Christophe Melon
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View article: Chamber implant for chronic optical recordings from the cerebral cortex of marmosets
Chamber implant for chronic optical recordings from the cerebral cortex of marmosets Open
Currently, our chamber already provides a durable solution for long-term imaging in marmosets. Yet, we discuss a few straightforward modifications that may improve its performance even further.
View article: Chamber Implant for Chronic Optical Recordings from the Cerebral Cortex of Marmosets
Chamber Implant for Chronic Optical Recordings from the Cerebral Cortex of Marmosets Open
We describe a novel imaging chamber for chronic optical recordings from the marmoset cerebral cortex, together with the surgery needed for its implantation and that of an associated headpost. MRI data allow optimizing positioning on the sk…
View article: Cocaine withdrawal enhances subthalamic reward sensitivity
Cocaine withdrawal enhances subthalamic reward sensitivity Open
High-frequency stimulation of the subthalamic nucleus (STN) has shown therapeutic potential in preclinical models of addiction. However, its rewarding properties remain unclear. Here, we show that cocaine withdrawal enhances STN intracrani…
View article: Treatment with bark extracts of Voacanga africana attenuates motor coordination deficit, depressive-like behavior and microglial reaction, in a mouse model of early Parkinson's disease
Treatment with bark extracts of Voacanga africana attenuates motor coordination deficit, depressive-like behavior and microglial reaction, in a mouse model of early Parkinson's disease Open
Background: Voacanga africana (VOC) has been widely used for many years in the African traditional medicine system for the treatment of a wide range of diseases, including mental disorders but VOC has never been tested in vivo in the conte…
View article: Inhibition of cholinergic interneurons potentiates corticostriatal transmission in D1 receptor-expressing medium-sized spiny neurons and restores motor learning in parkinsonian condition
Inhibition of cholinergic interneurons potentiates corticostriatal transmission in D1 receptor-expressing medium-sized spiny neurons and restores motor learning in parkinsonian condition Open
SUMMARY Striatal cholinergic interneurons (CINs) respond to salient or reward prediction-related stimuli after conditioning with brief pauses in their activity, implicating them in learning and action selection. This pause is lost in anima…
View article: Enhanced differentiation of human induced pluripotent stem cells toward the midbrain dopaminergic neuron lineage through GLYPICAN-4 downregulation
Enhanced differentiation of human induced pluripotent stem cells toward the midbrain dopaminergic neuron lineage through GLYPICAN-4 downregulation Open
Enhancing the differentiation potential of human induced pluripotent stem cells (hiPSC) into disease-relevant cell types is instrumental for their widespread application in medicine. Here, we show that hiPSCs downregulated for the signalin…
View article: Inhibition of the Mitochondrial Glutamate Carrier SLC25A22 in Astrocytes Leads to Intracellular Glutamate Accumulation
Inhibition of the Mitochondrial Glutamate Carrier SLC25A22 in Astrocytes Leads to Intracellular Glutamate Accumulation Open
The solute carrier family 25 (SLC25) drives the import of a large diversity of metabolites into mitochondria, a key cellular structure involved in many metabolic functions. Mutations of the mitochondrial glutamate carrier SLC25A22 (also na…