Christophe Baudouin
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View article: Influence of continuous positive airway pressure on optic nerve head vascularization in patients with severe obstructive sleep apnea syndrome: an OCT-angiography study
Influence of continuous positive airway pressure on optic nerve head vascularization in patients with severe obstructive sleep apnea syndrome: an OCT-angiography study Open
Objective : To evaluate the influence of continuous positive airway pressure (CPAP) on the vascularization of the optic nerve head using optical coherence tomography angiography (OCT-A) in patients with severe obstructive sleep apnea syndr…
View article: TRPA1 inhibition reduces ocular pain and corneal neurogenic inflammation in a mouse model of dry eye disease
TRPA1 inhibition reduces ocular pain and corneal neurogenic inflammation in a mouse model of dry eye disease Open
Dry eye disease (DED) is characterized by neurosensory abnormalities, complicating the management of ocular pain, and is further worsened by significant ocular inflammation. Although multiple inflammatory pathways contribute to DED, the ro…
View article: <scp>Drug</scp> ‐ <scp>Induced Periocular and Ocular Surface Disorders</scp> : An <scp>EAACI</scp> Position Paper
<span>Drug</span> ‐ <span>Induced Periocular and Ocular Surface Disorders</span> : An <span>EAACI</span> Position Paper Open
Various systemic and topical medications can induce ocular and periocular cutaneous adverse effects (AEs), ranging from mild to severe. These AEs may lead to ocular surface (OS) damage and, in some cases, life‐threatening complications. Dr…
View article: A Model to Estimate the Unmedicated Intraocular Pressure of Patients on Glaucoma Medications
A Model to Estimate the Unmedicated Intraocular Pressure of Patients on Glaucoma Medications Open
Précis: This report presents a model that can be used to determine the IOP-lowering effect of a glaucoma procedure or treatment when a medication washout is not ethical or not possible to be performed. Background: The effect of individual …
View article: From Molecular Understanding and Pathophysiology to Disease Management; A Practical Approach and Guidance to the Management of the Ocular Manifestations of Cystinosis
From Molecular Understanding and Pathophysiology to Disease Management; A Practical Approach and Guidance to the Management of the Ocular Manifestations of Cystinosis Open
Cystinosis is a rare lysosomal storage disease characterised by cystine crystal formation within cells. In the eyes, crystals accumulate in the cornea causing photophobia, loss of visual acuity, and corneal complications. Strict adherence …
View article: Transmission interference microscopy of anterior human eye
Transmission interference microscopy of anterior human eye Open
Cellular imaging of the human anterior eye is critical for understanding complex ophthalmic diseases, yet current techniques are constrained by a limited field of view or insufficient contrast. Here, we demonstrate that Ernst Abbe’s founda…
View article: Association Between Preserved Glaucoma Eye Drops Exposure and Glaucoma Surgery Occurrence: A Nationwide 10-Year Outcome Study
Association Between Preserved Glaucoma Eye Drops Exposure and Glaucoma Surgery Occurrence: A Nationwide 10-Year Outcome Study Open
The risk of glaucoma surgery was associated with the level of exposure to preserved glaucoma eye drops in this nationwide cohort study. Large-scale, randomized studies would be beneficial to investigate whether PF eye drops could decrease …
View article: The arterial stiffness and pulse pressure are predictors of intraocular pressure in a middle-aged population
The arterial stiffness and pulse pressure are predictors of intraocular pressure in a middle-aged population Open
View article: TFOS DEWS III: Management and Therapy
TFOS DEWS III: Management and Therapy Open
This report provides an evidence-based review of current strategies to manage dry eye disease (DED). First-line management focuses on methods to replenish, conserve, and stimulate the tear film, with an emphasis on ocular supplements, whic…
View article: Deficiency of antioxidant enzyme PRDX6 and mucosal chemokine CXCL17: unraveling the factors behind oxidative stress and mucosal homeostasis disruption in dry eye disease
Deficiency of antioxidant enzyme PRDX6 and mucosal chemokine CXCL17: unraveling the factors behind oxidative stress and mucosal homeostasis disruption in dry eye disease Open
This study aimed to identify dysregulated proteins in Schirmer strip samples (ScS) from Sjögren's syndrome dry eye (SSDE) patients to uncover key biological processes using untargeted proteomics. The focus then shifted to two dysregulated …
View article: A narrative literature review about alpha‐lipoic acid role in dry eye and ocular surface disease
A narrative literature review about alpha‐lipoic acid role in dry eye and ocular surface disease Open
Ocular surface diseases (OSD) include various conditions that affect the eye's surface, causing discomfort and pain. One such condition, dry eye disease (DED), is a multifactorial disorder that significantly impacts patients' quality of li…
View article: Parainflammation in the Ocular System: Considerations on the Underlying Mechanisms and Treatment of Dry Eye Disease
Parainflammation in the Ocular System: Considerations on the Underlying Mechanisms and Treatment of Dry Eye Disease Open
View article: Adherence and Persistence on Prostaglandin Analogues for Glaucoma: A Systematic Review and Meta-Analysis
Adherence and Persistence on Prostaglandin Analogues for Glaucoma: A Systematic Review and Meta-Analysis Open
Suboptimal adherence and persistence with PGAs are common, with further decreases as duration lengthens. These findings may underscore the value of procedural glaucoma treatments that do not depend on daily patient engagement with topical …
View article: A phase III study comparing preservative-free latanoprost eye drop emulsion with preserved latanoprost in open-angle glaucoma or ocular hypertension
A phase III study comparing preservative-free latanoprost eye drop emulsion with preserved latanoprost in open-angle glaucoma or ocular hypertension Open
Background/Objectives To evaluate the efficacy and safety of preservative-free latanoprost eye drop emulsion in reducing intraocular pressure (IOP) versus preserved latanoprost in open-angle glaucoma (OAG) or ocular hypertension (OHT). Met…
View article: Management and toxicological analysis of ocular hypertension after EyeCee® ONE intraocular lens implantation: a case series
Management and toxicological analysis of ocular hypertension after EyeCee® ONE intraocular lens implantation: a case series Open
View article: Arid3c identifies an uncharacterized subpopulation of V2 interneurons during embryonic spinal cord development
Arid3c identifies an uncharacterized subpopulation of V2 interneurons during embryonic spinal cord development Open
Motor activity is organized by neuronal networks composed of motor neurons and a wide variety of pre-motor interneuron populations located in the brainstem and spinal cord. Differential expression and single-cell RNA sequencing studies rec…
View article: Evaluation of a new classification system for measuring the progression of ocular cystinosis: an analysis of 64 patients
Evaluation of a new classification system for measuring the progression of ocular cystinosis: an analysis of 64 patients Open
Aims To analyse the correlation between the physician categories defined by the 3C classification (crystal-complication-compliance) and the ocular manifestations of nephropathic cystinosis. Methods The last visit data of 64 patients aged b…
View article: Evaluation of Rho kinase inhibitor effects on neuroprotection and neuroinflammation in an ex-vivo retinal explant model
Evaluation of Rho kinase inhibitor effects on neuroprotection and neuroinflammation in an ex-vivo retinal explant model Open
Y-33075 demonstrates marked neuroprotective and anti-inflammatory effects, surpassing the other tested ROCKis (Y-27632 and H-1152) in preventing RGC death and reducing microglial inflammatory responses. These findings highlight its potenti…
View article: Three-Dimensional Microarchitecture of Lamina Cribrosa Pores in High and Normal Tension Glaucoma Using Optical Coherence Tomography
Three-Dimensional Microarchitecture of Lamina Cribrosa Pores in High and Normal Tension Glaucoma Using Optical Coherence Tomography Open
Précis: The lamina cribrosa (LC) pores of patients with high-tension glaucoma (HTG) appear to take a more tortuous pathway than the LC pores of patients with non-glaucomatous (NG). Objective: To compare the LC pore microarchitecture in pat…
View article: Multimodal Approach in Dry Eye Disease Combining In Vivo Confocal Microscopy and HLA-DR Expression
Multimodal Approach in Dry Eye Disease Combining In Vivo Confocal Microscopy and HLA-DR Expression Open
The IVCM grading score represents an interesting point of commonality among clinical parameters, imaging, and molecular investigation of the ocular surface.
View article: Preservatives and ocular surface disease: A review
Preservatives and ocular surface disease: A review Open
Ocular surface disease (OSD) is a complex condition that can cause a range of symptoms (e.g, dryness, irritation, and pain) and can significantly impact the quality of life of affected individuals. Iatrogenic OSD, a common finding in patie…
View article: Assessment of corneal nerve regeneration after axotomy in a compartmentalized microfluidic chip model with automated 3D high resolution live-imaging
Assessment of corneal nerve regeneration after axotomy in a compartmentalized microfluidic chip model with automated 3D high resolution live-imaging Open
Introduction Damage to the corneal nerves can result in discomfort and chronic pain, profoundly impacting the quality of life of patients. Development of novel in vitro method is crucial to better understand corneal nerve regeneration and …
View article: Lhx4 surpasses its paralog Lhx3 in promoting the differentiation of spinal V2a interneurons
Lhx4 surpasses its paralog Lhx3 in promoting the differentiation of spinal V2a interneurons Open
View article: The PRAMOS Study: PRostaglandin Analogues Monotherapy—Awareness Survey on Ocular Surface Involvement
The PRAMOS Study: PRostaglandin Analogues Monotherapy—Awareness Survey on Ocular Surface Involvement Open
View article: Oxygénothérapie hyperbare et maladies oculaires : une revue de la littérature
Oxygénothérapie hyperbare et maladies oculaires : une revue de la littérature Open
View article: Pharmacogenomic Analysis of Response to Topical Tumor Necrosis Factor α Antagonist Licaminlimab (OCS-02) in Dry Eye Disease [RETRACTED]
Pharmacogenomic Analysis of Response to Topical Tumor Necrosis Factor α Antagonist Licaminlimab (OCS-02) in Dry Eye Disease [RETRACTED] Open
The CC genotype of rs1800693, relatively common in patients with DED, was strongly associated with response to licaminlimab and decreased inflammatory cytokine gene expression in ocular surface cells during treatment. This study is one of …
View article: Review of clinical outcomes of a cationic emulsion tear substitute in patients with dry eye disease
Review of clinical outcomes of a cationic emulsion tear substitute in patients with dry eye disease Open
First‐line options for the treatment of dry eye disease (DED) rely on artificial tears (ATs), among which cationic emulsion (CE)‐based ATs have been developed in order to mimic the healthy tear film for an improved restoration of the ocula…
View article: Expanded biochemical analyses of human tear fluid: Polyvalent faces of the schirmer strip
Expanded biochemical analyses of human tear fluid: Polyvalent faces of the schirmer strip Open
View article: Implementing an artificial intelligence system to comprehensively manage people with glaucoma: a blueprint
Implementing an artificial intelligence system to comprehensively manage people with glaucoma: a blueprint Open
View article: Profiling tear film enzymes reveals major metabolic pathways involved in the homeostasis of the ocular surface
Profiling tear film enzymes reveals major metabolic pathways involved in the homeostasis of the ocular surface Open