Christopher A. Beaudoin
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View article: Structural electrobiology: architecture of the bioelectric code
Structural electrobiology: architecture of the bioelectric code Open
Bioelectrical signalling is fundamental for regulating biological processes in all forms of life. Ion channels and transporters generate and propagate electrical currents by selectively allowing ions to flow across membranes in response to…
View article: Similarity of drug targets to human microbiome metaproteome promotes pharmacological promiscuity
Similarity of drug targets to human microbiome metaproteome promotes pharmacological promiscuity Open
View article: The voltage-gated sodium channel β3 subunit modulates C6 glioma cell motility independently of channel activity
The voltage-gated sodium channel β3 subunit modulates C6 glioma cell motility independently of channel activity Open
Our data reveals a novel and unexpected role for the VGSC β3 subunit in orchestrating actin organization and negatively regulating cell migration in glioma cells which may potentially explain clinical correlations with glioma severity.
View article: Structural implications of glycosylation on the voltage-gated sodium channel β3-subunit
Structural implications of glycosylation on the voltage-gated sodium channel β3-subunit Open
Voltage-gated sodium (Na V ) channel α-subunits are modulated by associated β-subunits that affect their localization, trafficking and gating behaviour. The β-subunits are members of the immunoglobulin (Ig) domain family of cell-adhesion m…
View article: A novel SCN3B in-frame codon deletion in a Brugada syndrome patient: Implications for disrupted NaV1.5 function
A novel SCN3B in-frame codon deletion in a Brugada syndrome patient: Implications for disrupted NaV1.5 function Open
View article: Isoform-specific N-linked glycosylation of NaV channel α-subunits alters β-subunit binding sites
Isoform-specific N-linked glycosylation of NaV channel α-subunits alters β-subunit binding sites Open
Voltage-gated sodium channel α-subunits (NaV1.1–1.9) initiate and propagate action potentials in neurons and myocytes. The NaV β-subunits (β1–4) have been shown to modulate α-subunit properties. Homo-oligomerization of β-subunits on neighb…
View article: Anticancer Effects of New Disulfiram Analogs
Anticancer Effects of New Disulfiram Analogs Open
Disulfiram (DSF), an irreversible aldehyde dehydrogenase 2 (ALDH2) inhibitor, is an U.S. Food and Drug Administration (FDA)-approved drug for the treatment of chronic alcoholism. Recent studies have reported an interesting antitumor activi…
View article: Isoform-specific N-linked glycosylation of voltage-gated sodium channel alpha-subunits alters beta-subunit binding sites
Isoform-specific N-linked glycosylation of voltage-gated sodium channel alpha-subunits alters beta-subunit binding sites Open
Voltage-gated sodium channel beta-subunits (Nav1.1-1.9) initiate and propagate action potentials in neurons and myocytes. The Nav beta-subunits (beta1-4) have been shown to modulate beta-subunit properties. Homo-oligomerization of beta-sub…
View article: Similarity of drug targets to human microbiome metaproteome promotes pharmacological promiscuity
Similarity of drug targets to human microbiome metaproteome promotes pharmacological promiscuity Open
Similarity between candidate drug targets and human proteins is commonly assessed to minimize the occurrence of side effects. Although numerous drugs have been found to disrupt the health of the human microbiome, no comprehensive compariso…
View article: Modelling and Molecular Dynamics Predict the Structure and Interactions of the Glycine Receptor Intracellular Domain
Modelling and Molecular Dynamics Predict the Structure and Interactions of the Glycine Receptor Intracellular Domain Open
Glycine receptors (GlyRs) are glycine-gated inhibitory pentameric ligand-gated ion channels composed of α or α + β subunits. A number of structures of these proteins have been reported, but to date, these have only revealed details of the …
View article: SARS-CoV-2 Omicron subvariant spike N405 unlikely to rapidly deamidate
SARS-CoV-2 Omicron subvariant spike N405 unlikely to rapidly deamidate Open
The RGD motif on the SARS-CoV-2 spike protein has been suggested to interact with RGD-binding integrins αVβ3 and α5β1 to enhance viral cell entry and alter downstream signaling cascades. The D405N mutation on the Omicron subvariant spike p…
View article: In silico analysis of mutations near S1/S2 cleavage site in SARS‐CoV‐2 spike protein reveals increased propensity of glycosylation in Omicron strain
In silico analysis of mutations near S1/S2 cleavage site in SARS‐CoV‐2 spike protein reveals increased propensity of glycosylation in Omicron strain Open
Cleavage of the severe respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) spike protein has been demonstrated to contribute to viral‐cell fusion and syncytia formation. Studies have shown that variants of concern (VOC) and variants of interes…
View article: Unheeded SARS-CoV-2 proteins? A deep look into negative-sense RNA
Unheeded SARS-CoV-2 proteins? A deep look into negative-sense RNA Open
SARS-CoV-2 is a novel positive-sense single-stranded RNA virus from the Coronaviridae family (genus Betacoronavirus), which has been established as causing the COVID-19 pandemic. The genome of SARS-CoV-2 is one of the largest among known R…
View article: Are There Hidden Genes in DNA/RNA Vaccines?
Are There Hidden Genes in DNA/RNA Vaccines? Open
Due to the fast global spreading of the Severe Acute Respiratory Syndrome Coronavirus – 2 (SARS-CoV-2), prevention and treatment options are direly needed in order to control infection-related morbidity, mortality, and economic losses. Alt…
View article: Searching for New Z-DNA/Z-RNA Binding Proteins Based on Structural Similarity to Experimentally Validated Zα Domain
Searching for New Z-DNA/Z-RNA Binding Proteins Based on Structural Similarity to Experimentally Validated Zα Domain Open
Z-DNA and Z-RNA are functionally important left-handed structures of nucleic acids, which play a significant role in several molecular and biological processes including DNA replication, gene expression regulation and viral nucleic acid se…
View article: Can the SARS-CoV-2 Spike Protein Bind Integrins Independent of the RGD Sequence?
Can the SARS-CoV-2 Spike Protein Bind Integrins Independent of the RGD Sequence? Open
The RGD motif in the Severe Acute Syndrome Coronavirus 2 (SARS-CoV-2) spike protein has been predicted to bind RGD-recognizing integrins. Recent studies have shown that the spike protein does, indeed, interact with α V β 3 and α 5 β 1 inte…
View article: Predicted structural mimicry of spike receptor-binding motifs from highly pathogenic human coronaviruses
Predicted structural mimicry of spike receptor-binding motifs from highly pathogenic human coronaviruses Open
Summary Viruses often encode proteins that mimic host proteins in order to facilitate infection. Little work has been done to understand the potential mimicry of the SARS-CoV-2, SARS-CoV, and MERS-CoV spike proteins, particularly the recep…
View article: Predicted structural mimicry of spike receptor-binding motifs from highly pathogenic human coronaviruses
Predicted structural mimicry of spike receptor-binding motifs from highly pathogenic human coronaviruses Open
Viruses often encode proteins that mimic host proteins in order to facilitate infection. Little work has been done to understand the potential mimicry of the SARS-CoV-2, SARS-CoV, and MERS-CoV spike proteins, particularly the receptor-bind…
View article: SARS-CoV-2 3D database: understanding the coronavirus proteome and evaluating possible drug targets
SARS-CoV-2 3D database: understanding the coronavirus proteome and evaluating possible drug targets Open
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a rapidly growing infectious disease, widely spread with high mortality rates. Since the release of the SARS-CoV-2 genome sequence in March 2020, there has been an interna…
View article: Unheeded SARS-CoV-2 proteins? A deep look into negative-sense RNA
Unheeded SARS-CoV-2 proteins? A deep look into negative-sense RNA Open
SARS-CoV-2 is a novel positive-sense single-stranded RNA virus from the Coronaviridae family (genus Betacoronavirus ), which has been established as causing the COVID-19 pandemic. The genome of SARS-CoV-2 is one of the largest among known …
View article: Producing polished prokaryotic pangenomes with the Panaroo pipeline
Producing polished prokaryotic pangenomes with the Panaroo pipeline Open
View article: Producing Polished Prokaryotic Pangenomes with the Panaroo Pipeline
Producing Polished Prokaryotic Pangenomes with the Panaroo Pipeline Open
Population-level comparisons of prokaryotic genomes must take into account the substantial differences in gene content, resulting from frequent horizontal gene transfer, gene duplication and gene loss. However, the automated annotation of …
View article: Genetic Characterization of the Gut Microbiome of Hajj Pilgrims
Genetic Characterization of the Gut Microbiome of Hajj Pilgrims Open
Hajj, the annual Islamic pilgrimage to Makkah, Saudi Arabia, is a unique mass gathering event that brings more than 2 million individuals from around the world. Several public health considerations, such as the spread of infectious disease…
View article: The Emperor of All Maladies: A Biography of Cancer
The Emperor of All Maladies: A Biography of Cancer Open
A s both a medical student and a cancer patient, I found that the Pulitzer Prize–winning book The Emperor of All Maladies: A Biography of Cancer by Siddhartha Mukherjee, D.Phil., MD (Simon and Schuster, 2010), gave me at once a dose of kno…