Christopher Dinh
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View article: Enhancing Minds in Motion® as a virtual program delivery model for people living with dementia and their care partners
Enhancing Minds in Motion® as a virtual program delivery model for people living with dementia and their care partners Open
The Alzheimer Society of Ontario’s Minds in Motion (MiM) program improves physical function and well-being of people living with dementia (PLWD) and their care partners (CP) (Regan et al., 2019). With the COVID-19 pandemic, there was an ur…
View article: A lectin that targets specific bacteria for killing on DNA-based extracellular traps
A lectin that targets specific bacteria for killing on DNA-based extracellular traps Open
Animal defenses directed against bacteria include DNA-based extracellular traps (ETs) that are produced by innate immune cells. ET-bound bacteria are prevented from further tissue dissemination and are eventually killed by ET-bound antibac…
View article: Social amoebae establish a protective interface with their bacterial associates by lectin agglutination
Social amoebae establish a protective interface with their bacterial associates by lectin agglutination Open
Dictyostelium social amoebae agglutinate bacteria with a secreted lectin to optimize their survival during feeding.
View article: A terpene synthase-cytochrome P450 cluster in Dictyostelium discoideum produces a novel trisnorsesquiterpene
A terpene synthase-cytochrome P450 cluster in Dictyostelium discoideum produces a novel trisnorsesquiterpene Open
Terpenoids are enormously diverse, but our knowledge of their biosynthesis and functions is limited. Here we report on a terpene synthase (DdTPS8)-cytochrome P450 (CYP521A1) gene cluster that produces a novel C12 trisnorsesquiterpene and a…
View article: Cooperative predation in the social amoebae Dictyostelium discoideum
Cooperative predation in the social amoebae Dictyostelium discoideum Open
The eukaryotic amoeba Dictyostelium discoideum is commonly used to study sociality. The amoebae cooperate during development, exhibiting altruism, cheating, and kin-discrimination, but growth while preying on bacteria has been considered a…
View article: Microbiome management in the social amoeba Dictyostelium discoideum compared to humans
Microbiome management in the social amoeba Dictyostelium discoideum compared to humans Open
Social amoebae and humans use common strategies to orchestrate their interactions with the bacteria in their respective environments and within their bodies. These strategies include the elimination of bacteria by phagocytosis, the establi…
View article: Lectins modulate the microbiota of social amoebae
Lectins modulate the microbiota of social amoebae Open
Sticky bacteria tolerated as future food Dictyostelium discoideum amoebae consume bacteria until the supply is exhausted. Then the amoeba cells clump together into a “slug” and initiate a complex multicellular reproductive phase. Specializ…
View article: Gene Prioritization by Compressive Data Fusion and Chaining
Gene Prioritization by Compressive Data Fusion and Chaining Open
Data integration procedures combine heterogeneous data sets into predictive models, but they are limited to data explicitly related to the target object type, such as genes. Collage is a new data fusion approach to gene prioritization. It …