Christopher Chiaro
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View article: Cross-Tissue Comparison of Epigenetic Aging Clocks in Humans
Cross-Tissue Comparison of Epigenetic Aging Clocks in Humans Open
Epigenetic clocks are a common group of tools used to measure biological aging – the progressive deterioration of cells, tissues and organs. Epigenetic clocks have been trained almost exclusively using blood-based tissues but there is grow…
View article: Activation of Peroxisome Proliferator-Activated Receptor-β/δ (PPARβ/δ) in Keratinocytes by Endogenous Fatty Acids
Activation of Peroxisome Proliferator-Activated Receptor-β/δ (PPARβ/δ) in Keratinocytes by Endogenous Fatty Acids Open
Nuclear hormone receptors exist in dynamic equilibrium between transcriptionally active and inactive complexes dependent on interactions with ligands, proteins, and chromatin. The present studies examined the hypothesis that endogenous lig…
View article: Cross-tissue comparison of telomere length and quality metrics of DNA among individuals aged 8 to 70 years
Cross-tissue comparison of telomere length and quality metrics of DNA among individuals aged 8 to 70 years Open
Telomere length (TL) is an important biomarker of cellular aging, yet its links with health outcomes may be complicated by use of different tissues. We evaluated within- and between-individual variability in TL and quality metrics of DNA a…