Christopher R. Bowie
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View article: Predicting Response to Pro‐Cognitive Interventions in Mood Disorders: A Systematic Review by the International Society for Bipolar Disorders Targeting Cognition Task Force
Predicting Response to Pro‐Cognitive Interventions in Mood Disorders: A Systematic Review by the International Society for Bipolar Disorders Targeting Cognition Task Force Open
Introduction Major depressive disorder (MDD) and bipolar disorder (BD) are often associated with persistent cognitive deficits that impair psychosocial functioning. While pro‐cognitive interventions show promise, trial findings are inconsi…
View article: Home-based cognitive remediation and transcranial direct current stimulation to enhance cognition in older adults with major depressive disorder or mild cognitive impairment: An open label study
Home-based cognitive remediation and transcranial direct current stimulation to enhance cognition in older adults with major depressive disorder or mild cognitive impairment: An open label study Open
This study demonstrates that home-based CR+tDCS is feasible and safe in patients with MCI or rMDD, and could improve cognition in patients and quality of life in study partners. Randomized controlled trials are needed to confirm these find…
View article: Individualized frequency and montage tACS to engage theta-gamma coupling and enhance working memory in mild cognitive impairment
Individualized frequency and montage tACS to engage theta-gamma coupling and enhance working memory in mild cognitive impairment Open
Mild Cognitive Impairment (MCI) is a clinical prodromal stage of Alzheimer’s disease. Enhancing executive functions in patients with MCI could optimize cognitive compensatory mechanisms and slow cognitive decline. The prefrontal cortex (PF…
View article: E-Cog: An online training platform for cognitive health interventions based on the ADDIE model
E-Cog: An online training platform for cognitive health interventions based on the ADDIE model Open
Background Online learning is an accessible and cost-effective solution to deliver training in healthcare. In-person training has long supported mental health practitioners in delivering cognitive health interventions, however for many und…
View article: Formulating Cognitive Functioning to Guide Personalised Treatment for People Diagnosed With Mental Disorders
Formulating Cognitive Functioning to Guide Personalised Treatment for People Diagnosed With Mental Disorders Open
Introduction Objective and subjective cognitive impairment are highly prevalent in mental disorders and transdiagnostic phenomena. Cognitive impairment is associated with poorer functional outcomes and therefore requires treatment, but lit…
View article: Impact of Activation Therapy for Inpatients With Major Depression: Primary and Secondary Outcomes From a Randomised Controlled Trial
Impact of Activation Therapy for Inpatients With Major Depression: Primary and Secondary Outcomes From a Randomised Controlled Trial Open
Introduction Inpatient depression is associated with high morbidity and significant cognitive impairment. Inpatient treatment often focuses on short‐term stabilization with medication. Readmission rates are high. We examined the impact of …
View article: iCogCA to Promote Cognitive Health Through Digital Group Interventions for Individuals Living With a Schizophrenia Spectrum Disorder: Protocol for a Nonrandomized Concurrent Controlled Trial
iCogCA to Promote Cognitive Health Through Digital Group Interventions for Individuals Living With a Schizophrenia Spectrum Disorder: Protocol for a Nonrandomized Concurrent Controlled Trial Open
Background Cognitive impairments are a key aspect of schizophrenia spectrum disorders (SSDs), significantly affecting clinical and functional outcomes. The COVID-19 pandemic has heightened concerns about mental health services and cognitiv…
View article: Cognitive Remediation for Psychosis in Virtual Reality (ThinkTactic VR): Qualitative, Iterative, and User-Centered Codevelopment Study
Cognitive Remediation for Psychosis in Virtual Reality (ThinkTactic VR): Qualitative, Iterative, and User-Centered Codevelopment Study Open
Background Cognitive remediation improves cognition and psychosocial functioning in individuals with psychotic disorders. The use of virtual reality (VR) to deliver cognitive remediation in immersive environments that mimic real cognitivel…
View article: Predictors of mental health and academic outcomes in first-year university students: Identifying prevention and early-intervention targets – CORRIGENDUM
Predictors of mental health and academic outcomes in first-year university students: Identifying prevention and early-intervention targets – CORRIGENDUM Open
View article: Client Perspectives on Addressing Intimacy, Romance and Sexuality in Early Psychosis Intervention Programmes
Client Perspectives on Addressing Intimacy, Romance and Sexuality in Early Psychosis Intervention Programmes Open
Objective This study investigated the perspectives of clients in early psychosis intervention programmes regarding the types, quality and relevance of information they desire and receive, particularly related to intimacy, romance and sexua…
View article: Cognitive remediation for patients with late-life schizophrenia: A follow-up pilot study
Cognitive remediation for patients with late-life schizophrenia: A follow-up pilot study Open
An intensive, prolonged and flexible CR was feasible and well-tolerated, showing promise in improving executive function of patients with LLS. Larger and randomized controlled trials are needed in this population.
View article: Cognitive Remediation for Psychosis in Virtual Reality (ThinkTactic VR): Qualitative, Iterative, and User-Centered Codevelopment Study (Preprint)
Cognitive Remediation for Psychosis in Virtual Reality (ThinkTactic VR): Qualitative, Iterative, and User-Centered Codevelopment Study (Preprint) Open
BACKGROUND Cognitive remediation improves cognition and psychosocial functioning in individuals with psychotic disorders. The use of virtual reality (VR) to deliver cognitive remediation in immersive environments that mimic real cognitive…
View article: Acceptability, engagement, and efficacy of cognitive remediation for cognitive outcomes in young adults with first-episode psychosis and social anxiety: A randomized-controlled trial
Acceptability, engagement, and efficacy of cognitive remediation for cognitive outcomes in young adults with first-episode psychosis and social anxiety: A randomized-controlled trial Open
Social anxiety disorder (SAD) is a frequent comorbidity in first-episode psychosis (FEP) and may increase cognitive impairments. Cognitive remediation (CR) is an effective treatment for cognition, particularly in a group format. This study…
View article: Cognitive predictors of response to interpersonal and social rhythm therapy in mood disorders
Cognitive predictors of response to interpersonal and social rhythm therapy in mood disorders Open
Background There has been increasing interest in examining the potential moderating effects that cognitive functioning has on treatment outcome in bipolar disorder (BD) and major depressive disorder (MDD). Therefore, the aim of this explor…
View article: iCogCA to Promote Cognitive Health Through Digital Group Interventions for Individuals Living With a Schizophrenia Spectrum Disorder: Protocol for a Nonrandomized Concurrent Controlled Trial (Preprint)
iCogCA to Promote Cognitive Health Through Digital Group Interventions for Individuals Living With a Schizophrenia Spectrum Disorder: Protocol for a Nonrandomized Concurrent Controlled Trial (Preprint) Open
BACKGROUND Cognitive impairments are a key aspect of schizophrenia spectrum disorders (SSDs), significantly affecting clinical and functional outcomes. The COVID-19 pandemic has heightened concerns about mental health services and cogniti…
View article: Thinking About the Future of Cognitive Remediation Therapy Revisited: What Is Left to Solve Before Patients Have Access?
Thinking About the Future of Cognitive Remediation Therapy Revisited: What Is Left to Solve Before Patients Have Access? Open
In our previous paper on the Future of Cognitive Remediation published more than 10 years ago, we envisaged an imminent and wide implementation of cognitive remediation therapies into mental health services. This optimism was misplaced. De…
View article: Cognitive function based on theta-gamma coupling vs. clinical diagnosis in older adults with mild cognitive impairment with or without major depressive disorder
Cognitive function based on theta-gamma coupling vs. clinical diagnosis in older adults with mild cognitive impairment with or without major depressive disorder Open
Whether individuals with mild cognitive impairment (MCI) and a history of major depressive disorder (MDD) are at a higher risk for cognitive decline than those with MCI alone is still not clear. Previous work suggests that a reduction in p…
View article: Efficacy and safety of established and off‐label ADHD drug therapies for cognitive impairment or attention‐deficit hyperactivity disorder symptoms in bipolar disorder: A systematic review by the ISBD Targeting Cognition Task Force
Efficacy and safety of established and off‐label ADHD drug therapies for cognitive impairment or attention‐deficit hyperactivity disorder symptoms in bipolar disorder: A systematic review by the ISBD Targeting Cognition Task Force Open
Background Abnormalities in dopamine and norepinephrine signaling are implicated in cognitive impairments in bipolar disorder (BD) and attention‐deficit hyperactivity disorder (ADHD). This systematic review by the ISBD Targeting Cognition …
View article: Heterogeneity of Cognition in Older Adults with Remitted Major Depressive Disorder: A Latent Profile Analysis
Heterogeneity of Cognition in Older Adults with Remitted Major Depressive Disorder: A Latent Profile Analysis Open
View article: The PACt‐MD randomized clinical trial: Prevention of Alzheimer’s dementia with Cognitive remediation plus transcranial direct current stimulation in Mild cognitive impairment and Depression
The PACt‐MD randomized clinical trial: Prevention of Alzheimer’s dementia with Cognitive remediation plus transcranial direct current stimulation in Mild cognitive impairment and Depression Open
Background Interventions to prevent cognitive decline and dementia in high‐risk populations such as those with remitted Major Depressive Disorder (rMDD) or Mild Cognitive Impairment (MCI) are urgently needed. Method PACt‐MD was a double‐bl…
View article: Cognitive Function based on Theta‐Gamma Coupling vs. Clinical Diagnosis in Older Adults with Mild Cognitive Impairment with or without Major Depressive Disorder
Cognitive Function based on Theta‐Gamma Coupling vs. Clinical Diagnosis in Older Adults with Mild Cognitive Impairment with or without Major Depressive Disorder Open
Background Whether individuals with mild cognitive impairment (MCI) and a history of major depressive disorder (MDD) are at a higher risk for cognitive decline than those with MCI alone is still not clear. Previous work suggests that a red…
View article: Comparing the distribution of neuropsychiatric symptoms among individuals with depression and mild cognitive impairment
Comparing the distribution of neuropsychiatric symptoms among individuals with depression and mild cognitive impairment Open
Background Neuropsychiatric symptoms (NPS) are common during the course of neurocognitive disorders. NPS have been previously reported in early and late stages of Alzheimer’s Disease. However, our understanding of NPS in high‐risk states f…
View article: Table of Contents
Table of Contents Open
View article: Characterization and prediction of individual functional outcome trajectories in schizophrenia spectrum disorders (PREDICTS study): Study protocol
Characterization and prediction of individual functional outcome trajectories in schizophrenia spectrum disorders (PREDICTS study): Study protocol Open
Schizophrenia spectrum disorders (SSDs) are associated with significant functional impairments, disability, and low rates of personal recovery, along with tremendous economic costs linked primarily to lost productivity and premature mortal…
View article: Disseminating action‐based cognitive remediation to an early psychosis network: Clinician perspectives on feasibility and implementation barriers
Disseminating action‐based cognitive remediation to an early psychosis network: Clinician perspectives on feasibility and implementation barriers Open
Aim Action‐based cognitive remediation (ABCR) is a group cognitive remediation treatment that aims to improve neurocognitive impairments experienced in patients with severe mental illness. Developed in research settings, ABCR is not yet wi…
View article: PAS‐MCI: Design and rationale for a randomized controlled trial to enhance prefrontal cortical plasticity and working memory in individuals with amnestic mild cognitive impairment
PAS‐MCI: Design and rationale for a randomized controlled trial to enhance prefrontal cortical plasticity and working memory in individuals with amnestic mild cognitive impairment Open
Amnestic Mild Cognitive Impairment (aMCI) is a prodromal stage to Alzheimer’s disease dementia (AD). Improving prefrontal cortical function in individuals with MCI could prevent progression from aMCI to AD. A key mechanism that has been li…
View article: Table of Contents
Table of Contents Open
View article: Efficacy of Remotely Delivered Evidence-Based Psychosocial Treatments for Schizophrenia-Spectrum Disorders: A Series of Systematic Reviews and Meta-Analyses
Efficacy of Remotely Delivered Evidence-Based Psychosocial Treatments for Schizophrenia-Spectrum Disorders: A Series of Systematic Reviews and Meta-Analyses Open
Background Schizophrenia is among the most persistent and debilitating mental health conditions worldwide. The American Psychological Association (APA) has identified 10 psychosocial treatments with evidence for treating schizophrenia and …
View article: Assessing the Role of Past Depression in Patients with Mild Cognitive Impairment, with and without Biomarkers for Alzheimer’s Disease
Assessing the Role of Past Depression in Patients with Mild Cognitive Impairment, with and without Biomarkers for Alzheimer’s Disease Open
Major depressive disorder (MDD) is a risk factor for Alzheimer’s disease (AD). Cerebrovascular disease (CVD) is implicated in MDD and AD. Our study compared participants with AD positive and negative cerebrospinal fluid (CSF) biomarkers on…
View article: Neurophysiological and other features of working memory in older adults at risk for dementia
Neurophysiological and other features of working memory in older adults at risk for dementia Open