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View article: Determinants of malnutrition among children under 5 years in refugee and internally displaced person populations: a protocol for systematic review and meta-analysis
Determinants of malnutrition among children under 5 years in refugee and internally displaced person populations: a protocol for systematic review and meta-analysis Open
Introduction Malnutrition is a critical global health issue, particularly among the vulnerable children whose socioeconomic, sociocultural and environmental characteristics are unique. Malnutrition significantly increases the risk of morta…
View article: Corticosteroids for treatment of leptospirosis
Corticosteroids for treatment of leptospirosis Open
Based on the very low certainty of evidence attributable to our analyses, we do not know whether corticosteroids compared with no intervention, no intervention beyond standard of care, or placebo, reduce all-cause mortality, increase the r…
View article: Experience conducting COVID-19 vaccine effectiveness studies in response to the COVID-19 pandemic in Japan and the Philippines: lessons for future epidemics and potential pandemics
Experience conducting COVID-19 vaccine effectiveness studies in response to the COVID-19 pandemic in Japan and the Philippines: lessons for future epidemics and potential pandemics Open
Problem: Once COVID-19 vaccines were rolled out, there was a need to monitor real-world vaccine effectiveness to accumulate evidence to inform policy and risk communication. This was especially true in Japan and the Philippines, given hist…
View article: Outcomes and experiences of Indigenous patients in Newfoundland and Labrador’s bariatric surgery program: a pilot study
Outcomes and experiences of Indigenous patients in Newfoundland and Labrador’s bariatric surgery program: a pilot study Open
As a response to TRC's Calls to Action, our study shows bariatric surgery outcomes in Newfoundland and Labrador were similar for Indigenous and non-Indigenous patients. Given their lower satisfaction with postoperative decrease in weight, …
View article: Prevalence and epidemiology of Mycoplasma genitalium and the absence of macrolide resistance in M. genitalium among pregnant women attending antenatal care in Zambia
Prevalence and epidemiology of Mycoplasma genitalium and the absence of macrolide resistance in M. genitalium among pregnant women attending antenatal care in Zambia Open
Introduction Mycoplasma genitalium (MG) is a sexually transmitted bacterium of public health importance, associated with genitourinary disorders, and adverse reproductive and perinatal outcomes. Global data on MG prevalence and antimicrobi…
View article: Sociobehavioural factors associated with SARS-CoV-2 infection and COVID-19 vaccine effectiveness against medically attended, symptomatic SARS-CoV-2 infection in the Philippines: a prospective case-control study (FASCINATE-P study)
Sociobehavioural factors associated with SARS-CoV-2 infection and COVID-19 vaccine effectiveness against medically attended, symptomatic SARS-CoV-2 infection in the Philippines: a prospective case-control study (FASCINATE-P study) Open
Objective: We examined sociobehavioural factors associated with SARS-CoV-2 infection and estimated COVID-19 vaccine effectiveness against symptomatic SARS-CoV-2 infection in the Philippines. Such studies are limited in low- and middle-inco…
View article: APSIM's Soil N Model Review for Future Development
APSIM's Soil N Model Review for Future Development Open
The accurate simulation of soil nitrogen (N) cycling is central to the process-based model Agricultural Production Systems sIMulator (APSIM) and increasingly the focus of modellers globally on account of a growing emphasis on quantifying N…
View article: Phylogenetic Study of Local Patterns Influenza A(H3N2) Virus Transmission in a Semi‐Isolated Population in a Remote Island in Japan Between 2011 and 2013
Phylogenetic Study of Local Patterns Influenza A(H3N2) Virus Transmission in a Semi‐Isolated Population in a Remote Island in Japan Between 2011 and 2013 Open
Background Influenza A outbreak risk is impacted by the potential for importation and local transmission. Reconstructing transmission history with phylogenetic analysis of genetic sequences can help assess outbreak risk but relies on regul…
View article: Stop to smell the virtual roses: a mixed-methods pilot study on the impact of multisensory virtual reality nature experiences on feelings of relaxation
Stop to smell the virtual roses: a mixed-methods pilot study on the impact of multisensory virtual reality nature experiences on feelings of relaxation Open
Introduction This study aimed to investigate the psychological and physiological impacts of audio-visual (AV) and audio-visual-olfactory (AVO) stimuli within an immersive virtual nature environment. Methods Twenty-two nurses from the menta…
View article: Factors associated with COVID-19 in-hospital death and COVID-19 vaccine effectiveness against COVID-19 hospitalization in the Philippines during pre-omicron and omicron period: A case-control study (MOTIVATE-P study)
Factors associated with COVID-19 in-hospital death and COVID-19 vaccine effectiveness against COVID-19 hospitalization in the Philippines during pre-omicron and omicron period: A case-control study (MOTIVATE-P study) Open
COVID-19 vaccine effectiveness (VE) studies are limited in low- and middle-income countries. A case-control study was conducted among COVID-19 and other pneumonia patients admitted to a hospital in the Philippines during the pre-Omicron an…
View article: Clinical Characteristics and Risk Factors for Severe Japanese Spotted Fever: A Retrospective Multicenter Study in the Nagasaki Prefecture, Western Japan
Clinical Characteristics and Risk Factors for Severe Japanese Spotted Fever: A Retrospective Multicenter Study in the Nagasaki Prefecture, Western Japan Open
Japanese spotted fever (JSF) is a tick-borne rickettsial disease prevalent in western Japan with an increasing incidence and geographical distribution. This retrospective study aimed to describe the clinical features of JSF and identify fa…
View article: Characteristics of snakebite patients due to <i>Naja samarensis</i> in the Philippines: a prospective hospital-based study
Characteristics of snakebite patients due to <i>Naja samarensis</i> in the Philippines: a prospective hospital-based study Open
Background Little is known about snakebites by Naja samarensis, a species unique to the Philippines. The aim here is to describe the clinical and epidemiological characteristics of patients bitten by this medically important cobra in the E…
View article: 5162 Oral LUM-201 Restores Pulsatile Growth Hormone Secretion and Growth Response in Moderate Pediatric Growth Hormone Deficiency (PGHD): Key Discoveries from Phase 2 of OraGrowtH212 Trial
5162 Oral LUM-201 Restores Pulsatile Growth Hormone Secretion and Growth Response in Moderate Pediatric Growth Hormone Deficiency (PGHD): Key Discoveries from Phase 2 of OraGrowtH212 Trial Open
Disclosure: F. Cassorla: Consulting Fee; Self; Lumos Pharma, Inc. Research Investigator; Self; Lumos Pharma, Inc. R. Roman: Research Investigator; Self; Lumos Pharma, Inc. M.L. Johnson: Consulting Fee; Self; Lumos Pharma, Inc. A. Avila: Re…
View article: Core Outcome Set development for LEPtospirosis trials (COS-LEP): a study protocol to develop a core outcome set for the evaluation of clinical therapeutic interventions for human Leptospirosis
Core Outcome Set development for LEPtospirosis trials (COS-LEP): a study protocol to develop a core outcome set for the evaluation of clinical therapeutic interventions for human Leptospirosis Open
Background Leptospirosis is a zoonotic bacterial infection occurring worldwide. It is of particular public health concern due to its global distribution, epidemic potential and high mortality without appropriate treatment. The method for t…
View article: Actinomyces funkei bacteraemia and infected pulmonary cavities in an intravenous drug user: a case report
Actinomyces funkei bacteraemia and infected pulmonary cavities in an intravenous drug user: a case report Open
Background Actinomyces spp. are most commonly found in human commensal flora; however, they have also been shown to cause suppurative infections. We present a case of a rare Actinomyces funkei bacteraemia from an infected deep vein thrombo…
View article: A pilot study of dimeticone oils versus sodium carbonate treatment for tungiasis: A randomized cohort trial in Homa Bay County, Kenya
A pilot study of dimeticone oils versus sodium carbonate treatment for tungiasis: A randomized cohort trial in Homa Bay County, Kenya Open
Background Tungiasis is a cutaneous parasitosis caused by the female flea Tunga penetrans . Two-component dimeticone (NYDA) is the only treatment for tungiasis recommended by the World Health Organization; however, this topical drug is not…
View article: SafeVRwards: Designing a complementary virtual reality module to the Safewards framework intended to relax and manage conflict in mental health wards
SafeVRwards: Designing a complementary virtual reality module to the Safewards framework intended to relax and manage conflict in mental health wards Open
Background Aggression and negative activation in mental health inpatient units pose significant challenges for both patients and staff with severe physical and psychological ramifications. The Safewards model is an evidence-based conflict-…
View article: Deep Learning Enhances Detection of Extracapsular Extension in Prostate Cancer from mpMRI of 1001 Patients
Deep Learning Enhances Detection of Extracapsular Extension in Prostate Cancer from mpMRI of 1001 Patients Open
Extracapsular extension (ECE) is detected in approximately one-third of newly diagnosed prostate cancer (PCa) cases at stage T3a or higher and is associated with increased rates of positive surgical margins and early biochemical recurrence…
View article: Phylogenetic study of local patterns influenza A(H3N2) virus transmission in a semi-isolated population in a remote island in Japan between 2011-2013
Phylogenetic study of local patterns influenza A(H3N2) virus transmission in a semi-isolated population in a remote island in Japan between 2011-2013 Open
Background The spatial spread and importation risk of influenza A viruses in rural settings remains unclear due to the sparsity of representative spatiotemporal sequence data. Methods Nasopharyngeal (NPS) samples of Rapid Influenza Diagnos…
View article: Correction: Unique characteristics of new complete blood count parameters, the Immature Platelet Fraction and the Immature Platelet Fraction Count, in dengue patients
Correction: Unique characteristics of new complete blood count parameters, the Immature Platelet Fraction and the Immature Platelet Fraction Count, in dengue patients Open
[This corrects the article DOI: 10.1371/journal.pone.0258936.].
View article: Antibiotic prophylaxis for leptospirosis
Antibiotic prophylaxis for leptospirosis Open
We do not know if antibiotics versus placebo or another antibiotic has little or have no effect on all-cause mortality or leptospirosis infection because the certainty of evidence is low or very low. We do not know if antibiotics versus pl…
View article: Antibiotics for treatment of leptospirosis
Antibiotics for treatment of leptospirosis Open
As the certainty of evidence is very low, we do not know if antibiotics provide little to no effect on all-cause mortality, serious adverse events, or adverse events considered non-serious. There is a lack of definitive rigorous data from …
View article: Opportunities for Managing Pain and Anxiety in the Intensive Care Unit Using Virtual Reality: Perspectives from Bedside Care Providers
Opportunities for Managing Pain and Anxiety in the Intensive Care Unit Using Virtual Reality: Perspectives from Bedside Care Providers Open
Purpose: Virtual reality (VR) is a promising nonpharmacological tool to decrease pain and anxiety in the intensive care unit (ICU). Limited work, however, has been conducted on the functional implications of using VR to support intubated I…