Paul C. Beard
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View article: High-resolution imaging of ultrasonic fields through a multimode optical fiber
High-resolution imaging of ultrasonic fields through a multimode optical fiber Open
High-resolution ultrasound and photoacoustic imaging with flexible, lightweight probes is highly desirable for applications ranging from handheld clinical diagnostics to minimally invasive endoscopy and industrial inspection in confined en…
View article: Sensitive broadband ultrasound sensor based on a low-loss high-Q fused-silica plano-concave microresonator
Sensitive broadband ultrasound sensor based on a low-loss high-Q fused-silica plano-concave microresonator Open
Optical ultrasound sensors can achieve high sensitivity, small element size, and broadband frequency response. Polymer plano-concave microresonators (PCMRs) are among the most sensitive ultrasound sensors, but achieving further increases i…
View article: P188 Preliminary assessment of high resolution 3D photoacoustic imaging in rheumatoid arthritis compared to ultrasound doppler
P188 Preliminary assessment of high resolution 3D photoacoustic imaging in rheumatoid arthritis compared to ultrasound doppler Open
Background/Aims Photoacoustic imaging (PAI) technique works by delivering pulsed-laser light to the skin surface. The light penetrates deeply into the joint where it is absorbed by the synovial-blood vessels produced by inflammation. This …
View article: Sustained real-time and video-rate interventional optical ultrasound imaging
Sustained real-time and video-rate interventional optical ultrasound imaging Open
These results constitute the first-ever sustained, real-time dynamic imaging using a side-viewing single-element OpUS probe via rapid actuation, which enables a wide range of applications in minimally invasive surgical guidance.
View article: Three-Dimensional Whole-Body Small Animal Photoacoustic Tomography Using a Multi-View Fabry-Perot Scanner
Three-Dimensional Whole-Body Small Animal Photoacoustic Tomography Using a Multi-View Fabry-Perot Scanner Open
Photoacoustic tomography (PAT) has the potential to become a widely used imaging tool in preclinical studies of small animals. This is because it can provide non-invasive, label free images of whole-body mouse anatomy, in a manner which is…
View article: Non-iterative model-based inversion for low channel-count optical ultrasound imaging
Non-iterative model-based inversion for low channel-count optical ultrasound imaging Open
Ultrasound image reconstruction is typically performed using the computationally efficient delay-and-sum algorithm. However, this algorithm is suboptimal for systems of low channel counts, where it causes significant image artefacts. These…
View article: Supplementary Video from Short-wave infrared imaging enables high-contrast fluorescence-guided surgery in neuroblastoma
Supplementary Video from Short-wave infrared imaging enables high-contrast fluorescence-guided surgery in neuroblastoma Open
Supplementary video showing fluorescence-guided resection of a subcutaneous model of Neuroblastoma injected with anti-GD2 fluorescence probes
View article: Supplementary Data from Short-wave infrared imaging enables high-contrast fluorescence-guided surgery in neuroblastoma
Supplementary Data from Short-wave infrared imaging enables high-contrast fluorescence-guided surgery in neuroblastoma Open
Supplementary methods and figures
View article: Supplementary Data from Short-wave infrared imaging enables high-contrast fluorescence-guided surgery in neuroblastoma
Supplementary Data from Short-wave infrared imaging enables high-contrast fluorescence-guided surgery in neuroblastoma Open
Supplementary methods and figures
View article: Supplementary Video from Short-wave infrared imaging enables high-contrast fluorescence-guided surgery in neuroblastoma
Supplementary Video from Short-wave infrared imaging enables high-contrast fluorescence-guided surgery in neuroblastoma Open
Supplementary video showing fluorescence-guided resection of a subcutaneous model of Neuroblastoma injected with anti-GD2 fluorescence probes
View article: Multimodal optical ultrasound imaging: Real-time imaging under concurrent CT or MRI
Multimodal optical ultrasound imaging: Real-time imaging under concurrent CT or MRI Open
Optical ultrasound (OpUS) imaging is an ultrasound modality that utilizes fiber-optic ultrasound sources and detectors to perform pulse-echo ultrasound imaging. These probes can be constructed entirely from glass optical fibers and plastic…
View article: Towards clinical application of freehand optical ultrasound imaging
Towards clinical application of freehand optical ultrasound imaging Open
Freehand optical ultrasound (OpUS) imaging is an emerging ultrasound imaging paradigm that uses an array of fibre-optic, photoacoustic ultrasound sources and a single fibre-optic ultrasound detector to perform ultrasound imaging without th…
View article: Dual-modality rigid endoscope for photoacoustic imaging and white light videoscopy
Dual-modality rigid endoscope for photoacoustic imaging and white light videoscopy Open
The proposed endoscope design offers several advantages including the high acoustic sensitivity and wide detection bandwidth of the FP sensor, dual-mode imaging capability, compact footprint, and an all-optical distal end for improved safe…
View article: Laser frequency noise characterization using high-finesse plano–concave optical microresonators
Laser frequency noise characterization using high-finesse plano–concave optical microresonators Open
Characterizing laser frequency noise is essential for applications including optical sensing and coherent optical communications. Accurate measurement of ultra-narrow linewidth lasers over a wide frequency range using existing methods is s…
View article: Spatially resolved readout of a Fabry–Perot ultrasound sensor interrogated through a multimode optical fiber using wavefront shaping
Spatially resolved readout of a Fabry–Perot ultrasound sensor interrogated through a multimode optical fiber using wavefront shaping Open
The spatially resolved interrogation of a Fabry–Perot ultrasound sensor using a laser beam focused through a multimode fiber is demonstrated. To scan the beam across the sensor as required to read it out, optical wavefront shaping was empl…
View article: All-optical ultrasound catheter for rapid B-mode oesophageal imaging
All-optical ultrasound catheter for rapid B-mode oesophageal imaging Open
All-optical ultrasound (OpUS) is an imaging paradigm that uses light to both generate and receive ultrasound, and has progressed from benchtop to in vivo studies in recent years, demonstrating promise for minimally invasive surgical applic…
View article: Figure 1 from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma
Figure 1 from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma Open
Multispectral NIR-I/SWIR fluorescence imaging device. Photograph of the custom multispectral NIR-I/SWIR fluorescence imaging system alongside its schematic representation. The spectral characteristics of the device are shown including the …
View article: Figure 2 from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma
Figure 2 from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma Open
Overview of the in vivo preclinical study. A, Six to 8-week-old athymic nude female mice LAN-1 xenografts were injected with either anti–GD2-IR800 or anti–GD-IR12. The control mice were not injected. Mice were imaged at 24, 48, 72, and 96 …
View article: Supplementary Data from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma
Supplementary Data from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma Open
Supplementary methods and figures
View article: Supplementary Data from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma
Supplementary Data from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma Open
Supplementary methods and figures
View article: Figure 6 from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma
Figure 6 from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma Open
Imaging of stained cell pellets beneath tissue-mimicking material using multispectral NIR-I/SWIR fluorescence imaging. A, Microcentrifuges tubes containing pellets of 2 × 106 GD2-positive cells (LAN-1) and GD2-negative cells (SUPT1-WT) sta…
View article: Supplementary Video from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma
Supplementary Video from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma Open
Supplementary video showing fluorescence-guided resection of a subcutaneous model of Neuroblastoma injected with anti-GD2 fluorescence probes
View article: Supplementary Video from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma
Supplementary Video from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma Open
Supplementary video showing fluorescence-guided resection of a subcutaneous model of Neuroblastoma injected with anti-GD2 fluorescence probes
View article: Figure 2 from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma
Figure 2 from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma Open
Overview of the in vivo preclinical study. A, Six to 8-week-old athymic nude female mice LAN-1 xenografts were injected with either anti–GD2-IR800 or anti–GD-IR12. The control mice were not injected. Mice were imaged at 24, 48, 72, and 96 …
View article: Figure 1 from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma
Figure 1 from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma Open
Multispectral NIR-I/SWIR fluorescence imaging device. Photograph of the custom multispectral NIR-I/SWIR fluorescence imaging system alongside its schematic representation. The spectral characteristics of the device are shown including the …
View article: Figure 3 from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma
Figure 3 from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma Open
In vitro validation of anti–GD2-IR800 and anti–GD2-IR12. A, Binding specificity of anti–GD2-IR800 and anti–GD2-IR12 conjugates assessed by flow cytometry in three GD2-positive cell lines (KELLY, LAN-1, and SUPT1-GD2) and in the negative co…
View article: Figure 7 from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma
Figure 7 from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma Open
Biological evaluation of anti–GD2-IR800 and anti–GD2-IR12 using a preclinical NIR-I imaging system in vivo. A, IVIS Spectrum images of the exposed tumors at 24, 48, 72, and 96 hours postinjection of anti–GD2-IR800 (n = 3) and anti–GD2-IR12…