Christopher E. Pollard
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View article: Utilization of mechanistic modelling and simulation to analyse fenspiride proarrhythmic potency – Role of physiological and other non‐drug related parameters
Utilization of mechanistic modelling and simulation to analyse fenspiride proarrhythmic potency – Role of physiological and other non‐drug related parameters Open
It can be hypothesized that the clinically observed arrhythmia cases were not directly caused by fenspiride alone but a combination of multiple factors, including comedications.
View article: Predicting Drug Safety and Communicating Risk: Benefits of a Bayesian Approach
Predicting Drug Safety and Communicating Risk: Benefits of a Bayesian Approach Open
Drug toxicity is a major source of attrition in drug discovery and development. Pharmaceutical companies routinely use preclinical data to predict clinical outcomes and continue to invest in new assays to improve predictions. However, ther…
View article: Predicting drug safety and communicating risk: benefits of a Bayesian approach
Predicting drug safety and communicating risk: benefits of a Bayesian approach Open
Drug toxicity is a major source of attrition in drug discovery and development. Pharmaceutical companies routinely use preclinical data to predict clinical outcomes and continue to invest in new assays to improve predictions. However, ther…
View article: An Analysis of the Relationship Between Preclinical and Clinical QT Interval-Related Data
An Analysis of the Relationship Between Preclinical and Clinical QT Interval-Related Data Open
There has been significant focus on drug-induced QT interval prolongation caused by block of the human ether-a-go-go-related gene (hERG)-encoded potassium channel. Regulatory guidance has been implemented to assess QT interval prolongation…
View article: From the Cover: High-Throughput Imaging of Cardiac Microtissues for the Assessment of Cardiac Contraction during Drug Discovery
From the Cover: High-Throughput Imaging of Cardiac Microtissues for the Assessment of Cardiac Contraction during Drug Discovery Open
Cardiotoxicity is a common cause of attrition in preclinical and clinical drug development. Current in vitro approaches have two main limitations, they either are limited to low throughput methods not amendable to drug discovery or lack th…