Christopher Abraham
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View article: CT and MRI Based Preop Evaluation of Femoral and Tibial Tunnels in ACL Reconstruction
CT and MRI Based Preop Evaluation of Femoral and Tibial Tunnels in ACL Reconstruction Open
View article: Dual-excitation multispectral fluorescence lifetime imaging handheld endoscope for label-free metabolic and biochemical imaging of the oral mucosa
Dual-excitation multispectral fluorescence lifetime imaging handheld endoscope for label-free metabolic and biochemical imaging of the oral mucosa Open
This work introduces a dual-excitation, multispectral-detection, frequency-domain fluorescence lifetime imaging (FLIM) handheld endoscopy system for comprehensive autofluorescence imaging of the oral mucosa. The excitation wavelengths and …
View article: Dosimetric evaluation of carbon-fiber reinforced polyetheretherketone (CFR-PEEK) spinal hardware for clinical synchrocyclotron proton system planning
Dosimetric evaluation of carbon-fiber reinforced polyetheretherketone (CFR-PEEK) spinal hardware for clinical synchrocyclotron proton system planning Open
View article: Large language models to help appeal denied radiotherapy services
Large language models to help appeal denied radiotherapy services Open
Background Large language model (LLM) artificial intelligences have potential to perform myriad healthcare tasks but should be validated in specific clinical use cases before deployment. One use case is to help physicians appeal insurer de…
View article: RADT-01. BASELINE HIPPOCAMPAL VOLUME AS A PREDICTOR OF NEUROCOGNITIVE CHANGES AFTER WBRT OR HA-WBRT: SECONDARY ANALYSIS OF NRG ONCOLOGY CC001
RADT-01. BASELINE HIPPOCAMPAL VOLUME AS A PREDICTOR OF NEUROCOGNITIVE CHANGES AFTER WBRT OR HA-WBRT: SECONDARY ANALYSIS OF NRG ONCOLOGY CC001 Open
PURPOSE Hippocampal volume (HV) is a predictor of neurocognitive function (NCF) in neurodegenerative disease. The role of patient-specific anatomic variables has not been well investigated in patients with brain metastases. This work aimed…
View article: In silico trial of simulation-free hippocampal-avoidance whole brain adaptive radiotherapy
In silico trial of simulation-free hippocampal-avoidance whole brain adaptive radiotherapy Open
Simulation-free HA-WBRT, with commercially available systems, was clinically feasible via plan-quality metrics and timing, in silico.
View article: Stereotactic Radiosurgery vs Conventional Radiotherapy for Localized Vertebral Metastases of the Spine
Stereotactic Radiosurgery vs Conventional Radiotherapy for Localized Vertebral Metastases of the Spine Open
Importance Spine metastasis can be treated with high-dose radiation therapy with advanced delivery technology for long-term tumor and pain control. Objective To assess whether patient-reported pain relief was improved with stereotactic rad…
View article: A pilot phase Ib study to evaluate tadalafil to overcome immunosuppression during chemoradiotherapy for IDH-wild-type glioblastoma
A pilot phase Ib study to evaluate tadalafil to overcome immunosuppression during chemoradiotherapy for IDH-wild-type glioblastoma Open
Background Myeloid-derived suppressor cells (MDSCs) are critical regulators of immunosuppression and radioresistance in glioblastoma (GBM). The primary objective of this pilot phase Ib study was to validate the on-target effect of tadalafi…
View article: Clinical application of a template‐guided automated planning routine
Clinical application of a template‐guided automated planning routine Open
Purpose Determine the dosimetric quality and the planning time reduction when utilizing a template‐based automated planning application. Methods A software application integrated through the treatment planning system application programing…
View article: 624 A phase I/II study evaluating the safety and efficacy of a novel long-acting interleukin-7, NT-I7, for patients with newly diagnosed high-grade gliomas after chemoradiotherapy
624 A phase I/II study evaluating the safety and efficacy of a novel long-acting interleukin-7, NT-I7, for patients with newly diagnosed high-grade gliomas after chemoradiotherapy Open
Background Standard of care after surgery for high-grade gliomas (HGG), including glioblastoma (GBM) and anaplastic astrocytoma, is radiation therapy (RT) and temozolomide (TMZ). Unfortunately, lymphopenia commonly occurs after treatment, …
View article: CTIM-10. A PHASE II STUDY OF RETIFANLIMAB (PD-1 INHIBITOR) IN COMBINATION WITH BEVACIZUMAB AND HYPOFRACTIONATED RADIOTHERAPY FOR RECURRENT GLIOBLASTOMA: NCT03532295
CTIM-10. A PHASE II STUDY OF RETIFANLIMAB (PD-1 INHIBITOR) IN COMBINATION WITH BEVACIZUMAB AND HYPOFRACTIONATED RADIOTHERAPY FOR RECURRENT GLIOBLASTOMA: NCT03532295 Open
INTRODUCTION Immunotherapies targeting PD-1 in recurrent glioblastoma (rGBM) have shown limited activity. We hypothesize combining therapies targeting immunosuppressive pathways with cytotoxic and antiangiogenic therapies will improve surv…
View article: Neoadjuvant stereotactic radiosurgery for brain metastases: a new paradigm
Neoadjuvant stereotactic radiosurgery for brain metastases: a new paradigm Open
OBJECTIVE For patients with surgically accessible solitary metastases or oligometastatic disease, treatment often involves resection followed by postoperative stereotactic radiosurgery (SRS). This strategy has several potential drawbacks, …
View article: Simulation-Free Radiation Therapy: An Emerging Form of Treatment Planning to Expedite Plan Generation for Patients Receiving Palliative Radiation Therapy
Simulation-Free Radiation Therapy: An Emerging Form of Treatment Planning to Expedite Plan Generation for Patients Receiving Palliative Radiation Therapy Open
View article: SPCR-01 RAPIDPLAN HIPPOCAMPAL SPARING WHOLE BRAIN MODEL VERSION 2 - HOW FAR CAN WE REDUCE THE DOSE?
SPCR-01 RAPIDPLAN HIPPOCAMPAL SPARING WHOLE BRAIN MODEL VERSION 2 - HOW FAR CAN WE REDUCE THE DOSE? Open
BACKGROUND Whole-brain radiotherapy (WBRT) has been the standard palliative treatment for patients with brain metastases due to its effectiveness, availability, and ease of administration. Recent clinical trials have shown that limiting ra…
View article: Percutaneous recanalization of a thrombosed Meso-Rex shunt
Percutaneous recanalization of a thrombosed Meso-Rex shunt Open
Extra-hepatic portal vein obstruction can cause severe portal hypertension. Meso-rex shunting is a surgical option to bypass the extrahepatic portal venous obstruction, connecting the superior mesenteric vein to the left portal vein, resto…
View article: RapidPlan hippocampal sparing whole brain model version 2—how far can we reduce the dose?
RapidPlan hippocampal sparing whole brain model version 2—how far can we reduce the dose? Open
Whole-brain radiotherapy has been the standard palliative treatment for patients with brain metastases due to its effectiveness, availability, and ease of administration. Recent clinical trials have shown that limiting radiation dose to th…
View article: Association of Pretreatment Hippocampal Volume With Neurocognitive Function in Patients Treated With Hippocampal Avoidance Whole Brain Radiation Therapy for Brain Metastases: Secondary Analysis of NRG Oncology/RTOG 0933
Association of Pretreatment Hippocampal Volume With Neurocognitive Function in Patients Treated With Hippocampal Avoidance Whole Brain Radiation Therapy for Brain Metastases: Secondary Analysis of NRG Oncology/RTOG 0933 Open
View article: CTIM-07. A PHASE I/II STUDY EVALUATING THE SAFETY AND EFFICACY OF A NOVEL LONG-ACTING INTERLEUKIN-7, NT-I7, FOR PATIENTS WITH NEWLY DIAGNOSED HIGH-GRADE GLIOMAS AFTER CHEMORADIOTHERAPY
CTIM-07. A PHASE I/II STUDY EVALUATING THE SAFETY AND EFFICACY OF A NOVEL LONG-ACTING INTERLEUKIN-7, NT-I7, FOR PATIENTS WITH NEWLY DIAGNOSED HIGH-GRADE GLIOMAS AFTER CHEMORADIOTHERAPY Open
BACKGROUND Lymphopenia is common after standard radiation therapy (RT) and temozolomide (TMZ) in high-grade gliomas (HGG) and correlates with shorter survival. Interleukin-7 (IL-7), a T-cell proliferation cytokine, is inappropriately low i…
View article: 396 NT-I7, a long-acting interleukin-7, promotes expansion of CD8 T cells and NK cells and immune activation in patients with newly diagnosed high-grade gliomas after chemoradiation
396 NT-I7, a long-acting interleukin-7, promotes expansion of CD8 T cells and NK cells and immune activation in patients with newly diagnosed high-grade gliomas after chemoradiation Open
Background Lymphopenia is common after chemoradiation for treatment of high-grade gliomas (HGG) and is associated with reduced survival.1 Interleukin-7 (IL-7) promotes T-cell maturation and proliferation and is inappropriately l…
View article: Clinical Workflow for Planning and Treating Palliative Patients on Diagnostic Images
Clinical Workflow for Planning and Treating Palliative Patients on Diagnostic Images Open
View article: Evaluation of interim MRI changes during limited-field radiation therapy for glioblastoma and implications for treatment planning
Evaluation of interim MRI changes during limited-field radiation therapy for glioblastoma and implications for treatment planning Open
View article: Salvage therapies for radiation-relapsed isocitrate dehydrogenase-mutant astrocytoma and 1p/19q codeleted oligodendroglioma
Salvage therapies for radiation-relapsed isocitrate dehydrogenase-mutant astrocytoma and 1p/19q codeleted oligodendroglioma Open
Background Optimal management for recurrent IDH-mutant glioma after radiation therapy (RT) is not well-defined. This study assesses practice patterns for managing recurrent IDH-mutant astrocytoma (Astro) and 1p/19q codeleted oligodendrogli…
View article: A feasibility study to evaluate early treatment response of brain metastases one week after stereotactic radiosurgery using perfusion weighted imaging
A feasibility study to evaluate early treatment response of brain metastases one week after stereotactic radiosurgery using perfusion weighted imaging Open
PWI at week 1 after SRS may have borderline association with LR. Tumors <2.0cm3 have low risk of LR after SRS and may be low-yield for predictive biomarker studies. Information regarding sample size and potential challenges for future imag…
View article: Treatment of oligometastatic lung cancer with brain metastases using stereotactic radiosurgery (SRS) and stereotactic body radiation therapy (SBRT)
Treatment of oligometastatic lung cancer with brain metastases using stereotactic radiosurgery (SRS) and stereotactic body radiation therapy (SBRT) Open
View article: Impact of Facility Radiation Patient Volume on Overall Survival in Patients with Muscle Invasive Bladder Cancer Undergoing Trimodality Bladder Preservation Therapy
Impact of Facility Radiation Patient Volume on Overall Survival in Patients with Muscle Invasive Bladder Cancer Undergoing Trimodality Bladder Preservation Therapy Open
Background: There is an association between higher hospital and urologist case volume and improved survival outcomes for patients with bladder cancer. Less data on facility volume and outcomes exists following trimodality bladder preservat…
View article: Long-Term Survival without Systemic and Immune Therapy after Synchronous Thoracic and Brain Stereotactic Radiation for Oligometastatic NSCLC
Long-Term Survival without Systemic and Immune Therapy after Synchronous Thoracic and Brain Stereotactic Radiation for Oligometastatic NSCLC Open
View article: OTHR-03. ENHANCEMENT OF T1W-GAD MRI IS ASSOCIATED WITH POST-SRS LOCAL CONTROL OF NSCLC BRAIN METASTASES
OTHR-03. ENHANCEMENT OF T1W-GAD MRI IS ASSOCIATED WITH POST-SRS LOCAL CONTROL OF NSCLC BRAIN METASTASES Open
BACKGROUND: Local control (LC) of brain metastasis (BM) is an important clinical endpoint. To date predictors of LC have been limited to patient and treatment related factors. Quantitative imaging features predictive of LC have not been we…
View article: TRLS-02. A PILOT STUDY OF EVALUATING EARLY TREATMENT RESPONSE OF BRAIN METASTASES AFTER STEREOTACTIC RADIOSURGERY USING DYNAMIC SUSCEPTIBILITY-WEIGHTED PERFUSION MAGNETIC RESONANCE IMAGING
TRLS-02. A PILOT STUDY OF EVALUATING EARLY TREATMENT RESPONSE OF BRAIN METASTASES AFTER STEREOTACTIC RADIOSURGERY USING DYNAMIC SUSCEPTIBILITY-WEIGHTED PERFUSION MAGNETIC RESONANCE IMAGING Open
PURPOSE: To determine if dynamic susceptibility-weighted perfusion magnetic resonance imaging (DSC-PMR) can be used to predict local recurrence (LR) of brain metastases after stereotactic radiosurgery (SRS). METHODS: This is a prospective …
View article: RADI-19. EVALUATION OF BRAIN METASTASIS LOCAL CONTROL POST RADIOSURGERY VIA MACHINE LEARNING AND RADIOMICS
RADI-19. EVALUATION OF BRAIN METASTASIS LOCAL CONTROL POST RADIOSURGERY VIA MACHINE LEARNING AND RADIOMICS Open
Stereotactic radiosurgery can be used to treat multiple, surgically inaccessible, metastatic brain lesions in a single, minimally invasive outpatient procedure. For brain metastasis, stereotactic radiosurgery can provide excellent local co…
View article: A propensity analysis comparing definitive chemo-radiotherapy for muscle-invasive squamous cell carcinoma of the bladder vs. urothelial carcinoma of the bladder using the National Cancer Database
A propensity analysis comparing definitive chemo-radiotherapy for muscle-invasive squamous cell carcinoma of the bladder vs. urothelial carcinoma of the bladder using the National Cancer Database Open