Christophe Isnard
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View article: <i>Lactobacillus delbrueckii</i> subsp. <i>allosunkii</i> and <i>lactis</i> as emerging human uropathogens in elderly patients
<i>Lactobacillus delbrueckii</i> subsp. <i>allosunkii</i> and <i>lactis</i> as emerging human uropathogens in elderly patients Open
Lactobacillus delbrueckii has been considered a very rare cause of human urinary tract infections (UTIs). However, little is known about its clinical significance and antimicrobial susceptibility, and genomic data from clinical isolates ar…
View article: Impact of an antimicrobial stewardship program on the appropriate use of carbapenems in a French university hospital (CARBACAI study)
Impact of an antimicrobial stewardship program on the appropriate use of carbapenems in a French university hospital (CARBACAI study) Open
Implementing an educational antimicrobial stewardship program for hospital CP proper use had a positive impact. Educational reminders are essential to support these improvements.
View article: Phenotypic and genomic changes in enteric <i>Klebsiella</i> populations during long-term ICU patient hospitalization: the role of RamR regulation
Phenotypic and genomic changes in enteric <i>Klebsiella</i> populations during long-term ICU patient hospitalization: the role of RamR regulation Open
Acquired antimicrobial resistance and metabolic changes are central for bacterial host adaptation during the long-term hospitalization of patients. We aimed to analyze the genomic and phenotypic evolution of enteric Klebsiella populations …
View article: Outcomes of <i>Enterococcus faecalis</i> infective endocarditis according to MIC of amoxicillin: a multicentric study
Outcomes of <i>Enterococcus faecalis</i> infective endocarditis according to MIC of amoxicillin: a multicentric study Open
Background The incidence of Enterococcus faecalis infective endocarditis is increasing over time. Data on the impact of minimum inhibitory concentration (MIC) of amoxicillin on treatment outcomes are scarce. The objective of this study was…
View article: Phenotypic and genomic changes in enteric<i>Klebsiella</i>populations during long-term ICU patient hospitalization: The role of RamR regulation
Phenotypic and genomic changes in enteric<i>Klebsiella</i>populations during long-term ICU patient hospitalization: The role of RamR regulation Open
Acquired antimicrobial resistance and metabolic changes are central for bacterial host adaptation during the long-term hospitalization of patients. We aimed to analyze the genomic and phenotypic evolution of enteric Klebsiella populations …
View article: Evaluation of ceftolozane-tazobactam susceptibility on a French nationwide collection of Enterobacterales
Evaluation of ceftolozane-tazobactam susceptibility on a French nationwide collection of Enterobacterales Open
Overall, C/T showed good activity against wild-type Enterobacterales, AmpC producers, and ESBL-producing Escherichia coli but is less active against ESBL-producing Klebsiella pneumoniae, and CRE. E-test® led to an underestimation of the MI…
View article: Improvement of patient care through hirudotherapy and the management of leeches from their reception to their disposal in France
Improvement of patient care through hirudotherapy and the management of leeches from their reception to their disposal in France Open
Despite the absence of clear guidelines and heterogeneous practices, this study reveals the importance of a standard procedure including leech management practices before use, antibiotic prophylaxis and application and disposal guides. The…
View article: Unexpected Cell Wall Alteration-Mediated Bactericidal Activity of the Antifungal Caspofungin against Vancomycin-Resistant Enterococcus faecium
Unexpected Cell Wall Alteration-Mediated Bactericidal Activity of the Antifungal Caspofungin against Vancomycin-Resistant Enterococcus faecium Open
Enterococcus faecium has become a major opportunistic pathogen with the emergence of vancomycin-resistant enterococci (VRE). As part of the gut microbiota, they have to cope with numerous stresses, including effects of antibiotics and othe…
View article: Landscape of in vivo Fitness-Associated Genes of Enterobacter cloacae Complex
Landscape of in vivo Fitness-Associated Genes of Enterobacter cloacae Complex Open
Species of the Enterobacter cloacae complex (ECC) represent an increasing cause of hospital-acquired infections and commonly exhibit multiple antibiotic resistances. In order to identify genes that may play a role in its ability to coloniz…
View article: Paradoxical High-Level Spiramycin Resistance and Erythromycin Susceptibility due to 23S rRNA Mutation in <i>Streptococcus constellatus</i>
Paradoxical High-Level Spiramycin Resistance and Erythromycin Susceptibility due to 23S rRNA Mutation in <i>Streptococcus constellatus</i> Open
Objectives: The aim of the study was to characterize phenotypically and genotypically an uncommon mechanism of resistance to macrolides, lincosamides, and streptogramins (MLS) in a Streptococcus milleri group clinical isolate. Materials an…
View article: <i>In Vitro</i> Activity of Ceftolozane-Tazobactam against Enterobacter cloacae Complex Clinical Isolates with Different β-Lactam Resistance Phenotypes
<i>In Vitro</i> Activity of Ceftolozane-Tazobactam against Enterobacter cloacae Complex Clinical Isolates with Different β-Lactam Resistance Phenotypes Open
The study evaluated the in vitro activity of ceftolozane-tazobactam (C/T) against 94 unique clinical isolates of Enterobacter cloacae complex (ECC). No difference was observed according to the ECC cluster.
View article: Genetic characterization of a VanG-type vancomycin-resistant Enterococcus faecium clinical isolate
Genetic characterization of a VanG-type vancomycin-resistant Enterococcus faecium clinical isolate Open
This is, to the best of our knowledge, the first report of a VanG-type vancomycin-resistant strain of E. faecium. Despite the alarm pulled because of the therapeutic problems caused by VRE, our work shows that new resistant loci can still …
View article: Novel chromosome-encoded<i>erm</i>(47) determinant responsible for constitutive MLS<sub>B</sub>resistance in<i>Helcococcus kunzii</i>
Novel chromosome-encoded<i>erm</i>(47) determinant responsible for constitutive MLS<sub>B</sub>resistance in<i>Helcococcus kunzii</i> Open
This is the first description of a novel MLSB resistance determinant, named erm(47). The prevalence of this gene among Gram-positive cocci must be further investigated to determine its clinical significance.
View article: Fatal nosocomial meningitis caused by Mycoplasma hominis in an adult patient: case report and review of the literature
Fatal nosocomial meningitis caused by Mycoplasma hominis in an adult patient: case report and review of the literature Open
Meningitis due to Mycoplasma hominis in adults is rarely described, with only three cases having been reported to date. A case of fatal meningitis in a 39-year-old patient after a neurosurgical procedure for a subarachnoid haemorrhage is r…
View article: Landscape of Resistance-Nodulation-Cell Division (RND)-Type Efflux Pumps in Enterobacter cloacae Complex
Landscape of Resistance-Nodulation-Cell Division (RND)-Type Efflux Pumps in Enterobacter cloacae Complex Open
In Gram-negative bacteria, the active efflux is an important mechanism of antimicrobial resistance, but little is known about the Enterobacter cloacae complex (ECC). It is mediated primarily by pumps belonging to the RND (resistance-nodula…
View article: Complex Regulation Pathways of AmpC-Mediated β-Lactam Resistance in Enterobacter cloacae Complex
Complex Regulation Pathways of AmpC-Mediated β-Lactam Resistance in Enterobacter cloacae Complex Open
Enterobacter cloacae complex (ECC), an opportunistic pathogen causing numerous infections in hospitalized patients worldwide, is able to resist β-lactams mainly by producing the AmpC β-lactamase enzyme. AmpC expression is highly inducible …
View article: Identification and Clinical Significance of Helcococcus kunzii in Human Samples
Identification and Clinical Significance of Helcococcus kunzii in Human Samples Open
From 2008 to 2013, 39 Helcococcus kunzii strains were collected from human clinical specimens (79% from foot ulcers), and 85% of the 39 patients were infected. Matrix-assisted laser desorption ionization–time of flight (MALDI-TOF) mass spe…