Christopher G. Willett
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View article: Comorbibities, Opportunistic Infections, and Helminth Infections Among HIV-positive Patients at a Small Hospital in Delhi, India
Comorbibities, Opportunistic Infections, and Helminth Infections Among HIV-positive Patients at a Small Hospital in Delhi, India Open
Introduction: Immunosuppressed people with HIV/AIDS have increased risk for opportunistic infections (OIs), and poverty can exacerbate this risk. This retrospective cohort study describes the health situation of vulnerable patients receivi…
View article: Colon Cancer, Version 3.2024, NCCN Clinical Practice Guidelines in Oncology
Colon Cancer, Version 3.2024, NCCN Clinical Practice Guidelines in Oncology Open
Colorectal cancer (CRC) is the fourth most frequently diagnosed cancer and the second leading cause of cancer death in the United States. Management of disseminated metastatic CRC involves various active drugs, either in combination or as …
View article: Updates in the Management of Locally Advanced Rectal Cancer
Updates in the Management of Locally Advanced Rectal Cancer Open
A plethora of advancements in the management of locally advanced rectal cancer continue to be developed. Treatment strategies have primarily focused on modifying the current standard paradigm of rectal cancer management—including the compl…
View article: Characterization and modeling of bistable laminates for kinetic shading screens
Characterization and modeling of bistable laminates for kinetic shading screens Open
There is an critical need in kinetic envelope design to propose sustainable solutions that can adjust to changing outdoor conditions. Bistable composite laminates are compliant systems appealing for kinetic building envelopes because they …
View article: Anal Carcinoma, Version 2.2023, NCCN Clinical Practice Guidelines in Oncology
Anal Carcinoma, Version 2.2023, NCCN Clinical Practice Guidelines in Oncology Open
This discussion summarizes the NCCN Clinical Practice Guidelines for managing squamous cell anal carcinoma, which represents the most common histologic form of the disease. A multidisciplinary approach including physicians from gastroenter…
View article: Esophageal and Esophagogastric Junction Cancers, Version 2.2023, NCCN Clinical Practice Guidelines in Oncology
Esophageal and Esophagogastric Junction Cancers, Version 2.2023, NCCN Clinical Practice Guidelines in Oncology Open
Cancers originating in the esophagus or esophagogastric junction constitute a major global health problem. Esophageal cancers are histologically classified as squamous cell carcinoma (SCC) or adenocarcinoma, which differ in their etiology,…
View article: Related Article from Epigenetic Markers in Rectal Cancer
Related Article from Epigenetic Markers in Rectal Cancer Open
Related Article from Epigenetic Markers in Rectal Cancer
View article: Data from Epigenetic Markers in Rectal Cancer
Data from Epigenetic Markers in Rectal Cancer Open
DNA methylation changes in rectal cancer may serve as a new screening marker and a tool for monitoring recurrence. Importantly, these changes may also function as a predictive marker to allow appropriate exclusion of (neo)adjuvant therapie…
View article: Related Article from Epigenetic Markers in Rectal Cancer
Related Article from Epigenetic Markers in Rectal Cancer Open
Related Article from Epigenetic Markers in Rectal Cancer
View article: Data from Epigenetic Markers in Rectal Cancer
Data from Epigenetic Markers in Rectal Cancer Open
DNA methylation changes in rectal cancer may serve as a new screening marker and a tool for monitoring recurrence. Importantly, these changes may also function as a predictive marker to allow appropriate exclusion of (neo)adjuvant therapie…
View article: Supplementary Table S1 from Long-term Consequences of Pelvic Irradiation: Toxicities, Challenges, and Therapeutic Opportunities with Pharmacologic Mitigators
Supplementary Table S1 from Long-term Consequences of Pelvic Irradiation: Toxicities, Challenges, and Therapeutic Opportunities with Pharmacologic Mitigators Open
Summary of Patient Related Factors Associated with Pelvic Radiation Disease
View article: Supplementary Table S1 from Long-term Consequences of Pelvic Irradiation: Toxicities, Challenges, and Therapeutic Opportunities with Pharmacologic Mitigators
Supplementary Table S1 from Long-term Consequences of Pelvic Irradiation: Toxicities, Challenges, and Therapeutic Opportunities with Pharmacologic Mitigators Open
Summary of Patient Related Factors Associated with Pelvic Radiation Disease
View article: Data from Long-term Consequences of Pelvic Irradiation: Toxicities, Challenges, and Therapeutic Opportunities with Pharmacologic Mitigators
Data from Long-term Consequences of Pelvic Irradiation: Toxicities, Challenges, and Therapeutic Opportunities with Pharmacologic Mitigators Open
A percentage of long-term cancer survivors who receive pelvic irradiation will develop treatment-related late effects, collectively termed pelvic radiation disease. Thus, there is a need to prevent or ameliorate treatment-related late effe…
View article: Data from Long-term Consequences of Pelvic Irradiation: Toxicities, Challenges, and Therapeutic Opportunities with Pharmacologic Mitigators
Data from Long-term Consequences of Pelvic Irradiation: Toxicities, Challenges, and Therapeutic Opportunities with Pharmacologic Mitigators Open
A percentage of long-term cancer survivors who receive pelvic irradiation will develop treatment-related late effects, collectively termed pelvic radiation disease. Thus, there is a need to prevent or ameliorate treatment-related late effe…
View article: Rectal Cancer, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology
Rectal Cancer, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology Open
This selection from the NCCN Guidelines for Rectal Cancer focuses on management of malignant polyps and resectable nonmetastatic rectal cancer because important updates have been made to these guidelines. These recent updates include redra…
View article: Gastric Cancer, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology
Gastric Cancer, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology Open
Gastric cancer is the third leading cause of cancer-related deaths worldwide. Over 95% of gastric cancers are adenocarcinomas, which are typically classified based on anatomic location and histologic type. Gastric cancer generally carries …
View article: Transfer learning for fluence map prediction in adrenal stereotactic body radiation therapy
Transfer learning for fluence map prediction in adrenal stereotactic body radiation therapy Open
Objective: To design a deep transfer learning framework for modeling fluence map predictions for stereotactic body radiation therapy (SBRT) of adrenal cancer and similar sites that usually have a small number of cases. Approach: We develop…
View article: Treatment of Locally Advanced/Metastatic Colorectal Cancer
Treatment of Locally Advanced/Metastatic Colorectal Cancer Open
Few treatment advances have been observed in recent years for the treatment of advanced colorectal cancer (CRC). The goal remains to find approaches beyond FOLFOX and bevacizumab that will prolong remission. Immunotherapy for patients with…
View article: Deep Learning–Based Fluence Map Prediction for Pancreas Stereotactic Body Radiation Therapy With Simultaneous Integrated Boost
Deep Learning–Based Fluence Map Prediction for Pancreas Stereotactic Body Radiation Therapy With Simultaneous Integrated Boost Open
The DL framework can effectively plan pancreas SBRT cases within 2 minutes. The predicted plans are clinically deliverable, with plan quality approaching that of manual planning.
View article: Phase III Trial of Trimodality Therapy With Cisplatin, Fluorouracil, Radiotherapy, and Surgery Compared With Surgery Alone for Esophageal Cancer: CALGB 9781
Phase III Trial of Trimodality Therapy With Cisplatin, Fluorouracil, Radiotherapy, and Surgery Compared With Surgery Alone for Esophageal Cancer: CALGB 9781 Open
The primary treatment modality for patients with carcinoma of the esophagus or gastroesophageal junction has been surgery, although primary radiation therapy with concurrent chemotherapy produces similar results. As both have curative pote…
View article: An interpretable planning bot for pancreas stereotactic body radiation therapy
An interpretable planning bot for pancreas stereotactic body radiation therapy Open
Pancreas stereotactic body radiotherapy treatment planning requires planners to make sequential, time consuming interactions with the treatment planning system (TPS) to reach the optimal dose distribution. We seek to develop a reinforcemen…
View article: Fluence Map Prediction Using Deep Learning Models – Direct Plan Generation for Pancreas Stereotactic Body Radiation Therapy
Fluence Map Prediction Using Deep Learning Models – Direct Plan Generation for Pancreas Stereotactic Body Radiation Therapy Open
Purpose: Treatment planning for pancreas stereotactic body radiation therapy (SBRT) is a difficult and time-consuming task. In this study, we aim to develop a novel deep learning framework to generate clinical-quality plans by direct predi…
View article: NCCN Guidelines Insights: Rectal Cancer, Version 6.2020
NCCN Guidelines Insights: Rectal Cancer, Version 6.2020 Open
The NCCN Guidelines for Rectal Cancer provide recommendations for the diagnosis, evaluation, treatment, and follow-up of patients with rectal cancer. These NCCN Guidelines Insights summarize the panel discussion behind recent important upd…
View article: Trimodal Therapy Approaches for Localized Rectal Cancer
Trimodal Therapy Approaches for Localized Rectal Cancer Open
Excellent long-term outcomes and manageable toxicity are being achieved with contemporary treatment strategies for rectal cancer. Short-course radiotherapy is now an acceptable standard. Total neoadjuvant therapy (TNT), which incorporates …