Christopher A. Guidry
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View article: From past to present: A comparison of interpersonal firearm violence between historically graded neighborhoods of Kansas City
From past to present: A comparison of interpersonal firearm violence between historically graded neighborhoods of Kansas City Open
Historically redlined communities have higher rates of IFV in Kansas City, Kansas.
View article: Incidence of Pneumonia Following Bronchoscopy and Bronchoalveolar Lavage in Burn Patients
Incidence of Pneumonia Following Bronchoscopy and Bronchoalveolar Lavage in Burn Patients Open
The standard modality for diagnosis of smoke inhalational injury in burn patients is bronchoscopy with or without bronchoalveolar lavage (BAL). However, the risks associated with these procedures are poorly described in established literat…
View article: 2581. Desirability of Outcome Ranking and Response Adjusted for Antibiotic Risk (DOOR/RADAR) Post-Hoc Analysis Supports Equipoise for Antibiotic Initiation Strategies in ICU-Acquired Pneumonia
2581. Desirability of Outcome Ranking and Response Adjusted for Antibiotic Risk (DOOR/RADAR) Post-Hoc Analysis Supports Equipoise for Antibiotic Initiation Strategies in ICU-Acquired Pneumonia Open
Background Pneumonia is the most common ICU-acquired infection and source of potential sepsis in ICU populations but can be difficult to diagnose in real-time. Despite limited data, rapid initiation of antibiotics is endorsed by society gu…
View article: Exploring the Relationship between Fluid Administration and Postinjury Multiple Organ Failure: The Fluid and Organ Failure in Trauma Resuscitation Study (FORTRESS), Phase I
Exploring the Relationship between Fluid Administration and Postinjury Multiple Organ Failure: The Fluid and Organ Failure in Trauma Resuscitation Study (FORTRESS), Phase I Open
View article: Outcomes after ultramassive transfusion in the modern era: An Eastern Association for the Surgery of Trauma multicenter study
Outcomes after ultramassive transfusion in the modern era: An Eastern Association for the Surgery of Trauma multicenter study Open
BACKGROUND Despite the widespread institution of modern massive transfusion protocols with balanced blood product ratios, survival for patients with traumatic hemorrhage receiving ultramassive transfusion (UMT) (defined as ≥20 U of packed …
View article: Recent Anti-Microbial Exposure Is Associated with More Complications after Elective Surgery
Recent Anti-Microbial Exposure Is Associated with More Complications after Elective Surgery Open
Recent anti-microbial exposure is associated with more complications of elective surgery. Anti-microbial drug-induced alterations in microbiome-related inflammatory responses may play a role, highlighting an opportunity for pre-surgical in…
View article: Longer-Duration Antimicrobial Therapy Does Not Prevent Treatment Failure in High-Risk Patients with Complicated Intra-Abdominal Infections
Longer-Duration Antimicrobial Therapy Does Not Prevent Treatment Failure in High-Risk Patients with Complicated Intra-Abdominal Infections Open
We were able to identify patients at high risk for treatment failure in the STOP-IT trial. Such patients did not benefit from a longer course of antibiotic administration. Further study is needed to determine the optimum duration of antimi…
View article: Novel Method Suggests Global Superiority of Short-Duration Antibiotics for Intra-abdominal Infections
Novel Method Suggests Global Superiority of Short-Duration Antibiotics for Intra-abdominal Infections Open
Desirability of outcome ranking and response adjusted for duration of antibiotic risk (DOOR/RADAR) are novel and innovative methods of evaluating data in antibiotic trials. We analyzed data from a noninferiority trial of short-course antim…
View article: Unplanned Reoperation Following Colorectal Surgery: Indications and Operations
Unplanned Reoperation Following Colorectal Surgery: Indications and Operations Open
View article: Risk Associated With Complications and Mortality After Urgent Surgery vs Elective and Emergency Surgery
Risk Associated With Complications and Mortality After Urgent Surgery vs Elective and Emergency Surgery Open
This study highlights the need for improved risk stratification on the basis of urgency because operations performed urgently have distinct rates of morbidity and mortality compared with procedures performed either electively or emergently…
View article: Effect of hypothermia on splenic leukocyte modulation and survival duration in severely septic rats
Effect of hypothermia on splenic leukocyte modulation and survival duration in severely septic rats Open
View article: Operative Start Time Does Not Affect Post-Operative Infection Risk
Operative Start Time Does Not Affect Post-Operative Infection Risk Open
Our data suggest that operative start times have no correlation with post-operative infectious complications. Further work is required to identify the source of the time-dependent outcome variability observed in previous studies.
View article: Obesity Is Not Associated with Antimicrobial Treatment Failure for Intra-Abdominal Infection
Obesity Is Not Associated with Antimicrobial Treatment Failure for Intra-Abdominal Infection Open
Background: Obesity and commonly associated comorbidities are known risk factors for the development of infections. However, the intensity and duration of antimicrobial treatment are rarely conditioned on body mass index (BMI). In particul…
View article: Comparative effectiveness of catheter salvage strategies for pediatric catheter-related bloodstream infections
Comparative effectiveness of catheter salvage strategies for pediatric catheter-related bloodstream infections Open
View article: Top Guns: The “Maverick” and “Goose” of Empiric Therapy
Top Guns: The “Maverick” and “Goose” of Empiric Therapy Open
A difference in nephrotoxicity was not observed between vancomycin and vancomycin/piperacillin-tazobactam-treated patients at our institution. Concomitant use as empiric therapy is appropriate, although larger sample sizes are needed to an…
View article: Do Polymicrobial Intra-Abdominal Infections Have Worse Outcomes than Monomicrobial Intra-Abdominal Infections?
Do Polymicrobial Intra-Abdominal Infections Have Worse Outcomes than Monomicrobial Intra-Abdominal Infections? Open
Contrary to our hypothesis, polymicrobial IAI do not have worse outcomes than monomicrobial infections. These results suggest polymicrobial IAI can be treated the same as monomicrobial IAI.
View article: Observations on Surgeons’ Case Selection, Morbidity, and Mortality Following Board Certification
Observations on Surgeons’ Case Selection, Morbidity, and Mortality Following Board Certification Open
Surgical experience significantly impacts patient selection. Surgeons with over 25 years of experience had lower complication rates. Experience had no impact on mortality.
View article: Vancomycin-Associated Nephrotoxicity: The Obesity Factor
Vancomycin-Associated Nephrotoxicity: The Obesity Factor Open
No difference in nephrotoxicity was observed between lean and obese patients treated with vancomycin at our institution.
View article: Whence Resistance?
Whence Resistance? Open
Antimicrobial pressure exerts a substantial effect on the development of subsequent infection. Our data demonstrate a high estimated rate of de novo emergence of resistance after treatment, which appears to be more common than patient-to-p…
View article: Temporal Trends in Blood Stream Infection Isolates from Surgical Patients
Temporal Trends in Blood Stream Infection Isolates from Surgical Patients Open
Although our hypothesis was only partly true, over the last 12 y, our institution clearly has witnessed a shift in the types of organisms causing BSIs. There was a decrease in the rates of BSI caused by gram-positive pathogens with an asso…
View article: Can Nasal Methicillin-Resistant <i>Staphylococcus aureus</i> Screening Be Used to Avoid Empiric Vancomycin Use in Intra-Abdominal Infection?
Can Nasal Methicillin-Resistant <i>Staphylococcus aureus</i> Screening Be Used to Avoid Empiric Vancomycin Use in Intra-Abdominal Infection? Open
A negative MRSA nasal screen indicates with near certainty the absence of MRSA as part of an IAI. In the setting of a recent screen, empiric vancomycin can be withheld. Further, rapid MRSA nasal screening could be used to forego or to disc…
View article: Reducing Accidental Dislodgement of the Percutaneous Endoscopic Gastrostomy
Reducing Accidental Dislodgement of the Percutaneous Endoscopic Gastrostomy Open
Background. The percutaneous endoscopic gastrostomy (PEG) is a ubiquitous feeding tube with high rates of accidental dislodgement, with significant morbidity and health care costs. We hypothesized use of a decoupling device is a safe and e…
View article: Trial of Short-Course Antimicrobial Therapy for Intraabdominal Infection
Trial of Short-Course Antimicrobial Therapy for Intraabdominal Infection Open
In patients with intraabdominal infections who had undergone an adequate source-control procedure, the outcomes after fixed-duration antibiotic therapy (approximately 4 days) were similar to those after a longer course of antibiotics (appr…