Christophe Langouët-Astrié
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View article: Global changes in <i>Staphylococcus aureus</i> virulence and metabolism during colonization of healthy skin
Global changes in <i>Staphylococcus aureus</i> virulence and metabolism during colonization of healthy skin Open
Staphylococcus aureus and its antibiotic-resistant derivative, methicillin-resistant S. aureus (MRSA), are the leading causative agents of skin and soft tissue infections globally. S. aureus transiently colonizes the skin of healthy adults…
View article: Matrix metalloproteinases mediate influenza A-associated shedding of the alveolar epithelial glycocalyx
Matrix metalloproteinases mediate influenza A-associated shedding of the alveolar epithelial glycocalyx Open
Background The alveolar epithelium is protected by a heparan sulfate-rich, glycosaminoglycan layer called the epithelial glycocalyx. It is cleaved in patients with acute respiratory distress syndrome (ARDS) and in murine models of influenz…
View article: Host-derived protease promotes aggregation of <i>Staphylococcus aureus</i> by cleaving the surface protein SasG
Host-derived protease promotes aggregation of <i>Staphylococcus aureus</i> by cleaving the surface protein SasG Open
Staphylococcus aureus is one of the leading causes of hospital-acquired infections, many of which begin following attachment and accumulation on indwelling medical devices or diseased tissue. These infections are often linked to the establ…
View article: Bacterial pneumonia-induced shedding of epithelial heparan sulfate inhibits the bactericidal activity of cathelicidin in a murine model
Bacterial pneumonia-induced shedding of epithelial heparan sulfate inhibits the bactericidal activity of cathelicidin in a murine model Open
Primary Staphylococcus aureus pneumonia causes pulmonary epithelial heparan sulfate (HS) shedding into the airspace. These highly sulfated HS fragments do not alter bacterial growth or transcription, but directly bind with host antimicrobi…
View article: Identifying genetic determinants of Streptococcus pyogenes-host interactions in a murine intact skin infection model
Identifying genetic determinants of Streptococcus pyogenes-host interactions in a murine intact skin infection model Open
Streptococcus pyogenes is an obligate human pathobiont associated with many disease states. Here, we present a model of S. pyogenes infection using intact murine epithelium. We were able to perform RNA sequencing to evaluate genetic change…
View article: Rgg2/Rgg3 quorum sensing is a determinant of<i>Streptococcus pyogenes</i>-host interactions in a murine intact skin infection model
Rgg2/Rgg3 quorum sensing is a determinant of<i>Streptococcus pyogenes</i>-host interactions in a murine intact skin infection model Open
Streptococcus pyogenes is an obligate human pathobiont associated with many disease states. Here, we present a novel model of S. pyogenes infection using intact murine epithelium. From this model, we were able to perform RNA sequencing to …
View article: Aging-Associated Augmentation of Gut Microbiome Virulence Capability Drives Sepsis Severity
Aging-Associated Augmentation of Gut Microbiome Virulence Capability Drives Sepsis Severity Open
Older adults suffer more frequent and worse outcomes from sepsis, a critical illness secondary to infection. The reasons underlying this unique susceptibility are incompletely understood.
View article: Data from Targeting CDK4/6 Represents a Therapeutic Vulnerability in Acquired BRAF/MEK Inhibitor–Resistant Melanoma
Data from Targeting CDK4/6 Represents a Therapeutic Vulnerability in Acquired BRAF/MEK Inhibitor–Resistant Melanoma Open
There is a clear need to identify targetable drivers of resistance and potential biomarkers for salvage therapy for patients with melanoma refractory to the combination of BRAF and MEK inhibition. In this study, we performed whole-exome se…
View article: Supplementary Tables and Figures from Targeting CDK4/6 Represents a Therapeutic Vulnerability in Acquired BRAF/MEK Inhibitor–Resistant Melanoma
Supplementary Tables and Figures from Targeting CDK4/6 Represents a Therapeutic Vulnerability in Acquired BRAF/MEK Inhibitor–Resistant Melanoma Open
Supplementary tables and figures
View article: Supplementary File S1 from Targeting CDK4/6 Represents a Therapeutic Vulnerability in Acquired BRAF/MEK Inhibitor–Resistant Melanoma
Supplementary File S1 from Targeting CDK4/6 Represents a Therapeutic Vulnerability in Acquired BRAF/MEK Inhibitor–Resistant Melanoma Open
WES MB1998 and MB2132
View article: Supplementary File S1 from Targeting CDK4/6 Represents a Therapeutic Vulnerability in Acquired BRAF/MEK Inhibitor–Resistant Melanoma
Supplementary File S1 from Targeting CDK4/6 Represents a Therapeutic Vulnerability in Acquired BRAF/MEK Inhibitor–Resistant Melanoma Open
WES MB1998 and MB2132
View article: Supplementary Tables and Figures from Targeting CDK4/6 Represents a Therapeutic Vulnerability in Acquired BRAF/MEK Inhibitor–Resistant Melanoma
Supplementary Tables and Figures from Targeting CDK4/6 Represents a Therapeutic Vulnerability in Acquired BRAF/MEK Inhibitor–Resistant Melanoma Open
Supplementary tables and figures
View article: Data from Targeting CDK4/6 Represents a Therapeutic Vulnerability in Acquired BRAF/MEK Inhibitor–Resistant Melanoma
Data from Targeting CDK4/6 Represents a Therapeutic Vulnerability in Acquired BRAF/MEK Inhibitor–Resistant Melanoma Open
There is a clear need to identify targetable drivers of resistance and potential biomarkers for salvage therapy for patients with melanoma refractory to the combination of BRAF and MEK inhibition. In this study, we performed whole-exome se…
View article: Aging-associated augmentation of gut microbiome virulence capability drives sepsis severity
Aging-associated augmentation of gut microbiome virulence capability drives sepsis severity Open
Prior research has focused on host factors as mediators of exaggerated sepsis-associated morbidity and mortality in older adults. This focus on the host, however, has failed to identify therapies that improve sepsis outcomes in the elderly…
View article: Host-derived protease promotes aggregation of<i>Staphylococcus aureus</i>by cleaving the surface protein SasG
Host-derived protease promotes aggregation of<i>Staphylococcus aureus</i>by cleaving the surface protein SasG Open
Staphylococcus aureus is one of the leading causes of hospital acquired infections, many of which begin following attachment and accumulation on indwelling medical devices or diseased tissue. These infections are often linked to establishm…
View article: Group B <i>Streptococcus</i> adaptation promotes survival in a hyperinflammatory diabetic wound environment
Group B <i>Streptococcus</i> adaptation promotes survival in a hyperinflammatory diabetic wound environment Open
Diabetic wounds have poor healing outcomes due to the presence of numerous pathogens and a dysregulated immune response. Group B Streptococcus (GBS) is commonly isolated from diabetic wound infections, but the mechanisms of GBS virulence d…
View article: The influenza-injured lung microenvironment promotes MRSA virulence, contributing to severe secondary bacterial pneumonia
The influenza-injured lung microenvironment promotes MRSA virulence, contributing to severe secondary bacterial pneumonia Open
View article: Group B Streptococcus Adaptation Promotes Survival in a Hyperinflammatory Diabetic Wound Environment
Group B Streptococcus Adaptation Promotes Survival in a Hyperinflammatory Diabetic Wound Environment Open
Diabetic wounds have poor healing outcomes due to the presence of numerous pathogens and a dysregulated immune response. Group B Streptococcus (GBS) is commonly isolated from diabetic wound infections, but the mechanisms of GBS virulence d…
View article: Heparan sulfate-dependent RAGE oligomerization is indispensable for pathophysiological functions of RAGE
Heparan sulfate-dependent RAGE oligomerization is indispensable for pathophysiological functions of RAGE Open
RAGE, a druggable inflammatory receptor, is known to function as an oligomer but the exact oligomerization mechanism remains poorly understood. Previously we have shown that heparan sulfate (HS) plays an active role in RAGE oligomerization…
View article: Author response: Heparan sulfate-dependent RAGE oligomerization is indispensable for pathophysiological functions of RAGE
Author response: Heparan sulfate-dependent RAGE oligomerization is indispensable for pathophysiological functions of RAGE Open
View article: Alveolar epithelial glycocalyx degradation mediates surfactant dysfunction and contributes to acute respiratory distress syndrome
Alveolar epithelial glycocalyx degradation mediates surfactant dysfunction and contributes to acute respiratory distress syndrome Open
Acute respiratory distress syndrome (ARDS) is a common cause of respiratory failure yet has few pharmacologic therapies, reflecting the mechanistic heterogeneity of lung injury. We hypothesized that damage to the alveolar epithelial glycoc…
View article: Targeting CDK4/6 Represents a Therapeutic Vulnerability in Acquired BRAF/MEK Inhibitor–Resistant Melanoma
Targeting CDK4/6 Represents a Therapeutic Vulnerability in Acquired BRAF/MEK Inhibitor–Resistant Melanoma Open
There is a clear need to identify targetable drivers of resistance and potential biomarkers for salvage therapy for patients with melanoma refractory to the combination of BRAF and MEK inhibition. In this study, we performed whole-exome se…
View article: Heparan Sulfate-dependent RAGE oligomerization is indispensable for pathophysiological functions of RAGE
Heparan Sulfate-dependent RAGE oligomerization is indispensable for pathophysiological functions of RAGE Open
RAGE, a druggable inflammatory receptor, is known to function as an oligomer but the exact oligomerization mechanism remains poorly understood. Previously we have shown that heparan sulfate (HS) plays an active role in RAGE oligomerization…
View article: Heparin as a therapy for COVID-19: current evidence and future possibilities
Heparin as a therapy for COVID-19: current evidence and future possibilities Open
Coronavirus disease 2019 (COVID-19), the clinical syndrome associated with infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has impacted nearly every country in the world. Despite an unprecedented focus of scienti…
View article: Measurement of ex vivo resistance to proteasome inhibitors, IMiDs, and daratumumab during multiple myeloma progression
Measurement of ex vivo resistance to proteasome inhibitors, IMiDs, and daratumumab during multiple myeloma progression Open
The oncogenic drivers and progression factors in multiple myeloma (MM) are heterogeneous and difficult to target therapeutically. Many different MM drugs have emerged, however, that attack various phenotypic aspects of malignant plasma cel…
View article: Sodium bicarbonate cotransporter NBCe2 gene variants increase sodium and bicarbonate transport in human renal proximal tubule cells
Sodium bicarbonate cotransporter NBCe2 gene variants increase sodium and bicarbonate transport in human renal proximal tubule cells Open
NBCe2 activity is stimulated by an increase in intracellular sodium and is hyper-responsive in hRPTCs carrying HV SLC4A5 rs7571842 through an aberrant HNF4A-mediated mechanism.
View article: RNA sequencing analysis of the developing chicken retina
RNA sequencing analysis of the developing chicken retina Open
View article: RNA-seq analysis of the developing chicken retina
RNA-seq analysis of the developing chicken retina Open
View article: Tricistronic Lentivirus vector construction using scar-less DNA assembly methods and web-based software j5 to help study GRK4
Tricistronic Lentivirus vector construction using scar-less DNA assembly methods and web-based software j5 to help study GRK4 Open
About one third of the world’s population is affected by hypertension, or high blood pressure, which increases an individual’s risk for cardiovascular disease. A major contributor to hypertension is dietary sodium intake. To assess an indi…