Christophe Malcus
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View article: Preliminary evaluation of a whole blood dual-platform flow cytometry protocol for CAR-T cell quantitation: Toward accreditation and clinical routine application
Preliminary evaluation of a whole blood dual-platform flow cytometry protocol for CAR-T cell quantitation: Toward accreditation and clinical routine application Open
Chimeric Antigen Receptor T-cells, commonly known as CAR-T cells, have represented a major scientific breakthrough in cancer cell therapy revolutionizing the treatment of haematological disorders. Pharmacokinetic studies highlighted the im…
View article: B‐cell immune deficiency in twin sisters expands the phenotype of <scp>MOPDI</scp>
B‐cell immune deficiency in twin sisters expands the phenotype of <span>MOPDI</span> Open
Microcephalic osteodysplastic primordial dwarfism type I (MOPDI) is a very rare and severe autosomal recessive disorder characterized by marked intrauterine growth retardation, skeletal dysplasia, microcephaly and brain malformations. MOPD…
View article: Pre–Covid-19, SARS-CoV-2–Negative Multisystem Inflammatory Syndrome in Children
Pre–Covid-19, SARS-CoV-2–Negative Multisystem Inflammatory Syndrome in Children Open
To The Editor:\nIn early 2020, multisystemic inflammatory syndrome in children (MIS-C) was recognized as an emerging life-threatening disease occurring 2 to 6 weeks after infection with severe acute respiratory syndrome coronavirus 2 (SARS…
View article: Correction to: Recombinant human interleukin-7 reverses T cell exhaustion ex vivo in critically ill COVID-19 patients
Correction to: Recombinant human interleukin-7 reverses T cell exhaustion ex vivo in critically ill COVID-19 patients Open
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View article: Polyclonal expansion of TCR Vβ 21.3 <sup>+</sup> CD4 <sup>+</sup> and CD8 <sup>+</sup> T cells is a hallmark of multisystem inflammatory syndrome in children
Polyclonal expansion of TCR Vβ 21.3 <sup>+</sup> CD4 <sup>+</sup> and CD8 <sup>+</sup> T cells is a hallmark of multisystem inflammatory syndrome in children Open
MIS-C is characterized by a polyclonal activation of Vβ21.3 + CD4 + and CD8 + T cells that poorly respond to SARS-CoV-2 antigens.
View article: LACC1 deficiency links juvenile arthritis with autophagy and metabolism in macrophages
LACC1 deficiency links juvenile arthritis with autophagy and metabolism in macrophages Open
Juvenile idiopathic arthritis is the most common chronic rheumatic disease in children, and its etiology remains poorly understood. Here, we explored four families with early-onset arthritis carrying homozygous loss-of-expression mutations…
View article: Superantigenic TCR Vbeta 21.3 signature in Multisystem Inflammatory Syndrome in Children
Superantigenic TCR Vbeta 21.3 signature in Multisystem Inflammatory Syndrome in Children Open
Objectives Multiple Inflammatory Syndrome in Children (MIS-C) is the most severe pediatric form of COVID-19 and occurs in previously healthy children. MIS-C combines features of Kawasaki disease and Toxic Shock Syndrome (TSS). Methods Chil…
View article: Torque Teno Virus Viral Load as a Marker of Immune Function in Allogeneic Haematopoietic Stem Cell Transplantation Recipients
Torque Teno Virus Viral Load as a Marker of Immune Function in Allogeneic Haematopoietic Stem Cell Transplantation Recipients Open
Torque teno virus (TTV) has been proposed as a surrogate biomarker of T-cell function in allogeneic–haematopoietic–stem-cell transplantation (allo-HSCT). Conflicting data exists regarding the value of TTV to assess the degree of immunosupp…
View article: Clinical Heterogeneity of Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked Syndrome: A French Multicenter Retrospective Study
Clinical Heterogeneity of Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked Syndrome: A French Multicenter Retrospective Study Open
The broad phenotypic heterogeneity of IPEX raises questions about modifying factors and justifies early FOXP3 sequencing in suspected cases.
View article: Issue Information
Issue Information Open
seeks to address the environmental, social, economic, and ethical challenges faced in our business and which are important to our diverse stakeholder groups.Since launching the initiative, we have focused on sharing our content with those …
View article: T-Lymphocytes Traffic into the Brain across the Blood-CSF Barrier: Evidence Using a Reconstituted Choroid Plexus Epithelium
T-Lymphocytes Traffic into the Brain across the Blood-CSF Barrier: Evidence Using a Reconstituted Choroid Plexus Epithelium Open
An emerging concept of normal brain immune surveillance proposes that recently and moderately activated central memory T lymphocytes enter the central nervous system (CNS) directly into the cerebrospinal fluid (CSF) via the choroid plexus.…
View article: Evaluation of a novel automated volumetric flow cytometer for absolute CD4+ T lymphocyte quantitation
Evaluation of a novel automated volumetric flow cytometer for absolute CD4+ T lymphocyte quantitation Open
Background Bead‐based single platform cytometry technology (SPT) is the gold standard when performing CD4 absolute counting. However, it presents drawbacks as precision depends on various critical steps (for example, pipetting methodology,…
View article: Effect of pneumatic tube transport on T lymphocyte subsets analysis
Effect of pneumatic tube transport on T lymphocyte subsets analysis Open
Background Pneumatic tube system (PTS) for transportation of blood specimens may present with advantages for hospital organization as it provides faster tube transfer from medical wards to routine labs. These characteristics are expected t…
View article: Increased Regulatory T-Cell Percentage Contributes to Poor CD4+ Lymphocytes Recovery: A 2-Year Prospective Study After Introduction of Antiretroviral Therapy
Increased Regulatory T-Cell Percentage Contributes to Poor CD4+ Lymphocytes Recovery: A 2-Year Prospective Study After Introduction of Antiretroviral Therapy Open
Background. The primary aim of this study was to determine the impact of regulatory T cells (Tregs) percentage on immune recovery in human immunodeficiency virus (HIV)-infected patients after antiretroviral therapy introduction. Methods. A…