Christopher Cluxton
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View article: Neoadjuvant chemoradiation in older Irish adult patients with oesophageal cancer: a retrospective institutional review of clinical outcomes and hematological toxicity
Neoadjuvant chemoradiation in older Irish adult patients with oesophageal cancer: a retrospective institutional review of clinical outcomes and hematological toxicity Open
In conclusion, in patients aged ≥ 70 years compared to those aged < 70 years, we confirm that neoadjuvant chemoradiation is tolerable. There was no evidence to suggest any differences in OS and DFS between the cohorts. Neoadjuvant therapy …
View article: Neoadjuvant chemoradiation in older Irish adult patients with oesophageal cancer: A retrospective institutional review of clinical outcomes and hematological toxicity
Neoadjuvant chemoradiation in older Irish adult patients with oesophageal cancer: A retrospective institutional review of clinical outcomes and hematological toxicity Open
Background and Objectives: Neoadjuvant chemo-radiotherapy improves survival compared with surgery alone in locally advanced oesophageal cancer. In the Chemo-Radiotherapy for Oesophageal cancer followed by Surgery Study (CROSS) randomised c…
View article: Prospective Clinical Trials to Advance the Study of Immune Checkpoint Inhibitor Toxicity
Prospective Clinical Trials to Advance the Study of Immune Checkpoint Inhibitor Toxicity Open
Immune checkpoint inhibitors (ICIs) are a class of drug that produces durable and sustained anti-tumour responses in a wide variety of malignancies. The exponential rise in their use has been mirrored by a rise in immune-related adverse ev…
View article: Prospective Clinical Trials to Advance the Study of Immunotherapy Toxicities
Prospective Clinical Trials to Advance the Study of Immunotherapy Toxicities Open
Immune checkpoint inhibitors (ICIs) are a class of drug that produces durable and sustained anti-tumour responses in a wide variety of malignancies. The exponential rise in their use has been mirrored by a rise in immune-related adverse ev…
View article: Suppression of Natural Killer cell NKG2D and CD226 anti-tumour cascades by platelet cloaked cancer cells: Implications for the metastatic cascade
Suppression of Natural Killer cell NKG2D and CD226 anti-tumour cascades by platelet cloaked cancer cells: Implications for the metastatic cascade Open
Tumour cell immune evasion is a principal hallmark of successful metastasis. Tumour cells in the vasculature adopt a platelet cloak that efficiently suppresses the innate immune system by directly inhibiting Natural Killer (NK) cells, whic…
View article: The Challenge of Cancer Pain Assessment.
The Challenge of Cancer Pain Assessment. Open
It is estimated that up to 80% of cancer patients experience disease related pain, and an estimated 65-80% of cancer patients with advanced disease suffer pain so severe that it negatively impacts their activities of daily living, disrupts…
View article: Composition of the Schistosoma mansoni worm secretome: Identification of immune modulatory Cyclophilin A
Composition of the Schistosoma mansoni worm secretome: Identification of immune modulatory Cyclophilin A Open
The helminth Schistosoma mansoni modulates the infected host's immune system to facilitate its own survival, by producing excretory/secretory molecules that interact with a variety of the host's cell types including those of the immune sys…
View article: Functional conservation of an ancestral Pellino protein in helminth species
Functional conservation of an ancestral Pellino protein in helminth species Open