Christophe Jamin
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View article: Interferon-α–Driven Stratification of B Cell Reveals Metabolic Reprogramming of Double Negative, Naive and Transitional cell subsets and Refines Molecular Classification in Sjögren’s Disease
Interferon-α–Driven Stratification of B Cell Reveals Metabolic Reprogramming of Double Negative, Naive and Transitional cell subsets and Refines Molecular Classification in Sjögren’s Disease Open
Sjögren’s disease (SjD) is a chronic autoimmune condition marked by lymphocytic infiltration of exocrine glands and production of autoantibodies such as anti-SSA/Ro, anti-SSB/La, and rheumatoid factor. B lymphocytes play a central role in …
View article: BiomiX, a user-friendly bioinformatic tool for democratized analysis and integration of multiomics data
BiomiX, a user-friendly bioinformatic tool for democratized analysis and integration of multiomics data Open
The analysis of single-omics and multi-omics integration in a standalone tool, along with MOFA implementation and its interpretability via literature, represents significant progress in the multi-omics field in line with the "Findable, Acc…
View article: Stratification according to autoantibody status in systemic sclerosis reveals distinct molecular signatures
Stratification according to autoantibody status in systemic sclerosis reveals distinct molecular signatures Open
Patients with SSc display varying biological profiles based on their serological status. The findings highlight the potential utility of serological status as a discriminating factor in disease severity and suggest its relevance in tailori…
View article: BiomiX, a User-Friendly Bioinformatic Tool for Automatized Multiomics Data Analysis and Integration
BiomiX, a User-Friendly Bioinformatic Tool for Automatized Multiomics Data Analysis and Integration Open
BiomiX addresses the data analysis bottleneck in high-throughput omics technologies, enabling the efficient, integrated analysis of multiomics data obtained from two cohorts. BiomiX incorporates diverse omics data. DESeq2/Limma packages an…
View article: Integration of multi-omics analysis reveals metabolic alterations of B lymphocytes in systemic lupus erythematosus
Integration of multi-omics analysis reveals metabolic alterations of B lymphocytes in systemic lupus erythematosus Open
B cells showed metabolic changes shared with their macroenvironment and unique changes directly or indirectly induced by IFN-α signalling. This study underscores the importance of understanding the interplay between B cells and their macro…
View article: YOUPI: Your powerful and intelligent tool for segmenting cells from imaging mass cytometry data
YOUPI: Your powerful and intelligent tool for segmenting cells from imaging mass cytometry data Open
The recent emergence of imaging mass cytometry technology has led to the generation of an increasing amount of high-dimensional data and, with it, the need for suitable performant bioinformatics tools dedicated to specific multiparametric …
View article: Abnormal B cell glycosylation in autoimmunity: A new potential treatment strategy
Abnormal B cell glycosylation in autoimmunity: A new potential treatment strategy Open
Systemic lupus erythematosus (SLE) and primary Sjögren’s syndrome (pSS) are two autoimmune diseases characterised by the production of pathogenic autoreactive antibodies. Their aetiology is poorly understood. Nevertheless, they have been s…
View article: Machine Learning for the Identification of a Common Signature for Anti–SSA/Ro 60 Antibody Expression Across Autoimmune Diseases
Machine Learning for the Identification of a Common Signature for Anti–SSA/Ro 60 Antibody Expression Across Autoimmune Diseases Open
Objective Anti‐Ro autoantibodies are among the most frequently detected extractable nuclear antigen autoantibodies, mainly associated with primary Sjögren's syndrome (SS), systemic lupus erythematosus (SLE), and undifferentiated connective…
View article: Metabolic Program of Regulatory B Lymphocytes and Influence in the Control of Malignant and Autoimmune Situations
Metabolic Program of Regulatory B Lymphocytes and Influence in the Control of Malignant and Autoimmune Situations Open
Metabolic pathways have been studied for a while in eukaryotic cells. During glycolysis, glucose enters into the cells through the Glut1 transporter to be phosphorylated and metabolized generating ATP molecules. Immune cells can use additi…
View article: Abatacept Promotes Regulatory B Cell Functions, Enhancing Their Ability to Reduce the Th1 Response in Rheumatoid Arthritis Patients through the Production of IL-10 and TGF-β
Abatacept Promotes Regulatory B Cell Functions, Enhancing Their Ability to Reduce the Th1 Response in Rheumatoid Arthritis Patients through the Production of IL-10 and TGF-β Open
Abatacept mimics natural CD152 and competes with CD28 for binding to CD80/CD86 on APC, such as B cells, thereby preventing T cell activation. However, its potential impact on B cells has not been identified. The aim of this study was to as…
View article: The diversity of the plasmablast signature across species and experimental conditions: A meta‐analysis
The diversity of the plasmablast signature across species and experimental conditions: A meta‐analysis Open
Antibody‐secreting cells (ASC) are divided into two principal subsets, including the long‐lived plasma cell (PC) subset residing in the bone marrow and the short‐lived subset, also called plasmablast (PB). PB are described as a proliferati…
View article: IL-21 and IFN-alpha have both opposite and redundant role on human innate precursors and memory B-cell differentiation
IL-21 and IFN-alpha have both opposite and redundant role on human innate precursors and memory B-cell differentiation Open
Immunological memory is essential for effective immune protection upon antigen rechallenge. Memory B cells encompass multiple subsets, heterogeneous in terms of phenotypes, origins and precursors, anatomical localization, and functional re…
View article: Hyposialylation Must Be Considered to Develop Future Therapies in Autoimmune Diseases
Hyposialylation Must Be Considered to Develop Future Therapies in Autoimmune Diseases Open
Autoimmune disease development depends on multiple factors, including genetic and environmental. Abnormalities such as sialylation levels and/or quality have been recently highlighted. The adjunction of sialic acid at the terminal end of g…
View article: Integrative Analysis Reveals a Molecular Stratification of Systemic Autoimmune Diseases
Integrative Analysis Reveals a Molecular Stratification of Systemic Autoimmune Diseases Open
Objective Clinical heterogeneity, a hallmark of systemic autoimmune diseases, impedes early diagnosis and effective treatment, issues that may be addressed if patients could be classified into groups defined by molecular pattern. This stud…
View article: Judges in the Lab: No Precedent Effects, No Common/Civil Law Differences
Judges in the Lab: No Precedent Effects, No Common/Civil Law Differences Open
In our lab, 299 real judges from seven major jurisdictions (Argentina, Brazil, China, France, Germany, India, and USA) spend up to fifty-five minutes to judge an international criminal appeals case and determine the appropriate prison sent…
View article: O31 Integrative analysis reveals a molecular stratification of systemic autoimmune diseases
O31 Integrative analysis reveals a molecular stratification of systemic autoimmune diseases Open
Background Clinical heterogeneity, a hallmark of systemic autoimmune diseases (SADs) impedes early diagnosis and effective treatment, issues that may be addressed if patients could be grouped into a molecular defined stratification. Method…
View article: Integrative Analysis Reveals a Molecular Stratification of Systemic Autoimmune Diseases
Integrative Analysis Reveals a Molecular Stratification of Systemic Autoimmune Diseases Open
SUMMARY Background Clinical heterogeneity, a hallmark of systemic autoimmune diseases (SADs) impedes early diagnosis and effective treatment, issues that may be addressed if patients could be grouped into a molecular defined stratification…
View article: Molecular Characterization of Monocyte Subsets Reveals Specific and Distinctive Molecular Signatures Associated With Cardiovascular Disease in Rheumatoid Arthritis
Molecular Characterization of Monocyte Subsets Reveals Specific and Distinctive Molecular Signatures Associated With Cardiovascular Disease in Rheumatoid Arthritis Open
Objectives: This study, developed within the Innovative Medicines Initiative Joint Undertaking project PRECISESADS framework, aimed at functionally characterize the monocyte subsets in RA patients, and analyze their involvement in the incr…
View article: Peripheral-blood b-cell subset disturbances in inflammatory joint diseases induced by Tropheryma whipplei
Peripheral-blood b-cell subset disturbances in inflammatory joint diseases induced by Tropheryma whipplei Open
Our study provides data on peripheral-blood B-cell disturbances that may have implications for the diagnosis and pathogenetic understanding of WD.
View article: The regulatory capacity of B cells directs the aggressiveness of CLL
The regulatory capacity of B cells directs the aggressiveness of CLL Open
Chronic lymphocytic leukemia (CLL) is associated with abnormal T-cell responses responsible for defective anti-tumor activities. Intriguingly, CLL B cells share phenotypical characteristics with regulatory B (Breg) cells suggesting that th…