Christopher Capaldo
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View article: Claudin Barriers on the Brink: How Conflicting Tissue and Cellular Priorities Drive IBD Pathogenesis
Claudin Barriers on the Brink: How Conflicting Tissue and Cellular Priorities Drive IBD Pathogenesis Open
Inflammatory bowel diseases (IBDs) are characterized by acute or chronic recurring inflammation of the intestinal mucosa, often with increasing severity over time. Life-long morbidities and diminishing quality of life for IBD patients comp…
View article: Interferon gamma upregulates the cytokine receptors IFNGR1 and TNFRSF1A in HT-29-MTX E12 cells
Interferon gamma upregulates the cytokine receptors IFNGR1 and TNFRSF1A in HT-29-MTX E12 cells Open
The intestinal mucosa protects the body from physical damage, pathogens, and antigens. However, inflammatory bowel diseases (IBDs) patients suffer from poor mucosal tissue function, including the lack of an effective cellular and/or mucus …
View article: Tumor Suppressor Scribble Regulates Assembly of Tight Junctions in the Intestinal Epithelium
Tumor Suppressor Scribble Regulates Assembly of Tight Junctions in the Intestinal Epithelium Open
Formation of the epithelial barrier and apico-basal cell polarity represent two characteristics and mutually dependent features of differentiated epithelial monolayers. They are controlled by special adhesive structures, tight junctions (T…
View article: Indoles derived from intestinal microbiota act via type I interferon signaling to limit graft-versus-host disease
Indoles derived from intestinal microbiota act via type I interferon signaling to limit graft-versus-host disease Open
The intestinal microbiota in allogeneic bone marrow transplant (allo-BMT) recipients modulates graft-versus-host disease (GVHD), a systemic inflammatory state initiated by donor T cells that leads to colitis, a key determinant of GVHD seve…
View article: Layered defense: how mucus and tight junctions seal the intestinal barrier
Layered defense: how mucus and tight junctions seal the intestinal barrier Open
The colonic mucosa provides a vital defensive barrier separating the body from the microbial populations residing in the intestinal lumen. Indeed, growing evidence shows that loss of this barrier may cause disease or exacerbate disease pro…
View article: Regulation of claudin/zonula occludens-1 complexes by hetero-claudin interactions
Regulation of claudin/zonula occludens-1 complexes by hetero-claudin interactions Open
Claudins are tetraspan transmembrane tight-junction proteins that regulate epithelial barriers. In the distal airspaces of the lung, alveolar epithelial tight junctions are crucial to regulate airspace fluid. Chronic alcohol abuse weakens …
View article: Claudin-based barrier differentiation in the colonic epithelial crypt niche involves Hopx/Klf4 and Tcf7l2/Hnf4-α cascades
Claudin-based barrier differentiation in the colonic epithelial crypt niche involves Hopx/Klf4 and Tcf7l2/Hnf4-α cascades Open
Colonic enterocytes form a rapidly renewing epithelium and barrier to luminal antigens. During renewal, coordinated expression of the claudin family of genes is vital to maintain the epithelial barrier. Disruption of this process contribut…
View article: P-169 Claudin 23 Regulation by TCF7l2 and HNF4-Alpha Promotes Epithelial Barrier Function
P-169 Claudin 23 Regulation by TCF7l2 and HNF4-Alpha Promotes Epithelial Barrier Function Open
Colonic enterocytes form a rapidly renewing epithelium and barrier to luminal antigens. During colonocyte differentiation, coordinated claudin gene expression is vital to epithelia barrier maintenance and disruption of this process is beli…