Christopher E. Pedigo
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View article: Profilin1 is required for prevention of mitotic catastrophe in murine and human glomerular diseases
Profilin1 is required for prevention of mitotic catastrophe in murine and human glomerular diseases Open
The progression of proteinuric kidney diseases is associated with podocyte loss, but the mechanisms underlying this process remain unclear. Podocytes reenter the cell cycle to repair double-stranded DNA breaks. However, unsuccessful repair…
View article: Cell Cycle and Senescence Regulation by Podocyte Histone Deacetylase 1 and 2
Cell Cycle and Senescence Regulation by Podocyte Histone Deacetylase 1 and 2 Open
Significance Statement The loss of integrity of the glomerular filtration barrier results in proteinuria that is often attributed to podocyte loss. Yet how damaged podocytes are lost remains unknown. Germline loss of murine podocyte-associ…
View article: POS-384 EFFECT OF ANG-3070 IN THE PASSIVE HEYMANN NEPHRITIS RAT MODEL OF PRIMARY PROTEINURIC KIDNEY DISEASE
POS-384 EFFECT OF ANG-3070 IN THE PASSIVE HEYMANN NEPHRITIS RAT MODEL OF PRIMARY PROTEINURIC KIDNEY DISEASE Open
Primary proteinuric kidney diseases (PPKD) as a group are an important cause of end-stage kidney disease (ESKD). Many receptor tyrosine kinases, including platelet-derived growth factor receptor (PDGFR), contribute to the progression of PP…
View article: Inhibiting calpain 1 and 2 in cyclin G associated kinase–knockout mice mitigates podocyte injury
Inhibiting calpain 1 and 2 in cyclin G associated kinase–knockout mice mitigates podocyte injury Open
Evidence for reduced expression of cyclin G associated kinase (GAK) in glomeruli of patients with chronic kidney disease was observed in the Nephroseq human database, and GAK was found to be associated with the decline in kidney function. …
View article: Combination of Oral Tripterygium Glycosides and angiotensin II receptor blockers for treatment of clinical stage diabetic kidney disease: A systematic review and meta-analysis of randomized controlled trials
Combination of Oral Tripterygium Glycosides and angiotensin II receptor blockers for treatment of clinical stage diabetic kidney disease: A systematic review and meta-analysis of randomized controlled trials Open
As the standard of care for diabetic kidney disease (DKD), angiotensin receptor blockers (ARBs) does not prevent the development of end-stage kidney disease (ESKD) in DKD patients. Tripterygium glucosides (TG) have been widely used for the…
View article: Identification of Podocyte Cargo Proteins by Proteomic Analysis of Clathrin-Coated Vesicles
Identification of Podocyte Cargo Proteins by Proteomic Analysis of Clathrin-Coated Vesicles Open
Background Clathrin-mediated endocytosis (CME) plays a fundamental role in podocyte health. Genetic ablation of genes implicated in CME has been shown to cause severe proteinuria and foot process effacement in mice. However, little is know…
View article: Inhibition of Endocytosis of Clathrin-Mediated Angiotensin II Receptor Type 1 in Podocytes Augments Glomerular Injury
Inhibition of Endocytosis of Clathrin-Mediated Angiotensin II Receptor Type 1 in Podocytes Augments Glomerular Injury Open
Significance Statement The amelioration of proteinuria resulting from inhibition of the renin-angiotensin pathway is thought to be predominantly caused by reduction in intraglomerular pressure. However, because studies have produced confli…
View article: ATP-binding cassette A1 deficiency causes cardiolipin-driven mitochondrial dysfunction in podocytes
ATP-binding cassette A1 deficiency causes cardiolipin-driven mitochondrial dysfunction in podocytes Open
Fibroblasts from patients with Tangier disease carrying ATP-binding cassette A1 (ABCA1) loss-of-function mutations are characterized by cardiolipin accumulation, a mitochondrial-specific phospholipid. Suppression of ABCA1 expression occurs…
View article: Podocyte histone deacetylase activity regulates murine and human glomerular diseases
Podocyte histone deacetylase activity regulates murine and human glomerular diseases Open
We identified 2 genes, histone deacetylase 1 (HDAC1) and HDAC2, contributing to the pathogenesis of proteinuric kidney diseases, the leading cause of end-stage kidney disease. mRNA expression profiling from proteinuric mouse glomeruli was …
View article: Vinculin is required to maintain glomerular barrier integrity
Vinculin is required to maintain glomerular barrier integrity Open
Cell-matrix interactions and podocyte intercellular junctions are key for maintaining the glomerular filtration barrier. Vinculin, a cytoplasmic protein, couples actin filaments to integrin-mediated cell-matrix adhesions and to cadherin-ba…
View article: Local TNF causes NFATc1-dependent cholesterol-mediated podocyte injury
Local TNF causes NFATc1-dependent cholesterol-mediated podocyte injury Open
High levels of circulating TNF and its receptors, TNFR1 and TNFR2, predict the progression of diabetic kidney disease (DKD), but their contribution to organ damage in DKD remains largely unknown. Here, we investigated the function of local…