Christopher M. Flores
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View article: Metabolism and disposition of JNJ-10450232 (NTM-006) in rats, dogs, monkeys and humans
Metabolism and disposition of JNJ-10450232 (NTM-006) in rats, dogs, monkeys and humans Open
JNJ-10450232 (NTM-006), a novel non-opioid, non-nonsteroidal anti-inflammatory drug with structural similarities to acetaminophen, demonstrated anti-pyretic and/or analgesic activities in preclinical models and humans and reduced potential…
View article: Preclinical safety assessment of JNJ-10450232 (NTM-006), a structural analog of acetaminophen, that does not cause hepatotoxicity at supratherapeutic doses
Preclinical safety assessment of JNJ-10450232 (NTM-006), a structural analog of acetaminophen, that does not cause hepatotoxicity at supratherapeutic doses Open
JNJ-10450232 (NTM-006) is a new molecular entity that is structurally related to acetaminophen. A comprehensive non-clinical safety program was conducted to support first-in-human and clinical efficacy studies based on preclinical data sug…
View article: Revealing Unknown Benefits of Existing Medications to Aid the Discovery of New Treatments for Post‐Traumatic Stress Disorder
Revealing Unknown Benefits of Existing Medications to Aid the Discovery of New Treatments for Post‐Traumatic Stress Disorder Open
The medications identified in this analysis provide targets for further research in studies that are designed to examine specific hypotheses regarding these medications and the incidence of PTSD. This work may aid in discovering novel ther…
View article: Black men wanted: an instrumental case study exploring the situational factors related to the retention of African American male high school teachers.
Black men wanted: an instrumental case study exploring the situational factors related to the retention of African American male high school teachers. Open
As the nation’s high school student population becomes increasingly diverse, the declining number of minority teachers, particularly African American male teachers is becoming an area of concern. This instrumental case study of African Ame…
View article: Sex differences in the role of atypical PKC within the basolateral nucleus of the amygdala in a mouse hyperalgesic priming model
Sex differences in the role of atypical PKC within the basolateral nucleus of the amygdala in a mouse hyperalgesic priming model Open
Though sex differences in chronic pain have been consistently described in the literature, their underlying neural mechanisms are poorly understood. Previous work in humans has demonstrated that men and women differentially invoke distinct…
View article: TRPV1 antagonist JNJ-39439335 (mavatrep) demonstrates proof of pharmacology in healthy men: a first-in-human, double-blind, placebo-controlled, randomized, sequential group study
TRPV1 antagonist JNJ-39439335 (mavatrep) demonstrates proof of pharmacology in healthy men: a first-in-human, double-blind, placebo-controlled, randomized, sequential group study Open
This double-blind, randomized, placebo-controlled, sequential group, phase 1 study was designed to assess in healthy men, the safety, tolerability, pharmacokinetics, and translational pharmacodynamics of JNJ-39439335 (mavatrep), a transien…
View article: Benzo[<i>d</i>]imidazole Transient Receptor Potential Vanilloid 1 Antagonists for the Treatment of Pain: Discovery of <i>trans</i>-2-(2-{2-[2-(4-Trifluoromethyl-phenyl)-vinyl]-1<i>H</i>-benzimidazol-5-yl}-phenyl)-propan-2-ol (Mavatrep)
Benzo[<i>d</i>]imidazole Transient Receptor Potential Vanilloid 1 Antagonists for the Treatment of Pain: Discovery of <i>trans</i>-2-(2-{2-[2-(4-Trifluoromethyl-phenyl)-vinyl]-1<i>H</i>-benzimidazol-5-yl}-phenyl)-propan-2-ol (Mavatrep) Open
Reported herein is the design, synthesis, and pharmacologic characterization of a class of TRPV1 antagonists constructed on a benzo[d]imidazole platform that evolved from a biaryl amide lead. This design composes three sections: a 2-substi…