Explanipedia

#302 Long-term efficacy and impact on quality of life of difelikefalin treatment in haemodialysed patients with moderate-to-severe chronic kidney disease associated pruritus Open

Anne Lemy, Sophie Herman, Christophe Lelubre, Serge Treille de Grandsaigne · 2025

Background and Aims Chronic kidney disease associated pruritus (CKD-aP) is a frequent symptom in patients undergoing maintenance dialysis. It has been associated with reduced quality of life (QoL), depression, sleep disturbance and increas…

Implementation and sustainability study of a patient’s own medications management policy in the hospital using the RE-AIM framework Open

Camille Hoornaert, Larissa Zubryckyj, Christophe Lelubre, Sophie Lorent, Stéphanie Pochet · 2025

Objective The main objective was to develop a policy for the management of patients’ own medications (POM) in a tertiary university hospital and to evaluate the outcomes of its implementation. The secondary objective was to explore the eff…

Mepolizumab in patients with lymphoid-variant hypereosinophilic syndrome: A multicenter prospective study Open

Julien Catherine, Sina Karimi, Laurent Dewispelaere, Christophe Lelubre, Liliane Schandené , et al. · 2025

Assessment of the Inter-Frequency Amplitude Ratio (1000/500 Hz) in cVEMP and oVEMP for the Diagnosis of Ménière’s Disease Open

S Drabkin, Antonino Maniaci, Mario Lentini, Giannicola Iannella, Sophie Tainmont , et al. · 2024

Objectives: to retrospectively evaluate the clinical relevance of the 1000/500 Hz inter-frequency amplitude ratio (IFAR) in cervical and ocular vestibular evoked myogenic potentials (cVEMPs and oVEMPs) in patients with unilateral definite …

Electroneurography and peripheral neuropathy in diabetic subjects in Lubumbashi Open

Jean-Paul Ngoy Mande, Eunice Bilonda Mbuyamba, Paul Musa Obadia, Dophra Ngoy Nkulu, Célestin Banza Lubaba , et al. · 2024

INTRODUCTION : The practice of electroneurography is not common in Congolese environment, which makes early diagnosis of peripheral neuropathies such as those due to diabetes difficult. OBJECTIVE To characterize the electroneurography para…

Will ChatGPT soon replace otolaryngologists? Open

Quentin Mat, Giovanni Briganti, Antonino Maniaci, Christophe Lelubre · 2024

Influence of a Surgical Mask on Voice Analysis in Dysphonic Patients During the COVID‐19 Pandemic Open

Rupal Mehta, Quentin Mat, Antonino Maniaci, Christophe Lelubre, Jean‐Pierre Duterme · 2024

Objective COVID‐19 has radically changed medical practice. The main objective of this study was to assess the impact of surgical mask (SM) on voice quality analyzes in a group of patient with different common benign vocal organic pathologi…

Influence of the Electrode Montage to Detect Ocular Vestibular Evoked Myogenic Potentials Open

Quentin Mat, Naïma Deggouj, Jean‐Pierre Duterme, Sophie Tainmont, Christophe Lelubre , et al. · 2023

Objective To compare ocular vestibular evoked myogenic potentials (oVEMPs) obtained with three different electrode montages (infra-orbital vs belly-tendon vs chin) in a group of healthy subjects. To assess the electrical activity recorded …

Plasma fibrinogen: An important piece of the COVID-19 ICU delirium puzzle? Open

Sarah Saxena, Alexandre‐Raphael Wery, Adrian Khelif, Marie-Laure Nisolle, Christophe Lelubre , et al. · 2022

Influence of a surgical mask on voice analysis in healthy subjects in the <span>COVID</span> ‐19 pandemic: A cross‐over study Open

Rupal Mehta, Quentin Mat, Christophe Lelubre, Jérôme R. Lechien, Jean‐Pierre Duterme · 2022

Prevalence and Impact of Atrial Fibrillation on Intra-Hospital Mortality in Patients Aged ≥75 Years Open

Christophe de Terwangne, Christophe Lelubre, Pierre Hanotier, Antoine de Meester, Olivier Descamps , et al. · 2022

Using Narrow Band CE-Chirps to Elicit Cervical Vestibular Evoked Myogenic Potentials Open

Quentin Mat, Naïma Deggouj, Jean‐Pierre Duterme, Sophie Tainmont, Christophe Lelubre , et al. · 2021

Objectives: To compare the effects of Narrow band CE-Chirps (NB CE-Chirps) and tone bursts (TBs) at 500 Hz and 1000 Hz on the amplitudes and latencies in cervical vestibular evoked myogenic potentials (cVEMPs). Design: Thirty-one healthy a…

512 - The impact of the Health Crisis on the psychological feeling of patients during the second wave of Covid-19 in Geriatric wards. Open

S. Higuet, L. Berte, F. Kromar, Christophe Lelubre, J P Praet , et al. · 2021

Objectives During the Covid Health crisis, Belgium is one of the countries that currently counts a very high rate mortality among the elderly population.With more than 24,000 deaths, including more than 10 000 nursing home patients (for a …

Intraoperative imaging with mobile CT in endoscopic pituitary surgery: An early experience Open

C. Chaskis, Jean‐Pierre Duterme, Nabil Daoudi, Zakariae Benyaich, Nathalie Gauquier , et al. · 2021

Optimizing Ocular Vestibular Evoked Myogenic Potentials With Narrow Band CE-Chirps Open

Quentin Mat, Jean‐Pierre Duterme, Sophie Tainmont, Christophe Lelubre, Mario Manto · 2021

Objectives: To evaluate the effects of narrow band CE-Chirp (NB CE-Chirp) on the amplitudes and latencies in ocular vestibular evoked myogenic potentials (oVEMPs) at 500 and 1000 Hz in comparison with tone burst (TB). Design: Twenty-one he…

Spherization of red blood cells and platelet margination in COPD patients Open

Karim Zouaoui Boudjeltia, Christos Kotsalos, Daniel Ribeiro de Sousa, Alexandre Fontaine Rousseau, Christophe Lelubre , et al. · 2020

Red blood cells (RBCs) in pathological situations undergo biochemical and conformational changes, leading to alterations in rheology involved in cardiovascular events. The shape of RBCs in volunteers and stable and exacerbated chronic obst…

Spherization of red blood cells and platelets margination in COPD patients Open

Karim Zouaoui Boudjeltia, Christos Kotsalos, Daniel Malta Ribeiro, Alexandre Fontaine Rousseau, Christophe Lelubre , et al. · 2020

Rationale There are important interactions between Red Blood Cells (RBCs) and platelets in the bloodstream. These interactions lead to a phenomenon called margination. RBCs in pathological situations undergo biochemical and conformational …

Identification and characterization of the Onchocerca volvulus Excretory Secretory Product Ov28CRP, a putative GM2 activator protein Open

Ferdinand Ngale Njume, Stephen Mbigha Ghogomu, Robert Adamu Shey, Lea Olive Tchouate Gainkam, Philippe Poelvoorde , et al. · 2019

Onchocerca volvulus is the nematode pathogen responsible for human onchocerciasis also known as "River blindness", a neglected tropical disease that affects up to 18 million people worldwide. Helminths Excretory Secretory Products (ESPs) c…

Prediction and validation of the structural features of Ov58GPCR, an immunogenic determinant of Onchocerca volvulus Open

Robert Adamu Shey, Stephen Mbigha Ghogomu, Ferdinand Ngale Njume, Lea Olive Tchouate Gainkam, Philippe Poelvoorde , et al. · 2018

Onchocerciasis is a severely debilitating yet neglected tropical disease (NTD) that creates social stigma, generates and perpetuates poverty, and leads ultimately in some cases to irreversible unilateral or bilateral blindness if untreated…

Data on myeloperoxidase-oxidized low-density lipoproteins stimulation of cells to induce release of resolvin-D1 Open

Damien Dufour, Alia Khalil, Vincent Nuyens, Alexandre Fontaine Rousseau, Cédric Delporte , et al. · 2018

This article present data related to the publication entitled "Native and myeloperoxidase-oxidized low-density lipoproteins act in synergy to induce release of resolvin-D1 from endothelial cells" (Dufour et al., 2018). The supporting mater…

Mitochondrial fragmentation affects neither the sensitivity to TNFα-induced apoptosis of Brucella-infected cells nor the intracellular replication of the bacteria Open

Elodie Lobet, Kévin Willemart, Noëlle Ninane, Catherine Demazy, Jarosław Sędzicki , et al. · 2018

The sicker the patient, the more likely that transfusion will be beneficial Open

Jean‐Louis Vincent, Christophe Lelubre · 2017

Although there is a general consensus that decisions to transfuse should not be based on hemoglobin concentrations alone (1), many people still limit blood transfusions to patients with hemoglobin concentrations less than 7 g/dL, because t…

Relationship between oxidative stress and erectile function Open

Thierry Roumeguère, Pierre Van Antwerpen, Hanie Fathi, Alexandre Fontaine Rousseau, Luc Vanhamme , et al. · 2017

The aim of this study was to investigate markers of inflammation and oxidative stress in the corpus cavernosum (CC) and to compare levels of inflammatory markers recorded in CC to venous blood from the arm to examine the potential impact o…

Leukocyte phosphodiesterase expression after lipopolysaccharide and during sepsis and its relationship with HLA-DR expression Open

Christophe Lelubre, Hayfa Medfai, Israa Akl, Jenneke Leentjens, Matthijs Kox , et al. · 2017

Phosphodiesterases (PDEs) may modulate inflammatory pathways, but PDE expression is poorly documented in humans with sepsis. Using quantitative PCR on whole blood leukocytes, we characterized PDE mRNA expression in healthy volunteers (n = …

The presence of modified nucleosides in extracellular fluids leads to the specific incorporation of 5-chlorocytidine into RNA and modulates the transcription and translation Open

Caroline Noyon, Thierry Roumeguère, Cédric Delporte, Damien Dufour, Melissa Cortese , et al. · 2017

Apolipoprotein L Expression Correlates with Neutrophil Cell Death in Critically Ill Patients Open

Israa Akl, Christophe Lelubre, Pierrick Uzureau, Michaël Piagnerelli, Patrick Biston , et al. · 2016

Delayed neutrophil apoptosis has been demonstrated in sepsis and may contribute to organ damage. It has recently been proposed that apolipoprotein L (ApoL) may be involved in programmed cell death, but the expression and functions of ApoLs…

Anemia management after acute brain injury Open

Christophe Lelubre, Pierre Bouzat, Ilaria Alice Crippa, Fabio Silvio Taccone · 2016

A spatio-temporal model for spontaneous thrombus formation in cerebral aneurysms Open

Orestis Malaspinas, Alexis Turjman, Daniel Ribeiro de Sousa, Guillermo Garcı́a-Cardeña, Martine Raes , et al. · 2015

We propose a new numerical model to describe thrombus formation in cerebral aneurysms. This model combines CFD simulations with a set of bio-mechanical processes identified as being the most important to describe the phenomena at a large s…

Expression of apolipoproteins L in neutrophils during sepsis Open

Israa Akl, Christophe Lelubre, Michaël Piagnerelli, Patrick Biston, Pierrick Uzureau , et al. · 2015

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