
Background Atrial Fibrillation (AF) is strongly associated with the development of Left Atrial (LA) remodeling. Animal studies pointed to an important role of metabolic deregulation in AF, yet few studies have assessed LA myocardial metabo…
View article: Sodium-<i>myo</i>-inositol cotransporter-1, SMIT1, promotes cardiac hypertrophy and fibrosis induced by pressure overload in mice
Sodium-<i>myo</i>-inositol cotransporter-1, SMIT1, promotes cardiac hypertrophy and fibrosis induced by pressure overload in mice Open
Aims Recent clinical studies have reported that myo -inositol is consistently elevated in plasma of patients with heart failure (HF), yet its role in cardiac dysfunction remains poorly understood. Myo -inositol is specifically transported …
View article: Acute heart failure: mechanisms and pre-clinical models—a Scientific Statement of the ESC Working Group on Myocardial Function
Acute heart failure: mechanisms and pre-clinical models—a Scientific Statement of the ESC Working Group on Myocardial Function Open
While chronic heart failure (CHF) treatment has considerably improved patient prognosis and survival, the therapeutic management of acute heart failure (AHF) has remained virtually unchanged in the last decades. This is partly due to the s…
View article: Dual antiplatelet therapy is associated with high α-tubulin acetylation in circulating platelets from coronary artery disease patients
Dual antiplatelet therapy is associated with high α-tubulin acetylation in circulating platelets from coronary artery disease patients Open
Platelet inhibition is the main treatment strategy to prevent atherothrombotic complications after acute coronary syndrome or percutaneous coronary intervention. Despite dual antiplatelet therapy (DAPT) combining aspirin and a P2Y12
View article: Unsuspected diabetic ketoacidosis after myocardial infarction in a patient treated with SGLT2 inhibitor increased length of stay in the hospital: how can it be prevented? A case report
Unsuspected diabetic ketoacidosis after myocardial infarction in a patient treated with SGLT2 inhibitor increased length of stay in the hospital: how can it be prevented? A case report Open
Background As the use of sodium–glucose co-transporter 2 inhibitors (SGLT2is) has expanded beyond glucose-lowering therapy in type 2 diabetes mellitus (T2DM), including chronic kidney disease and heart failure, there has also been an incre…
View article: Impact of early versus class I–triggered surgery on postoperative survival in severe aortic regurgitation: An observational study from the Aortic Valve Insufficiency and Ascending Aorta Aneurysm International Registry
Impact of early versus class I–triggered surgery on postoperative survival in severe aortic regurgitation: An observational study from the Aortic Valve Insufficiency and Ascending Aorta Aneurysm International Registry Open
View article: Mean platelet volume: a prognostic marker in heart failure with preserved ejection fraction
Mean platelet volume: a prognostic marker in heart failure with preserved ejection fraction Open
Heart failure (HF) with preserved ejection fraction (HFpEF) is associated with high burden of comorbidities known to increase the mean platelet volume (MPV). This parameter has been associated with morbidity and mortality in HF. However, t…
View article: 3D histopathology of stenotic aortic valve cusps using ex vivo microfocus computed tomography
3D histopathology of stenotic aortic valve cusps using ex vivo microfocus computed tomography Open
Background Calcific aortic stenosis (AS) is the most prevalent heart valve disease in developed countries. The aortic valve cusps progressively thicken and the valve does not open fully due to the presence of calcifications. In vivo imagin…
View article: Dexamethasone Modulates the Cytokine Response but Not COVID-19-Induced Coagulopathy in Critically Ill
Dexamethasone Modulates the Cytokine Response but Not COVID-19-Induced Coagulopathy in Critically Ill Open
Severe forms of coronavirus 2019 (COVID-19) disease are caused by an exaggerated systemic inflammatory response and subsequent inflammation-related coagulopathy. Anti-inflammatory treatment with low dose dexamethasone has been shown to red…
View article: Prognostic Implications of Discordant Low-Gradient Severe Aortic Stenosis
Prognostic Implications of Discordant Low-Gradient Severe Aortic Stenosis Open
Survival of DLG-SAS is better than that of HG-SAS and worse than that of MAS patients. At comparable MG, the lower the AVAi, the worse the prognosis, whereas at comparable AVAi, the higher the MG, the worse the prognosis. These data argue …