Christopher Gingles
YOU?
Author Swipe
Constrictive pericarditis requiring pericardiectomy: an unusual first presentation of extra-articular rheumatoid arthritis—a case report Open
Background We report an unusual case of rheumatoid arthritis presenting for the first time with pericardial constriction and bilateral pleural calcification, in the absence of prior articular disease. Case summary A 46-year-old Caucasian m…
View article: Association between mitochondrial function measured by 31P magnetic resonance spectroscopy and physical performance in older people with functional impairment
Association between mitochondrial function measured by 31P magnetic resonance spectroscopy and physical performance in older people with functional impairment Open
Background Mitochondrial dysfunction is a potential therapeutic target to improve skeletal muscle function, but the contribution of mitochondrial dysfunction to impaired skeletal muscle performance in older people remains unclear. The aim …
View article: 42 Is Mitochondrial Function Measured by 31P Magnetic Resonance Spectroscopy Associated with Physical Performance in Older People with Functional Impairment?
42 Is Mitochondrial Function Measured by 31P Magnetic Resonance Spectroscopy Associated with Physical Performance in Older People with Functional Impairment? Open
Background Mitochondrial dysfunction has been proposed as a therapeutic target to improve muscle strength and endurance, but the contribution that mitochondrial dysfunction makes to impaired skeletal muscle performance in older people rema…
Antiphospholipid syndrome leading to paradoxical embolus and stroke via secundum atrial septal defect Open
We have presented a case of a 22-year-old man, presenting with cerebral infarct, subsequently found to have antiphospholipid syndrome (APS), deep venous thrombosis, pulmonary embolism and atrial septal defect (ASD), thereby confirming the …
View article: Effect of allopurinol on phosphocreatine recovery and muscle function in older people with impaired physical function: a randomised controlled trial
Effect of allopurinol on phosphocreatine recovery and muscle function in older people with impaired physical function: a randomised controlled trial Open
Background Allopurinol has vascular antioxidant effects and participates in purinergic signalling within muscle. We tested whether allopurinol could improve skeletal muscle energetics and physical function in older people with impaired phy…
Allopurinol treatment adversely impacts left ventricular mass regression in patients with well-controlled hypertension Open
Treatment with high-dose allopurinol in normouricemic controlled hypertensive patients and LV hypertrophy is detrimental. It results in reduced LV mass regression and increased oxidative stress over a 12-month period. This may be because o…
LOWERING URIC ACID IN NORMOURICAEMIC HYPERTENSIVE PATIENTS HAS AN ADVERSE EFFECT ON LEFT VENTRICULAR HYPERTROPHY REGRESSION Open
Objective: Urate is the most abundant aqueous antioxidant in humans but is pro-oxidant under certain conditions. Allopurinol has been shown to regress left ventricular hypertrophy (LVH) in cohorts with established cardiovascular and cardio…