L.C. Bainbridge
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View article: The NEON (Nerve rEpair Or Not) trial: a randomized controlled trial of microsurgical repair <i>versus</i> nerve alignment for digital nerve injury
The NEON (Nerve rEpair Or Not) trial: a randomized controlled trial of microsurgical repair <i>versus</i> nerve alignment for digital nerve injury Open
Background Digital nerves provide sensibility to the fingers. They are commonly injured through accidental sharp laceration. The aim of the NEON (Nerve rEpair Or Not) study was to investigate whether microsurgical suture repair of lacerate…
View article: Collagenase injection versus limited fasciectomy surgery to treat Dupuytren’s contracture in adult patients in the UK: DISC, a non-inferiority RCT and economic evaluation
Collagenase injection versus limited fasciectomy surgery to treat Dupuytren’s contracture in adult patients in the UK: DISC, a non-inferiority RCT and economic evaluation Open
Background Dupuytren’s contracture is caused by nodules and cords which pull the fingers towards the palm of the hand. Treatments include limited fasciectomy surgery, collagenase injection and needle fasciotomy. There is limited evidence c…
View article: Cost-effectiveness of replacing <i>versus</i> discarding the nail in children with nail bed injury
Cost-effectiveness of replacing <i>versus</i> discarding the nail in children with nail bed injury Open
Lay Summary Every year in the UK, around 10 000 children need to have operations to mend injuries to the bed of their fingernails. Currently, most children have their fingernail placed back on the injured nail bed after the operation. The …
View article: Effectiveness of nail bed repair in children with or without replacing the fingernail: NINJA multicentre randomized clinical trial
Effectiveness of nail bed repair in children with or without replacing the fingernail: NINJA multicentre randomized clinical trial Open
Background Surgery for nail bed injuries in children is common. One of the key surgical decisions is whether to replace the nail plate following nail bed repair. The aim of this RCT was to assess the clinical effectiveness and cost-effecti…
View article: Protocol for surgical and non-surgical treatment for metacarpal shaft fractures in adults: an observational feasibility study
Protocol for surgical and non-surgical treatment for metacarpal shaft fractures in adults: an observational feasibility study Open
Introduction Metacarpal shaft fractures (MSF) are common traumatic hand injuries that usually affect young people of working age. They place a significant burden on healthcare resources and society; however, there is a lack of evidence to …
View article: The effect of the COVID-19 lockdown on hand trauma surgery utilization
The effect of the COVID-19 lockdown on hand trauma surgery utilization Open
Aims The aim of this study was to evaluate the need for hand trauma services during the COVID-19 pandemic lockdown, specifically related to surgical requirements. This will provide useful information for planning and resource allocation in…
View article: Identifying collagen VI as a target of fibrotic diseases regulated by CREBBP/EP300
Identifying collagen VI as a target of fibrotic diseases regulated by CREBBP/EP300 Open
Significance Fibrosis remains a major unmet medical need as therapeutic targets discovered in animal models have failed to translate. A major challenge for identifying novel targets is the limited availability of early-stage human disease …
View article: 3D Printing and Growth Induced Bending based on PET-RAFT Polymerization
3D Printing and Growth Induced Bending based on PET-RAFT Polymerization Open
4D printing has steadily become an emerging area of advanced manufacturing research and has produced some truly fantastic innovations. Previously we have demonstrated the 3D printing process based on PET-RAFT polymerization, and its subseq…
View article: A randomised feasibility trial comparing needle fasciotomy with limited fasciectomy treatment for Dupuytren’s contractures
A randomised feasibility trial comparing needle fasciotomy with limited fasciectomy treatment for Dupuytren’s contractures Open