Christopher Frampton
YOU?
Author Swipe
View article: Risk Factors for Early-Onset Colorectal Cancer: The Role of Diet, Lifestyle and Obesity
Risk Factors for Early-Onset Colorectal Cancer: The Role of Diet, Lifestyle and Obesity Open
Background. Colorectal cancer (CRC) is the third most commonly diagnosed cancer globally, and remains the second leading cause of cancer-related mortality. The incidence of early-onset colorectal cancer (EOCRC) among young adults before th…
View article: Predicting Cognitive Change During Treatment for Inpatient Depression: Secondary Analysis From a Randomized Controlled Trial
Predicting Cognitive Change During Treatment for Inpatient Depression: Secondary Analysis From a Randomized Controlled Trial Open
Introduction Individuals hospitalized with depression are particularly impacted by cognitive impairment. Identifying variables that predict improvements in cognition across treatment may inform more targeted and effective treatment approac…
View article: New Zealand Joint Registry Surgeon‐Level Feedback: The Influence of Reporting Timeframe on Distribution of Reasons for Revision Following Total Knee Arthroplasty
New Zealand Joint Registry Surgeon‐Level Feedback: The Influence of Reporting Timeframe on Distribution of Reasons for Revision Following Total Knee Arthroplasty Open
Background National joint registries have improved arthroplasty surgery by creating databases that monitor implant performance and recognize early implant failure. The New Zealand Joint Registry (NZJR) provides surgeon reports on individua…
View article: Soluble urokinase plasminogen activator receptor (suPAR) for risk stratification from undifferentiated acute chest pain through to convalescence after acute coronary syndromes
Soluble urokinase plasminogen activator receptor (suPAR) for risk stratification from undifferentiated acute chest pain through to convalescence after acute coronary syndromes Open
Aim The performance of plasma soluble urokinase plasminogen activator receptor (suPAR) for prediction of heart failure (HF) readmission or death within 5 years was assessed in patients incurring (i) initially undifferentiated chest pain an…
View article: Chicken liver and eggshell crackers are a safe and affordable animal source food for overcoming micronutrient deficits during pregnancy and lactation in Indonesia: a double-blind, cluster randomized controlled trial (SISTIK Growth Study)
Chicken liver and eggshell crackers are a safe and affordable animal source food for overcoming micronutrient deficits during pregnancy and lactation in Indonesia: a double-blind, cluster randomized controlled trial (SISTIK Growth Study) Open
Background Poor diets and micronutrient deficiencies during pregnancy and lactation are common in Indonesia, potentially affecting linear growth. National maternal programs focus predominantly on iron-folic acid (IFA) supplementation, but …
View article: Do the Ten-Year Functional Outcomes and Revision Rates of Total Hip Arthroplasty in Obese and Morbidly Obese Patients Justify Restricting Their Access to Surgery?
Do the Ten-Year Functional Outcomes and Revision Rates of Total Hip Arthroplasty in Obese and Morbidly Obese Patients Justify Restricting Their Access to Surgery? Open
The ten-year functional outcomes and revision rates of THA do not justify restricting access to surgery on the basis of BMI.
View article: Do patient-reported outcome scores better identify outlier surgical practice compared with revision rates for total knee arthroplasty?
Do patient-reported outcome scores better identify outlier surgical practice compared with revision rates for total knee arthroplasty? Open
Background and purpose: The New Zealand Joint Registry provides surgeon-level feedback on revision rate and Oxford scores for primary total knee replacement (TKR). Potential outliers are identified using revision rate. Using patient-report…
View article: Psychological interventions for adult earthquake-related post-traumatic stress disorder: systematic review and meta-analysis.
Psychological interventions for adult earthquake-related post-traumatic stress disorder: systematic review and meta-analysis. Open
Psychological interventions are associated with good outcomes among adults with earthquake-related PTSD. The most evidence currently exists for CBT-based interventions, which are recommended as first-line treatments. Efficient intervention…
View article: Incidence, prevalence and mortality of rheumatoid arthritis in Canterbury, Aotearoa New Zealand
Incidence, prevalence and mortality of rheumatoid arthritis in Canterbury, Aotearoa New Zealand Open
Background There is relatively little research regarding the frequency of rheumatoid arthritis (RA) in Canterbury and no previous studies comparing the mortality of RA in Aotearoa New Zealand to a general population. Aims To determine the …
View article: Colchicine Concentrations and Relationship With Colchicine Efficacy and Adverse Events: Post Hoc Analysis of a Randomized Clinical Trial of Colchicine for Gout Flare Prophylaxis
Colchicine Concentrations and Relationship With Colchicine Efficacy and Adverse Events: Post Hoc Analysis of a Randomized Clinical Trial of Colchicine for Gout Flare Prophylaxis Open
Objective Our objective was to examine the relationship between colchicine plasma concentrations and clinical and demographic factors and to determine the relationship between colchicine concentrations and colchicine efficacy and colchicin…
View article: Clinical Efficacy of Ovine Forestomach Matrix and Collagen/Oxidised Regenerated Cellulose for the Treatment of Venous Leg Ulcers: A Retrospective Comparative Real‐World Evidence Study
Clinical Efficacy of Ovine Forestomach Matrix and Collagen/Oxidised Regenerated Cellulose for the Treatment of Venous Leg Ulcers: A Retrospective Comparative Real‐World Evidence Study Open
Venous leg ulcers (VLUs) are traditionally managed with standard‐of‐care dressings, compression and appropriate adjunctive venous interventions for pathologic venous reflux. Due to pathophysiological complexity and underlying patient comor…
View article: Impact of Activation Therapy for Inpatients With Major Depression: Primary and Secondary Outcomes From a Randomised Controlled Trial
Impact of Activation Therapy for Inpatients With Major Depression: Primary and Secondary Outcomes From a Randomised Controlled Trial Open
Introduction Inpatient depression is associated with high morbidity and significant cognitive impairment. Inpatient treatment often focuses on short‐term stabilization with medication. Readmission rates are high. We examined the impact of …
View article: Treatment Outcomes of Cognitive Behavioural Therapy for Earthquake‐Related Distress
Treatment Outcomes of Cognitive Behavioural Therapy for Earthquake‐Related Distress Open
Background Cognitive behavioural therapy (CBT) is an effective treatment for post‐traumatic stress disorder (PTSD), but few studies have examined its effectiveness among individuals exposed to natural disasters. Group CBT could be an effic…
View article: Differences associated with different prior mental disorders among earthquake-exposed treatment-seeking individuals
Differences associated with different prior mental disorders among earthquake-exposed treatment-seeking individuals Open
Background History of prior mental disorder, particularly post-traumatic stress disorder (PTSD), increases risk for PTSD following subsequent trauma exposure. However, limited research has examined differences associated with specific prio…
View article: Sex-based differences in risk of revision for infection after hip, knee, shoulder, and ankle arthroplasty in osteoarthritis patients: a multinational registry study of 4,800,000 implants
Sex-based differences in risk of revision for infection after hip, knee, shoulder, and ankle arthroplasty in osteoarthritis patients: a multinational registry study of 4,800,000 implants Open
Background and purpose: We aimed to determine sex differences for periprosthetic joint infections after primary arthroplasty of the hip, knee, ankle, and shoulder in osteoarthritis patients in an international perspective.Methods: This is …
View article: Limb Salvage via Surgical Soft-tissue Reconstruction With Ovine Forestomach Matrix Grafts: A Prospective Study
Limb Salvage via Surgical Soft-tissue Reconstruction With Ovine Forestomach Matrix Grafts: A Prospective Study Open
Background: Complex and chronic lower extremity defects present a surgical challenge and can progress to eventual amputation if closure is not achieved. In addition to morbidity and mortality, these defects have a significant impact on pat…
View article: Phosphodiesterase 9 Inhibition Combined With Valsartan and With Sacubitril/Valsartan in Experimental Ovine Heart Failure
Phosphodiesterase 9 Inhibition Combined With Valsartan and With Sacubitril/Valsartan in Experimental Ovine Heart Failure Open
Background LCZ696 (sacubitril/valsartan) antagonizes the renin–angiotensin system while simultaneously augmenting the natriuretic peptides (NPs). Inhibition of phosphodiesterase 9 inhibition (PDE9i), which hydrolyses NP‐generated cGMP may …
View article: Fecal Myeloperoxidase Levels Reflect Disease Activity in Children With Crohn’s Disease
Fecal Myeloperoxidase Levels Reflect Disease Activity in Children With Crohn’s Disease Open
Background Crohn’s disease (CD) is a major form of inflammatory bowel disease (IBD) which has relapsing and remitting symptoms. Better ways to detect and monitor active disease are required for early diagnosis and optimal outcomes. We asse…
View article: Five- and ten-year follow-up of medial unicompartmental knee arthroplasties in obese and non-obese patients
Five- and ten-year follow-up of medial unicompartmental knee arthroplasties in obese and non-obese patients Open
Aims The aim of this study was to determine whether obesity had a detrimental effect on the long-term performance and survival of medial unicompartmental knee arthroplasties (UKAs). Methods This study reviewed prospectively collected funct…
View article: Intraoperative ‘space suits’ do not reduce periprosthetic joint infections in shoulder arthroplasty
Intraoperative ‘space suits’ do not reduce periprosthetic joint infections in shoulder arthroplasty Open
Aims Body exhaust suits or surgical helmet systems (colloquially, ‘space suits’) are frequently used in many forms of arthroplasty, with the aim of providing personal protection to surgeons and, perhaps, reducing periprosthetic joint infec…
View article: Protocol for a randomised controlled trial of ketamine versus ketamine and behavioural activation therapy for adults with treatment-resistant depression in the community
Protocol for a randomised controlled trial of ketamine versus ketamine and behavioural activation therapy for adults with treatment-resistant depression in the community Open
Introduction Although short-term benefits follow parenteral ketamine for treatment-resistant major depressive disorder (TR-MDD), there are challenges that prevent routine use of ketamine by clinicians. These include acute dissociative effe…
View article: The effect of age on emotion processing in individuals with mood disorders and in healthy individuals
The effect of age on emotion processing in individuals with mood disorders and in healthy individuals Open
Introduction Emotion processing is an essential part of interpersonal relationships and social interactions. Changes in emotion processing have been found in both mood disorders and in aging, however, the interaction between such factors h…
View article: My orthopaedic surgeon suggests a unicompartmental knee replacement: a detailed look at the long-term outcomes of a single surgeon’s practice
My orthopaedic surgeon suggests a unicompartmental knee replacement: a detailed look at the long-term outcomes of a single surgeon’s practice Open
aim: This single surgeon case series with up to 29-year follow-up evaluated the survival of the Oxford unicompartmental knee replacement (UKR) for isolated medial compartment osteoarthritis. method: Four hundred and four knees in 330 patie…
View article: Designing and validating a research questionnaire - Part 2
Designing and validating a research questionnaire - Part 2 Open
Validity and reliability refer to the accuracy and consistency of a research tool. In the previous article in this series, we examined the development of a research questionnaire. In this article, we discuss the methods of determining the …
View article: Rheumatoid interstitial lung disease in Canterbury, Aotearoa New Zealand – A retrospective cohort study
Rheumatoid interstitial lung disease in Canterbury, Aotearoa New Zealand – A retrospective cohort study Open
Clinically evident RA-ILD occurred in approximately 5 % of individuals with RA. Mortality was increased almost fourfold compared to the general population. Radiologic extent was the most important prognostic factor.
View article: Randomized controlled trial of effects of a familiarization video and patient‐controlled Entonox inhalation on patient stress levels and clinical efficacy of flexible sigmoidoscopy without analgesia or sedation for investigation of fresh rectal bleeding
Randomized controlled trial of effects of a familiarization video and patient‐controlled Entonox inhalation on patient stress levels and clinical efficacy of flexible sigmoidoscopy without analgesia or sedation for investigation of fresh rectal bleeding Open
Background and Aim Flexible sigmoidoscopy (FS) without analgesia or sedation can be unpleasant for patients, resulting in unsatisfactory examinations. Prior familiarization videos (FVs) and intra‐procedural Entonox inhalation have shown in…
View article: Effect of surgeon‐specific feedback on surgical outcomes: a systematic review of the literature
Effect of surgeon‐specific feedback on surgical outcomes: a systematic review of the literature Open
Background Surgeon‐specific outcome reporting provides an opportunity for quality assurance and improved surgical results. It is becoming increasingly prevalent and remains contentious amongst surgeons. The purpose of this systematic revie…
View article: Immediate effect of caffeine on sympathetic nerve activity: why coffee is safe? A single-centre crossover study
Immediate effect of caffeine on sympathetic nerve activity: why coffee is safe? A single-centre crossover study Open
View article: Rising Kawasaki disease incidence in New Zealand: analysis of national population incidence and outcomes 2000–2017
Rising Kawasaki disease incidence in New Zealand: analysis of national population incidence and outcomes 2000–2017 Open
Objective The recent epidemiology of Kawasaki disease (KD) in New Zealand (NZ) is unknown. Our aim was to describe the incidence, seasonal variation, long-term outcomes and mortality for KD in NZ. Design Retrospective national database ana…
View article: Consensus-defined sarcopenia predicts adverse outcomes after elective abdominal surgery: meta-analysis
Consensus-defined sarcopenia predicts adverse outcomes after elective abdominal surgery: meta-analysis Open
Background Sarcopenia refers to the progressive age- or pathology-associated loss of skeletal muscle. When measured radiologically as reduced muscle mass, sarcopenia has been shown to independently predict morbidity and mortality after ele…