Christopher Aisenbrey
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View article: Biophysical investigations of the membrane interactions of collagen VI-derived host defense peptides
Biophysical investigations of the membrane interactions of collagen VI-derived host defense peptides Open
View article: Elucidating the conformational behavior and membrane-destabilizing capability of the antimicrobial peptide ecPis-4s
Elucidating the conformational behavior and membrane-destabilizing capability of the antimicrobial peptide ecPis-4s Open
View article: Self-assembly of spin-labeled antimicrobial peptides magainin 2 and PGLa in lipid bilayers
Self-assembly of spin-labeled antimicrobial peptides magainin 2 and PGLa in lipid bilayers Open
View article: Elucidating the Conformational Behavior and Membrane-Destabilizing Capability of the Antimicrobial Peptide Ecpis-4s
Elucidating the Conformational Behavior and Membrane-Destabilizing Capability of the Antimicrobial Peptide Ecpis-4s Open
View article: Hydration-Temperature Dependent Fluorescence Spectra of Laurdan Conformers in a Dppc Membrane
Hydration-Temperature Dependent Fluorescence Spectra of Laurdan Conformers in a Dppc Membrane Open
View article: Hydration-Temperature Dependent Fluorescence Spectra of Laurdan Conformers in a Dppc Membrane
Hydration-Temperature Dependent Fluorescence Spectra of Laurdan Conformers in a Dppc Membrane Open
View article: Structural analysis of the NK-lysin-derived peptide NK-2 upon interaction with bacterial membrane mimetics consisting of phosphatidylethanolamine and phosphatidylglycerol
Structural analysis of the NK-lysin-derived peptide NK-2 upon interaction with bacterial membrane mimetics consisting of phosphatidylethanolamine and phosphatidylglycerol Open
View article: The Mechanism of Action of SAAP-148 Antimicrobial Peptide as Studied with NMR and Molecular Dynamics Simulations
The Mechanism of Action of SAAP-148 Antimicrobial Peptide as Studied with NMR and Molecular Dynamics Simulations Open
Background: SAAP-148 is an antimicrobial peptide derived from LL-37. It exhibits excellent activity against drug-resistant bacteria and biofilms while resisting degradation in physiological conditions. Despite its optimal pharmacological p…
View article: Lipid saturation and head group composition have a pronounced influence on the membrane insertion equilibrium of amphipathic helical polypeptides
Lipid saturation and head group composition have a pronounced influence on the membrane insertion equilibrium of amphipathic helical polypeptides Open
View article: Epimers l- and d-Phenylseptin: How the relative stereochemistry affects the peptide-membrane interactions
Epimers l- and d-Phenylseptin: How the relative stereochemistry affects the peptide-membrane interactions Open
View article: Revealing the Mechanisms of Synergistic Action of Two Magainin Antimicrobial Peptides
Revealing the Mechanisms of Synergistic Action of Two Magainin Antimicrobial Peptides Open
The study of peptide-lipid and peptide-peptide interactions as well as their topology and dynamics using biophysical and structural approaches have changed our view how antimicrobial peptides work and function. It has become obvious that b…
View article: Structure, membrane topology and influence of cholesterol of the membrane proximal region: transmembrane helical anchor sequence of gp41 from HIV
Structure, membrane topology and influence of cholesterol of the membrane proximal region: transmembrane helical anchor sequence of gp41 from HIV Open
View article: Copper-binding motifs Xxx-His or Xxx-Zzz-His (ATCUN) linked to an antimicrobial peptide: Cu-binding, antimicrobial activity and ROS production
Copper-binding motifs Xxx-His or Xxx-Zzz-His (ATCUN) linked to an antimicrobial peptide: Cu-binding, antimicrobial activity and ROS production Open
View article: Structure, interactions and membrane topology of HIV gp41 ectodomain sequences
Structure, interactions and membrane topology of HIV gp41 ectodomain sequences Open
View article: Characterization of the DNA and Membrane Interactions of a Bioreducible Cell-Penetrating Foldamer in its Monomeric and Dimeric Form
Characterization of the DNA and Membrane Interactions of a Bioreducible Cell-Penetrating Foldamer in its Monomeric and Dimeric Form Open
The biophysical properties of a designed bioreducible oligourea foldamer, which shows excellent transfection activities in its dimeric form are presented. Binding isotherms of the monomer as well as of the dimer to both DNA and lipid membr…
View article: Structure, interactions and membrane topology of HIV gp41 ectodomain sequences
Structure, interactions and membrane topology of HIV gp41 ectodomain sequences Open
View article: Solid–State NMR Investigations of the MHC II Transmembrane Domains: Topological Equilibria and Lipid Interactions
Solid–State NMR Investigations of the MHC II Transmembrane Domains: Topological Equilibria and Lipid Interactions Open
View article: Investigations of the Structure, Topology, and Interactions of the Transmembrane Domain of the Lipid-Sorting Protein p24 Being Highly Selective for Sphingomyelin-C18
Investigations of the Structure, Topology, and Interactions of the Transmembrane Domain of the Lipid-Sorting Protein p24 Being Highly Selective for Sphingomyelin-C18 Open
The p24 proteins play an important role in the secretory pathway where they selectively connect various cargo to other proteins, thereby being involved in the controlled assembly and disassembly of the coat protein complexes and lipid sort…
View article: Helicobacter pylori Adapts to Chronic Infection and Gastric Disease via pH-Responsive BabA-Mediated Adherence
Helicobacter pylori Adapts to Chronic Infection and Gastric Disease via pH-Responsive BabA-Mediated Adherence Open
View article: 20+ Years and no End in Sight: Histidine-Rich Designer Peptides with pH-Dependent Membrane Topology and with Multifacet Biomedical Potential
20+ Years and no End in Sight: Histidine-Rich Designer Peptides with pH-Dependent Membrane Topology and with Multifacet Biomedical Potential Open
View article: Histidine‐rich designer peptides of the LAH4 family promote cell delivery of a multitude of cargo
Histidine‐rich designer peptides of the LAH4 family promote cell delivery of a multitude of cargo Open
The histidine‐rich designer peptides of the LAH4 family exhibit potent antimicrobial, transfection, transduction and cell‐penetrating properties. They form non‐covalent complexes with their cargo, which often carry a negative overall charg…
View article: A Coiled-Coil Peptide Shaping Lipid Bilayers upon Fusion
A Coiled-Coil Peptide Shaping Lipid Bilayers upon Fusion Open
View article: Membrane topologies of the PGLa antimicrobial peptide and a transmembrane anchor sequence by Dynamic Nuclear Polarization/solid-state NMR spectroscopy
Membrane topologies of the PGLa antimicrobial peptide and a transmembrane anchor sequence by Dynamic Nuclear Polarization/solid-state NMR spectroscopy Open
View article: Magainin 2-PGLa Interactions in Membranes - Two Peptides that Exhibit Synergistic Enhancement of Antimicrobial Activity
Magainin 2-PGLa Interactions in Membranes - Two Peptides that Exhibit Synergistic Enhancement of Antimicrobial Activity Open
The structural requirements for the synergistic enhancement of antimicrobial activities of the cationic linear peptides PGLa and magainin 2 were investigated. In a first step the antimicrobial activities were evaluated for a number of modi…
View article: On the design of supramolecular assemblies made of peptides and lipid bilayers
On the design of supramolecular assemblies made of peptides and lipid bilayers Open
Figure 4 shows the helical wheel representations of PGLa, LAH4 at acidic pH, scrambled magainin 2 and Htt17.Residues 2-21 of a scrambled magainin 2 sequence are shown that exhibit high antimicrobial efficiency.The carboxy-terminus has been…