Christopher D. Paddock
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View article: Murine Typhus – A Horse in Zebra’s Clothing
Murine Typhus – A Horse in Zebra’s Clothing Open
View article: Microsatellite loci support recent speciation of Ambylomma maculatum s.l., Koch, 1944 (Acari: Ixodidae) morphotypes II and III
Microsatellite loci support recent speciation of Ambylomma maculatum s.l., Koch, 1944 (Acari: Ixodidae) morphotypes II and III Open
In the United States, the Amblyomma maculatum sensu lato (s.l.) group is represented by two, distinct allopatric clusters of hard ticks identified as morphotype II in the eastern US and morphotype III in the southwestern states. Previous s…
View article: Ecologic Risk Factors for Infestation of Rhipicephalus sanguineus s.l. in a Rocky Mountain Spotted Fever-Endemic Area of Eastern Arizona
Ecologic Risk Factors for Infestation of Rhipicephalus sanguineus s.l. in a Rocky Mountain Spotted Fever-Endemic Area of Eastern Arizona Open
Rocky Mountain spotted fever (RMSF) is a deadly tick-borne disease caused by the bacterium Rickettsia rickettsii . An ongoing epidemic of RMSF is affecting tribal communities in Arizona, with nearly 500 cases and 28 deaths since 2003. The …
View article: <i>Tropheryma whipplei</i> Infections, Mexico, 2019–2021
<i>Tropheryma whipplei</i> Infections, Mexico, 2019–2021 Open
Whipple's disease is rarely diagnosed in Latin America. We describe 2 patients with Tropheryma whipplei infection diagnosed in Mexico during 2019-2021. Diagnoses were confirmed by histopathology, electron microscopy, immunohistochemistry, …
View article: A wolf at the door: the ecology, epidemiology, and emergence of community- and urban-level Rocky Mountain spotted fever in the Americas
A wolf at the door: the ecology, epidemiology, and emergence of community- and urban-level Rocky Mountain spotted fever in the Americas Open
RMSF, a tickborne infection caused by Rickettsia rickettsii , produces severe and fatal disease in humans and dogs. Since the beginning of the 21st century, cases have risen dramatically, most notably in Mexico and Brazil, where outbreaks …
View article: Molecular identification and antibiotic clearance of <i>Mycoplasma arginini</i> and <i>Mycoplasma orale</i> from cell cultures infected with <i>Rickettsia</i> or <i>Ehrlichia</i> species
Molecular identification and antibiotic clearance of <i>Mycoplasma arginini</i> and <i>Mycoplasma orale</i> from cell cultures infected with <i>Rickettsia</i> or <i>Ehrlichia</i> species Open
Mycoplasma (Class: Mollicutes) contamination in cell cultures is a universal concern for research laboratories. Some estimates report contamination in up to 35% of continuous cell lines. Various commercial antibiotic treatments can success…
View article: Severe and Fatal Rocky Mountain Spotted Fever After Exposure in Tecate, Mexico — California, July 2023–January 2024
Severe and Fatal Rocky Mountain Spotted Fever After Exposure in Tecate, Mexico — California, July 2023–January 2024 Open
Rocky Mountain spotted fever (RMSF) is a tickborne disease endemic in areas of the Americas. Persistent high incidence of the disease exists in northern Mexico, perpetuated by local populations of brown dog ticks (Rhipicephalus sanguineus …
View article: Migration of <i>Amblyomma maculatum</i> Ticks and <i>Rickettsia parkeri</i> into the Northeastern United States
Migration of <i>Amblyomma maculatum</i> Ticks and <i>Rickettsia parkeri</i> into the Northeastern United States Open
We document a case of Rickettsia parkeri rickettsiosis in a patient in Connecticut, USA, who became ill after a bite from a Gulf Coast tick (Amblyomma maculatum). We used PCR to amplify R. parkeri DNA from the detached tick. The patient sh…
View article: Rocky Mountain Spotted Fever in Mexico: A Call to Action
Rocky Mountain Spotted Fever in Mexico: A Call to Action Open
Rocky Mountain spotted fever (RMSF) is an ongoing public health crisis in Mexico, particularly in states bordering the United States. The national highest incidence and mortality of RMSF occur in this region, resulting in a case-fatality r…
View article: Rocky Mountain spotted fever is a neglected tropical disease in Latin America
Rocky Mountain spotted fever is a neglected tropical disease in Latin America Open
Rocky Mountain spotted fever (RMSF), a severe and extraordinarily lethal infectious disease, has emerged as a widespread public health crisis among predominantly vulnerable populations in several countries of Latin America, particularly ev…
View article: Rocky Mountain Spotted Fever Mimicking Multisystem Inflammatory Syndrome in Hospitalized Children, Sonora, Mexico
Rocky Mountain Spotted Fever Mimicking Multisystem Inflammatory Syndrome in Hospitalized Children, Sonora, Mexico Open
We describe 5 children who had Rocky Mountain spotted fever (RMSF) and manifested clinical symptoms similar to multisystem inflammatory syndrome in Sonora, Mexico, where RMSF is hyperendemic. Physicians should consider RMSF in differential…
View article: A mutation associated with resistance to synthetic pyrethroids is widespread in US populations of the tropical lineage of Rhipicephalus sanguineus s.l
A mutation associated with resistance to synthetic pyrethroids is widespread in US populations of the tropical lineage of Rhipicephalus sanguineus s.l Open
The brown dog tick, Rhipicephalus sanguineus sensu lato (s.l.), is an important vector for Rickettsia rickettsii, causative agent of Rocky Mountain spotted fever. Current public health prevention and control efforts to protect people invol…
View article: The emergence of Rocky Mountain spotted fever in the southwestern United States and northern Mexico requires a binational One Health approach
The emergence of Rocky Mountain spotted fever in the southwestern United States and northern Mexico requires a binational One Health approach Open
Rocky Mountain spotted fever (RMSF) is an international and quintessential One Health problem. This paper synthesizes recent knowledge in One Health, binational RMSF concerns, and veterinary and human medical perspectives to this fatal, re…
View article: <i>Rickettsia</i> species identified in adult, host-seeking <i>Dermacentor occidentalis</i> (Acari: Ixodidae) from Baja California, Mexico, and Oregon and Washington, United States
<i>Rickettsia</i> species identified in adult, host-seeking <i>Dermacentor occidentalis</i> (Acari: Ixodidae) from Baja California, Mexico, and Oregon and Washington, United States Open
The Pacific Coast tick (Dermacentor occidentalis Marx, 1892) is a frequently encountered and commonly reported human-biting tick species that has been recorded from most of California and parts of southwestern Oregon, southcentral Washingt…
View article: Pathology and <i>Monkeypox virus</i> Localization in Tissues From Immunocompromised Patients With Severe or Fatal Mpox
Pathology and <i>Monkeypox virus</i> Localization in Tissues From Immunocompromised Patients With Severe or Fatal Mpox Open
Background Pathology and Monkeypox virus (MPXV) tissue tropism in severe and fatal human mpox is not thoroughly described but can help elucidate the disease pathogenesis and the role of coinfections in immunocompromised patients. Methods W…
View article: A Mutation Associated with Resistance to Synthetic Pyrethroids is Widespread in Us Populations of the Tropical Lineage of <i>Rhipicephalus Sanguineus</i> S.L
A Mutation Associated with Resistance to Synthetic Pyrethroids is Widespread in Us Populations of the Tropical Lineage of <i>Rhipicephalus Sanguineus</i> S.L Open
View article: The Brief Case: A traveler’s tale—imported scrub typhus in a child returning from Bangladesh
The Brief Case: A traveler’s tale—imported scrub typhus in a child returning from Bangladesh Open
View article: <i>Anaplasma bovis</i>–Like Infections in Humans, United States, 2015–2017
<i>Anaplasma bovis</i>–Like Infections in Humans, United States, 2015–2017 Open
We detected the DNA of an Anaplasma bovis-like bacterium in blood specimens from 4 patients from the United States with suspected tickborne illnesses. Initial molecular characterization of this novel agent reveals identity to A. bovis-like…
View article: Corrigendum: Characterization of a novel transitional group Rickettsia species (Rickettsia tillamookensis sp. nov.) from the western black-legged tick, Ixodes pacificus
Corrigendum: Characterization of a novel transitional group Rickettsia species (Rickettsia tillamookensis sp. nov.) from the western black-legged tick, Ixodes pacificus Open
Microbiology Society journals contain high-quality research papers and topical review articles. We are a not-for-profit publisher and we support and invest in the microbiology community, to the benefit of everyone. This supports our princi…
View article: Redescription of the larval stage of Dermacentor parumapertus Neumann (Acari: Ixodidae), with notes on hosts
Redescription of the larval stage of Dermacentor parumapertus Neumann (Acari: Ixodidae), with notes on hosts Open
The larva of the ixodid tick Dermacentor parumapertus Neumann, chiefly a parasite of hares and rabbits, is redescribed using scanning electron micrographs of seven specimens derived from two engorged females collected from two black-tailed…
View article: Correction: A forty-year review of Rocky Mountain spotted fever cases in California shows clinical and epidemiologic changes
Correction: A forty-year review of Rocky Mountain spotted fever cases in California shows clinical and epidemiologic changes Open
[This corrects the article DOI: 10.1371/journal.pntd.0010738.].
View article: Neuroinvasive Onchocerca lupi Infection in a Ten-Year-Old Girl
Neuroinvasive Onchocerca lupi Infection in a Ten-Year-Old Girl Open
The nematode Onchocerca lupi is an emerging human pathogen. Though its life cycle is not well studied, it likely infects humans after a bite from a black fly vector, which in turn acquires infective microfilariae from an infected canid. Th…
View article: A forty-year review of Rocky Mountain spotted fever cases in California shows clinical and epidemiologic changes
A forty-year review of Rocky Mountain spotted fever cases in California shows clinical and epidemiologic changes Open
Rocky Mountain spotted fever (RMSF) is a life-threatening tick-borne disease documented in North, Central, and South America. In California, RMSF is rare; nonetheless, recent fatal cases highlight ecological cycles of the two genera of tic…
View article: Predicting the northward expansion of tropical lineage Rhipicephalus sanguineus sensu lato ticks in the United States and its implications for medical and veterinary health
Predicting the northward expansion of tropical lineage Rhipicephalus sanguineus sensu lato ticks in the United States and its implications for medical and veterinary health Open
The tropical lineage within the Rhipicephalus sanguineus species complex is cause for growing concern in the U.S. based on its prominent role in creating and perpetuating multiple recently identified outbreaks of Rocky Mountain spotted fev…
View article: Detection and Isolation of<i>Rickettsia tillamookensis</i>(Rickettsiales: Rickettsiaceae) From<i>Ixodes pacificus</i>(Acari: Ixodidae) From Multiple Regions of California
Detection and Isolation of<i>Rickettsia tillamookensis</i>(Rickettsiales: Rickettsiaceae) From<i>Ixodes pacificus</i>(Acari: Ixodidae) From Multiple Regions of California Open
The western black-legged tick (Ixodes pacificus) is the most frequently identified human-biting tick species in the western United States and the principal vector of at least three recognized bacterial pathogens of humans. A potentially pa…
View article: Autopsy Histopathologic Cardiac Findings in 2 Adolescents Following the Second COVID-19 Vaccine Dose
Autopsy Histopathologic Cardiac Findings in 2 Adolescents Following the Second COVID-19 Vaccine Dose Open
To the Editor.—We read with concern the manuscript by Gill et al1 that described autopsy findings for 2 adolescents who died after COVID-19 vaccination. The authors correctly stated that the Centers for Disease Control and Prevention (CDC)…
View article: Association between Growth Rate and Pathogenicity of Spotted Fever Group Rickettsia
Association between Growth Rate and Pathogenicity of Spotted Fever Group Rickettsia Open
Rickettsia parkeri and Rickettsia amblyommatis are spotted fever group Rickettsia (SFGR) associated with Amblyomma ticks. R. parkeri is a recognized human pathogen that causes an eschar-associated febrile illness, while R. amblyommatis has…
View article: Complete Genome Sequence of Rickettsia parkeri Strain Black Gap
Complete Genome Sequence of Rickettsia parkeri Strain Black Gap Open
A unique genotype of Rickettsia parkeri , designated R. parkeri strain Black Gap, has thus far been associated exclusively with the North American tick, Dermacentor parumapertus . The compete genome consists of a single circular chromosome…
View article: Phylogenetic Differentiation of Rickettsia parkeri Reveals Broad Dispersal and Distinct Clustering within North American Strains
Phylogenetic Differentiation of Rickettsia parkeri Reveals Broad Dispersal and Distinct Clustering within North American Strains Open
Since 1937, when Rickettsia parkeri was originally identified in Amblyomma maculatum group ticks, the recognized range and associated vectors for this pathogen have expanded significantly. In recent years, R. parkeri has been identified in…
View article: Characterization of a novel transitional group Rickettsia species (Rickettsia tillamookensis sp. nov.) from the western black-legged tick, Ixodes pacificus
Characterization of a novel transitional group Rickettsia species (Rickettsia tillamookensis sp. nov.) from the western black-legged tick, Ixodes pacificus Open
A previously unrecognized Rickettsia species was isolated in 1976 from a pool of Ixodes pacificus ticks collected in 1967 from Tillamook County, Oregon, USA. The isolate produced low fever and mild scrotal oedema following intraperitoneal …