Christian Larroque
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View article: Exploring Southern Ecuador’s Traditional Medicine: Biological Screening of Plant Extracts and Metabolites
Exploring Southern Ecuador’s Traditional Medicine: Biological Screening of Plant Extracts and Metabolites Open
Ecuador stands as a nation inheriting a profound ancestral legacy in the utilization of medicinal plants, reflective of the rich biodiversity embraced by various ethnic groups. Despite this heritage, many of these therapeutic resources rem…
View article: Constituents and Selective BuChE Inhibitory Activity of the Essential Oil from Hypericum aciculare Kunth
Constituents and Selective BuChE Inhibitory Activity of the Essential Oil from Hypericum aciculare Kunth Open
A potential source of new inhibitors of cholinesterase enzymes are certain compounds of natural plant origin; therefore, in the study described herein we have determined the chemical composition and the acetylcholinesterase (AChE) and buty…
View article: Improving dental epithelial junction on dental implants with bioengineered peptides
Improving dental epithelial junction on dental implants with bioengineered peptides Open
Introduction: The functionalization of titanium (Ti) and titanium alloys (Ti6Al4V) implant surfaces via material-specific peptides influence host/biomaterial interaction. The impact of using peptides as molecular linkers between cells and …
View article: Supplementary Material and Methods; Figure Legends from Inhibition of CD39 Enzymatic Function at the Surface of Tumor Cells Alleviates Their Immunosuppressive Activity
Supplementary Material and Methods; Figure Legends from Inhibition of CD39 Enzymatic Function at the Surface of Tumor Cells Alleviates Their Immunosuppressive Activity Open
Supplementary material and methods and supplementary figure legends.
View article: Supplementary Material and Methods; Figure Legends from Inhibition of CD39 Enzymatic Function at the Surface of Tumor Cells Alleviates Their Immunosuppressive Activity
Supplementary Material and Methods; Figure Legends from Inhibition of CD39 Enzymatic Function at the Surface of Tumor Cells Alleviates Their Immunosuppressive Activity Open
Supplementary material and methods and supplementary figure legends.
View article: Supplementary Figure 4 from Inhibition of CD39 Enzymatic Function at the Surface of Tumor Cells Alleviates Their Immunosuppressive Activity
Supplementary Figure 4 from Inhibition of CD39 Enzymatic Function at the Surface of Tumor Cells Alleviates Their Immunosuppressive Activity Open
Representative IHC staining of CD39 expression in human normal and tumor tissues (clone HPA014067).
View article: Supplementary Figure 1 from Inhibition of CD39 Enzymatic Function at the Surface of Tumor Cells Alleviates Their Immunosuppressive Activity
Supplementary Figure 1 from Inhibition of CD39 Enzymatic Function at the Surface of Tumor Cells Alleviates Their Immunosuppressive Activity Open
Validation of CD39 IHC.
View article: Supplementary Figure 4 from Inhibition of CD39 Enzymatic Function at the Surface of Tumor Cells Alleviates Their Immunosuppressive Activity
Supplementary Figure 4 from Inhibition of CD39 Enzymatic Function at the Surface of Tumor Cells Alleviates Their Immunosuppressive Activity Open
Representative IHC staining of CD39 expression in human normal and tumor tissues (clone HPA014067).
View article: Data from Inhibition of CD39 Enzymatic Function at the Surface of Tumor Cells Alleviates Their Immunosuppressive Activity
Data from Inhibition of CD39 Enzymatic Function at the Surface of Tumor Cells Alleviates Their Immunosuppressive Activity Open
The ectonucleotidases CD39 and CD73 hydrolyze extracellular adenosine triphosphate (ATP) and adenosine diphosphate (ADP) to generate adenosine, which binds to adenosine receptors and inhibits T-cell and natural killer (NK)–cell responses, …
View article: Data from Inhibition of CD39 Enzymatic Function at the Surface of Tumor Cells Alleviates Their Immunosuppressive Activity
Data from Inhibition of CD39 Enzymatic Function at the Surface of Tumor Cells Alleviates Their Immunosuppressive Activity Open
The ectonucleotidases CD39 and CD73 hydrolyze extracellular adenosine triphosphate (ATP) and adenosine diphosphate (ADP) to generate adenosine, which binds to adenosine receptors and inhibits T-cell and natural killer (NK)–cell responses, …
View article: Supplementary Figure 3 from Inhibition of CD39 Enzymatic Function at the Surface of Tumor Cells Alleviates Their Immunosuppressive Activity
Supplementary Figure 3 from Inhibition of CD39 Enzymatic Function at the Surface of Tumor Cells Alleviates Their Immunosuppressive Activity Open
Representative IHC staining of CD39 expression in vascular endothelial cells and lymphocytes from various normal tissues (clone HPA014067).
View article: Supplementary Figure 1 from Inhibition of CD39 Enzymatic Function at the Surface of Tumor Cells Alleviates Their Immunosuppressive Activity
Supplementary Figure 1 from Inhibition of CD39 Enzymatic Function at the Surface of Tumor Cells Alleviates Their Immunosuppressive Activity Open
Validation of CD39 IHC.
View article: Supplementary Figure 2 from Inhibition of CD39 Enzymatic Function at the Surface of Tumor Cells Alleviates Their Immunosuppressive Activity
Supplementary Figure 2 from Inhibition of CD39 Enzymatic Function at the Surface of Tumor Cells Alleviates Their Immunosuppressive Activity Open
Representative IHC staining of CD39 expression in vascular endothelial cells and lymphocytes from various normal tissues (clone 22A9).
View article: Supplementary Figure 5 from Inhibition of CD39 Enzymatic Function at the Surface of Tumor Cells Alleviates Their Immunosuppressive Activity
Supplementary Figure 5 from Inhibition of CD39 Enzymatic Function at the Surface of Tumor Cells Alleviates Their Immunosuppressive Activity Open
CD39 ATPase activity can be assessed by measuring exogenous ATP consumption or phosphate release.
View article: Supplementary Figure 2 from Inhibition of CD39 Enzymatic Function at the Surface of Tumor Cells Alleviates Their Immunosuppressive Activity
Supplementary Figure 2 from Inhibition of CD39 Enzymatic Function at the Surface of Tumor Cells Alleviates Their Immunosuppressive Activity Open
Representative IHC staining of CD39 expression in vascular endothelial cells and lymphocytes from various normal tissues (clone 22A9).
View article: Supplementary Figure 3 from Inhibition of CD39 Enzymatic Function at the Surface of Tumor Cells Alleviates Their Immunosuppressive Activity
Supplementary Figure 3 from Inhibition of CD39 Enzymatic Function at the Surface of Tumor Cells Alleviates Their Immunosuppressive Activity Open
Representative IHC staining of CD39 expression in vascular endothelial cells and lymphocytes from various normal tissues (clone HPA014067).
View article: Supplementary Figure 5 from Inhibition of CD39 Enzymatic Function at the Surface of Tumor Cells Alleviates Their Immunosuppressive Activity
Supplementary Figure 5 from Inhibition of CD39 Enzymatic Function at the Surface of Tumor Cells Alleviates Their Immunosuppressive Activity Open
CD39 ATPase activity can be assessed by measuring exogenous ATP consumption or phosphate release.
View article: The organizer of chromatin topology RIF1 ensures cellular resilience to DNA replication stress
The organizer of chromatin topology RIF1 ensures cellular resilience to DNA replication stress Open
Eukaryotic genomes are duplicated from thousands of replication origins that fire sequentially forming a defined spatiotemporal pattern of replication clusters. The temporal order of DNA replication is determined by chromatin architecture …
View article: Constituents, Enantiomeric Content, and ChE Inhibitory Activity of the Essential Oil from Hypericum laricifolium Juss. Aerial Parts Collected in Ecuador
Constituents, Enantiomeric Content, and ChE Inhibitory Activity of the Essential Oil from Hypericum laricifolium Juss. Aerial Parts Collected in Ecuador Open
The physical properties, chemical composition, enantiomer distribution, and cholinesterase (ChE) inhibitory activity were determined for a steam-distilled essential oil (EO), with a yield of 0.15 ± 0.05 % (w/w), from H. laricifolium aerial…
View article: Paleoseismological investigations of the La Rouvière fault, unexpected source of the 11-11-2019, Mw 4.9 Le Teil surface rupturing earthquake (Cévennes fault system, France)
Paleoseismological investigations of the La Rouvière fault, unexpected source of the 11-11-2019, Mw 4.9 Le Teil surface rupturing earthquake (Cévennes fault system, France) Open
This document synthesizes illustrations of the 2019 Le Teil earthquake surface effects and of the further paleoseismological investigations. The reported outcrops were described to the attendance of the 2022 INQUA PATA Days that were held …
View article: Targeting the splicing isoforms of spleen tyrosine kinase affects the viability of colorectal cancer cells
Targeting the splicing isoforms of spleen tyrosine kinase affects the viability of colorectal cancer cells Open
Spleen tyrosine kinase (Syk) expression have been both positively and negatively associated with tumorigenesis. Our goal was to evaluate the contribution of Syk and its two splice variants, full length Syk (L) and short isoform Syk (S), in…
View article: Chemical Characterization and Biological Activity of the Essential Oil from Araucaria brasiliensis Collected in Ecuador
Chemical Characterization and Biological Activity of the Essential Oil from Araucaria brasiliensis Collected in Ecuador Open
The purpose of this study was to determine the chemical composition, physical properties, enantiomeric composition and cholinesterase inhibitory activity of the essential oil (EO) steam-distilled from the leaves of the plant Araucaria bras…
View article: The 2019 Le Teil surface-rupturing earthquake along the La Rouvière Fault within the Cévennes fault system (France): What does paleoseismology reveal?
The 2019 Le Teil surface-rupturing earthquake along the La Rouvière Fault within the Cévennes fault system (France): What does paleoseismology reveal? Open
The 2019-11-1, Mw4.9 Le Teil earthquake occurred within the NE termination of the Cévennes faults system (CFS) in southern France, along the La Rouvière fault (LRF), an Oligocene normal fault which was not known to be potentially active. T…
View article: Selective BuChE Inhibitory Activity, Chemical Composition, and Enantiomeric Content of the Essential Oil from Salvia leucantha Cav. Collected in Ecuador
Selective BuChE Inhibitory Activity, Chemical Composition, and Enantiomeric Content of the Essential Oil from Salvia leucantha Cav. Collected in Ecuador Open
The essential oil (EO) of Salvia leucantha Cav. was isolated by steam distillation of the aerial parts collected in the South of Ecuador. Its physical properties were evaluated and the chemical composition of the oil was determined by GC-M…
View article: Chemical Composition and Anticholinesterase Activity of the Essential Oil of Leaves and Flowers from the Ecuadorian Plant Lepechinia paniculata (Kunth) Epling
Chemical Composition and Anticholinesterase Activity of the Essential Oil of Leaves and Flowers from the Ecuadorian Plant Lepechinia paniculata (Kunth) Epling Open
This work aimed to study the chemical composition, cholinesterase inhibitory activity, and enantiomeric analysis of the essential oil from the aerial parts (leaves and flowers) of the plant Lepechinia paniculata (Kunth) Epling from Ecuador…
View article: A Novel Chemical Profile of a Selective In Vitro Cholinergic Essential Oil from Clinopodium taxifolium (Kunth) Govaerts (Lamiaceae), a Native Andean Species of Ecuador
A Novel Chemical Profile of a Selective In Vitro Cholinergic Essential Oil from Clinopodium taxifolium (Kunth) Govaerts (Lamiaceae), a Native Andean Species of Ecuador Open
A novel chemical profile essential oil, distilled from the aerial parts of Clinopodium taxifolium (Kunth) Govaerts (Lamiaceae), was analysed by Gas Chromatography-Mass Spectrometry (GC-MS, qualitative analysis) and Gas Chromatography with …
View article: Chemical composition and selective BuChE inhibitory activity of the essential oils from aromatic plants used to prepare the traditional Ecuadorian beverage horchata lojana
Chemical composition and selective BuChE inhibitory activity of the essential oils from aromatic plants used to prepare the traditional Ecuadorian beverage horchata lojana Open
According to the main components of the EOs distilled from the five groups of horchata lojana plants, four aromatic profiles have been defined: (i) neral + geranial + carvone, (ii) neral + geranial + myrcene; (iii) geranial + methyl eugeno…
View article: Distribution of de novo Donor-Specific Antibody Subclasses Quantified by Mass Spectrometry: High IgG3 Proportion Is Associated With Antibody-Mediated Rejection Occurrence and Severity
Distribution of de novo Donor-Specific Antibody Subclasses Quantified by Mass Spectrometry: High IgG3 Proportion Is Associated With Antibody-Mediated Rejection Occurrence and Severity Open
Donor-specific antibodies (DSAs) are the main risk factor for antibody-mediated rejection (ABMR) and graft loss but could have variable pathogenicity according to their IgG subclass composition. Luminex-based test might lack sensitivity fo…
View article: Chemical Composition and Anticholinesterase Activity of the Essential Oil from the Ecuadorian Plant Salvia pichinchensis Benth
Chemical Composition and Anticholinesterase Activity of the Essential Oil from the Ecuadorian Plant Salvia pichinchensis Benth Open
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