Christopher C. Striebich
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View article: A Randomized, Placebo‐Controlled Trial of Hydroxychloroquine in Incomplete Lupus
A Randomized, Placebo‐Controlled Trial of Hydroxychloroquine in Incomplete Lupus Open
Objective Patients with features of systemic lupus erythematosus (SLE) who do not fulfill classification criteria can be designated as incomplete lupus erythematosus (ILE). This condition includes individuals with a high risk of progressio…
View article: A phase 2 trial of hydroxychloroquine in individuals at risk for rheumatoid arthritis
A phase 2 trial of hydroxychloroquine in individuals at risk for rheumatoid arthritis Open
Background Individuals with serum elevations of anti‐cyclic citrullinated peptide (anti‐CCP) antibodies are at increased risk for future rheumatoid arthritis (RA). No pharmacologic interventions have been approved for the prevention of RA …
View article: STUDY OF ANTI-MALARIALS IN INCOMPLETE LUPUS – THE SMILE TRIAL
STUDY OF ANTI-MALARIALS IN INCOMPLETE LUPUS – THE SMILE TRIAL Open
O056 / #121 Topic: AS23 - SLE-Diagnosis, Manifestations, & Outcomes ABSTRACT CONCURRENT SESSION 09: SLE THERAPY – REVISITING OLD DRUGS AND UNLOCKING HIDDEN POTENTIAL OF NEW MEDICATIONS 24-05-2025 10:40 AM - 11:40 AM Background/Purpose Pati…
View article: Systemic inflammation and lymphocyte activation precede rheumatoid arthritis
Systemic inflammation and lymphocyte activation precede rheumatoid arthritis Open
Some autoimmune diseases, including rheumatoid arthritis (RA), are preceded by a critical subclinical phase of disease activity. Proactive clinical management is hampered by a lack of biological understanding of this subclinical ‘at-risk’ …
View article: Cytomegalovirus chronic retinal necrosis with ganciclovir resistance: a case report
Cytomegalovirus chronic retinal necrosis with ganciclovir resistance: a case report Open
Background Cytomegalovirus (CMV) chronic retinal necrosis (CRN) is a rare viral retinal infection that occurs in mildly immunocompromised people. It shares some features with both acute retinal necrosis and CMV retinitis. It is typically t…
View article: Decay-Accelerating Factor Differentially Associates With Complement-Mediated Damage in Synovium After Meniscus Tear as Compared to Anterior Cruciate Ligament Injury
Decay-Accelerating Factor Differentially Associates With Complement-Mediated Damage in Synovium After Meniscus Tear as Compared to Anterior Cruciate Ligament Injury Open
We have reported that anterior cruciate ligament (ACL) injury leads to the differential dysregulation of the complement system in the synovium as compared to meniscus tear (MT) and proposed this as a mechanism for a greater post-injury pre…
View article: Multifaceted immune dysregulation characterizes individuals at-risk for rheumatoid arthritis
Multifaceted immune dysregulation characterizes individuals at-risk for rheumatoid arthritis Open
Molecular markers of autoimmunity, such as antibodies to citrullinated protein antigens (ACPA), are detectable prior to inflammatory arthritis (IA) in rheumatoid arthritis (RA) and may define a state that is ‘at-risk’ for future RA. Here w…
View article: Potential causal role of synovial complement system activation in the development of post-traumatic osteoarthritis after anterior cruciate ligament injury or meniscus tear
Potential causal role of synovial complement system activation in the development of post-traumatic osteoarthritis after anterior cruciate ligament injury or meniscus tear Open
Anterior cruciate ligament (ACL) injury and meniscal tear (MT) are major causal factors for developing post-traumatic osteoarthritis (PTOA), but the biological mechanism(s) are uncertain. After these structural damages, the synovium could …
View article: 610 The Study of Anti-Malarials in Incomplete Lupus Erythematosus (SMILE): An Interim Report
610 The Study of Anti-Malarials in Incomplete Lupus Erythematosus (SMILE): An Interim Report Open
Background Laboratory and clinical features of systemic lupus erythematosus (SLE) may precede the onset of clinically apparent and classifiable disease. Autoantibodies and cytokines have been shown to be present in the blood years before a…
View article: Preferences and Insights for Participation in a Rheumatoid Arthritis Clinical Prevention Trial: A <scp>Mixed‐Methods</scp> Study
Preferences and Insights for Participation in a Rheumatoid Arthritis Clinical Prevention Trial: A <span>Mixed‐Methods</span> Study Open
Objective In rheumatoid arthritis (RA), anti–citrullinated protein antibodies (ACPA) can be elevated prior to inflammatory arthritis (IA). The potential to intervene in people with ACPA positivity underpins the development of prevention tr…
View article: Antibodies to Citrullinated Protein Antigens, Rheumatoid Factor Isotypes and the Shared Epitope and the Near-Term Development of Clinically-Apparent Rheumatoid Arthritis
Antibodies to Citrullinated Protein Antigens, Rheumatoid Factor Isotypes and the Shared Epitope and the Near-Term Development of Clinically-Apparent Rheumatoid Arthritis Open
Background/Purpose In rheumatoid arthritis (RA) autoantibodies including antibodies to citrullinated protein antigens (ACPA) and rheumatoid factor (RF) can be predictive of incident clinical RA. However, there is limited understanding of h…
View article: Diminished cytokine-induced Jak/STAT signaling is associated with rheumatoid arthritis and disease activity
Diminished cytokine-induced Jak/STAT signaling is associated with rheumatoid arthritis and disease activity Open
Rheumatoid arthritis (RA) is a systemic and incurable autoimmune disease characterized by chronic inflammation in synovial lining of joints. To identify the signaling pathways involved in RA, its disease activity, and treatment response, w…
View article: Perceived Stress and Inflammatory Arthritis: A Prospective Investigation in the Studies of the Etiologies of Rheumatoid Arthritis Cohort
Perceived Stress and Inflammatory Arthritis: A Prospective Investigation in the Studies of the Etiologies of Rheumatoid Arthritis Cohort Open
Objective The aim of this study was to determine the association of perceived stress with incident inflammatory arthritis (IA) defined as having at least 1 joint consistent with rheumatoid arthritis (RA)–like synovitis based on examination…
View article: A double-blind, placebo-controlled, phase II, randomized study of lovastatin therapy in the treatment of mildly active rheumatoid arthritis
A double-blind, placebo-controlled, phase II, randomized study of lovastatin therapy in the treatment of mildly active rheumatoid arthritis Open
Objectives 3-hydroxy-3-methylglutaryl coenzyme-A (HMG Co-A) reductase inhibitors (statins) are standard treatment for hyperlipidaemia. In addition to lipid-lowering abilities, statins exhibit multiple anti-inflammatory effects. The objecti…
View article: A Systems Immunology Approach Identifies Cytokine-Induced STAT Signaling Pathways Critical to Rheumatoid Arthritis Disease Activity and Treatment Response
A Systems Immunology Approach Identifies Cytokine-Induced STAT Signaling Pathways Critical to Rheumatoid Arthritis Disease Activity and Treatment Response Open
Rheumatoid arthritis (RA), a chronic autoimmune disease characterized by circulating autoantibodies, involves many cytokine-mediated signaling pathways in multiple immune cell subsets. Most studies of immune cells in RA have limitations, s…
View article: The association between omega-3 fatty acid biomarkers and inflammatory arthritis in an anti-citrullinated protein antibody positive population
The association between omega-3 fatty acid biomarkers and inflammatory arthritis in an anti-citrullinated protein antibody positive population Open
n-3 FAs may potentially lower the risk of transition from anti-CCP positivity to IA, an observation that warrants further investigation.
View article: Editorial: Prevention of Rheumatoid Arthritis: Now Is the Time, but How to Proceed?
Editorial: Prevention of Rheumatoid Arthritis: Now Is the Time, but How to Proceed? Open
View article: Increased pretreatment serum IFN-β/α ratio predicts non-response to tumour necrosis factor α inhibition in rheumatoid arthritis
Increased pretreatment serum IFN-β/α ratio predicts non-response to tumour necrosis factor α inhibition in rheumatoid arthritis Open