Christopher G. Wood
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View article: Hearing Loss, Brain Structure, Cognition, and Dementia Risk in the Framingham Heart Study
Hearing Loss, Brain Structure, Cognition, and Dementia Risk in the Framingham Heart Study Open
Importance Age-related hearing loss is a potentially modifiable risk factor for cognitive impairment and dementia. Objective To investigate the association of hearing loss with brain structure changes, cognitive function, and incident deme…
View article: A streamlined <scp>Emergency Department</scp> approach to moderate risk chest pain in patients with no pre‐existing coronary artery disease: A pilot study
A streamlined <span>Emergency Department</span> approach to moderate risk chest pain in patients with no pre‐existing coronary artery disease: A pilot study Open
Objective Moderate risk patients with chest pain and no previously diagnosed coronary artery disease (CAD) who present to ED require further risk stratification. We hypothesise that management of these patients by ED physicians can decreas…
View article: Evaluating practical QUIC website fingerprinting defenses for the masses
Evaluating practical QUIC website fingerprinting defenses for the masses Open
Website fingerprinting (WF) is a well-known threat to users' web privacy. New Internet standards, such as QUIC, include padding to support defenses against WF. Previous work on QUIC WF only analyzes the effectiveness of defenses when users…
View article: Data from Assessing Metabolic Intervention with a Glutaminase Inhibitor in Real-Time by Hyperpolarized Magnetic Resonance in Acute Myeloid Leukemia
Data from Assessing Metabolic Intervention with a Glutaminase Inhibitor in Real-Time by Hyperpolarized Magnetic Resonance in Acute Myeloid Leukemia Open
Acute myeloid leukemia (AML) is an aggressive hematopoietic disease characterized by glutamine-dependent metabolism. A novel glutaminase (GLS) inhibitor, CB-839, is currently under evaluation for treatment of hematopoietic malignancies and…
View article: Supplementary Methods from Sarcomatoid Renal Cell Carcinoma Has a Distinct Molecular Pathogenesis, Driver Mutation Profile, and Transcriptional Landscape
Supplementary Methods from Sarcomatoid Renal Cell Carcinoma Has a Distinct Molecular Pathogenesis, Driver Mutation Profile, and Transcriptional Landscape Open
Supplemental Methods 1. Exome sequencing pipeline Supplemental Methods 2. RNA seq pipeline Supplemental Methods 3. DNA methylation profiling pipeline Supplemental Methods 4. Fluorescence in situ hybridization Supplemental Methods 5. TCGA s…
View article: Data from Cytoplasmic Sequestration of p27 via AKT Phosphorylation in Renal Cell Carcinoma
Data from Cytoplasmic Sequestration of p27 via AKT Phosphorylation in Renal Cell Carcinoma Open
Purpose: p27 localization and expression has prognostic and predictive value in cancer. Little is known regarding expression patterns of p27 in renal cell carcinoma (RCC) or how p27 participates in disease progression or response to therap…
View article: Supplementary Table 6 from Next-Generation Sequencing of Translocation Renal Cell Carcinoma Reveals Novel RNA Splicing Partners and Frequent Mutations of Chromatin-Remodeling Genes
Supplementary Table 6 from Next-Generation Sequencing of Translocation Renal Cell Carcinoma Reveals Novel RNA Splicing Partners and Frequent Mutations of Chromatin-Remodeling Genes Open
XLSX file - 39K, List of somatic mutations discovered in exome sequencing in MITF/TFE TRCC cases.
View article: Data from Results of the ADAPT Phase 3 Study of Rocapuldencel-T in Combination with Sunitinib as First-Line Therapy in Patients with Metastatic Renal Cell Carcinoma
Data from Results of the ADAPT Phase 3 Study of Rocapuldencel-T in Combination with Sunitinib as First-Line Therapy in Patients with Metastatic Renal Cell Carcinoma Open
Purpose:Rocapuldencel-T is an autologous immunotherapy prepared from mature monocyte-derived dendritic cells (DC), coelectroporated with amplified tumor RNA plus CD40L RNA. This pivotal phase III trial was initiated to investigate the safe…
View article: Supplementary Table 10-12 from DNA Methylation Signature Reveals Cell Ontogeny of Renal Cell Carcinomas
Supplementary Table 10-12 from DNA Methylation Signature Reveals Cell Ontogeny of Renal Cell Carcinomas Open
Supplementary Table 10: List of samples misclassified among the clear-cell renal cell carcinomas dataset with the corresponding new classification. Among those, many of them have been demonstrated to belong to the C4 cluster of long non-co…
View article: Figures S1-S10 from Sarcomatoid Renal Cell Carcinoma Has a Distinct Molecular Pathogenesis, Driver Mutation Profile, and Transcriptional Landscape
Figures S1-S10 from Sarcomatoid Renal Cell Carcinoma Has a Distinct Molecular Pathogenesis, Driver Mutation Profile, and Transcriptional Landscape Open
Figure S1. Biphasic histologic components of sarcomatoid renal cell carcinoma. The macrodissected paired epithelioid or carcinomatous (E) and spindled or sarcomatoid (S) components of clear cell RCC (upper panel), Papillary RCC (middle pan…
View article: Table S1 from Results of the ADAPT Phase 3 Study of Rocapuldencel-T in Combination with Sunitinib as First-Line Therapy in Patients with Metastatic Renal Cell Carcinoma
Table S1 from Results of the ADAPT Phase 3 Study of Rocapuldencel-T in Combination with Sunitinib as First-Line Therapy in Patients with Metastatic Renal Cell Carcinoma Open
subsequent standard of care treaments
View article: Supplementary Figures from Autotaxin–Lysophosphatidic Acid Signaling Axis Mediates Tumorigenesis and Development of Acquired Resistance to Sunitinib in Renal Cell Carcinoma
Supplementary Figures from Autotaxin–Lysophosphatidic Acid Signaling Axis Mediates Tumorigenesis and Development of Acquired Resistance to Sunitinib in Renal Cell Carcinoma Open
PDF file 353K, Supplemental Figure 1. Identification of ATX/ENPP2 in sunitinib-treated RCC endothelium. (A) Gene expression analyses of known endothelial markers between anti-CD31-coated magnetic beads-bound renal endothelial population an…
View article: Supplementary Tables from Potential Susceptibility Loci Identified for Renal Cell Carcinoma by Targeting Obesity-Related Genes
Supplementary Tables from Potential Susceptibility Loci Identified for Renal Cell Carcinoma by Targeting Obesity-Related Genes Open
Table S1. Obesity relevant pathways selected from Biocarta, KEGG and Reactome pathway databases Table S2. Meta-analysis of 21 SNPs in phase I MDA-GWAS and phase II NCI-GWAS Table S3. Validation of 19 SNPs in phase III MDA-Oncoarray Table S…
View article: Data from Autotaxin–Lysophosphatidic Acid Signaling Axis Mediates Tumorigenesis and Development of Acquired Resistance to Sunitinib in Renal Cell Carcinoma
Data from Autotaxin–Lysophosphatidic Acid Signaling Axis Mediates Tumorigenesis and Development of Acquired Resistance to Sunitinib in Renal Cell Carcinoma Open
Purpose: Sunitinib is currently considered as the standard treatment for advanced renal cell carcinoma (RCC). We aimed to better understand the mechanisms of sunitinib action in kidney cancer treatment and in the development of acquired re…
View article: Data from Effects of Adjuvant Sorafenib and Sunitinib on Cardiac Function in Renal Cell Carcinoma Patients without Overt Metastases: Results from ASSURE, ECOG 2805
Data from Effects of Adjuvant Sorafenib and Sunitinib on Cardiac Function in Renal Cell Carcinoma Patients without Overt Metastases: Results from ASSURE, ECOG 2805 Open
Purpose: Sunitinib and sorafenib are used widely in the treatment of renal cell carcinoma (RCC). These agents are associated with a significant incidence of cardiovascular (CV) dysfunction and left ventricular ejection fraction (LVEF) decl…
View article: Table S1 from Results of the ADAPT Phase 3 Study of Rocapuldencel-T in Combination with Sunitinib as First-Line Therapy in Patients with Metastatic Renal Cell Carcinoma
Table S1 from Results of the ADAPT Phase 3 Study of Rocapuldencel-T in Combination with Sunitinib as First-Line Therapy in Patients with Metastatic Renal Cell Carcinoma Open
subsequent standard of care treaments
View article: Figure 1S from Results of the ADAPT Phase 3 Study of Rocapuldencel-T in Combination with Sunitinib as First-Line Therapy in Patients with Metastatic Renal Cell Carcinoma
Figure 1S from Results of the ADAPT Phase 3 Study of Rocapuldencel-T in Combination with Sunitinib as First-Line Therapy in Patients with Metastatic Renal Cell Carcinoma Open
Consort diagram
View article: Supplementary Table 1 from Next-Generation Sequencing of Translocation Renal Cell Carcinoma Reveals Novel RNA Splicing Partners and Frequent Mutations of Chromatin-Remodeling Genes
Supplementary Table 1 from Next-Generation Sequencing of Translocation Renal Cell Carcinoma Reveals Novel RNA Splicing Partners and Frequent Mutations of Chromatin-Remodeling Genes Open
XLSX file - 20K, Clinicopathological features of MITF/TFE TRCC samples selected in our cohort for RNA and exome sequencing.
View article: Supplementary Tables S7 from Sarcomatoid Renal Cell Carcinoma Has a Distinct Molecular Pathogenesis, Driver Mutation Profile, and Transcriptional Landscape
Supplementary Tables S7 from Sarcomatoid Renal Cell Carcinoma Has a Distinct Molecular Pathogenesis, Driver Mutation Profile, and Transcriptional Landscape Open
Table S7a. Ingenuity Pathway Analysis of SRCC vs RCC Table S7b. Ingenuity Pathway Analysis of SccRCC vs advanced stage ccRCC Table S7c. Ingenuity Pathway Analysis of E vs S components of ccRCC
View article: Supplementary Table 5 from Next-Generation Sequencing of Translocation Renal Cell Carcinoma Reveals Novel RNA Splicing Partners and Frequent Mutations of Chromatin-Remodeling Genes
Supplementary Table 5 from Next-Generation Sequencing of Translocation Renal Cell Carcinoma Reveals Novel RNA Splicing Partners and Frequent Mutations of Chromatin-Remodeling Genes Open
XLSX file - 10K, List of all ccRCC included from the TCGA with the identified translocations in each sample.
View article: Data from Potential Susceptibility Loci Identified for Renal Cell Carcinoma by Targeting Obesity-Related Genes
Data from Potential Susceptibility Loci Identified for Renal Cell Carcinoma by Targeting Obesity-Related Genes Open
Background: Obesity is an established risk factor for renal cell carcinoma (RCC). Although genome-wide association studies (GWAS) of RCC have identified several susceptibility loci, additional variants might be missed due to the highly con…
View article: Supplementary Figures from Autotaxin–Lysophosphatidic Acid Signaling Axis Mediates Tumorigenesis and Development of Acquired Resistance to Sunitinib in Renal Cell Carcinoma
Supplementary Figures from Autotaxin–Lysophosphatidic Acid Signaling Axis Mediates Tumorigenesis and Development of Acquired Resistance to Sunitinib in Renal Cell Carcinoma Open
PDF file 353K, Supplemental Figure 1. Identification of ATX/ENPP2 in sunitinib-treated RCC endothelium. (A) Gene expression analyses of known endothelial markers between anti-CD31-coated magnetic beads-bound renal endothelial population an…
View article: Supplementary Table 2 from Next-Generation Sequencing of Translocation Renal Cell Carcinoma Reveals Novel RNA Splicing Partners and Frequent Mutations of Chromatin-Remodeling Genes
Supplementary Table 2 from Next-Generation Sequencing of Translocation Renal Cell Carcinoma Reveals Novel RNA Splicing Partners and Frequent Mutations of Chromatin-Remodeling Genes Open
XLSX file - 12K, List of fusion transcripts identified in our dataset with validation accuracy.
View article: Data from Genomic DNA Hypomethylation and Risk of Renal Cell Carcinoma: A Case–Control Study
Data from Genomic DNA Hypomethylation and Risk of Renal Cell Carcinoma: A Case–Control Study Open
Purpose: Genomic DNA hypomethylation is a hallmark of most cancer genomes, promoting genomic instability and cell transformation. In the present study, we sought to determine whether global DNA methylation in peripheral blood is associated…
View article: Data from Macrophage HIF-1α Is an Independent Prognostic Indicator in Kidney Cancer
Data from Macrophage HIF-1α Is an Independent Prognostic Indicator in Kidney Cancer Open
Purpose:Clear cell renal cell carcinoma (ccRCC) is frequently associated with inactivation of the von Hippel–Lindau tumor suppressor, resulting in activation of HIF-1α and HIF-2α. The current paradigm, established using mechanistic cell-ba…
View article: Data from Potential Susceptibility Loci Identified for Renal Cell Carcinoma by Targeting Obesity-Related Genes
Data from Potential Susceptibility Loci Identified for Renal Cell Carcinoma by Targeting Obesity-Related Genes Open
Background: Obesity is an established risk factor for renal cell carcinoma (RCC). Although genome-wide association studies (GWAS) of RCC have identified several susceptibility loci, additional variants might be missed due to the highly con…
View article: Data from Genomic Heterogeneity of Translocation Renal Cell Carcinoma
Data from Genomic Heterogeneity of Translocation Renal Cell Carcinoma Open
Purpose: Translocation renal cell carcinoma (tRCC) is a rare subtype of kidney cancer involving the TFEB/TFE3 genes. We aimed to investigate the genomic and epigenetic features of this entity.Experimental Design: Cytogenomic analysis was c…
View article: Data from DNA Methylation Signature Reveals Cell Ontogeny of Renal Cell Carcinomas
Data from DNA Methylation Signature Reveals Cell Ontogeny of Renal Cell Carcinomas Open
Purpose: DNA methylation is a heritable covalent modification that is developmentally regulated and is critical in tissue-type definition. Although genotype–phenotype correlations have been described for different subtypes of renal cell ca…
View article: Supplementary Table 4 from Next-Generation Sequencing of Translocation Renal Cell Carcinoma Reveals Novel RNA Splicing Partners and Frequent Mutations of Chromatin-Remodeling Genes
Supplementary Table 4 from Next-Generation Sequencing of Translocation Renal Cell Carcinoma Reveals Novel RNA Splicing Partners and Frequent Mutations of Chromatin-Remodeling Genes Open
XLSX file - 172K, List of genes that have been reported previously to be involved in translocations.