Christopher J. Edge
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View article: Three classes of propofol binding sites on GABAA receptors
Three classes of propofol binding sites on GABAA receptors Open
Propofol is a widely used anesthetic and sedative that acts as a positive allosteric modulator of gamma-aminobutyric acid type A (GABAA) receptors. Several potential propofol binding sites that may mediate this effect have been …
View article: Author Correction: Brain clearance is reduced during sleep and anesthesia
Author Correction: Brain clearance is reduced during sleep and anesthesia Open
View article: Brain clearance is reduced during sleep and anesthesia
Brain clearance is reduced during sleep and anesthesia Open
It has been suggested that the function of sleep is to actively clear metabolites and toxins from the brain. Enhanced clearance is also said to occur during anesthesia. Here, we measure clearance and movement of fluorescent molecules in th…
View article: Medical conditions that affect the risk of diving
Medical conditions that affect the risk of diving Open
View article: The pathophysiologies of diving diseases
The pathophysiologies of diving diseases Open
View article: Xenon treatment after severe traumatic brain injury improves locomotor outcome, reduces acute neuronal loss and enhances early beneficial neuroinflammation: a randomized, blinded, controlled animal study
Xenon treatment after severe traumatic brain injury improves locomotor outcome, reduces acute neuronal loss and enhances early beneficial neuroinflammation: a randomized, blinded, controlled animal study Open
Background Traumatic brain injury (TBI) is a major cause of morbidity and mortality, but there are no clinically proven treatments that specifically target neuronal loss and secondary injury development following TBI. In this study, we eva…
View article: Noble gas neuroprotection: xenon and argon protect against hypoxic–ischaemic injury in rat hippocampus in vitro via distinct mechanisms
Noble gas neuroprotection: xenon and argon protect against hypoxic–ischaemic injury in rat hippocampus in vitro via distinct mechanisms Open
Xenon and argon are equally effective as neuroprotectants against hypoxia-ischaemia in vitro, with both gases preventing injury development. Although xenon's neuroprotective effect may be mediated by inhibition of the N-methyl-d-aspartate …
View article: Xenon improves long-term cognitive function, reduces neuronal loss and chronic neuroinflammation, and improves survival after traumatic brain injury in mice
Xenon improves long-term cognitive function, reduces neuronal loss and chronic neuroinflammation, and improves survival after traumatic brain injury in mice Open
View article: A Novel <em>In Vitro</em> Model of Blast Traumatic Brain Injury
A Novel <em>In Vitro</em> Model of Blast Traumatic Brain Injury Open
Traumatic brain injury is a leading cause of death and disability in military and civilian populations. Blast traumatic brain injury results from the detonation of explosive devices, however, the mechanisms that underlie the brain damage r…
View article: A Novel <em>In Vitro</em> Model of Blast Traumatic Brain Injury
A Novel <em>In Vitro</em> Model of Blast Traumatic Brain Injury Open
Traumatic brain injury is a leading cause of death and disability in military and civilian populations. Blast traumatic brain injury results from the detonation of explosive devices, however, the mechanisms that underlie the brain damage r…
View article: Xenon Protects against Blast-Induced Traumatic Brain Injury in an <i>In Vitro</i> Model
Xenon Protects against Blast-Induced Traumatic Brain Injury in an <i>In Vitro</i> Model Open
The aim of this study was to evaluate the neuroprotective efficacy of the inert gas xenon as a treatment for patients with blast-induced traumatic brain injury in an in vitro laboratory model. We developed a novel blast traumatic brain inj…
View article: Activation and modulation of recombinant glycine and GABA<sub>A</sub>receptors by 4‐halogenated analogues of propofol
Activation and modulation of recombinant glycine and GABA<sub>A</sub>receptors by 4‐halogenated analogues of propofol Open
Background and Purpose Glycine receptors are important players in pain perception and movement disorders and therefore important therapeutic targets. Glycine receptors can be modulated by the intravenous anaesthetic propofol (2,6‐diisoprop…