Christopher A. Pennell
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View article: A Mouse Model of Neurotoxicity Induced by Human CD19-Specific CAR T-cells: CAR T-cells Accumulate in the Subarachnoid Space Prior to Trafficking into the Brain Parenchyma 3807
A Mouse Model of Neurotoxicity Induced by Human CD19-Specific CAR T-cells: CAR T-cells Accumulate in the Subarachnoid Space Prior to Trafficking into the Brain Parenchyma 3807 Open
Description Immune cell-associated neurotoxicity syndrome (ICANS) is a common morbidity associated with human CD19-specific chimeric antigen receptor T-cell (CAR19) immunotherapy. The etiology of ICANS is not well understood but is thought…
View article: 1050 Neurotoxicity induced by human CD19-specific CAR T-cells in a mouse model: CAR T-cells enter the brain parenchyma from the subarachnoid space and increase spontaneous neuronal signaling
1050 Neurotoxicity induced by human CD19-specific CAR T-cells in a mouse model: CAR T-cells enter the brain parenchyma from the subarachnoid space and increase spontaneous neuronal signaling Open
View article: Human BH3-only protein, Noxa, is a major contributor to proliferative metabolism and apoptosis in the CD8+T cell immune response
Human BH3-only protein, Noxa, is a major contributor to proliferative metabolism and apoptosis in the CD8+T cell immune response Open
Human Noxa, the smallest BH3-only Bcl-2 protein, was originally identified as pro-apoptotic, but has since also been shown to promote cell growth in both malignant and activated normal T cells by facilitating proliferative metabolism (Lowm…
View article: Human CD19-specific switchable CAR T-cells are efficacious as constitutively active CAR T-cells but cause less morbidity in a mouse model of human CD19<sup>+</sup> malignancy
Human CD19-specific switchable CAR T-cells are efficacious as constitutively active CAR T-cells but cause less morbidity in a mouse model of human CD19<sup>+</sup> malignancy Open
Current Food and Drug Administration (FDA)-approved CD19-specific chimeric antigen receptor (CAR) T-cell therapies for B-cell malignancies are constitutively active and while efficacious, can cause morbidity and mortality. Their toxicities…
View article: Murine CAR19 Tregs suppress acute graft-versus-host disease and maintain graft-versus-tumor responses
Murine CAR19 Tregs suppress acute graft-versus-host disease and maintain graft-versus-tumor responses Open
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) efficacy is complicated by graft-versus-host disease (GVHD), a leading cause of morbidity and mortality. Regulatory T cells (Tregs) have shown efficacy in preventing GVHD. Howe…
View article: Development of B-1 cells: segregation of phosphatidyl choline-specific B cells to the B-1 population occurs after immunoglobulin gene expression
Development of B-1 cells: segregation of phosphatidyl choline-specific B cells to the B-1 population occurs after immunoglobulin gene expression Open
Adult mice have two easily recognizable subsets of B cells: the predominant resting population of the spleen, called B-2, and those called B-1, which predominate in coelomic cavities and can express CD5. Some antibody specificities appear …
View article: Demystifying Cancer Immunotherapy for Lay Audiences
Demystifying Cancer Immunotherapy for Lay Audiences Open
Immunotherapy is now mainstream. Advertisements are ubiquitous in print and visual media for immune based-therapies for various conditions and diseases. Smaller companies that develop novel immunotherapies are often quickly acquired by lar…
View article: Supplementary material to "Wintertime Spatial Distribution of Ammonia and its Emission Sources in the Great Salt Lake Region"
Supplementary material to "Wintertime Spatial Distribution of Ammonia and its Emission Sources in the Great Salt Lake Region" Open
S1 Study area S2 Observations of NH3 from Twin Otter aircraft S2.1 Surface level NH3 from Twin Otter (missed approaches) S2.2 Ground site and Twin Otter comparison S3 UDAQ emission inventory S4 USU inventory S5 Footprint model S5.1 Modelle…
View article: Wintertime Spatial Distribution of Ammonia and its Emission Sources in the Great Salt Lake Region
Wintertime Spatial Distribution of Ammonia and its Emission Sources in the Great Salt Lake Region Open
Ammonium-containing aerosols are a major component of winter time air pollution in many densely populated regions around the world. Especially in mountain basins, the formation of persistent cold air pool (PCAP) periods can enhance particu…
View article: IMMU-23. TARGETING THE CD200 CHECKPOINT TO ENHANCE IMMUNOTHERAPY FOR CNS TUMORS
IMMU-23. TARGETING THE CD200 CHECKPOINT TO ENHANCE IMMUNOTHERAPY FOR CNS TUMORS Open
Numerous clinical trials targeting immune checkpoints have failed to enhance survival in patients with CNS tumors. We are targeting a unique checkpoint, CD200, which controls the immune system through paired inhibitory and activation recep…
View article: Virus-specific memory T cells populate tumors and can be repurposed for tumor immunotherapy
Virus-specific memory T cells populate tumors and can be repurposed for tumor immunotherapy Open
View article: Treatment Combining CD200 Immune Checkpoint Inhibitor and Tumor-Lysate Vaccination after Surgery for Pet Dogs with High-Grade Glioma
Treatment Combining CD200 Immune Checkpoint Inhibitor and Tumor-Lysate Vaccination after Surgery for Pet Dogs with High-Grade Glioma Open
Recent advances in immunotherapy have included inhibition of immune checkpoint proteins in the tumor microenvironment and tumor lysate-based vaccination strategies. We combined these approaches in pet dogs with high-grade glioma. Administr…
View article: CADD-14. TARGETING THE CD200 CHECKPOINT FOR THE FIGHT AGAINST CENTRAL NERVOUS SYSTEM TUMORS
CADD-14. TARGETING THE CD200 CHECKPOINT FOR THE FIGHT AGAINST CENTRAL NERVOUS SYSTEM TUMORS Open
Numerous ongoing clinical trials targeting immune checkpoints have failed to enhance survival in patients with CNS tumors. We are targeting a unique checkpoint, CD200, which controls the immune system through paired inhibitory and activati…
View article: Human CD19-Targeted Mouse T Cells Induce B Cell Aplasia and Toxicity in Human CD19 Transgenic Mice
Human CD19-Targeted Mouse T Cells Induce B Cell Aplasia and Toxicity in Human CD19 Transgenic Mice Open
View article: Monomeric annexin A2 is an oxygen-regulated toll-like receptor 2 ligand and adjuvant
Monomeric annexin A2 is an oxygen-regulated toll-like receptor 2 ligand and adjuvant Open
This novel finding adds to the known functions of ANXA2 and suggests ways to exploit it as a vaccine adjuvant. ANXA2-antigen fusion peptides could be developed for patients as "off-the-shelf" agents containing common tumor antigens. Altern…
View article: CD8+ T Cell-Independent Immune-Mediated Mechanisms of Anti-Tumor Activity
CD8+ T Cell-Independent Immune-Mediated Mechanisms of Anti-Tumor Activity Open
Despite the growing number of preclinical and clinical trials focused on immunotherapy for the treatment of malignant gliomas, the prognosis for this disease remains grim. Cancer immunotherapy seeks to recruit an effective immune response …